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1A4I

HUMAN TETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004488molecular_functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
B0003824molecular_functioncatalytic activity
B0004488molecular_functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Functional Information from PDB Data
site_idAC1
Number of Residues25
DetailsBINDING SITE FOR RESIDUE NDP A 302
ChainResidue
ATHR148
AGLY217
AGLN218
ACYS236
AGLY237
AILE238
AGLY276
AHOH314
AHOH365
AHOH367
AHOH404
AGLY172
AHOH411
AHOH426
AHOH435
AHOH436
AHOH443
AHOH466
AARG173
ASER174
AVAL177
AHIS196
ASER197
AALA215
ATHR216

site_idAC2
Number of Residues26
DetailsBINDING SITE FOR RESIDUE NDP B 302
ChainResidue
BTHR148
BGLY172
BARG173
BSER174
BVAL177
BHIS196
BSER197
BALA215
BTHR216
BGLY217
BGLN218
BMET221
BCYS236
BGLY237
BILE238
BTHR279
BHOH309
BHOH343
BHOH364
BHOH371
BHOH374
BHOH405
BHOH417
BHOH477
BHOH490
BHOH519

Functional Information from PROSITE/UniProt
site_idPS00766
Number of Residues26
DetailsTHF_DHG_CYH_1 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. EsEVMkyItsLNeDstvhgFLVQLPL
ChainResidueDetails
AGLU78-LEU103

site_idPS00767
Number of Residues9
DetailsTHF_DHG_CYH_2 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. PGGVGPMTV
ChainResidueDetails
APRO272-VAL280

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"evidences":[{"source":"PubMed","id":"10828945","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10828945","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DIA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DIB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10828945","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9519408","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DIA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DIB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DIG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues289
DetailsRegion: {"description":"Methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase (D/C) domain","evidences":[{"source":"PubMed","id":"1881876","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues2
Detailsa catalytic site defined by CSA, PubMed 10828945, 9519408, 11904299
ChainResidueDetails
ALYS56
AGLN100

site_idMCSA1
Number of Residues3
DetailsM-CSA 389
ChainResidueDetails
ALYS56activator
AGLN100activator
AASP125electrostatic stabiliser

site_idMCSA2
Number of Residues3
DetailsM-CSA 458
ChainResidueDetails
ASER49activator
ALYS56proton shuttle (general acid/base)
AGLN100activator

site_idMCSA3
Number of Residues3
DetailsM-CSA 389
ChainResidueDetails
BLYS56activator
BGLN100activator
BASP125electrostatic stabiliser

site_idMCSA4
Number of Residues3
DetailsM-CSA 458
ChainResidueDetails
BSER49activator
BLYS56proton shuttle (general acid/base)
BGLN100activator

239803

PDB entries from 2025-08-06

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