1CVR
Crystal structure of the Arg specific cysteine proteinase gingipain R (RGPB)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE H37 A 501 |
| Chain | Residue |
| A | ASP163 |
| A | GLN282 |
| A | TYR283 |
| A | TRP284 |
| A | MET288 |
| A | HOH640 |
| A | HOH724 |
| A | HOH772 |
| A | THR191 |
| A | PRO192 |
| A | GLY210 |
| A | HIS211 |
| A | GLY212 |
| A | HIS221 |
| A | VAL242 |
| A | CYS244 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 502 |
| Chain | Residue |
| A | GLU161 |
| A | HIS166 |
| A | ASP292 |
| A | HOH717 |
| A | HOH818 |
| A | HOH882 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 503 |
| Chain | Residue |
| A | ASP78 |
| A | PHE249 |
| A | GLU258 |
| A | HOH632 |
| A | HOH672 |
| A | HOH690 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 504 |
| Chain | Residue |
| A | VAL100 |
| A | ASP103 |
| A | TYR105 |
| A | GLU107 |
| A | HOH716 |
| A | HOH819 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 505 |
| Chain | Residue |
| A | GLU293 |
| A | GLU296 |
| A | HIS302 |
| A | HOH619 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 506 |
| Chain | Residue |
| A | HIS221 |
| A | ASP328 |
| A | HOH646 |
| A | HOH677 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 507 |
| Chain | Residue |
| A | GLU152 |
| A | HIS211 |
| A | TRP284 |
| A | LYS327 |
| A | HOH724 |
| A | HOH920 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 508 |
| Chain | Residue |
| A | GLU119 |
| A | ASP387 |
| A | GLU405 |
| A | HOH712 |
| A | HOH922 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 509 |
| Chain | Residue |
| A | HIS130 |
| A | ASN134 |
| A | HOH852 |
| A | HOH921 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"10523290","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1CVR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"23558682","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10523290","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1CVR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"1CVR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"1CVR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IEF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"4IEF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | a catalytic site defined by CSA, PubMed 10523290 |
| Chain | Residue | Details |
| A | GLY212 | |
| A | GLU152 | |
| A | HIS211 | |
| A | CYS244 | |
| A | CYS244 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 806 |
| Chain | Residue | Details |
| A | GLU152 | electrostatic stabiliser |
| A | HIS211 | proton acceptor, proton donor |
| A | GLY212 | electrostatic stabiliser |
| A | CYS244 | electrostatic stabiliser |
