1XO2

Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	ALS BEAMLINE 5.0.1
Synchrotron site	ALS
Beamline	5.0.1
Detector technology	CCD
Collection date	2004-02-23
Wavelength(s)	1.0
Spacegroup name	P 65 2 2
Unit cell lengths	66.162, 66.162, 448.596
Unit cell angles	90.00, 90.00, 120.00

Refinement procedure

Resolution	20.000 - 2.900
Rwork	0.260
R-free	0.31300
Structure solution method	MOLECULAR REPLACEMENT
Starting model (for MR)	1jow
RMSD bond length	0.008
RMSD bond angle	1.380
Data reduction software	TRUNCATE
Data scaling software	CCP4 ((TRUNCATE))
Phasing software	AMoRE
Refinement software	CNS

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	50.000	2.880
High resolution limit [Å]	2.800	2.800
Rmerge	0.122	0.730
Number of reflections	14353
<I/σ(I)>	18.3	3.1
Completeness [%]	91.5	90.9
Redundancy	8.16

Crystallization Conditions

crystal ID	method	pH	temperature	details
1