1FRB

FR-1 PROTEIN/NADPH/ZOPOLRESTAT COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001758	molecular_function	retinal dehydrogenase (NAD+) activity
A	0004032	molecular_function	aldose reductase (NADPH) activity
A	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)+] activity
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005764	cellular_component	lysosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0016918	molecular_function	retinal binding
A	0019751	biological_process	polyol metabolic process
A	0042572	biological_process	retinol metabolic process
A	0042574	biological_process	retinal metabolic process
A	0045550	molecular_function	geranylgeranyl reductase activity
A	0047718	molecular_function	indanol dehydrogenase activity
A	0052650	molecular_function	all-trans-retinol dehydrogenase (NADP+) activity
A	0070401	molecular_function	NADP+ binding
A	0070402	molecular_function	NADPH binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	33
Details	BINDING SITE FOR RESIDUE NDP A 350

Chain	Residue
A	GLY18
A	GLN183
A	TYR209
A	SER210
A	PRO211
A	LEU212
A	GLY213
A	SER214
A	PRO215
A	ASP216
A	ALA245
A	THR19
A	ILE260
A	PRO261
A	LYS262
A	SER263
A	VAL264
A	THR265
A	ARG268
A	GLU271
A	ASN272
A	ZST351
A	TRP20
A	HOH536
A	HOH540
A	HOH731
A	HOH739
A	LYS21
A	ASP43
A	TYR48
A	TRP111
A	SER159
A	ASN160

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ZST A 351

Chain	Residue
A	TRP20
A	TYR48
A	HIS110
A	TRP111
A	GLN113
A	PHE122
A	CYS298
A	LEU300
A	THR303
A	MET306
A	PRO310
A	NDP350
A	HOH567
A	HOH571
A	HOH732

---

Functional Information from PROSITE/UniProt

site_id	PS00062
Number of Residues	18
Details	ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MeelvdqglVKALGVSNF

Chain	Residue	Details
A	MET144-PHE161

---

site_id	PS00063
Number of Residues	16
Details	ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPKSVTpsRIqENiQV

Chain	Residue	Details
A	ILE260-VAL275

---

site_id	PS00798
Number of Residues	18
Details	ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDCAyaycnEneVG

Chain	Residue	Details
A	GLY38-GLY55

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	62
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7578036","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Lowers pKa of active site Tyr","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1mrq

Chain	Residue	Details
A	TYR48
A	ASP43
A	HIS110
A	LYS77

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1mrq

Chain	Residue	Details
A	TYR48
A	LYS77

---