Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

12DL

Native structure of the cytoplasmic lattice (CPL) asymmetric unit from mouse MII eggs

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AA	0001701	biological_process	in utero embryonic development
AA	0004668	molecular_function	protein-arginine deiminase activity
AA	0005515	molecular_function	protein binding
AA	0005634	cellular_component	nucleus
AA	0005737	cellular_component	cytoplasm
AA	0007010	biological_process	cytoskeleton organization
AA	0007028	biological_process	cytoplasm organization
AA	0008104	biological_process	intracellular protein localization
AA	0015631	molecular_function	tubulin binding
AA	0040016	biological_process	embryonic cleavage
AA	0042802	molecular_function	identical protein binding
AA	0043143	biological_process	regulation of translation by machinery localization
AA	0044725	biological_process	epigenetic programming in the zygotic pronuclei
AA	0045111	cellular_component	intermediate filament cytoskeleton
AA	0060473	cellular_component	cortical granule
AA	0140089	biological_process	protein storage
AA	0140094	molecular_function	structural constituent of cytoplasmic lattice
AA	0140095	cellular_component	cytoplasmic lattice
AA	1990917	cellular_component	ooplasm
AB	0001701	biological_process	in utero embryonic development
AB	0004668	molecular_function	protein-arginine deiminase activity
AB	0005515	molecular_function	protein binding
AB	0005634	cellular_component	nucleus
AB	0005737	cellular_component	cytoplasm
AB	0007010	biological_process	cytoskeleton organization
AB	0007028	biological_process	cytoplasm organization
AB	0008104	biological_process	intracellular protein localization
AB	0015631	molecular_function	tubulin binding
AB	0040016	biological_process	embryonic cleavage
AB	0042802	molecular_function	identical protein binding
AB	0043143	biological_process	regulation of translation by machinery localization
AB	0044725	biological_process	epigenetic programming in the zygotic pronuclei
AB	0045111	cellular_component	intermediate filament cytoskeleton
AB	0060473	cellular_component	cortical granule
AB	0140089	biological_process	protein storage
AB	0140094	molecular_function	structural constituent of cytoplasmic lattice
AB	0140095	cellular_component	cytoplasmic lattice
AB	1990917	cellular_component	ooplasm
AC	0001701	biological_process	in utero embryonic development
AC	0004668	molecular_function	protein-arginine deiminase activity
AC	0005515	molecular_function	protein binding
AC	0005634	cellular_component	nucleus
AC	0005737	cellular_component	cytoplasm
AC	0007010	biological_process	cytoskeleton organization
AC	0007028	biological_process	cytoplasm organization
AC	0008104	biological_process	intracellular protein localization
AC	0015631	molecular_function	tubulin binding
AC	0040016	biological_process	embryonic cleavage
AC	0042802	molecular_function	identical protein binding
AC	0043143	biological_process	regulation of translation by machinery localization
AC	0044725	biological_process	epigenetic programming in the zygotic pronuclei
AC	0045111	cellular_component	intermediate filament cytoskeleton
AC	0060473	cellular_component	cortical granule
AC	0140089	biological_process	protein storage
AC	0140094	molecular_function	structural constituent of cytoplasmic lattice
AC	0140095	cellular_component	cytoplasmic lattice
AC	1990917	cellular_component	ooplasm
AD	0001701	biological_process	in utero embryonic development
AD	0004668	molecular_function	protein-arginine deiminase activity
AD	0005515	molecular_function	protein binding
AD	0005634	cellular_component	nucleus
AD	0005737	cellular_component	cytoplasm
AD	0007010	biological_process	cytoskeleton organization
AD	0007028	biological_process	cytoplasm organization
AD	0008104	biological_process	intracellular protein localization
AD	0015631	molecular_function	tubulin binding
AD	0040016	biological_process	embryonic cleavage
AD	0042802	molecular_function	identical protein binding
AD	0043143	biological_process	regulation of translation by machinery localization
AD	0044725	biological_process	epigenetic programming in the zygotic pronuclei
AD	0045111	cellular_component	intermediate filament cytoskeleton
AD	0060473	cellular_component	cortical granule
AD	0140089	biological_process	protein storage
AD	0140094	molecular_function	structural constituent of cytoplasmic lattice
AD	0140095	cellular_component	cytoplasmic lattice
AD	1990917	cellular_component	ooplasm
AE	0001701	biological_process	in utero embryonic development
AE	0004668	molecular_function	protein-arginine deiminase activity
AE	0005515	molecular_function	protein binding
AE	0005634	cellular_component	nucleus
AE	0005737	cellular_component	cytoplasm
AE	0007010	biological_process	cytoskeleton organization
AE	0007028	biological_process	cytoplasm organization
AE	0008104	biological_process	intracellular protein localization
AE	0015631	molecular_function	tubulin binding
AE	0040016	biological_process	embryonic cleavage
AE	0042802	molecular_function	identical protein binding
AE	0043143	biological_process	regulation of translation by machinery localization
AE	0044725	biological_process	epigenetic programming in the zygotic pronuclei
AE	0045111	cellular_component	intermediate filament cytoskeleton
AE	0060473	cellular_component	cortical granule
AE	0140089	biological_process	protein storage
AE	0140094	molecular_function	structural constituent of cytoplasmic lattice
