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冠狀病毒
冠狀病毒,2020. 由David S. Goodsell @ RCSB PDB原圖修改

最近爆發的新型冠狀病毒傳染病(Novel Coronavirus disease 2019: COVID-19)對全世界的人們都構成了嚴重威脅。 為了儘早了解新病毒(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)以開發出有效的抗病毒藥物,已經有很多科研人員開始了相關蛋白結構的研究,並且將所獲得結構數據存儲與PDB。 PDBj為用戶提供了COVID-19相關數據一覽的門戶頁面,並將於每週三更新當日新發佈的相關數據。

有關該病毒蛋白質的解說,請參見下面的“當月的分子”頁面。

“所有結構”標籤的頁面則逐一羅列了所有的數據,包括由同一研究組提交的系列數據群。 “代表性結構”標籤的頁面精選具有相同胺基酸序列的結構數據中的高分辨率數據,不重複選擇具有同一胺基酸序列的數據,即使該數據可能包含不同的配體。 “最新條目”標籤內包含本週新更新數據。

Created: 2020-03-11 (last edited: 3 weeks ago)2020-09-03
所有結構 (390)代表性結構 (167)最新條目 (19)
7CHB
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CRYSTAL STRUCTURE OF THE SARS-COV-2 RBD IN COMPLEX WITH BD-236 FAB
Descriptor:BD-236 Fab heavy chain, BD-236 Fab light chain, SARS-coV-2 Receptor Binding Domain, ...
Authors:Junyu, X., Qinyu, Z.
Deposit date:2020-07-05
Release date:2020-09-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the SARS-CoV-2 S RBD in complex with BD-236 Fab
To Be Published
7CHE
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CRYSTAL STRUCTURE OF THE SARS-COV-2 RBD IN COMPLEX WITH BD-236 FAB AND BD-368-2 FAB
Descriptor:BD-236 Fab heavy chain, BD-236 Fab light chain, SARS-coV-2 Receptor Binding Domain, ...
Authors:Xiao, J., Zhu, Q.
Deposit date:2020-07-05
Release date:2020-09-16
Method:X-RAY DIFFRACTION (3.416 Å)
Cite:Crystal structure of the SARS-CoV-2 RBD in complex with BD-236 Fab and BD-368-2 Fab
To Be Published
7A5R
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COMPLEX OF SARS-COV-2 SPIKE AND CR3022 FAB (NON-UNIFORM REFINEMENT)
Descriptor:CR3022 Fab Heavy Chain, CR3022 Fab Light Chain, Spike glycoprotein, ...
Authors:Wrobel, A.G., Benton, D.J., Rosenthal, P.B., Gamblin, S.J.
Deposit date:2020-08-21
Release date:2020-09-16
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein
To be published
7CH4
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CRYSTAL STRUCTURE OF THE SARS-COV-2 S RBD IN COMPLEX WITH BD-604 FAB
Descriptor:BD-604 Fab H, BD-604 Fab L, Spike glycoprotein
Authors:Du, S., Xiao, J.Y.
Deposit date:2020-07-05
Release date:2020-09-16
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Crystal structure of the SARS-CoV-2 S RBD in complex with BD-604 Fab
To Be Published
7A5S
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COMPLEX OF SARS-COV-2 SPIKE AND CR3022 FAB (HOMOGENEOUS REFINEMENT)
Descriptor:CR3022 Fab Heavy Chain, CR3022 Fab Light Chain, Spike glycoprotein, ...
Authors:Wrobel, A.G., Benton, D.J., Rosenthal, P.B., Gamblin, S.J.
Deposit date:2020-08-21
Release date:2020-09-16
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein
To be published
7CX9
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CRYSTAL STRUCTURE OF THE SARS-COV-2 MAIN PROTEASE IN COMPLEX WITH INZ-1
Descriptor:3C protein, 3-iodanyl-1~{H}-indazole-7-carbaldehyde, GLYCEROL, ...
Authors:Zeng, R., Liu, X.L., Qiao, J.X., Nan, J.S., Wang, Y.F., Li, Y.S., Yang, S.Y., Lei, J.
Deposit date:2020-09-01
Release date:2020-09-16
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Crystal structure of the SARS-CoV-2 main protease in complex with INZ-1
To Be Published
7A97
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SARS-COV-2 SPIKE GLYCOPROTEIN WITH 2 ACE2 BOUND
Descriptor:Spike glycoprotein, Angiotensin-converting enzyme 2
Authors:Benton, D.J., Wrobel, A.G., Rosenthal, P.B., Gamblin, S.J.
