1FIT
FHIT (FRAGILE HISTIDINE TRIAD PROTEIN)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0001650 | cellular_component | fibrillar center |
A | 0003824 | molecular_function | catalytic activity |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006163 | biological_process | purine nucleotide metabolic process |
A | 0006915 | biological_process | apoptotic process |
A | 0015964 | biological_process | diadenosine triphosphate catabolic process |
A | 0016740 | molecular_function | transferase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0031625 | molecular_function | ubiquitin protein ligase binding |
A | 0032435 | biological_process | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
A | 0042802 | molecular_function | identical protein binding |
A | 0043530 | molecular_function | adenosine 5'-monophosphoramidase activity |
A | 0047352 | molecular_function | adenylylsulfate-ammonia adenylyltransferase activity |
A | 0047627 | molecular_function | adenylylsulfatase activity |
A | 0047710 | molecular_function | bis(5'-adenosyl)-triphosphatase activity |
A | 0072332 | biological_process | intrinsic apoptotic signaling pathway by p53 class mediator |
Functional Information from PDB Data
site_id | AVE |
Number of Residues | 1 |
Details | CATALYTIC HISTIDINE. |
Chain | Residue |
A | HIS96 |
Functional Information from PROSITE/UniProt
site_id | PS00892 |
Number of Residues | 19 |
Details | HIT_1 HIT domain signature. QdgpeAgQtVkHVHVHVLP |
Chain | Residue | Details |
A | GLN83-PRO101 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Tele-AMP-histidine intermediate => ECO:0000269|PubMed:15182206, ECO:0000269|PubMed:9323207 |
Chain | Residue | Details |
A | HIS96 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:9261067, ECO:0007744|PDB:3FIT |
Chain | Residue | Details |
A | HIS8 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:9323207, ECO:0007744|PDB:5FIT |
Chain | Residue | Details |
A | ASN27 | |
A | GLN83 | |
A | GLY89 | |
A | HIS98 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | SITE: Important for induction of apoptosis => ECO:0000269|PubMed:16407838 |
Chain | Residue | Details |
A | TYR114 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine; by SRC => ECO:0000269|PubMed:15007172 |
Chain | Residue | Details |
A | TYR114 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:15007172 |
Chain | Residue | Details |
A | TYR145 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 5fit |
Chain | Residue | Details |
A | GLN83 | |
A | HIS96 | |
A | HIS94 |
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 101 |
Chain | Residue | Details |
A | GLN83 | electrostatic stabiliser, hydrogen bond donor |
A | HIS94 | electrostatic stabiliser, increase electrophilicity, increase nucleophilicity |
A | HIS96 | metal ligand, nucleofuge, nucleophile |
A | HIS98 | electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor |