6FUT

Complement factor D in complex with the inhibitor (S)-3'-(aminomethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-[1,1'-biphenyl]-3-carboxamide

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	SLS BEAMLINE X10SA
Synchrotron site	SLS
Beamline	X10SA
Temperature [K]	100
Detector technology	PIXEL
Collection date	2008-12-12
Detector	DECTRIS PILATUS 2M
Wavelength(s)	1.00
Spacegroup name	P 21 21 21
Unit cell lengths	46.225, 77.041, 84.898
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	57.050 - 1.500
R-factor	0.15908
Rwork	0.158
R-free	0.18382
RMSD bond length	0.026
RMSD bond angle	2.469
Data reduction software	XDS
Data scaling software	XSCALE
Phasing software	PHASER
Refinement software	REFMAC (5.8.0189)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	57.100	1.510
High resolution limit [Å]	1.460	1.460
Rmerge		0.512
Number of reflections	52456
<I/σ(I)>	15.1	3.2
Completeness [%]	98.0
Redundancy	5.68

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION, SITTING DROP		293	22-25% PEG3350, 100 mM HEPES pH 7.5