Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE NDP A 302 |
Chain | Residue |
A | THR148 |
A | GLY217 |
A | GLN218 |
A | CYS236 |
A | GLY237 |
A | ILE238 |
A | GLY276 |
A | HOH314 |
A | HOH365 |
A | HOH367 |
A | HOH404 |
A | GLY172 |
A | HOH411 |
A | HOH426 |
A | HOH435 |
A | HOH436 |
A | HOH443 |
A | HOH466 |
A | ARG173 |
A | SER174 |
A | VAL177 |
A | HIS196 |
A | SER197 |
A | ALA215 |
A | THR216 |
site_id | AC2 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE NDP B 302 |
Chain | Residue |
B | THR148 |
B | GLY172 |
B | ARG173 |
B | SER174 |
B | VAL177 |
B | HIS196 |
B | SER197 |
B | ALA215 |
B | THR216 |
B | GLY217 |
B | GLN218 |
B | MET221 |
B | CYS236 |
B | GLY237 |
B | ILE238 |
B | THR279 |
B | HOH309 |
B | HOH343 |
B | HOH364 |
B | HOH371 |
B | HOH374 |
B | HOH405 |
B | HOH417 |
B | HOH477 |
B | HOH490 |
B | HOH519 |
Functional Information from PROSITE/UniProt
site_id | PS00766 |
Number of Residues | 26 |
Details | THF_DHG_CYH_1 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. EsEVMkyItsLNeDstvhgFLVQLPL |
Chain | Residue | Details |
A | GLU78-LEU103 | |
site_id | PS00767 |
Number of Residues | 9 |
Details | THF_DHG_CYH_2 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. PGGVGPMTV |
Chain | Residue | Details |
A | PRO272-VAL280 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | LEU57 | |
B | LEU57 | |
Chain | Residue | Details |
A | ILE53 | |
A | GLN100 | |
A | GLY273 | |
B | ILE53 | |
B | GLN100 | |
B | GLY273 | |
Chain | Residue | Details |
A | ARG173 | |
A | LYS198 | |
B | ARG173 | |
B | LYS198 | |
Chain | Residue | Details |
A | ALA2 | |
B | ALA2 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | a catalytic site defined by CSA, PubMed 10828945, 9519408, 11904299 |
Chain | Residue | Details |
A | LYS56 | |
A | GLN100 | |
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 389 |
Chain | Residue | Details |
A | LEU57 | activator |
A | LEU101 | activator |
A | GLY126 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 3 |
Details | M-CSA 458 |
Chain | Residue | Details |
A | ASN50 | activator |
A | LEU57 | proton shuttle (general acid/base) |
A | LEU101 | activator |
site_id | MCSA3 |
Number of Residues | 3 |
Details | M-CSA 389 |
Chain | Residue | Details |
B | LEU57 | activator |
B | LEU101 | activator |
B | GLY126 | electrostatic stabiliser |
site_id | MCSA4 |
Number of Residues | 3 |
Details | M-CSA 458 |
Chain | Residue | Details |
B | ASN50 | activator |
B | LEU57 | proton shuttle (general acid/base) |
B | LEU101 | activator |