7CMM

Crystal structure of TEAD1-YBD in complex with K-975

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	SLS BEAMLINE X06DA
Synchrotron site	SLS
Beamline	X06DA
Temperature [K]	100
Detector technology	PIXEL
Collection date	2016-02-05
Detector	DECTRIS PILATUS 2M-F
Wavelength(s)	1
Spacegroup name	P 21 21 2
Unit cell lengths	147.990, 151.810, 67.530
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	10.000 - 3.500
R-factor	0.2363
Rwork	0.234
R-free	0.28400
Structure solution method	MOLECULAR REPLACEMENT
Starting model (for MR)	3kys
Data reduction software	XDS
Data scaling software	XDS
Phasing software	MOLREP
Refinement software	PHENIX (1.17.1_3660)

Data quality characteristics

	Overall	Inner shell	Outer shell
Low resolution limit [Å]	49.330	49.330	3.830
High resolution limit [Å]	3.500	8.570	3.500
Rmerge	0.546	0.070	3.290
Rmeas	0.562	0.072	3.377
Rpim	0.129	0.017	0.758
Total number of observations	369455	24984	90791
Number of reflections	19877	1484	4647
<I/σ(I)>	8	34.7	1.3
Completeness [%]	99.7	99.5	99.7
Redundancy	18.6	16.8	19.5
CC(1/2)	0.989	0.997	0.614

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, SITTING DROP		277	ammonium sulfate, PEG 3350, Bis-Tris