8UXA
 
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8X9Z
 | | P-hexon capsomer of the VZV C-Capsid | | Descriptor: | CVC1, Capsid vertex component 2, Large tegument protein deneddylase, ... | | Authors: | Nan, W, Lei, C, Xiangxi, W. | | Deposit date: | 2023-12-01 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Insights into varicella-zoster virus assembly from the B- and C-capsid at near-atomic resolution structures
Hlife, 2, 2024
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8ZIF
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8ZIL
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8ZO8
 | | Respirasome open state 3 in presence of metformin (SC-MetO3) | | Descriptor: | (4S,7R)-4-hydroxy-N,N,N-trimethyl-7-(octadecanoyloxy)-4,10-dioxo-3,5,9-trioxa-4lambda~5~-phosphaheptacosan-1-aminium, (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | Authors: | Teng, F, He, Z.X, Hu, Y.Q, Xu, C.Y, Guo, R.Y, Zhou, L. | | Deposit date: | 2024-05-28 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
Nat.Struct.Mol.Biol., 2025
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8ZOU
 | | Respirasome open state 2 in presence of metformin (SC-MetO2) | | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, ... | | Authors: | Teng, F, He, Z.X, Hu, Y.Q, Xu, C.Y, Guo, R.Y, Zhou, L. | | Deposit date: | 2024-05-29 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
Nat.Struct.Mol.Biol., 2025
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8ZR9
 | | Cryo-EM structure of AbCapV filemant bound with 3',3'-cGAMP | | Descriptor: | 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, CGAMP-activated phospholipase CapV | | Authors: | Kong, J.P, Li, Z.X, Ke, S.Y, Xiao, Y.B. | | Deposit date: | 2024-06-04 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Molecular mechanisms of CBASS phospholipase effector CapV mediated membrane disruption.
Nat Commun, 16, 2025
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8ZSK
 | | Complex I from respirasome closed state 1 bound by metformin and CoQ10, alternative orientation (SC-MetC1-ii) | | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, ... | | Authors: | Teng, F, He, Z.X, Hu, Y.Q, Xu, C.Y, Guo, R.Y, Zhou, L. | | Deposit date: | 2024-06-05 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
Nat.Struct.Mol.Biol., 2025
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8ZSL
 | | Complex I from respirasome closed state 1 bound by metformin and CoQ10 (SC-MetC1-i) | | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | | Authors: | Teng, F, He, Z.X, Hu, Y.Q, Xu, C.Y, Guo, R.Y, Zhou, L. | | Deposit date: | 2024-06-05 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
Nat.Struct.Mol.Biol., 2025
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8ZSM
 | | Complex I from respirasome closed state 1 bound by metformin (SC-MetC1-iii) | | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | | Authors: | Teng, F, He, Z.X, Hu, Y.Q, Xu, C.Y, Guo, R.Y, Zhou, L. | | Deposit date: | 2024-06-05 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
Nat.Struct.Mol.Biol., 2025
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8ZSN
 | | Respirasome closed state 1 in the absence of biguanide (SC-ApoC) | | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | | Authors: | Teng, F, He, Z.X, Hu, Y.Q, Xu, C.Y, Guo, R.Y, Zhou, L. | | Deposit date: | 2024-06-05 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
Nat.Struct.Mol.Biol., 2025
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8ZSO
 | | Respirasome close state 2 in presence of metformin (SC-MetC2) | | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | | Authors: | Teng, F, He, Z.X, Hu, Y.Q, Xu, C.Y, Guo, R.Y, Zhou, L. | | Deposit date: | 2024-06-05 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
Nat.Struct.Mol.Biol., 2025
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8ZSQ
 | | Respirasome closed state 1 bound by metformin (SC-MetC1) | | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | | Authors: | Teng, F, He, Z.X, Hu, Y.Q, Xu, C.Y, Guo, R.Y, Zhou, L. | | Deposit date: | 2024-06-05 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
Nat.Struct.Mol.Biol., 2025
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8ZUX
 | | Structure of G668R-hPCC | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, BICARBONATE ION, MAGNESIUM ION, ... | | Authors: | Ni, F, Yan, H, Wang, Q, Ma, J. | | Deposit date: | 2024-06-10 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.68 Å) | | Cite: | Nanoscale conformational dynamics of human propionyl-CoA carboxylase.
