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冠状病毒
冠状病毒,2020. 由David S. Goodsell @ RCSB PDB原图修改

最近爆发的新型冠状病毒传染病(Novel Coronavirus disease 2019: COVID-19)对全世界的人们都构成了严重威胁。 为了尽早了解新病毒(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)以开发出有效的抗病毒药物,已经有很多科研人員开始了相关蛋白结构的研究,并且将所获得的结构数据存储于PDB。 PDBj为用户提供了COVID-19相关数据一览的门户页面,并将于每周三更新当日新发布的相关数据。

有关该病毒蛋白质的解说,请参见下面的“当月的分子”页面。

“所有结构”标签的页面则逐一罗列了所有的结构数据,包括由同一研究组提交的系列数据群。 “代表性结构”标签的页面精选具有相同氨基酸序列的结构数据中的高分辨率数据,不重复选择具同一氨基酸序列的数据,即使该数据可能包含不同配体。 “最新条目”标签内包含本周新更新数据。

Created: 2020-03-11 (last edited: 4 weeks ago)2020-10-28
所有结构 (550)代表性结构 (235)最新条目 (9)
7CT5
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S PROTEIN OF SARS-COV-2 IN COMPLEX BOUND WITH T-ACE2
Descriptor:Spike glycoprotein, Angiotensin-converting enzyme 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, L., Bi, W.W., Zhang, Y.Y., Yan, R.H., Li, Y.N., Zhou, Q., Dang, B.B.
Deposit date:2020-08-18
Release date:2020-11-18
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Engineered Trimeric ACE2 Binds "Three-up" Spike Protein to Potently Inhibit SARS-CoVs and Mutants
To Be Published
7KOA
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ROOM TEMPERATURE STRUCTURE OF SARS-COV-2 NSP10/16 METHYLTRANSFERASE IN A COMPLEX WITH CAP-0 AND SAM DETERMINED BY PINK-BEAM SERIAL CRYSTALLOGRAPHY
Descriptor:2'-O-methyltransferase, Non-structural protein 10, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, ...
Authors:Wilamowski, M., Sherrell, D.A., Minasov, G., Shuvalova, L., Lavens, A., Henning, R., Maltseva, N., Rosas-Lemus, M., Kim, Y., Satchell, K.J.F., Srajer, V., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-11-07
Release date:2020-11-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Room Temperature Structure of SARS-CoV-2 Nsp10/Nsp16 Methyltransferase in a Complex with Cap-0 and SAM Determined by Pink-Beam Serial Crystallography
To Be Published
7CDI
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CRYSTAL STRUCTURE OF SARS-COV-2 ANTIBODY P2C-1F11 WITH RBD
Descriptor:Spike protein S1, antibody P2C-1F11 heavy chain, antibody P2C-1F11 light chain, ...
Authors:Wang, X., Zhang, L., Ge, J., Wang, R.
Deposit date:2020-06-19
Release date:2020-11-18
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Crystal structure of SARS-CoV-2 antibody P2C-1F11 and RBD
To be published
7KOK
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2, C111S MUTANT, IN COMPLEX WITH PLP_SNYDER496
Descriptor:Papain-like protease, 5-[(E)-(hydroxyimino)methyl]-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide, ZINC ION, ...
Authors:Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-11-09
Release date:2020-11-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with PLP_Snyder496
to be published
7KOL
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2 IN COMPLEX WITH PLP_SNYDER496
Descriptor:Papain-Like Protease, 5-[(E)-(hydroxyimino)methyl]-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide, ZINC ION, ...
Authors:Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-11-09
Release date:2020-11-18
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:The crystal structure of Papain-Like Protease of SARS CoV-2 in complex with PLP_Snyder496
to be published
7KOJ
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2, C111S MUTANT, IN COMPLEX WITH PLP_SNYDER494
Descriptor:Papain-like protease, 2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]-5-{[(prop-2-en-1-yl)carbamoyl]amino}benzamide, ZINC ION, ...