AE	0140095	cellular_component	cytoplasmic lattice
AE	1990917	cellular_component	ooplasm
AF	0001701	biological_process	in utero embryonic development
AF	0004668	molecular_function	protein-arginine deiminase activity
AF	0005515	molecular_function	protein binding
AF	0005634	cellular_component	nucleus
AF	0005737	cellular_component	cytoplasm
AF	0007010	biological_process	cytoskeleton organization
AF	0007028	biological_process	cytoplasm organization
AF	0008104	biological_process	intracellular protein localization
AF	0015631	molecular_function	tubulin binding
AF	0040016	biological_process	embryonic cleavage
AF	0042802	molecular_function	identical protein binding
AF	0043143	biological_process	regulation of translation by machinery localization
AF	0044725	biological_process	epigenetic programming in the zygotic pronuclei
AF	0045111	cellular_component	intermediate filament cytoskeleton
AF	0060473	cellular_component	cortical granule
AF	0140089	biological_process	protein storage
AF	0140094	molecular_function	structural constituent of cytoplasmic lattice
AF	0140095	cellular_component	cytoplasmic lattice
AF	1990917	cellular_component	ooplasm
AG	0001701	biological_process	in utero embryonic development
AG	0004668	molecular_function	protein-arginine deiminase activity
AG	0005515	molecular_function	protein binding
AG	0005634	cellular_component	nucleus
AG	0005737	cellular_component	cytoplasm
AG	0007010	biological_process	cytoskeleton organization
AG	0007028	biological_process	cytoplasm organization
AG	0008104	biological_process	intracellular protein localization
AG	0015631	molecular_function	tubulin binding
AG	0040016	biological_process	embryonic cleavage
AG	0042802	molecular_function	identical protein binding
AG	0043143	biological_process	regulation of translation by machinery localization
AG	0044725	biological_process	epigenetic programming in the zygotic pronuclei
AG	0045111	cellular_component	intermediate filament cytoskeleton
AG	0060473	cellular_component	cortical granule
AG	0140089	biological_process	protein storage
AG	0140094	molecular_function	structural constituent of cytoplasmic lattice
AG	0140095	cellular_component	cytoplasmic lattice
AG	1990917	cellular_component	ooplasm
AH	0001701	biological_process	in utero embryonic development
AH	0004668	molecular_function	protein-arginine deiminase activity
AH	0005515	molecular_function	protein binding
AH	0005634	cellular_component	nucleus
AH	0005737	cellular_component	cytoplasm
AH	0007010	biological_process	cytoskeleton organization
AH	0007028	biological_process	cytoplasm organization
AH	0008104	biological_process	intracellular protein localization
AH	0015631	molecular_function	tubulin binding
AH	0040016	biological_process	embryonic cleavage
AH	0042802	molecular_function	identical protein binding
AH	0043143	biological_process	regulation of translation by machinery localization
AH	0044725	biological_process	epigenetic programming in the zygotic pronuclei
AH	0045111	cellular_component	intermediate filament cytoskeleton
AH	0060473	cellular_component	cortical granule
AH	0140089	biological_process	protein storage
AH	0140094	molecular_function	structural constituent of cytoplasmic lattice
AH	0140095	cellular_component	cytoplasmic lattice
AH	1990917	cellular_component	ooplasm
AI	0001701	biological_process	in utero embryonic development
AI	0004668	molecular_function	protein-arginine deiminase activity
AI	0005515	molecular_function	protein binding
AI	0005634	cellular_component	nucleus
AI	0005737	cellular_component	cytoplasm
AI	0007010	biological_process	cytoskeleton organization
AI	0007028	biological_process	cytoplasm organization
AI	0008104	biological_process	intracellular protein localization
AI	0015631	molecular_function	tubulin binding
AI	0040016	biological_process	embryonic cleavage
AI	0042802	molecular_function	identical protein binding
AI	0043143	biological_process	regulation of translation by machinery localization
AI	0044725	biological_process	epigenetic programming in the zygotic pronuclei
AI	0045111	cellular_component	intermediate filament cytoskeleton
AI	0060473	cellular_component	cortical granule
AI	0140089	biological_process	protein storage
AI	0140094	molecular_function	structural constituent of cytoplasmic lattice
AI	0140095	cellular_component	cytoplasmic lattice
AI	1990917	cellular_component	ooplasm
AJ	0001701	biological_process	in utero embryonic development
AJ	0004668	molecular_function	protein-arginine deiminase activity
AJ	0005515	molecular_function	protein binding
AJ	0005634	cellular_component	nucleus
AJ	0005737	cellular_component	cytoplasm
AJ	0007010	biological_process	cytoskeleton organization
AJ	0007028	biological_process	cytoplasm organization
AJ	0008104	biological_process	intracellular protein localization
AJ	0015631	molecular_function	tubulin binding
AJ	0040016	biological_process	embryonic cleavage
AJ	0042802	molecular_function	identical protein binding
AJ	0043143	biological_process	regulation of translation by machinery localization
AJ	0044725	biological_process	epigenetic programming in the zygotic pronuclei
AJ	0045111	cellular_component	intermediate filament cytoskeleton
AJ	0060473	cellular_component	cortical granule
AJ	0140089	biological_process	protein storage
AJ	0140094	molecular_function	structural constituent of cytoplasmic lattice
AJ	0140095	cellular_component	cytoplasmic lattice
AJ	1990917	cellular_component	ooplasm
