2WI3

Orally Active 2-Amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone

Refinement Statistics

Experimental method:X-RAY DIFFRACTION (1.9 Å)

Cell axes65.68289.17299.783
Cell angles90.0090.0090.00
SpacegroupI 2 2 2
Resolution limits65.94 - 1.90
the highest resolution shell value1.949 - 1.900
R-factor0.19992
R-work0.19772
the highest resolution shell value0.528
R-free0.24248
the highest resolution shell value0.498
RMSD bond length0.028
RMSD bond angle2.215

Data Collection Statistics

Resolution limits30.00 - 1.90
the highest resolution shell value -
Number of reflections21769
Rmerge_l_obs0.020
the highest resolution shell value0.180
Completeness92.8
Redundancy2
I/sigma(I)3

Crystallization Conditions

crystal IDmethodpHpH rangetemperatureunit
16.5

Crystallization Reagents

IDcrystal IDsolution IDreagent nameconcentrationdetails
Crystallization Reagents in Literatures*
IDcrystal IDsolutionreagent nameconcentration (unit)details
Annotated Information is extracted from Literature Info*