1CVR

Crystal structure of the Arg specific cysteine proteinase gingipain R (RGPB)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE H37 A 501

Chain	Residue
A	ASP163
A	GLN282
A	TYR283
A	TRP284
A	MET288
A	HOH640
A	HOH724
A	HOH772
A	THR191
A	PRO192
A	GLY210
A	HIS211
A	GLY212
A	HIS221
A	VAL242
A	CYS244

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 502

Chain	Residue
A	GLU161
A	HIS166
A	ASP292
A	HOH717
A	HOH818
A	HOH882

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 503

Chain	Residue
A	ASP78
A	PHE249
A	GLU258
A	HOH632
A	HOH672
A	HOH690

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 504

Chain	Residue
A	VAL100
A	ASP103
A	TYR105
A	GLU107
A	HOH716
A	HOH819

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 505

Chain	Residue
A	GLU293
A	GLU296
A	HIS302
A	HOH619

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 506

Chain	Residue
A	HIS221
A	ASP328
A	HOH646
A	HOH677

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 507

Chain	Residue
A	GLU152
A	HIS211
A	TRP284
A	LYS327
A	HOH724
A	HOH920

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 508

Chain	Residue
A	GLU119
A	ASP387
A	GLU405
A	HOH712
A	HOH922

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 509

Chain	Residue
A	HIS130
A	ASN134
A	HOH852
A	HOH921

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:10523290, ECO:0007744|PDB:1CVR

Chain	Residue	Details
A	HIS211

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:23558682, ECO:0000305|PubMed:10523290, ECO:0007744|PDB:1CVR

Chain	Residue	Details
A	CYS244

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	BINDING: BINDING => ECO:0007744|PDB:1CVR

Chain	Residue	Details
A	ASP78
A	GLU161
A	HIS166
A	PHE249
A	GLU258
A	ASP292
A	GLU293
A	GLU296
A	HIS302

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0007744|PDB:1CVR, ECO:0007744|PDB:4IEF

Chain	Residue	Details
A	VAL100
A	ASP103
A	TYR105
A	GLU107

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744|PDB:4IEF

Chain	Residue	Details
A	ASP384
A	GLU410

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	a catalytic site defined by CSA, PubMed 10523290

Chain	Residue	Details
A	GLY212
A	GLU152
A	HIS211
A	CYS244
A	CYS244

---

site_id	MCSA1
Number of Residues	4
Details	M-CSA 806

Chain	Residue	Details
A	GLU152	electrostatic stabiliser
A	HIS211	proton acceptor, proton donor
A	GLY212	electrostatic stabiliser
A	CYS244	electrostatic stabiliser

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