BA	0000122	biological_process	negative regulation of transcription by RNA polymerase II
BA	0000785	cellular_component	chromatin
BA	0000791	cellular_component	euchromatin
BA	0000792	cellular_component	heterochromatin
BA	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
BA	0003676	molecular_function	nucleic acid binding
BA	0004842	molecular_function	ubiquitin-protein transferase activity
BA	0005515	molecular_function	protein binding
BA	0005634	cellular_component	nucleus
BA	0005654	cellular_component	nucleoplasm
BA	0005657	cellular_component	replication fork
BA	0005694	cellular_component	chromosome
BA	0005829	cellular_component	cytosol
BA	0006511	biological_process	ubiquitin-dependent protein catabolic process
BA	0008270	molecular_function	zinc ion binding
BA	0008327	molecular_function	methyl-CpG binding
BA	0016363	cellular_component	nuclear matrix
BA	0016567	biological_process	protein ubiquitination
BA	0031507	biological_process	heterochromatin formation
BA	0042393	molecular_function	histone binding
BA	0042802	molecular_function	identical protein binding
BA	0044027	biological_process	negative regulation of gene expression via chromosomal CpG island methylation
BA	0044729	molecular_function	hemi-methylated DNA-binding
BA	0045944	biological_process	positive regulation of transcription by RNA polymerase II
BA	0050678	biological_process	regulation of epithelial cell proliferation
BA	0051247	biological_process	positive regulation of protein metabolic process
BA	0051865	biological_process	protein autoubiquitination
BA	0061630	molecular_function	ubiquitin protein ligase activity
BA	0062072	molecular_function	histone H3K9me2/3 reader activity
BA	0071168	biological_process	protein localization to chromatin
BA	0090307	biological_process	mitotic spindle assembly
BA	0140006	molecular_function	histone H3 reader activity
BA	0140234	molecular_function	histone H3K23 ubiquitin ligase activity
BA	0140248	molecular_function	histone H3K18 ubiquitin ligase activity
BA	0140851	molecular_function	histone H3K14 ubiquitin ligase activity
BA	0141055	molecular_function	histone H3 ubiquitin ligase activity
BA	0141119	biological_process	chromosomal DNA methylation maintenance following DNA replication
BB	0000122	biological_process	negative regulation of transcription by RNA polymerase II
BB	0000785	cellular_component	chromatin
BB	0000791	cellular_component	euchromatin
BB	0000792	cellular_component	heterochromatin
BB	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
BB	0003676	molecular_function	nucleic acid binding
BB	0004842	molecular_function	ubiquitin-protein transferase activity
BB	0005515	molecular_function	protein binding
BB	0005634	cellular_component	nucleus
BB	0005654	cellular_component	nucleoplasm
BB	0005657	cellular_component	replication fork
BB	0005694	cellular_component	chromosome
BB	0005829	cellular_component	cytosol
BB	0006511	biological_process	ubiquitin-dependent protein catabolic process
BB	0008270	molecular_function	zinc ion binding
BB	0008327	molecular_function	methyl-CpG binding
BB	0016363	cellular_component	nuclear matrix
BB	0016567	biological_process	protein ubiquitination
BB	0031507	biological_process	heterochromatin formation
BB	0042393	molecular_function	histone binding
BB	0042802	molecular_function	identical protein binding
BB	0044027	biological_process	negative regulation of gene expression via chromosomal CpG island methylation
BB	0044729	molecular_function	hemi-methylated DNA-binding
BB	0045944	biological_process	positive regulation of transcription by RNA polymerase II
BB	0050678	biological_process	regulation of epithelial cell proliferation
BB	0051247	biological_process	positive regulation of protein metabolic process
BB	0051865	biological_process	protein autoubiquitination
BB	0061630	molecular_function	ubiquitin protein ligase activity
BB	0062072	molecular_function	histone H3K9me2/3 reader activity
BB	0071168	biological_process	protein localization to chromatin
BB	0090307	biological_process	mitotic spindle assembly
BB	0140006	molecular_function	histone H3 reader activity
BB	0140234	molecular_function	histone H3K23 ubiquitin ligase activity
BB	0140248	molecular_function	histone H3K18 ubiquitin ligase activity
BB	0140851	molecular_function	histone H3K14 ubiquitin ligase activity
BB	0141055	molecular_function	histone H3 ubiquitin ligase activity
BB	0141119	biological_process	chromosomal DNA methylation maintenance following DNA replication
CA	0000209	biological_process	protein polyubiquitination
CA	0004842	molecular_function	ubiquitin-protein transferase activity
CA	0005515	molecular_function	protein binding
CA	0005737	cellular_component	cytoplasm
CA	0005886	cellular_component	plasma membrane
CA	0006511	biological_process	ubiquitin-dependent protein catabolic process
CA	0006513	biological_process	protein monoubiquitination
CA	0010008	cellular_component	endosome membrane
CA	0016567	biological_process	protein ubiquitination
CA	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
CA	0051865	biological_process	protein autoubiquitination
CA	0061631	molecular_function	ubiquitin conjugating enzyme activity
CA	0070936	biological_process	protein K48-linked ubiquitination
CA	0070979	biological_process	protein K11-linked ubiquitination
CA	0085020	biological_process	protein K6-linked ubiquitination
CB	0000209	biological_process	protein polyubiquitination
CB	0004842	molecular_function	ubiquitin-protein transferase activity
