8SE2
 
 | | Structure of Full-length Human Protein Kinase C Beta 1 (PKCBI) in the Active and Inactive Conformation Soaked in Manganese Chloride | | Descriptor: | CALCIUM ION, GLYCEROL, MANGANESE (II) ION, ... | | Authors: | Cong, A.T.Q, Witter, T.L, Bruinsma, E.S, Jayaraman, S, Hawse, J.R, Goetz, M.P, Schellenberg, M.J. | | Deposit date: | 2023-04-07 | | Release date: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Molecular Basis of Allosteric Regulation and Pharmaceutical Targeting of Protein Kinase C b
To Be Published
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8SE3
 | | Structure of Full-length Human Protein Kinase C Beta 1 (PKCBI) in the Active Conformation | | Descriptor: | GLYCEROL, Protein kinase C beta type, ZINC ION | | Authors: | Cong, A.T.Q, Witter, T.L, Bruinsma, E.S, Jayaraman, S, Hawse, J.R, Goetz, M.P, Schellenberg, M.J. | | Deposit date: | 2023-04-07 | | Release date: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Molecular Basis of Allosteric Regulation and Pharmaceutical Targeting of
Protein Kinase C b
To Be Published
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8SE4
 | | Structure of Full-length Human Protein Kinase C Beta 1 (PKCBI) in the Active and Inactive Conformation | | Descriptor: | ADENOSINE, Protein kinase C beta type, ZINC ION | | Authors: | Cong, A.T.Q, Witter, T.L, Bruinsma, E.S, Jayaraman, S, Hawse, J.R, Goetz, M.P, Schellenberg, M.J. | | Deposit date: | 2023-04-07 | | Release date: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Molecular Basis of Allosteric Regulation and Pharmaceutical Targeting of
Protein Kinase C b
To Be Published
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8V0J
 | | Structure of the complex between Human LIAS and H-protein in the presence of s-adenosyl-l-methionine | | Descriptor: | 6-THIOOCTANOIC ACID, FE3-S4 CLUSTER, Glycine cleavage system H protein, ... | | Authors: | Esakova, O.A, Warui, D.M, Neti, S.S, Alumasa, J.N, Booker, S.J. | | Deposit date: | 2023-11-17 | | Release date: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (2.58 Å) | | Cite: | Structural basis for the mechanism of the human lipoyl synthase (LIAS) and its complex with the H-protein
To Be Published
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8VX1
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8YDK
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8YDL
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9AZ3
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9CY9
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9D26
 | | A widespread heme dechelatase in healthy and pathogenic human microbiomes. | | Descriptor: | HmuS heme dechelatase, PROTOPORPHYRIN IX CONTAINING FE, SODIUM ION | | Authors: | Gauvin, C.C, Nath, A.K, Rodrigues da Silva, R, Akpoto, E, Dubois, J.L, Lawrence, C.M. | | Deposit date: | 2024-08-08 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | A widespread heme dechelatase in healthy and pathogenic human microbiomes.