Deposit date:2020-09-01
Release date:2020-09-16
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Receptor Binding and Priming of SARS-CoV-2 Spike for Membrane Fusion
To be published
7A95
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SARS-COV-2 SPIKE GLYCOPROTEIN WITH 1 ACE2 BOUND AND 1 RBD ERECT IN CLOCKWISE DIRECTION
Descriptor:Spike glycoprotein, Angiotensin-converting enzyme 2
Authors:Benton, D.J., Wrobel, A.G., Rosenthal, P.B., Gamblin, S.J.
Deposit date:2020-09-01
Release date:2020-09-16
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Receptor Binding and Priming of SARS-CoV-2 Spike for Membrane Fusion
To be published
7CHH
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CRYO-EM STRUCTURE OF THE SARS-COV-2 S-6P IN COMPLEX WITH BD-368-2 FABS
Descriptor:Spike glycoprotein, BD-368-2 Fab heavy chain, BD-368-2 Fab light chain, ...
Authors:Xiao, J., Zhu, Q., Wang, G.
Deposit date:2020-07-05
Release date:2020-09-16
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Cryo-EM structure of the SARS-CoV-2 S-6P in complex with BD-368-2 Fabs
To Be Published
7CHC
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CRYSTAL STRUCTURE OF THE SARS-COV-2 S RBD IN COMPLEX WITH BD-629 FAB AND BD-368-2 FAB
Descriptor:BD-629 Fab H, IGK@ protein, Spike glycoprotein, ...
Authors:Du, S., Xiao, J.Y.
Deposit date:2020-07-05
Release date:2020-09-16
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal structure of the SARS-CoV-2 S RBD in complex with BD-629 Fab and BD-368-2 Fab
To Be Published
7CH5
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CRYSTAL STRUCTURE OF THE SARS-COV-2 S RBD IN COMPLEX WITH BD-629 FAB
Descriptor:BD-629 Fab H, BD-629 Fab L, Spike glycoprotein
Authors:Du, S., Xiao, J.Y.
Deposit date:2020-07-05
Release date:2020-09-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the SARS-CoV-2 S RBD in complex with BD-629 Fab
To Be Published
7A91
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DISSOCIATED S1 DOMAIN OF SARS-COV-2 SPIKE BOUND TO ACE2 (NON-UNIFORM REFINEMENT)
Descriptor:Angiotensin-converting enzyme 2, Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Benton, D.J., Wrobel, A.G., Rosenthal, P.B., Gamblin, S.J.
Deposit date:2020-09-01
Release date:2020-09-16
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Receptor Binding and Priming of SARS-CoV-2 Spike for Membrane Fusion
To be published
7JZ0
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CRYSTAL STRUCTURE OF SARS-COV-2 NSP16/10 HETERODIMER IN COMPLEX WITH (M7GPPPA2M)PUPUPAPAPA (CAP-1) AND S-ADENOSYL-L-HOMOCYSTEINE (SAH).
Descriptor:2'-O-methyltransferase, Non-structural protein 10, RNA (5'-D(*(M7G))-R(P*(A2M)P*UP*U)-3'), ...
Authors:Minasov, G., Shuvalova, L., Rosas-Lemus, M., Kiryukhina, O., Brunzelle, J.S., Satchell, K.J.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-09-01
Release date:2020-09-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA2m)pUpUpApApA (Cap-1) and S-Adenosyl-L-homocysteine (SAH).
To Be Published
7A94
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SARS-COV-2 SPIKE GLYCOPROTEIN WITH 1 ACE2 BOUND
Descriptor:Spike glycoprotein, Angiotensin-converting enzyme 2, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Benton, D.J., Wrobel, A.G., Rosenthal, P.B., Gamblin, S.J.
Deposit date:2020-09-01
Release date:2020-09-16
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Receptor Binding and Priming of SARS-CoV-2 Spike for Membrane Fusion
To be published
7JYY
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CRYSTAL STRUCTURE OF SARS-COV-2 NSP16/10 HETERODIMER IN COMPLEX WITH (M7GPPPA)PUPUPAPAPA (CAP-0) AND S-ADENOSYLMETHIONINE (SAM).
Descriptor:2'-O-methyltransferase, Non-structural protein 10, RNA (5'-D(*(M7G))-R(P*AP*UP*UP*A)-3'), ...
Authors:Minasov, G., Shuvalova, L., Rosas-Lemus, M., Kiryukhina, O., Brunzelle, J.S., Satchell, K.J.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-09-01
Release date:2020-09-16
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA)pUpUpApApA (Cap-0) and S-Adenosylmethionine (SAM).
To Be Published
7A96
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SARS-COV-2 SPIKE GLYCOPROTEIN WITH 1 ACE2 BOUND AND 1 RBD ERECT IN ANTICLOCKWISE DIRECTION
Descriptor:Spike glycoprotein, Angiotensin-converting enzyme 2
Authors:Benton, D.J., Wrobel, A.G., Rosenthal, P.B., Gamblin, S.J.
