1BTH
STRUCTURE OF THROMBIN COMPLEXED WITH BOVINE PANCREATIC TRYPSIN INHIBITOR
Functional Information from GO Data
Chain | GOid | namespace | contents |
H | 0004252 | molecular_function | serine-type endopeptidase activity |
H | 0005509 | molecular_function | calcium ion binding |
H | 0006508 | biological_process | proteolysis |
H | 0007596 | biological_process | blood coagulation |
J | 0004252 | molecular_function | serine-type endopeptidase activity |
J | 0005576 | cellular_component | extracellular region |
J | 0006508 | biological_process | proteolysis |
J | 0007596 | biological_process | blood coagulation |
K | 0004252 | molecular_function | serine-type endopeptidase activity |
K | 0005509 | molecular_function | calcium ion binding |
K | 0006508 | biological_process | proteolysis |
K | 0007596 | biological_process | blood coagulation |
L | 0004252 | molecular_function | serine-type endopeptidase activity |
L | 0005576 | cellular_component | extracellular region |
L | 0006508 | biological_process | proteolysis |
L | 0007596 | biological_process | blood coagulation |
P | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
Q | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
Functional Information from PROSITE/UniProt
site_id | PS00134 |
Number of Residues | 6 |
Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
Chain | Residue | Details |
H | LEU53-CYS58 |
site_id | PS00135 |
Number of Residues | 12 |
Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAcqGDSGGPFV |
Chain | Residue | Details |
H | ASP189-VAL200 |
site_id | PS00280 |
Number of Residues | 19 |
Details | BPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FvyGGCrakrnnFksaedC |
Chain | Residue | Details |
P | PHE33-CYS51 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 44 |
Details | Region: {"description":"High affinity receptor-binding region which is also known as the TP508 peptide"} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | Active site: {"description":"Charge relay system"} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"873923","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 100 |
Details | Domain: {"description":"BPTI/Kunitz inhibitor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00031","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | Site: {"description":"Reactive bond for trypsin"} |
Chain | Residue | Details |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
H | ASP102 | |
H | SER195 | |
H | GLY193 | |
H | HIS57 |
site_id | CSA2 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
K | ASP102 | |
K | SER195 | |
K | GLY193 | |
K | HIS57 |
site_id | CSA3 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
H | ASP102 | |
H | SER195 | |
H | HIS57 | |
H | GLY196 |
site_id | CSA4 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
K | ASP102 | |
K | SER195 | |
K | HIS57 | |
K | GLY196 |
site_id | CSA5 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
H | ASP102 | |
H | SER195 | |
H | HIS57 |
site_id | CSA6 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
K | ASP102 | |
K | SER195 | |
K | HIS57 |