4UXQ
FGFR4 in complex with Ponatinib
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | DIAMOND BEAMLINE I04-1 |
| Synchrotron site | Diamond |
| Beamline | I04-1 |
| Temperature [K] | 100 |
| Detector technology | PIXEL |
| Detector | DECTRIS PILATUS 6M |
| Spacegroup name | P 1 21 1 |
| Unit cell lengths | 41.835, 58.371, 60.570 |
| Unit cell angles | 90.00, 96.48, 90.00 |
Refinement procedure
| Resolution | 20.000 - 1.850 |
| R-factor | 0.2048 |
| Rwork | 0.201 |
| R-free | 0.26810 |
| Structure solution method | OTHER |
| Starting model (for MR) | NONE |
| RMSD bond length | 0.010 |
| RMSD bond angle | 1.120 |
| Refinement software | BUSTER (2.11.5) |
Data quality characteristics
| Overall | Outer shell | |
| Low resolution limit [Å] | 30.000 | 1.950 |
| High resolution limit [Å] | 1.850 | 1.850 |
| Rmerge | 0.180 | 0.287 |
| Number of reflections | 14141 | |
| <I/σ(I)> | 7.3 | 2.6 |
| Completeness [%] | 57.0 | 8 |
| Redundancy | 4.6 | 2.6 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | 0.1MPCTP, PH4.5 0.1M (NH4)2SO4, 15% PEG3350 |