Authors:Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-11-09
Release date:2020-11-18
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The crystal structure of Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with PLP_Snyder494
to be published
7CDJ
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CRYSTAL STRUCTURE OF SARS-COV-2 ANTIBODY P2C-1A3 WITH RBD
Descriptor:Spike protein S1, antibody P2C-1A3 heavy chain, antibody P2C-1A3 light chain, ...
Authors:Wang, X., Zhang, L., Ge, J., Wang, R.
Deposit date:2020-06-19
Release date:2020-11-18
Method:X-RAY DIFFRACTION (3.396 Å)
Cite:Crystal structure of SARS-CoV-2 antibody P2C-1A3 and RBD
To Be Published
7KJR
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CRYO-EM STRUCTURE OF SARS-COV-2 ORF3A
Descriptor:Protein 3a, Apolipoprotein A-I, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
Authors:Kern, D.M., Hoel, C.M., Kotecha, A., Brohawn, S.G.
Deposit date:2020-10-26
Release date:2020-11-18
Method:ELECTRON MICROSCOPY (2.08 Å)
Cite:Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs.
Biorxiv, 2020
7KPH
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SARS-COV-2 MAIN PROTEASE IN MATURE FORM
Descriptor:3C-like proteinase
Authors:Noske, G.D., Nakamura, A.M., Gawriljuk, V.O., Lima, G.M.A., Zeri, A.C.M., Nascimento, A.F.Z., Oliva, G., Godoy, A.S.
Deposit date:2020-11-11
Release date:2020-11-18
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:SARS-CoV-2 Main Protease in mature form
To Be Published
7KKK
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SARS-COV-2 SPIKE IN COMPLEX WITH NEUTRALIZING NANOBODY NB6
Descriptor:SARS-CoV-2 spike glycoprotein, Synthetic nanobody Nb6, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
Science, 2020
7D4F
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STRUCTURE OF COVID-19 RNA-DEPENDENT RNA POLYMERASE BOUND TO SURAMIN
Descriptor:Non-structural protein 8, Non-structural protein 7, Non-structural protein 12, ...
Authors:Li, Z., Yin, W., Zhou, Z., Yu, X., Xu, H.
Deposit date:2020-09-23
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (2.57 Å)
Cite:Structural basis for repurposing a 100-years-old drug suramin for treating COVID-19
To Be Published
7KL9
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STRUCTURE OF THE SARS-COV-2 S 6P TRIMER IN COMPLEX WITH THE ACE2 PROTEIN DECOY, CTC-445.2 (STATE 4)
Descriptor:Spike glycoprotein, CTC-445.2 inhibitor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Barnes, C.O., Bjorkman, P.J.
Deposit date:2020-10-29
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2
Science, 2020
7C33
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MACRO DOMAIN OF SARS-COV-2 IN COMPLEX WITH ADP-RIBOSE
Descriptor:Macro domain from non-structural protein 3, ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Lin, M.H., Hsu, C.H.
Deposit date:2020-05-11
Release date:2020-11-11
Method:X-RAY DIFFRACTION (3.83 Å)
Cite:Structural, Biophysical, and Biochemical Elucidation of the SARS-CoV-2 Nonstructural Protein 3 Macro Domain.
Acs Infect Dis., 2020
7CZ4
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STRUCTURE OF SARS-COV-2 MACRO DOMAIN IN COMPLEX WITH ADP-RIBOSE
Descriptor:Macro domain from non-structural protein 3, ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Lin, M.H., Hsu, C.H.
Deposit date:2020-09-07
Release date:2020-11-11
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structural, Biophysical, and Biochemical Elucidation of the SARS-CoV-2 Nonstructural Protein 3 Macro Domain.
Acs Infect Dis., 2020
7KJ4
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SARS-COV-2 SPIKE GLYCOPROTEIN WITH THREE ACE2 BOUND
Descriptor:Spike glycoprotein, Angiotensin-converting enzyme 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, J., Xiao, T.S., Cai, Y.F., Chen, B.
Deposit date:2020-10-25
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro.