CB	0005515	molecular_function	protein binding
CB	0005737	cellular_component	cytoplasm
CB	0005886	cellular_component	plasma membrane
CB	0006511	biological_process	ubiquitin-dependent protein catabolic process
CB	0006513	biological_process	protein monoubiquitination
CB	0010008	cellular_component	endosome membrane
CB	0016567	biological_process	protein ubiquitination
CB	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
CB	0051865	biological_process	protein autoubiquitination
CB	0061631	molecular_function	ubiquitin conjugating enzyme activity
CB	0070936	biological_process	protein K48-linked ubiquitination
CB	0070979	biological_process	protein K11-linked ubiquitination
CB	0085020	biological_process	protein K6-linked ubiquitination
DA	0003674	molecular_function	molecular_function
DA	0005575	cellular_component	cellular_component
DA	0005737	cellular_component	cytoplasm
DA	0007283	biological_process	spermatogenesis
DA	0050727	biological_process	regulation of inflammatory response
DB	0003674	molecular_function	molecular_function
DB	0005575	cellular_component	cellular_component
DB	0005737	cellular_component	cytoplasm
DB	0007283	biological_process	spermatogenesis
DB	0050727	biological_process	regulation of inflammatory response
EA	0000226	biological_process	microtubule cytoskeleton organization
EA	0000278	biological_process	mitotic cell cycle
EA	0003924	molecular_function	GTPase activity
EA	0005200	molecular_function	structural constituent of cytoskeleton
EA	0005525	molecular_function	GTP binding
EA	0005634	cellular_component	nucleus
EA	0005737	cellular_component	cytoplasm
EA	0005856	cellular_component	cytoskeleton
EA	0005874	cellular_component	microtubule
EA	0005881	cellular_component	cytoplasmic microtubule
EA	0005929	cellular_component	cilium
EA	0015630	cellular_component	microtubule cytoskeleton
EA	0030182	biological_process	neuron differentiation
EA	0045121	cellular_component	membrane raft
FA	0000226	biological_process	microtubule cytoskeleton organization
FA	0000278	biological_process	mitotic cell cycle
FA	0003725	molecular_function	double-stranded RNA binding
FA	0005200	molecular_function	structural constituent of cytoskeleton
FA	0005525	molecular_function	GTP binding
FA	0005737	cellular_component	cytoplasm
FA	0005856	cellular_component	cytoskeleton
FA	0005874	cellular_component	microtubule
FA	0005879	cellular_component	axonemal microtubule
FA	0007017	biological_process	microtubule-based process
FA	0015630	cellular_component	microtubule cytoskeleton
FA	0030317	biological_process	flagellated sperm motility
FA	0036126	cellular_component	sperm flagellum
FA	0043209	cellular_component	myelin sheath
FA	0045171	cellular_component	intercellular bridge
FA	0045298	cellular_component	tubulin complex
FA	0072686	cellular_component	mitotic spindle
GA	0001701	biological_process	in utero embryonic development
GA	0005515	molecular_function	protein binding
GA	0005634	cellular_component	nucleus
GA	0005730	cellular_component	nucleolus
GA	0005737	cellular_component	cytoplasm
GA	0005739	cellular_component	mitochondrion
GA	0005794	cellular_component	Golgi apparatus
GA	0005829	cellular_component	cytosol
GA	0005938	cellular_component	cell cortex
GA	0006887	biological_process	exocytosis
GA	0007015	biological_process	actin filament organization
GA	0007566	biological_process	embryo implantation
GA	0008104	biological_process	intracellular protein localization
GA	0009566	biological_process	fertilization
GA	0009887	biological_process	animal organ morphogenesis
GA	0015631	molecular_function	tubulin binding
GA	0031647	biological_process	regulation of protein stability
GA	0032880	biological_process	regulation of protein localization
GA	0032991	cellular_component	protein-containing complex
GA	0040019	biological_process	positive regulation of embryonic development
GA	0043487	biological_process	regulation of RNA stability
GA	0045179	cellular_component	apical cortex
GA	0050727	biological_process	regulation of inflammatory response
GA	0051293	biological_process	establishment of spindle localization
GA	0051302	biological_process	regulation of cell division
GA	0051656	biological_process	establishment of organelle localization
GA	0060471	biological_process	cortical granule exocytosis
GA	0060473	cellular_component	cortical granule
GA	0065003	biological_process	protein-containing complex assembly
GA	0106333	cellular_component	subcortical maternal complex
GA	0140089	biological_process	protein storage
GA	0140094	molecular_function	structural constituent of cytoplasmic lattice
GA	0140095	cellular_component	cytoplasmic lattice
GB	0001701	biological_process	in utero embryonic development
GB	0005515	molecular_function	protein binding
GB	0005634	cellular_component	nucleus
GB	0005730	cellular_component	nucleolus
GB	0005737	cellular_component	cytoplasm
GB	0005739	cellular_component	mitochondrion
GB	0005794	cellular_component	Golgi apparatus
GB	0005829	cellular_component	cytosol
GB	0005938	cellular_component	cell cortex
GB	0006887	biological_process	exocytosis
GB	0007015	biological_process	actin filament organization
GB	0007566	biological_process	embryo implantation
GB	0008104	biological_process	intracellular protein localization
GB	0009566	biological_process	fertilization
GB	0009887	biological_process	animal organ morphogenesis
GB	0015631	molecular_function	tubulin binding
GB	0031647	biological_process	regulation of protein stability
