1BJT
TOPOISOMERASE II RESIDUES 409-1201
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00177 |
| Number of Residues | 9 |
| Details | TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSALS |
| Chain | Residue | Details |
| A | LEU447-SER455 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01384, ECO:0000269|PubMed:20485342, ECO:0000269|PubMed:9685374 |
| Chain | Residue | Details |
| A | TYR782 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00995, ECO:0000269|PubMed:18097402 |
| Chain | Residue | Details |
| A | GLU449 | |
| A | ASP526 | |
| A | ASP528 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Interaction with DNA => ECO:0000255|PROSITE-ProRule:PRU00995 |
| Chain | Residue | Details |
| A | LYS477 | |
| A | TYR734 | |
| A | SER740 | |
| A | TRP908 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Interaction with DNA => ECO:0000269|PubMed:20485342 |
| Chain | Residue | Details |
| A | ASN480 | |
| A | ARG650 | |
| A | LYS651 | |
| A | LYS700 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | SITE: Transition state stabilizer => ECO:0000269|PubMed:20485342 |
| Chain | Residue | Details |
| A | ARG781 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Important for DNA bending; intercalates between base pairs of target DNA => ECO:0000269|PubMed:18097402 |
| Chain | Residue | Details |
| A | ILE833 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by CK2 => ECO:0000269|PubMed:1316274 |
| Chain | Residue | Details |
| A | THR1086 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:1316274 |
| Chain | Residue | Details |
| A | SER1087 |