Structure, 2025
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8ZUY
 | | Structure of M695D-hPCC | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, BICARBONATE ION, MAGNESIUM ION, ... | | Authors: | Ni, F, Yan, H, Wang, Q, Ma, J. | | Deposit date: | 2024-06-10 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.63 Å) | | Cite: | Nanoscale conformational dynamics of human propionyl-CoA carboxylase.
Structure, 2025
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8ZUZ
 | | Structure of G131R-hPCC BCCP-BC Conformation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, BICARBONATE ION, MAGNESIUM ION, ... | | Authors: | Ni, F, Yan, H, Wang, Q, Ma, J. | | Deposit date: | 2024-06-11 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.73 Å) | | Cite: | Nanoscale conformational dynamics of human propionyl-CoA carboxylase.
Structure, 2025
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8ZV0
 | | Structure of G131R-hPCC BCCP-CT Conformation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, BICARBONATE ION, BIOTIN, ... | | Authors: | Ni, F, Yan, H, Wang, Q, Ma, J. | | Deposit date: | 2024-06-11 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Nanoscale conformational dynamics of human propionyl-CoA carboxylase.
Structure, 2025
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8ZV1
 | | Structure of R165Q-hPCC BCCP-BC Conformation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, BICARBONATE ION, BIOTIN, ... | | Authors: | Ni, F, Yan, H, Wang, Q, Ma, J. | | Deposit date: | 2024-06-11 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Nanoscale conformational dynamics of human propionyl-CoA carboxylase.
Structure, 2025
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8ZV2
 | | Structure of R165Q-hPCC BCCP-CT Conformation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, BIOTIN, MAGNESIUM ION, ... | | Authors: | Ni, F, Yan, H, Wang, Q, Ma, J. | | Deposit date: | 2024-06-11 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Nanoscale conformational dynamics of human propionyl-CoA carboxylase.
Structure, 2025
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8ZV3
 | | Structure of G202A/G203A-hPCC BCCP-BC Conformation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, BIOTIN, MAGNESIUM ION, ... | | Authors: | Ni, F, Yan, H, Wang, Q, Ma, J. | | Deposit date: | 2024-06-11 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.77 Å) | | Cite: | Nanoscale conformational dynamics of human propionyl-CoA carboxylase.
Structure, 2025
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8ZV4
 | | Structure of G202A/G203A-hPCC BCCP-CT Conformation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, BICARBONATE ION, MAGNESIUM ION, ... | | Authors: | Ni, F, Yan, H, Wang, Q, Ma, J. | | Deposit date: | 2024-06-11 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | Nanoscale conformational dynamics of human propionyl-CoA carboxylase.
Structure, 2025
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8ZV5
 | | Structure of D440Y-hPCC BCCP-BC Conformation | | Descriptor: | Propionyl-CoA carboxylase alpha chain, mitochondrial, Propionyl-CoA carboxylase beta chain | | Authors: | Ni, F, Yan, H, Wang, Q, Ma, J. | | Deposit date: | 2024-06-11 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Nanoscale conformational dynamics of human propionyl-CoA carboxylase.
Structure, 2025
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8ZV6
 | | Structure of D440Y-hPCC BCCP-CT Conformation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, BICARBONATE ION, BIOTIN, ... | | Authors: | Ni, F, Yan, H, Wang, Q, Ma, J. | | Deposit date: | 2024-06-11 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Nanoscale conformational dynamics of human propionyl-CoA carboxylase.
Structure, 2025
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8ZXZ
 | | Complex I form respirasome closed state bound by proguanil (SC-ProgC) | | Descriptor: | (4S,7R)-4-hydroxy-N,N,N-trimethyl-7-(octadecanoyloxy)-4,10-dioxo-3,5,9-trioxa-4lambda~5~-phosphaheptacosan-1-aminium, (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ... | | Authors: | Teng, F, He, Z.X, Hu, Y.Q, Xu, C.Y, Guo, R.Y, Zhou, L. | | Deposit date: | 2024-06-15 | | Release date: | 2025-11-19 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
Nat.Struct.Mol.Biol., 2025
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9CF5
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