1G30
THROMBIN INHIBITOR COMPLEX
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004252 | molecular_function | serine-type endopeptidase activity |
A | 0005576 | cellular_component | extracellular region |
A | 0006508 | biological_process | proteolysis |
A | 0007596 | biological_process | blood coagulation |
B | 0004252 | molecular_function | serine-type endopeptidase activity |
B | 0005509 | molecular_function | calcium ion binding |
B | 0006508 | biological_process | proteolysis |
B | 0007596 | biological_process | blood coagulation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE T87 B 1 |
Chain | Residue |
B | HIS57 |
B | SER195 |
B | VAL213 |
B | SER214 |
B | TRP215 |
B | GLY216 |
B | GLU217 |
B | GLY219 |
B | GLY226 |
B | HOH662 |
B | TYR60 |
B | TRP60 |
B | GLU97 |
B | ASN98 |
B | LEU99 |
B | ILE174 |
B | ASP189 |
B | ALA190 |
site_id | AC2 |
Number of Residues | 18 |
Details | BINDING SITE FOR CHAIN C OF HIRUDIN IIB |
Chain | Residue |
B | PHE34 |
B | GLN38 |
B | ARG67 |
B | ARG73 |
B | THR74 |
B | ARG75 |
B | ARG75 |
B | TYR76 |
B | LYS81 |
B | ILE82 |
B | MET84 |
B | HOH540 |
B | HOH694 |
C | HOH574 |
C | HOH586 |
C | HOH631 |
C | HOH654 |
C | HOH688 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 22 |
Details | Region: {"description":"High affinity receptor-binding region which is also known as the TP508 peptide"} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | Active site: {"description":"Charge relay system"} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"873923","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
B | ASP102 | |
B | HIS57 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
B | SER195 | |
B | GLY196 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
B | SER195 | |
B | GLY193 |
site_id | CSA4 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
B | ASP102 | |
B | SER195 | |
B | GLY193 | |
B | HIS57 |
site_id | CSA5 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
B | ASP102 | |
B | SER195 | |
B | HIS57 |
site_id | CSA6 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
B | ASP102 | |
B | SER195 | |
B | HIS57 | |
B | GLY196 |