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1EY2

HUMAN HOMOGENTISATE DIOXYGENASE WITH FE(II)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004411molecular_functionhomogentisate 1,2-dioxygenase activity
A0005515molecular_functionprotein binding
A0005829cellular_componentcytosol
A0006520biological_processamino acid metabolic process
A0006559biological_processL-phenylalanine catabolic process
A0006570biological_processtyrosine metabolic process
A0006572biological_processtyrosine catabolic process
A0042802molecular_functionidentical protein binding
A0046872molecular_functionmetal ion binding
A0051213molecular_functiondioxygenase activity
A0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE FE2 A 1001
ChainResidue
AHIS335
AGLU341
AHIS371
AHOH2231
AHOH2232

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:10876237, ECO:0007744|PDB:1EY2
ChainResidueDetails
AHIS335
AGLU341
AHIS371

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS98

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:O09173
ChainResidueDetails
ALYS414

Catalytic Information from CSA
site_idMCSA1
Number of Residues5
DetailsM-CSA 547
ChainResidueDetails
AHIS292electrostatic stabiliser, enhance reactivity
AHIS335metal ligand
AGLU341metal ligand
AHIS365proton acceptor, proton donor
AHIS371metal ligand

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PDB entries from 2024-11-06

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