10AC
 
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10AM
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10AW
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10BV
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10DB
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10DN
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10DW
 | | Structure of CRBN/DDB1dB-KAT2A-Compound4 ternary complex | | Descriptor: | (3S)-3-[4-({6-(3-tert-butyl-2-oxoimidazolidin-1-yl)-1-[(2S)-oxan-2-yl]-1H-imidazo[4,5-c]pyridin-4-yl}amino)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, Histone acetyltransferase KAT2A, ... | | Authors: | Ojeda, S, Fischer, E.S. | | Deposit date: | 2026-01-14 | | Release date: | 2026-08-12 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Degron-independent recruitment of KAT2A expands the target space of CRBN molecular glues.
Science, 393, 2026
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11KP
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12ER
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12ES
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12KZ
 | | Crystal structure of human KRAS G12C covalently bound to thiazol-2-yl piperidine compound 3 | | Descriptor: | 1,2-ETHANEDIOL, 1-[4-(1-{6-[4-(1,3-thiazol-2-yl)piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}azetidin-3-yl)piperazin-1-yl]propan-1-one, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Mohr, C. | | Deposit date: | 2026-04-10 | | Release date: | 2026-08-12 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Property-Biased Covalent DNA-Encoded Library Screening Enabled the Discovery of AM-8719, A Structurally Novel, CNS-Penetrant KRAS G12C Inhibitor
J.Med.Chem., 2026
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12LA
 | | Crystal structure of human KRAS G12C covalently bound to 4-methyl-thiazol-5-yl piperidine compound 4 | | Descriptor: | 1,2-ETHANEDIOL, 1-[4-(1-{6-[4-(4-methyl-1,3-thiazol-5-yl)piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}azetidin-3-yl)piperazin-1-yl]propan-1-one, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Mohr, C. | | Deposit date: | 2026-04-10 | | Release date: | 2026-08-12 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Property-Biased Covalent DNA-Encoded Library Screening Enabled the Discovery of AM-8719, A Structurally Novel, CNS-Penetrant KRAS G12C Inhibitor
J.Med.Chem., 2026
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12LB
 | | Crystal structure of human KRAS G12C covalently bound to 1,4-dimethyl-pyrazol-5-yl piperidine compound 5 | | Descriptor: | 1,2-ETHANEDIOL, 1-[4-(1-{6-[4-(1,4-dimethyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-(trifluoromethyl)pyrimidin-4-yl}azetidin-3-yl)piperazin-1-yl]propan-1-one, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Mohr, C. | | Deposit date: | 2026-04-10 | | Release date: | 2026-08-12 | | Method: | X-RAY DIFFRACTION (1.26 Å) | | Cite: | Property-Biased Covalent DNA-Encoded Library Screening Enabled the Discovery of AM-8719, A Structurally Novel, CNS-Penetrant KRAS G12C Inhibitor
J.Med.Chem., 2026
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12LC
 | | Crystal structure of human KRAS G12C covalently bound to AM-8719 | | Descriptor: | 1-(4-{(2R,3R)-1-[6-{4-[2-(3-methoxyoxetan-3-yl)-4-methylpyridin-3-yl]piperidin-1-yl}-2-(trifluoromethyl)pyrimidin-4-yl]-2-methylazetidin-3-yl}piperazin-1-yl)propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Mohr, C. | | Deposit date: | 2026-04-10 | | Release date: | 2026-08-12 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Property-Biased Covalent DNA-Encoded Library Screening Enabled the Discovery of AM-8719, A Structurally Novel, CNS-Penetrant KRAS G12C Inhibitor
J.Med.Chem., 2026
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21AZ
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21ED
 | | Crystal structure of human PHF20L1(85-142) | | Descriptor: | PHD finger protein 20-like protein 1 | | Authors: | Liu, Y, Huang, X, Shang, X. | | Deposit date: | 2025-12-10 | | Release date: | 2026-08-12 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | A revised model for PHF20L1 Tudor function: DNA binding overrides methylation selectivity on nucleosomes.
J.Biol.Chem., 302, 2026
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21EE
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21GL
 | | The atomic coordinate of p24 complex at pH 6.8 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane emp24 domain-containing protein 10, Transmembrane emp24 domain-containing protein 2, ... | | Authors: | Hua, Z.K, Zhang, D, Zhang, M, Yu, H.J. | | Deposit date: | 2025-12-11 | | Release date: | 2026-08-12 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Structure of the GPI-AP transporter in pH 6.8
To Be Published
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21GM
 | | The atomic coordinate of p24 complex at pH 7.5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane emp24 domain-containing protein 10, Transmembrane emp24 domain-containing protein 2, ... | | Authors: | Hua, Z.K, Zhang, D, Zhang, M, Yu, H.J. | | Deposit date: | 2025-12-11 | | Release date: | 2026-08-12 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of the GPI-AP transporter in pH 7.5
To Be Published
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21JG
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21KO
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21LT
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21WY
 | | resting conformation of PSCC1 | | Descriptor: | Ligand-gated ion channel pHCl-A | | Authors: | Wang, C. | | Deposit date: | 2026-01-02 | | Release date: | 2026-08-12 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structure of PSCC1
To Be Published
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22HG
 | | SARS-CoV-2 BA.3.2.2(RE.2.2) RBD in complex with human ACE2 and monoclonal antibody S2H97 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of monoclonal antibody S2H97, Light chain of monoclonal antibody S2H97, ... | | Authors: | Li, L.J, Qu, H, Wu, Q.L, Gao, G.F. | | Deposit date: | 2026-01-10 | | Release date: | 2026-08-12 | | Method: | ELECTRON MICROSCOPY (2.61 Å) | | Cite: | Receptor Binding, Immune Escape, and Cross-Species Transmission of SARS-CoV-2 Serum-Defined Lineage 7, BA.3.2.2(RE.2.2)
To Be Published
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22JW
 | | Perinereis linea erythrocruorin | | Descriptor: | CALCIUM ION, Extracellular globin A, Extracellular globin B, ... | | Authors: | Deng, J.X, Jiang, Y.L, Zhou, C.Z. | | Deposit date: | 2026-01-14 | | Release date: | 2026-08-12 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Structure of Perinereis linea erythrocruorin reveals a compact extracellular globin megacomplex.
Structure, 2026
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