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COVID-19特輯

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冠狀病毒
冠狀病毒，2020. 由David S. Goodsell @ RCSB PDB原圖修改

最近爆發的新型冠狀病毒傳染病（Novel Coronavirus disease 2019: COVID-19）對全世界的人們都構成了嚴重威脅。 為了儘早了解新病毒（Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2）以開發出有效的抗病毒藥物，已經有很多科研人員開始了相關蛋白結構的研究，並且將所獲得結構數據存儲與PDB。 PDBj為用戶提供了COVID-19相關數據一覽的門戶頁面，並將於每週三更新當日新發佈的相關數據。

有關該病毒蛋白質的解說，請參見下面的“當月的分子”頁面。

“所有結構”標籤的頁面則逐一羅列了所有的數據，包括由同一研究組提交的系列數據群。 “代表性結構”標籤的頁面精選具有相同胺基酸序列的結構數據中的高分辨率數據，不重複選擇具有同一胺基酸序列的數據，即使該數據可能包含不同的配體。 “最新條目”標籤內包含本週新更新數據。

Created: 2020-09-03 (last edited: more than 1 year ago)2022-09-02
所有結構 (5527)代表性結構 (2333)最新條目 (8)
9KUR
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BU of 9kur by Molmil
Crystal structure of mAb nCoV400Fab with SARS-CoV-2 N-CTD Complex
Descriptor: 400Fab Heavy chain, 400Fab Light chain, Nucleoprotein
Authors:Xue, S.J, Chen, S.D.
Deposit date:2024-12-04
Release date:2025-10-15
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural basis of a human antibody targeting SARS-CoV-2 nucleocapsid protein dimerization domain and interfering with RNA-binding.
Commun Biol, 8, 2025
7IBM
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BU of 7ibm by Molmil
PanDDA analysis group deposition -- SARS-CoV-2 Nsp1 crystal A05 (dataset 1) from the KIT library screening campaign, data used for ground state calculation
Descriptor: Host translation inhibitor nsp1
Authors:Lennartz, F, Weiss, M.S.
Deposit date:2025-05-27
Release date:2025-10-22
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Crystallographic fragment screening against SARS-CoV-2 nonstructural protein 1 using the F2X-Entry Screen and a newly developed fragment library.
Acta Crystallogr D Struct Biol, 2025
9HM2
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BU of 9hm2 by Molmil
A swapped dimeric form of ZO1/TJP1 PDZ2 in complex with the C-terminal peptide from protein E of SARS-CoV-2
Descriptor: Envelope small membrane protein, IODIDE ION, Tight junction protein ZO-1
Authors:Alvarez, F, Mechaly, A, Haouz, A, Caillet-Saguy, C.
Deposit date:2024-12-06
Release date:2025-10-22
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:HTRF-based identification of small molecules targeting SARS-CoV-2 E protein interaction with ZO-1 PDZ2
Biorxiv, 2025
9JTE
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BU of 9jte by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain complexed with fox ACE2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ...
Authors:Jun, L, Xiaoyan, N.
Deposit date:2024-10-04
Release date:2025-10-22
Method:X-RAY DIFFRACTION (3.66 Å)
Cite:Crystal structure of SARS-CoV-2 receptor binding domain complexed with fox ACE2
To Be Published
9D8H
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BU of 9d8h by Molmil
JN.1 SARS-COV-2 Spike 3-down conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Windsor, I.W, Wu, H.
Deposit date:2024-08-19
Release date:2025-10-29
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:SARS-CoV-2 JN.1 and KP.2 spike characteristics and neutralization of JN.1-derived sublineages and T cell responses from mice immunized with monovalent JN.1- and KP.2-adapted BNT162b2 COVID-19 vaccines
To Be Published
9D8J
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BU of 9d8j by Molmil
KP.2 SARS-COV-2 Spike 3-down conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Windsor, I.W, Wu, H.
Deposit date:2024-08-19
Release date:2025-10-29
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:SARS-CoV-2 JN.1 and KP.2 spike characteristics and neutralization of JN.1-derived sublineages and T cell responses from mice immunized with monovalent JN.1- and KP.2-adapted BNT162b2 COVID-19 vaccines
To Be Published
9H01
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BU of 9h01 by Molmil
nsp14 of SARS-CoV-2 in complex with a camelid nanobody
Descriptor: Guanine-N7 methyltransferase nsp14, ZINC ION, vhh anti-nsp14 of SARS-CoV-2
Authors:Gauffre, P, Ferron, F, Canard, B.
Deposit date:2024-10-07
Release date:2025-10-29
Method:X-RAY DIFFRACTION (2.533 Å)
Cite:Crystallographic structure of nsp14 full length from SARS-CoV-2, stabilised by a nanobody
To Be Published
9K6Y
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BU of 9k6y by Molmil
Cryo-EM structure of SARS-CoV-2 prototype spike protein in complex with H4 Fab (local refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H4, Light chain of H4, ...
Authors:Zhang, G, Li, L.J, Wu, Y, Gao, G.F.
Deposit date:2024-10-22
Release date:2025-10-29
Method:ELECTRON MICROSCOPY (2.67 Å)
Cite:Structural basis of SARS-CoV-2 prototype spike protein binding to H4 Fab
To Be Published

243911

數據於2025-10-29公開中

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