GB	0032880	biological_process	regulation of protein localization
GB	0032991	cellular_component	protein-containing complex
GB	0040019	biological_process	positive regulation of embryonic development
GB	0043487	biological_process	regulation of RNA stability
GB	0045179	cellular_component	apical cortex
GB	0050727	biological_process	regulation of inflammatory response
GB	0051293	biological_process	establishment of spindle localization
GB	0051302	biological_process	regulation of cell division
GB	0051656	biological_process	establishment of organelle localization
GB	0060471	biological_process	cortical granule exocytosis
GB	0060473	cellular_component	cortical granule
GB	0065003	biological_process	protein-containing complex assembly
GB	0106333	cellular_component	subcortical maternal complex
GB	0140089	biological_process	protein storage
GB	0140094	molecular_function	structural constituent of cytoplasmic lattice
GB	0140095	cellular_component	cytoplasmic lattice
HA	0000122	biological_process	negative regulation of transcription by RNA polymerase II
HA	0003714	molecular_function	transcription corepressor activity
HA	0005515	molecular_function	protein binding
HA	0005634	cellular_component	nucleus
HA	0005667	cellular_component	transcription regulator complex
HA	0005737	cellular_component	cytoplasm
HA	0005829	cellular_component	cytosol
HA	0005938	cellular_component	cell cortex
HA	0007015	biological_process	actin filament organization
HA	0007283	biological_process	spermatogenesis
HA	0007284	biological_process	spermatogonial cell division
HA	0030317	biological_process	flagellated sperm motility
HA	0032502	biological_process	developmental process
HA	0032991	cellular_component	protein-containing complex
HA	0040019	biological_process	positive regulation of embryonic development
HA	0044725	biological_process	epigenetic programming in the zygotic pronuclei
HA	0045666	biological_process	positive regulation of neuron differentiation
HA	0050769	biological_process	positive regulation of neurogenesis
HA	0051293	biological_process	establishment of spindle localization
HA	0051302	biological_process	regulation of cell division
HA	0051643	biological_process	endoplasmic reticulum localization
HA	0051646	biological_process	mitochondrion localization
HA	0060136	biological_process	embryonic process involved in female pregnancy
HA	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
HA	0097225	cellular_component	sperm midpiece
HA	0106333	cellular_component	subcortical maternal complex
HA	0140089	biological_process	protein storage
HA	0140094	molecular_function	structural constituent of cytoplasmic lattice
HA	0140095	cellular_component	cytoplasmic lattice
HB	0000122	biological_process	negative regulation of transcription by RNA polymerase II
HB	0003714	molecular_function	transcription corepressor activity
HB	0005515	molecular_function	protein binding
HB	0005634	cellular_component	nucleus
HB	0005667	cellular_component	transcription regulator complex
HB	0005737	cellular_component	cytoplasm
HB	0005829	cellular_component	cytosol
HB	0005938	cellular_component	cell cortex
HB	0007015	biological_process	actin filament organization
HB	0007283	biological_process	spermatogenesis
HB	0007284	biological_process	spermatogonial cell division
HB	0030317	biological_process	flagellated sperm motility
HB	0032502	biological_process	developmental process
HB	0032991	cellular_component	protein-containing complex
HB	0040019	biological_process	positive regulation of embryonic development
HB	0044725	biological_process	epigenetic programming in the zygotic pronuclei
HB	0045666	biological_process	positive regulation of neuron differentiation
HB	0050769	biological_process	positive regulation of neurogenesis
HB	0051293	biological_process	establishment of spindle localization
HB	0051302	biological_process	regulation of cell division
HB	0051643	biological_process	endoplasmic reticulum localization
HB	0051646	biological_process	mitochondrion localization
HB	0060136	biological_process	embryonic process involved in female pregnancy
HB	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
HB	0097225	cellular_component	sperm midpiece
HB	0106333	cellular_component	subcortical maternal complex
HB	0140089	biological_process	protein storage
HB	0140094	molecular_function	structural constituent of cytoplasmic lattice
HB	0140095	cellular_component	cytoplasmic lattice
IA	0001701	biological_process	in utero embryonic development
IA	0003723	molecular_function	RNA binding
IA	0005515	molecular_function	protein binding
IA	0005634	cellular_component	nucleus
IA	0005737	cellular_component	cytoplasm
IA	0005938	cellular_component	cell cortex
IA	0006468	biological_process	protein phosphorylation
IA	0007015	biological_process	actin filament organization
IA	0007566	biological_process	embryo implantation
IA	0009566	biological_process	fertilization
IA	0009880	biological_process	embryonic pattern specification
IA	0031297	biological_process	replication fork processing
IA	0032880	biological_process	regulation of protein localization
IA	0032991	cellular_component	protein-containing complex
IA	0035088	biological_process	establishment or maintenance of apical/basal cell polarity
IA	0045177	cellular_component	apical part of cell
IA	0045836	biological_process	positive regulation of meiotic nuclear division
IA	0051293	biological_process	establishment of spindle localization