Deposit date:2020-09-01
Release date:2020-09-16
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Receptor Binding and Priming of SARS-CoV-2 Spike for Membrane Fusion
To be published
7JVZ
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SARS COV-2 MAIN PROTEASE 3CLPRO, ROOM TEMPERATURE, DAMAGE FREE XFEL MONOCLINIC STRUCTURE
Descriptor:3C-like proteinase
Authors:Schmidt, M., Malla, T.
Deposit date:2020-08-24
Release date:2020-09-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:SARS CoV-2 MAIN PROTEASE 3CLpro, ROOM TEMPERATURE, DAMAGE FREE XFEL MONOCLINIC STRUCTURE
To Be Published
7A93
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SARS-COV-2 SPIKE GLYCOPROTEIN WITH 2 RBDS ERECT
Descriptor:Spike glycoprotein
Authors:Benton, D.J., Wrobel, A.G., Rosenthal, P.B., Gamblin, S.J.
Deposit date:2020-09-01
Release date:2020-09-16
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Receptor Binding and Priming of SARS-CoV-2 Spike for Membrane Fusion
To be published
7CHF
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CRYSTAL STRUCTURE OF THE SARS-COV-2 RBD IN COMPLEX WITH BD-604 FAB AND BD-368-2 FAB
Descriptor:BD-604 Fab heavy chain, BD-604 Fab light chain, SARS-coV-2 Receptor Binding Domain, ...
Authors:Xiao, J., Zhu, Q.
Deposit date:2020-07-05
Release date:2020-09-16
Method:X-RAY DIFFRACTION (2.674 Å)
Cite:Crystal structure of the SARS-CoV-2 RBD in complex with BD-604 Fab and BD-368-2 Fab
To Be Published
7JU7
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THE CRYSTAL STRUCTURE OF SARS-COV-2 MAIN PROTEASE IN COMPLEX WITH MASITINIB
Descriptor:3C-like proteinase, Masitinib, DIMETHYL SULFOXIDE, ...
Authors:Tan, K., Maltseva, N.I., Welk, L.F., Jedrzejczak, R.P., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-08-19
Release date:2020-09-09
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The crystal structure of SARS-CoV-2 Main Protease in complex with masitinib.
To Be Published
7JYC
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CRYSTAL STRUCTURE OF SARS-COV-2 MAIN PROTEASE (3CLPRO/MPRO) IN COMPLEX WITH COVALENT INHIBITOR NARLAPREVIR
Descriptor:3C-like proteinase, (1R,2S,5S)-3-[N-({1-[(tert-butylsulfonyl)methyl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-N-{(1S)-1-[(1R)-2-(cyclopropyla mino)-1-hydroxy-2-oxoethyl]pentyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide, DIMETHYL SULFOXIDE, ...
Authors:Andi, B., Kumaran, D., Kreitler, D.F., Soares, A.S., Shi, W., Jakoncic, J., Fuchs, M.R., Keereetaweep, J., Shanklin, J., McSweeney, S.
Deposit date:2020-08-30
Release date:2020-09-09
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Hepatitis C Virus NSP3/NSP4A Inhibitors as Promising Lead Compounds for the Design of New Covalent Inhibitors for SARS-CoV-2 3CLpro/Mpro Protease
To Be Published
7CJD
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CRYSTAL STRUCTURE OF THE SARS-COV-2 PLRO C111S MUTANT
Descriptor:Replicase polyprotein 1ab, ZINC ION, 1,2-ETHANEDIOL
Authors:Gao, X., Cui, S.
Deposit date:2020-07-10
Release date:2020-09-02
Last modified:2020-09-16
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Crystal structure of SARS-CoV-2 papain-like protease.
Acta Pharm Sin B, 2020
7CJM
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SARS COV-2 PLPRO IN COMPLEX WITH GRL0617
Descriptor:Non-structural protein 3, 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, ZINC ION
Authors:Fu, Z., Huang, H.
Deposit date:2020-07-11
Release date:2020-09-02
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:SARS CoV-2 PLpro in complex with 6-thioguanine
To Be Published
7C6U
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CRYSTAL STRUCTURE OF SARS-COV-2 COMPLEXED WITH GC376
Descriptor:3C-like proteinase, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid
Authors:Fu, L., Feng, Y., Qi, J., Gao, F.G.
Deposit date:2020-05-22
Release date:2020-09-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of SARS-CoV-2 complexed with GC376
To Be Published
7C6S
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CRYSTAL STRUCTURE OF THE SARS-COV-2 MAIN PROTEASE COMPLEXED WITH BOCEPREVIR
Descriptor:3C-like proteinase, boceprevir (bound form)
Authors:Fu, L., Feng, Y.
Deposit date:2020-05-22
Release date:2020-09-02
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of the SARS-CoV-2 main protease complexed with Boceprevir
To Be Published
168889
數據於2020-09-16公開中