2WI6

Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone

Refinement Statistics

Experimental method:X-RAY DIFFRACTION (2.18 Å)

Cell axes64.93087.95799.132
Cell angles90.0090.0090.00
SpacegroupI 2 2 2
Resolution limits65.80 - 2.18
the highest resolution shell value2.240 - 2.180
R-factor0.237
R-work0.23300
the highest resolution shell value0.291
R-free0.30400
the highest resolution shell value0.361
RMSD bond length0.020
RMSD bond angle2.096

Data Collection Statistics

Resolution limits30.00 - 2.18
the highest resolution shell value -
Number of reflections14988
Rmerge_l_obs0.050
the highest resolution shell value0.270
Completeness86.3
Redundancy3
the highest resolution shell value2
I/sigma(I)3

Crystallization Conditions

crystal IDmethodpHpH rangetemperatureunit
16.5

Crystallization Reagents

IDcrystal IDsolution IDreagent nameconcentrationdetails
Crystallization Reagents in Literatures*
IDcrystal IDsolutionreagent nameconcentration (unit)details
Annotated Information is extracted from Literature Info*