8CAA

Crystal structure of TEAD4 in complex with YTP-13

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	SLS BEAMLINE X10SA
Synchrotron site	SLS
Beamline	X10SA
Temperature [K]	100
Detector technology	PIXEL
Collection date	2016-12-03
Detector	DECTRIS PILATUS 6M
Wavelength(s)	1.000
Spacegroup name	P 21 21 21
Unit cell lengths	35.729, 89.397, 135.473
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	19.440 - 1.999
R-factor	0.2138
Rwork	0.213
R-free	0.23730
Structure solution method	MOLECULAR REPLACEMENT
RMSD bond length	0.008
RMSD bond angle	1.010
Data reduction software	autoPROC
Data scaling software	STARANISO
Phasing software	PHASER
Refinement software	BUSTER (2.11.8 (8-JUN-2022))

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	19.440	2.090
High resolution limit [Å]	2.000	2.000
Rmerge	0.135	1.323
Rmeas	0.151	1.436
Number of reflections	26699	1335
<I/σ(I)>	9.6	1.7
Completeness [%]	88.2	35.7
Redundancy	6.6	6.7
CC(1/2)	0.998	0.584

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, SITTING DROP		293	22% PEG 3350 (w/v) , 0.25 M ammonium citrate dibasic