IA	0051302	biological_process	regulation of cell division
IA	0065003	biological_process	protein-containing complex assembly
IA	0070201	biological_process	regulation of establishment of protein localization
IA	0106333	cellular_component	subcortical maternal complex
IA	0140089	biological_process	protein storage
IA	0140094	molecular_function	structural constituent of cytoplasmic lattice
IA	0140095	cellular_component	cytoplasmic lattice
IA	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
IA	2000781	biological_process	positive regulation of double-strand break repair
JA	0001701	biological_process	in utero embryonic development
JA	0003723	molecular_function	RNA binding
JA	0005515	molecular_function	protein binding
JA	0005634	cellular_component	nucleus
JA	0005737	cellular_component	cytoplasm
JA	0005938	cellular_component	cell cortex
JA	0006468	biological_process	protein phosphorylation
JA	0007015	biological_process	actin filament organization
JA	0007566	biological_process	embryo implantation
JA	0009566	biological_process	fertilization
JA	0009880	biological_process	embryonic pattern specification
JA	0031297	biological_process	replication fork processing
JA	0032880	biological_process	regulation of protein localization
JA	0032991	cellular_component	protein-containing complex
JA	0035088	biological_process	establishment or maintenance of apical/basal cell polarity
JA	0045177	cellular_component	apical part of cell
JA	0045836	biological_process	positive regulation of meiotic nuclear division
JA	0051293	biological_process	establishment of spindle localization
JA	0051302	biological_process	regulation of cell division
JA	0065003	biological_process	protein-containing complex assembly
JA	0070201	biological_process	regulation of establishment of protein localization
JA	0106333	cellular_component	subcortical maternal complex
JA	0140089	biological_process	protein storage
JA	0140094	molecular_function	structural constituent of cytoplasmic lattice
JA	0140095	cellular_component	cytoplasmic lattice
JA	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
JA	2000781	biological_process	positive regulation of double-strand break repair
KA	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
KA	0001933	biological_process	negative regulation of protein phosphorylation
KA	0003700	molecular_function	DNA-binding transcription factor activity
KA	0005515	molecular_function	protein binding
KA	0005576	cellular_component	extracellular region
KA	0005634	cellular_component	nucleus
KA	0005737	cellular_component	cytoplasm
KA	0005829	cellular_component	cytosol
KA	0007015	biological_process	actin filament organization
KA	0009749	biological_process	response to glucose
KA	0016020	cellular_component	membrane
KA	0032868	biological_process	response to insulin
KA	0040019	biological_process	positive regulation of embryonic development
KA	0045944	biological_process	positive regulation of transcription by RNA polymerase II
KA	0050821	biological_process	protein stabilization
KA	0051293	biological_process	establishment of spindle localization
KA	0051643	biological_process	endoplasmic reticulum localization
KA	0051646	biological_process	mitochondrion localization
KA	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
LA	0005515	molecular_function	protein binding
LA	0005634	cellular_component	nucleus
LA	0005694	cellular_component	chromosome
LA	0005737	cellular_component	cytoplasm
LA	0005739	cellular_component	mitochondrion
LA	0005813	cellular_component	centrosome
LA	0005938	cellular_component	cell cortex
LA	0006468	biological_process	protein phosphorylation
LA	0007015	biological_process	actin filament organization
LA	0007094	biological_process	mitotic spindle assembly checkpoint signaling
LA	0031297	biological_process	replication fork processing
LA	0032880	biological_process	regulation of protein localization
LA	0032991	cellular_component	protein-containing complex
LA	0040019	biological_process	positive regulation of embryonic development
LA	0043066	biological_process	negative regulation of apoptotic process
LA	0050769	biological_process	positive regulation of neurogenesis
LA	0051656	biological_process	establishment of organelle localization
LA	0090307	biological_process	mitotic spindle assembly
LA	0106333	cellular_component	subcortical maternal complex
LA	0140089	biological_process	protein storage
LA	0140094	molecular_function	structural constituent of cytoplasmic lattice
LA	0140095	cellular_component	cytoplasmic lattice
LA	1900006	biological_process	positive regulation of dendrite development
LA	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
LA	2000781	biological_process	positive regulation of double-strand break repair
MA	0000166	molecular_function	nucleotide binding
MA	0005524	molecular_function	ATP binding
NA	0003674	molecular_function	molecular_function
NA	0005575	cellular_component	cellular_component
NA	0005737	cellular_component	cytoplasm
NA	0008150	biological_process	biological_process
OA	0003674	molecular_function	molecular_function
OA	0005575	cellular_component	cellular_component
OA	0005737	cellular_component	cytoplasm
OA	0008150	biological_process	biological_process
PA	0003674	molecular_function	molecular_function
PA	0005575	cellular_component	cellular_component
PA	0005737	cellular_component	cytoplasm
PA	0008150	biological_process	biological_process
QA	0000209	biological_process	protein polyubiquitination