To Be Published
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9D35
 | | Proteasome core particle assembly intermediate 5-alpha/3-beta/Ump1 purified from Saccharomyces cerevisiae. | | Descriptor: | Probable proteasome subunit alpha type-7, Proteasome maturation factor UMP1, Proteasome subunit alpha type-1, ... | | Authors: | Chen, X, Kaur, M, Roelofs, J, Walters, K.J. | | Deposit date: | 2024-08-09 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Structure of Blm10:13S proteasome assembly intermediate reveals parallel assembly pathways for the proteasome core particle
To Be Published
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9D3I
 | | Proteasome core particle assembly intermediate 5-alpha/4-beta/Ump1 purified from Saccharomyces cerevisiae. | | Descriptor: | Probable proteasome subunit alpha type-7, Proteasome maturation factor UMP1, Proteasome subunit alpha type-1, ... | | Authors: | Chen, X, Kaur, M, Roelofs, J, Walters, K.J. | | Deposit date: | 2024-08-10 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | Structure of Blm10:13S proteasome assembly intermediate reveals parallel assembly pathways for the proteasome core particle
To Be Published
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9D41
 | | Crystal structure of N-terminal domain of Borealin (20-88) in complex with synthetic antibody fragment | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Borealin, CHLORIDE ION, ... | | Authors: | Filippova, E.V, Hou, J, Mukherjee, S, Kossiakoff, A.A. | | Deposit date: | 2024-08-12 | | Release date: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Crystal structure of N-terminal domain of Borealin (20-88) in complex with synthetic antibody fragment
To Be Published
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9D47
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9D48
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9D4A
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9D4B
 | | Discovery of SMD-3236, a Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers | | Descriptor: | (4R)-1-[(2S)-2-{4-[(1S,4S)-4-({4-[(12'S)-4'-chloro-5'-oxo-5'H-spiro[cyclohexane-1,7'-indolo[1,2-a]quinazolin]-10'-yl]piperidin-1-yl}methyl)cyclohexyl]-1H-1,2,3-triazol-1-yl}-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-(morpholin-4-yl)ethyl]-L-prolinamide, Elongin-B, Elongin-C, ... | | Authors: | Strickland, C. | | Deposit date: | 2024-08-12 | | Release date: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Discovery of SMD-3236, a Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers
To Be Published
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9D4C
 | | Proteasome core particle assembly intermediate Blm10:alpha-ring purified from Saccharomyces cerevisiae. | | Descriptor: | Probable proteasome subunit alpha type-7, Proteasome activator BLM10, Proteasome subunit alpha type-1, ... | | Authors: | Chen, X, Kaur, M, Roelofs, J, Walters, K.J. | | Deposit date: | 2024-08-12 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (2.75 Å) | | Cite: | Structure of Blm10:13S proteasome assembly intermediate reveals parallel assembly pathways for the proteasome core particle
To Be Published
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9D4U
 | | Core particle assembly intermediate Capless 13S purified from Saccharomyces cerevisiae | | Descriptor: | Probable proteasome subunit alpha type-7, Proteasome maturation factor UMP1, Proteasome subunit alpha type-1, ... | | Authors: | Chen, X, Kaur, M, Roelofs, J, Walters, K.J. | | Deposit date: | 2024-08-13 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (3.55 Å) | | Cite: | Structure of Blm10:13S proteasome assembly intermediate reveals parallel assembly pathways for the proteasome core particle
To Be Published
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9D57
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9D5O
 | | Crystal structure of the second bromodomain of human BRD2 in complex with 3IND | | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, Bromodomain-containing protein 2, methyl [(4S,6M,10aM)-6-(1H-indol-3-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetate | | Authors: | Nithianantham, S, Fischer, M. | | Deposit date: | 2024-08-14 | | Release date: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Positional isomers of Indolyl-benzodiazepines display dissimilar binding and recruitment of BET transcriptional regulators to targeted genomic loci.
Bioorg.Chem., 164, 2025
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9D5Q
 | | Crystal structure of KPC-2 complexed with compound 21 | | Descriptor: | ({7-bromo-2-oxo-1-[(1Z)-3-phenylprop-1-en-1-yl]-1,2-dihydroquinolin-4-yl}methyl)phosphonic acid, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, ... | | Authors: | Jacobs, L.M.C, Chen, Y. | | Deposit date: | 2024-08-14 | | Release date: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Hit to Lead Optimization of Heteroaryl Phosphonates Reversible, Broad-Spectrum Inhibitors of Serine and Metallo Carbapenemases.
To Be Published
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9D5R
 | | Crystal structure of KPC-2 complexed with compound 22 | | Descriptor: | Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, SULFATE ION, ... | | Authors: | Jacobs, L.M.C, Chen, Y. | | Deposit date: | 2024-08-14 | | Release date: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Hit to Lead Optimization of Heteroaryl Phosphonates Reversible, Broad-Spectrum Inhibitors of Serine and Metallo Carbapenemases.
To Be Published
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9D6N
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9D6O
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