COVID-19特輯

冠狀病毒，2020. 由David S. Goodsell @ RCSB PDB原圖修改

最近爆發的新型冠狀病毒傳染病（Novel Coronavirus disease 2019: COVID-19）對全世界的人們都構成了嚴重威脅。為了儘早了解新病毒（Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2）以開發出有效的抗病毒藥物，已經有很多科研人員開始了相關蛋白結構的研究，並且將所獲得結構數據存儲與PDB。 PDBj為用戶提供了COVID-19相關數據一覽的門戶頁面，並將於每週三更新當日新發佈的相關數據。

有關該病毒蛋白質的解說，請參見下面的“當月的分子”頁面。

“所有結構”標籤的頁面則逐一羅列了所有的數據，包括由同一研究組提交的系列數據群。 “代表性結構”標籤的頁面精選具有相同胺基酸序列的結構數據中的高分辨率數據，不重複選擇具有同一胺基酸序列的數據，即使該數據可能包含不同的配體。 “最新條目”標籤內包含本週新更新數據。

Created: 2020-09-03 (last edited: more than 1 year ago)

所有結構 (4459)代表性結構 (1984)最新條目 (16)

5SLY

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z1526504764
Descriptor:	1-(1-ethyl-1H-pyrazol-5-yl)-N-methylmethanamine, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.018 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SLZ

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2072621991
Descriptor:	2-(difluoromethoxy)-1-[(3aR,6aS)-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]ethan-1-one, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.54 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM0

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z32665176
Descriptor:	(1-benzofuran-2-yl)(4-methylpiperidin-1-yl)methanone, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.086 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM1

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z68277692
Descriptor:	N-methyl-N-[2-(pyridin-2-yl)ethyl]benzamide, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.941 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM2

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z3006151474
Descriptor:	(5S)-5-(difluoromethoxy)pyridin-2(5H)-one, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.781 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM3

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z943693514
Descriptor:	PHOSPHATE ION, Proofreading exoribonuclease nsp14, ZINC ION, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.198 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM4

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2856434944
Descriptor:	PHOSPHATE ION, Proofreading exoribonuclease nsp14, ZINC ION, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.16 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM5

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2856434807
Descriptor:	2-[4-(2-methoxyphenyl)piperazin-1-yl]ethanenitrile, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM6

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z1899842917
Descriptor:	3-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-5-methyl-1,3,4-thiadiazol-2(3H)-one, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.29 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM7

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z1247413608
Descriptor:	1-(methanesulfonyl)piperidin-4-ol, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM8

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2027158783
Descriptor:	N-(2,1,3-benzoxadiazol-4-yl)acetamide, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM9

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2234920345
Descriptor:	N-(2-methoxy-5-methylphenyl)-N'-4H-1,2,4-triazol-4-ylurea, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.01 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SMA

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2856434890
Descriptor:	4-methyl-N-phenylpiperazine-1-carboxamide, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.011 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SMB

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z419995480
Descriptor:	1-(morpholin-4-yl)-4-phenylbutan-1-one, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.181 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SMC

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2033637875
Descriptor:	N~2~-(4-cyano-3-methyl-1,2-thiazol-5-yl)-N~2~-methylglycinamide, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.19 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SMD

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z274575916
Descriptor:	2,4-dimethyl-6-(piperazin-1-yl)pyrimidine, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.826 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SME

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z437584380
Descriptor:	(4-chlorophenyl)(thiomorpholin-4-yl)methanone, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.91 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SMF

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z56791867
Descriptor:	N,N-diethyl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.011 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SMG

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2092370954
Descriptor:	3-amino-N-ethyl-N-methylbenzamide, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.87 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SMH

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2856434938
Descriptor:	1-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-methanamine, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.64 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SMI

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z71580604
Descriptor:	(2S)-N-(5-methylpyridin-2-yl)oxolane-2-carboxamide, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.08 Å)
Cite:	PanDDA analysis group deposition To Be Published

7MW2

Structure of the SARS-CoV-2 Spike trimer with all RBDs down in complex with the Fab fragment of human neutralizing antibody clone 6
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab of antibody clone 6, ...
Authors:	Hu, Y, Xiong, Y.
Deposit date:	2021-05-15
Release date:	2022-03-16
Last modified:	2023-11-01
Method:	ELECTRON MICROSCOPY (2.97 Å)
Cite:	Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617. Nat Commun, 13, 2022

7MW3

Structure of the SARS-CoV-2 Spike trimer with two RBDs down in complex with the Fab fragment of human neutralizing antibody clone 6
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Hu, Y, Xiong, Y.
Deposit date:	2021-05-15
Release date:	2022-03-16
Last modified:	2023-11-01
Method:	ELECTRON MICROSCOPY (3.15 Å)
Cite:	Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617. Nat Commun, 13, 2022

7MW4

Structure of the SARS-CoV-2 Spike trimer with one RBD down in complex with the Fab fragment of human neutralizing antibody clone 6
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Hu, Y, Xiong, Y.
Deposit date:	2021-05-15
Release date:	2022-03-16
Last modified:	2023-11-01
Method:	ELECTRON MICROSCOPY (3.42 Å)
Cite:	Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617. Nat Commun, 13, 2022

7MW5

Structure of the SARS-CoV-2 Spike trimer with one RBD down in complex with the Fab fragment of human neutralizing antibody clone 2
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab of antibody clone 2, ...
Authors:	Hu, Y, Xiong, Y.
Deposit date:	2021-05-15
Release date:	2022-03-16
Last modified:	2023-11-01
Method:	ELECTRON MICROSCOPY (3.42 Å)
Cite:	Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617. Nat Commun, 13, 2022

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