QA	0000775	cellular_component	chromosome, centromeric region
QA	0004842	molecular_function	ubiquitin-protein transferase activity
QA	0005515	molecular_function	protein binding
QA	0005634	cellular_component	nucleus
QA	0005654	cellular_component	nucleoplasm
QA	0005737	cellular_component	cytoplasm
QA	0005813	cellular_component	centrosome
QA	0005829	cellular_component	cytosol
QA	0005921	cellular_component	gap junction
QA	0006338	biological_process	chromatin remodeling
QA	0006511	biological_process	ubiquitin-dependent protein catabolic process
QA	0006513	biological_process	protein monoubiquitination
QA	0006915	biological_process	apoptotic process
QA	0007129	biological_process	homologous chromosome pairing at meiosis
QA	0008013	molecular_function	beta-catenin binding
QA	0016567	biological_process	protein ubiquitination
QA	0019005	cellular_component	SCF ubiquitin ligase complex
QA	0019904	molecular_function	protein domain specific binding
QA	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
QA	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
QA	0031519	cellular_component	PcG protein complex
QA	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
QA	0051457	biological_process	maintenance of protein location in nucleus
QA	0070936	biological_process	protein K48-linked ubiquitination
QA	0097602	molecular_function	cullin family protein binding
QA	0140677	molecular_function	molecular function activator activity
QA	0160072	molecular_function	ubiquitin ligase complex scaffold activity
QA	1904037	biological_process	positive regulation of epithelial cell apoptotic process
QA	1990444	molecular_function	F-box domain binding
QA	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
QA	1990757	molecular_function	ubiquitin ligase activator activity
QB	0000209	biological_process	protein polyubiquitination
QB	0000775	cellular_component	chromosome, centromeric region
QB	0004842	molecular_function	ubiquitin-protein transferase activity
QB	0005515	molecular_function	protein binding
QB	0005634	cellular_component	nucleus
QB	0005654	cellular_component	nucleoplasm
QB	0005737	cellular_component	cytoplasm
QB	0005813	cellular_component	centrosome
QB	0005829	cellular_component	cytosol
QB	0005921	cellular_component	gap junction
QB	0006338	biological_process	chromatin remodeling
QB	0006511	biological_process	ubiquitin-dependent protein catabolic process
QB	0006513	biological_process	protein monoubiquitination
QB	0006915	biological_process	apoptotic process
QB	0007129	biological_process	homologous chromosome pairing at meiosis
QB	0008013	molecular_function	beta-catenin binding
QB	0016567	biological_process	protein ubiquitination
QB	0019005	cellular_component	SCF ubiquitin ligase complex
QB	0019904	molecular_function	protein domain specific binding
QB	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
QB	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
QB	0031519	cellular_component	PcG protein complex
QB	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
QB	0051457	biological_process	maintenance of protein location in nucleus
QB	0070936	biological_process	protein K48-linked ubiquitination
QB	0097602	molecular_function	cullin family protein binding
QB	0140677	molecular_function	molecular function activator activity
QB	0160072	molecular_function	ubiquitin ligase complex scaffold activity
QB	1904037	biological_process	positive regulation of epithelial cell apoptotic process
QB	1990444	molecular_function	F-box domain binding
QB	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
QB	1990757	molecular_function	ubiquitin ligase activator activity
QC	0000209	biological_process	protein polyubiquitination
QC	0000775	cellular_component	chromosome, centromeric region
QC	0004842	molecular_function	ubiquitin-protein transferase activity
QC	0005515	molecular_function	protein binding
QC	0005634	cellular_component	nucleus
QC	0005654	cellular_component	nucleoplasm
QC	0005737	cellular_component	cytoplasm
QC	0005813	cellular_component	centrosome
QC	0005829	cellular_component	cytosol
QC	0005921	cellular_component	gap junction
QC	0006338	biological_process	chromatin remodeling
QC	0006511	biological_process	ubiquitin-dependent protein catabolic process
QC	0006513	biological_process	protein monoubiquitination
QC	0006915	biological_process	apoptotic process
QC	0007129	biological_process	homologous chromosome pairing at meiosis
QC	0008013	molecular_function	beta-catenin binding
QC	0016567	biological_process	protein ubiquitination
QC	0019005	cellular_component	SCF ubiquitin ligase complex
QC	0019904	molecular_function	protein domain specific binding
QC	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
QC	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
QC	0031519	cellular_component	PcG protein complex
QC	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
QC	0051457	biological_process	maintenance of protein location in nucleus
QC	0070936	biological_process	protein K48-linked ubiquitination
QC	0097602	molecular_function	cullin family protein binding
QC	0140677	molecular_function	molecular function activator activity
QC	0160072	molecular_function	ubiquitin ligase complex scaffold activity
QC	1904037	biological_process	positive regulation of epithelial cell apoptotic process
QC	1990444	molecular_function	F-box domain binding
QC	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
QC	1990757	molecular_function	ubiquitin ligase activator activity

Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNInsn.GsICLdiL

Chain	Residue	Details
CA	TYR74-LEU89

site_id	PS00213
Number of Residues	13
Details	LIPOCALIN Lipocalin signature. DVRd.NIFGAWFEA

Chain	Residue	Details
BA	ASP138-ALA150

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
FA	GLY140-GLY146
EA	GLY142-GLY148

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
FA	MET1-ILE4

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CqHnVCkdCL

Chain	Residue	Details
BA	CYS728-LEU737

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. ALAGftDgTVRIWDL

Chain	Residue	Details
HB	ALA402-LEU416

site_id	PS01359
Number of Residues	62
Details	ZF_PHD_1 Zinc finger PHD-type signature. CrfCkddenkpcrkcachvcggreapekq....................LlCde..Cdma.FHlyClkppltsvppepe................................WyCpsC

Chain	Residue	Details
BA	CYS307-CYS368

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P68371","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"UniProtKB","id":"P68371","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	1288
Details	Domain: {"description":"NACHT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00136","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	84
Details	Repeat: {"description":"LRR 1"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	82
Details	Repeat: {"description":"LRR 2"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	80
Details	Repeat: {"description":"LRR 3"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	80
Details	Repeat: {"description":"LRR 4"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	80
Details	Repeat: {"description":"LRR 5"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	82
Details	Repeat: {"description":"LRR 6"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	82
Details	Repeat: {"description":"LRR 7"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	84
Details	Repeat: {"description":"LRR 8"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	82
Details	Repeat: {"description":"LRR 9"}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	42
Details	Repeat: {"description":"LRR 10"}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	42
Details	Repeat: {"description":"LRR 11"}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00136","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	200
Details	Domain: {"description":"KH; atypical"}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	76
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	80
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	80
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	74
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	78
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	78
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	62
Details	Repeat: {"description":"WD 8"}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9H808","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	20
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q6TGC4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	3
Details	Motif: {"description":"MREC motif","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	1
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9BQE3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	1
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"PubMed","id":"16800626","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9BQE3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	78
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	136
Details	Region: {"description":"Tudor-like 2"}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	10
Details	Region: {"description":"Linker","evidences":[{"source":"UniProtKB","id":"Q96T88","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	12
Details	Region: {"description":"Histone H3R2me0 binding","evidences":[{"source":"UniProtKB","id":"Q96T88","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	2
Details	Region: {"description":"Required to promote base flipping","evidences":[{"source":"PubMed","id":"18772891","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	12
Details	Region: {"description":"Required for formation of a 5-methylcytosine-binding pocket"}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	46
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q96T88","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	2
Details	Site: {"description":"Histone H3K4me0 binding","evidences":[{"source":"UniProtKB","id":"Q96T88","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	4
Details	Site: {"description":"Histone H3R2me0 binding","evidences":[{"source":"UniProtKB","id":"Q96T88","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI45
Number of Residues	2
Details	Site: {"description":"Required to confer preferential recognition of cytosine over thymine","evidences":[{"source":"UniProtKB","id":"Q96T88","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI46
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"UniProtKB","id":"Q96T88","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI47
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q96T88","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI48
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q7TPK1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI49
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"UniProtKB","id":"Q96T88","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI50
Number of Residues	2
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI51
Number of Residues	177
Details	Region: {"description":"Interaction with the F-box domain of F-box proteins","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI52
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI53
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"UniProtKB","id":"P63208","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)