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COVID-19特辑

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冠状病毒
冠状病毒,2020. 由David S. Goodsell @ RCSB PDB原图修改

最近爆发的新型冠状病毒传染病(Novel Coronavirus disease 2019: COVID-19)对全世界的人们都构成了严重威胁。 为了尽早了解新病毒(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)以开发出有效的抗病毒药物,已经有很多科研人員开始了相关蛋白结构的研究,并且将所获得的结构数据存储于PDB。 PDBj为用户提供了COVID-19相关数据一览的门户页面,并将于每周三更新当日新发布的相关数据。

有关该病毒蛋白质的解说,请参见下面的“当月的分子”页面。

“所有结构”标签的页面则逐一罗列了所有的结构数据,包括由同一研究组提交的系列数据群。 “代表性结构”标签的页面精选具有相同氨基酸序列的结构数据中的高分辨率数据,不重复选择具同一氨基酸序列的数据,即使该数据可能包含不同配体。 “最新条目”标签内包含本周新更新数据。


Created: 2020-09-03 (last edited: more than 1 year ago)2020-12-02
9KUR
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BU of 9kur by Molmil
Crystal structure of mAb nCoV400Fab with SARS-CoV-2 N-CTD Complex
Descriptor: 400Fab Heavy chain, 400Fab Light chain, Nucleoprotein
Authors:Xue, S.J, Chen, S.D.
Deposit date:2024-12-04
Release date:2025-10-15
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural basis of a human antibody targeting SARS-CoV-2 nucleocapsid protein dimerization domain and interfering with RNA-binding.
Commun Biol, 8, 2025
7IBM
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BU of 7ibm by Molmil
PanDDA analysis group deposition -- SARS-CoV-2 Nsp1 crystal A05 (dataset 1) from the KIT library screening campaign, data used for ground state calculation
Descriptor: Host translation inhibitor nsp1
Authors:Lennartz, F, Weiss, M.S.
Deposit date:2025-05-27
Release date:2025-10-22
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Crystallographic fragment screening against SARS-CoV-2 nonstructural protein 1 using the F2X-Entry Screen and a newly developed fragment library.
Acta Crystallogr D Struct Biol, 2025
9HM2
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BU of 9hm2 by Molmil
A swapped dimeric form of ZO1/TJP1 PDZ2 in complex with the C-terminal peptide from protein E of SARS-CoV-2
Descriptor: Envelope small membrane protein, IODIDE ION, Tight junction protein ZO-1
Authors:Alvarez, F, Mechaly, A, Haouz, A, Caillet-Saguy, C.
Deposit date:2024-12-06
Release date:2025-10-22
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:HTRF-based identification of small molecules targeting SARS-CoV-2 E protein interaction with ZO-1 PDZ2
Biorxiv, 2025
9JTE
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BU of 9jte by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain complexed with fox ACE2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ...
Authors:Jun, L, Xiaoyan, N.
Deposit date:2024-10-04
Release date:2025-10-22
Method:X-RAY DIFFRACTION (3.66 Å)
Cite:Crystal structure of SARS-CoV-2 receptor binding domain complexed with fox ACE2
To Be Published

243531

数据于2025-10-22公开中

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