2VWI

Structure of the OSR1 kinase, a hypertension drug target

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	ESRF BEAMLINE BM14
Synchrotron site	ESRF
Beamline	BM14
Temperature [K]	101
Detector technology	CCD
Collection date	2006-06-15
Detector	ADSC CCD
Spacegroup name	P 21 21 21
Unit cell lengths	74.130, 99.900, 158.525
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	19.940 - 2.150
R-factor	0.253
Rwork	0.253
R-free	0.28700
Structure solution method	SIR
Starting model (for MR)	NONE
RMSD bond length	0.006
RMSD bond angle	0.964
Data reduction software	HKL-2000
Data scaling software	SCALEPACK
Phasing software	SOLVE
Refinement software	REFMAC (5.2.0005)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	20.000	2.230
High resolution limit [Å]	2.150	2.150
Rmerge	0.060	0.300
Number of reflections	65284
<I/σ(I)>	48.6	2.8
Completeness [%]	98.7	88.2
Redundancy	13.6	3.9

Crystallization Conditions

crystal ID	method	pH	temperature	details
1