Biorxiv, 2020
7KJ2
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SARS-COV-2 SPIKE GLYCOPROTEIN WITH ONE ACE2 BOUND
Descriptor:Spike glycoprotein, Angiotensin-converting enzyme 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, J., Xiao, T.S., Cai, Y.F., Chen, B.
Deposit date:2020-10-25
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro.
Biorxiv, 2020
7KJ3
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SARS-COV-2 SPIKE GLYCOPROTEIN WITH TWO ACE2 BOUND
Descriptor:Spike glycoprotein, Angiotensin-converting enzyme 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, J., Xiao, T.S., Cai, Y.F., Chen, B.
Deposit date:2020-10-25
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro.
Biorxiv, 2020
7KJ5
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SARS-COV-2 SPIKE GLYCOPROTEIN, PREFUSION WITH ONE RBD UP CONFORMATION
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Zhang, J., Xiao, T.S., Cai, Y.F., Chen, B.
Deposit date:2020-10-25
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro.
Biorxiv, 2020
7KKL
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SARS-COV-2 SPIKE IN COMPLEX WITH NEUTRALIZING NANOBODY MNB6
Descriptor:SARS-CoV-2 spike glycoprotein, Synthetic nanobody mNb6, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
Science, 2020
7CJF
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CRYSTAL STRUCTURE OF SARS-COV-2 RBD IN COMPLEX WITH A NEUTRALIZING ANTIBODY FAB
Descriptor:antibody heavy chain, antibody light chain, Spike glycoprotein, ...
Authors:Guo, Y., Li, X., Zhang, G., Fu, D., Schweizer, L., Zhang, H., Rao, Z.
Deposit date:2020-07-10
Release date:2020-11-11
Method:X-RAY DIFFRACTION (2.108 Å)
Cite:Crystal structure of SARS-CoV-2 RBD in complex with an antibody Fab
To Be Published
7KE4
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SARS-COV-2 D614G 3 RBD DOWN SPIKE PROTEIN TRIMER WITHOUT THE P986-P987 STABILIZING MUTATIONS (S-GSAS-D614G SUB-CLASS)
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Gobeil, S., Acharya, P.
Deposit date:2020-10-10
Release date:2020-11-04
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
Biorxiv, 2020
7D7T
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CRYSTAL STRUCTURE OF THE SARS-COV-2 PAPAIN-LIKE PROTEASE (PLPRO) C112S MUTANT BOUND TO COMPOUND S43
Descriptor:papain-like protease, ZINC ION, N-[(3-acetamidophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide
Authors:Liu, J., Wang, Y., Xu, X., Pan, L.
Deposit date:2020-10-05
Release date:2020-11-04
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Crystal structure of the SARS-CoV-2 papain-like protease (PLPro) C112S mutant
To Be Published
7KDL
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SARS-COV-2 D614G 1-RBD UP SPIKE PROTEIN TRIMER WITHOUT THE P986-P987 STABILIZING MUTATIONS (S-GSAS-D614G)
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Gobeil, S., Acharya, P.
Deposit date:2020-10-08
Release date:2020-11-04
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
Biorxiv, 2020
7KE7
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SARS-COV-2 D614G 3-RBD-DOWN SPIKE PROTEIN TRIMER WITHOUT THE P986-P987 STABILIZING MUTATIONS (S-GSAS-D614G SUB-CLASSIFICATION)
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Gobeil, S., Acharya, P.
Deposit date:2020-10-10
Release date:2020-11-04
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
Biorxiv, 2020
7ACS
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THE SARS-COV-2 NUCLEOCAPSID PHOSPHOPROTEIN N-TERMINAL DOMAIN IN COMPLEX WITH 7MER DSRNA
Descriptor:Nucleoprotein, RNA (5'-R(P*CP*AP*CP*UP*GP*AP*C)-3'), RNA (5'-R(P*GP*UP*CP*AP*GP*UP*G)-3')
Authors:Veverka, V.
Deposit date:2020-09-11
Release date:2020-11-04
Method:SOLUTION NMR
Cite:The SARS-CoV-2 nucleocapsid phosphoprotein N-terminal domain in complex with 7mer ssRNA
To Be Published
171313
数据于2020-11-18公开中