1FB1

CRYSTAL STRUCTURE OF HUMAN GTP CYCLOHYDROLASE I

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003934	molecular_function	GTP cyclohydrolase I activity
A	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0003934	molecular_function	GTP cyclohydrolase I activity
B	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0003934	molecular_function	GTP cyclohydrolase I activity
C	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0003934	molecular_function	GTP cyclohydrolase I activity
D	0046654	biological_process	tetrahydrofolate biosynthetic process
E	0003934	molecular_function	GTP cyclohydrolase I activity
E	0046654	biological_process	tetrahydrofolate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 300

Chain	Residue
A	CYS141
A	HIS144
A	CYS212
B	IPA302

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 300

Chain	Residue
B	CYS141
B	HIS144
B	CYS212
B	IPA303

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 300

Chain	Residue
C	HIS144
C	CYS212
D	IPA304
C	CYS141

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 300

Chain	Residue
D	CYS141
D	HIS144
D	CYS212
D	IPA305

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 300

Chain	Residue
A	IPA306
E	CYS141
E	HIS144
E	CYS212

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IPA B 302

Chain	Residue
A	HIS144
A	ZN300
B	GLY164
B	LEU165

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IPA B 303

Chain	Residue
B	CYS141
B	HIS143
B	HIS144
B	ZN300
C	LEU165
C	SER166

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IPA D 304

Chain	Residue
C	HIS143
C	HIS144
C	ZN300
D	GLY164
D	LEU165
D	SER166

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IPA D 305

Chain	Residue
D	HIS143
D	ZN300
E	SER166

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IPA A 306

Chain	Residue
A	LEU165
A	SER166
E	CYS141
E	HIS143
E	HIS144
E	ZN300

---

Functional Information from PROSITE/UniProt

site_id	PS00859
Number of Residues	17
Details	GTP_CYCLOHYDROL_1_1 GTP cyclohydrolase I signature 1. EMVivKDIdmfSmCEHH

Chain	Residue	Details
A	GLU128-HIS144

---

site_id	PS00860
Number of Residues	11
Details	GTP_CYCLOHYDROL_1_2 GTP cyclohydrolase I signature 2. SrRlQVQERLT

Chain	Residue	Details
A	SER176-THR186

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11087827","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17704208","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
A	HIS143
A	HIS210

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
B	HIS143
B	HIS210

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
C	HIS143
C	HIS210

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
D	HIS143
D	HIS210

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
E	HIS143
E	HIS210

---