Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004032 | molecular_function | aldose reductase (NADPH) activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016918 | molecular_function | retinal binding |
A | 0019751 | biological_process | polyol metabolic process |
A | 0042572 | biological_process | retinol metabolic process |
A | 0042574 | biological_process | retinal metabolic process |
A | 0052650 | molecular_function | all-trans-retinol dehydrogenase (NADP+) activity |
A | 0070401 | molecular_function | NADP+ binding |
A | 0070402 | molecular_function | NADPH binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 33 |
Details | BINDING SITE FOR RESIDUE NDP A 350 |
Chain | Residue |
A | GLY18 |
A | GLN183 |
A | TYR209 |
A | SER210 |
A | PRO211 |
A | LEU212 |
A | GLY213 |
A | SER214 |
A | PRO215 |
A | ASP216 |
A | ALA245 |
A | THR19 |
A | ILE260 |
A | PRO261 |
A | LYS262 |
A | SER263 |
A | VAL264 |
A | THR265 |
A | ARG268 |
A | GLU271 |
A | ASN272 |
A | ZST351 |
A | TRP20 |
A | HOH536 |
A | HOH540 |
A | HOH731 |
A | HOH739 |
A | LYS21 |
A | ASP43 |
A | TYR48 |
A | TRP111 |
A | SER159 |
A | ASN160 |
site_id | AC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE ZST A 351 |
Chain | Residue |
A | TRP20 |
A | TYR48 |
A | HIS110 |
A | TRP111 |
A | GLN113 |
A | PHE122 |
A | CYS298 |
A | LEU300 |
A | THR303 |
A | MET306 |
A | PRO310 |
A | NDP350 |
A | HOH567 |
A | HOH571 |
A | HOH732 |
Functional Information from PROSITE/UniProt
site_id | PS00062 |
Number of Residues | 18 |
Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MeelvdqglVKALGVSNF |
Chain | Residue | Details |
A | MET144-PHE161 | |
site_id | PS00063 |
Number of Residues | 16 |
Details | ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPKSVTpsRIqENiQV |
Chain | Residue | Details |
A | ILE260-VAL275 | |
site_id | PS00798 |
Number of Residues | 18 |
Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDCAyaycnEneVG |
Chain | Residue | Details |
A | GLY38-GLY55 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor |
Chain | Residue | Details |
A | CYS49 | |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: |
Chain | Residue | Details |
A | TRP111 | |
Chain | Residue | Details |
A | PRO211 | |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | SITE: Lowers pKa of active site Tyr => ECO:0000250 |
Chain | Residue | Details |
A | LEU78 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1mrq |
Chain | Residue | Details |
A | TYR48 | |
A | ASP43 | |
A | HIS110 | |
A | LYS77 | |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1mrq |
Chain | Residue | Details |
A | TYR48 | |
A | LYS77 | |