1BQQ
CRYSTAL STRUCTURE OF THE MT1-MMP--TIMP-2 COMPLEX
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| M | 0004222 | molecular_function | metalloendopeptidase activity |
| M | 0006508 | biological_process | proteolysis |
| M | 0008237 | molecular_function | metallopeptidase activity |
| M | 0008270 | molecular_function | zinc ion binding |
| M | 0031012 | cellular_component | extracellular matrix |
| T | 0004857 | molecular_function | enzyme inhibitor activity |
| T | 0005576 | cellular_component | extracellular region |
| T | 0005615 | cellular_component | extracellular space |
| T | 0008191 | molecular_function | metalloendopeptidase inhibitor activity |
| T | 0009725 | biological_process | response to hormone |
| T | 0030414 | molecular_function | peptidase inhibitor activity |
| T | 0031012 | cellular_component | extracellular matrix |
| T | 0034097 | biological_process | response to cytokine |
| T | 0046872 | molecular_function | metal ion binding |
| T | 0051045 | biological_process | negative regulation of membrane protein ectodomain proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA M 288 |
| Chain | Residue |
| M | ASP176 |
| M | ASN208 |
| M | GLY210 |
| M | ASP212 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN M 289 |
| Chain | Residue |
| M | HIS239 |
| M | HIS243 |
| M | HIS249 |
| T | CYS1001 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN M 290 |
| Chain | Residue |
| M | ASP188 |
| M | HIS201 |
| M | HIS214 |
| M | HIS186 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA M 291 |
| Chain | Residue |
| M | ASP193 |
| M | GLY194 |
| M | GLY196 |
| M | PHE198 |
| M | ASP216 |
| M | GLU219 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAVHELGHAL |
| Chain | Residue | Details |
| M | VAL236-LEU245 |
| site_id | PS00288 |
| Number of Residues | 13 |
| Details | TIMP Tissue inhibitors of metalloproteinases signature. CsCsPvHPQqaFC |
| Chain | Residue | Details |
| T | CYS1001-CYS1013 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"35177851","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9724659","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9724659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BUV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 125 |
| Details | Domain: {"description":"NTR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00295","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Region: {"description":"Involved in metalloproteinase-binding","evidences":[{"source":"PubMed","id":"17196980","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2E2D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17196980","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2E2D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Involved in metalloproteinase-binding","evidences":[{"source":"PubMed","id":"17196980","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2E2D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| M | MET257 | |
| M | GLU240 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| M | GLU240 |
