1C82

MECHANISM OF HYALURONAN BINDING AND DEGRADATION: STRUCTURE OF STREPTOCOCCUS PNEUMONIAE HYALURONATE LYASE IN COMPLEX WITH HYALURONIC ACID DISACCHARIDE AT 1.7 A RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005576	cellular_component	extracellular region
A	0005975	biological_process	carbohydrate metabolic process
A	0016829	molecular_function	lyase activity
A	0030246	molecular_function	carbohydrate binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:10716923

Chain	Residue	Details
A	ARG466
A	ASN516
A	LEU525

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	a catalytic site defined by CSA, PubMed 1084384

Chain	Residue	Details
A	TYR408
A	ASN349
A	HIS399

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site_id	MCSA1
Number of Residues	4
Details	M-CSA 439

Chain	Residue	Details
A	ARG466	modifies pKa
A	ASN516	modifies pKa
A	LEU525	proton shuttle (general acid/base)
A	MET579	modifies pKa

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