COVID-19特辑

冠状病毒，2020. 由David S. Goodsell @ RCSB PDB原图修改

最近爆发的新型冠状病毒传染病（Novel Coronavirus disease 2019: COVID-19）对全世界的人们都构成了严重威胁。为了尽早了解新病毒（Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2）以开发出有效的抗病毒药物，已经有很多科研人員开始了相关蛋白结构的研究，并且将所获得的结构数据存储于PDB。 PDBj为用户提供了COVID-19相关数据一览的门户页面，并将于每周三更新当日新发布的相关数据。

有关该病毒蛋白质的解说，请参见下面的“当月的分子”页面。

“所有结构”标签的页面则逐一罗列了所有的结构数据，包括由同一研究组提交的系列数据群。 “代表性结构”标签的页面精选具有相同氨基酸序列的结构数据中的高分辨率数据，不重复选择具同一氨基酸序列的数据，即使该数据可能包含不同配体。 “最新条目”标签内包含本周新更新数据。

Created: 2020-09-03 (last edited: more than 1 year ago)

所有结构 (4406)代表性结构 (1944)最新条目 (19)

5SLY

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z1526504764
Descriptor:	1-(1-ethyl-1H-pyrazol-5-yl)-N-methylmethanamine, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.018 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SLZ

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2072621991
Descriptor:	2-(difluoromethoxy)-1-[(3aR,6aS)-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]ethan-1-one, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.54 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM0

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z32665176
Descriptor:	(1-benzofuran-2-yl)(4-methylpiperidin-1-yl)methanone, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.086 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM1

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z68277692
Descriptor:	N-methyl-N-[2-(pyridin-2-yl)ethyl]benzamide, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.941 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM2

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z3006151474
Descriptor:	(5S)-5-(difluoromethoxy)pyridin-2(5H)-one, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.781 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM3

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z943693514
Descriptor:	PHOSPHATE ION, Proofreading exoribonuclease nsp14, ZINC ION, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.198 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM4

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2856434944
Descriptor:	PHOSPHATE ION, Proofreading exoribonuclease nsp14, ZINC ION, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.16 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM5

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2856434807
Descriptor:	2-[4-(2-methoxyphenyl)piperazin-1-yl]ethanenitrile, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM6

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z1899842917
Descriptor:	3-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]-5-methyl-1,3,4-thiadiazol-2(3H)-one, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.29 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM7

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z1247413608
Descriptor:	1-(methanesulfonyl)piperidin-4-ol, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM8

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2027158783
Descriptor:	N-(2,1,3-benzoxadiazol-4-yl)acetamide, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SM9

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2234920345
Descriptor:	N-(2-methoxy-5-methylphenyl)-N'-4H-1,2,4-triazol-4-ylurea, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.01 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SMA

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2856434890
Descriptor:	4-methyl-N-phenylpiperazine-1-carboxamide, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.011 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SMB

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z419995480
Descriptor:	1-(morpholin-4-yl)-4-phenylbutan-1-one, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.181 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SMC

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2033637875
Descriptor:	N~2~-(4-cyano-3-methyl-1,2-thiazol-5-yl)-N~2~-methylglycinamide, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.19 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SMD

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z274575916
Descriptor:	2,4-dimethyl-6-(piperazin-1-yl)pyrimidine, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.826 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SME

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z437584380
Descriptor:	(4-chlorophenyl)(thiomorpholin-4-yl)methanone, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.91 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SMF

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z56791867
Descriptor:	N,N-diethyl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.011 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SMG

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2092370954
Descriptor:	3-amino-N-ethyl-N-methylbenzamide, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.87 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SMH

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z2856434938
Descriptor:	1-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-methanamine, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.64 Å)
Cite:	PanDDA analysis group deposition To Be Published

5SMI

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NSP14 in complex with Z71580604
Descriptor:	(2S)-N-(5-methylpyridin-2-yl)oxolane-2-carboxamide, PHOSPHATE ION, Proofreading exoribonuclease nsp14, ...
Authors:	Imprachim, N, Yosaatmadja, Y, von-Delft, F, Bountra, C, Gileadi, O, Newman, J.A.
Deposit date:	2022-03-03
Release date:	2022-03-16
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.08 Å)
Cite:	PanDDA analysis group deposition To Be Published

7MW2

Structure of the SARS-CoV-2 Spike trimer with all RBDs down in complex with the Fab fragment of human neutralizing antibody clone 6
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab of antibody clone 6, ...
Authors:	Hu, Y, Xiong, Y.
Deposit date:	2021-05-15
Release date:	2022-03-16
Last modified:	2023-11-01
Method:	ELECTRON MICROSCOPY (2.97 Å)
Cite:	Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617. Nat Commun, 13, 2022

7MW3

Structure of the SARS-CoV-2 Spike trimer with two RBDs down in complex with the Fab fragment of human neutralizing antibody clone 6
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Hu, Y, Xiong, Y.
Deposit date:	2021-05-15
Release date:	2022-03-16
Last modified:	2023-11-01
Method:	ELECTRON MICROSCOPY (3.15 Å)
Cite:	Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617. Nat Commun, 13, 2022

7MW4

Structure of the SARS-CoV-2 Spike trimer with one RBD down in complex with the Fab fragment of human neutralizing antibody clone 6
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Hu, Y, Xiong, Y.
Deposit date:	2021-05-15
Release date:	2022-03-16
Last modified:	2023-11-01
Method:	ELECTRON MICROSCOPY (3.42 Å)
Cite:	Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617. Nat Commun, 13, 2022

7MW5

Structure of the SARS-CoV-2 Spike trimer with one RBD down in complex with the Fab fragment of human neutralizing antibody clone 2
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab of antibody clone 2, ...
Authors:	Hu, Y, Xiong, Y.
Deposit date:	2021-05-15
Release date:	2022-03-16
Last modified:	2023-11-01
Method:	ELECTRON MICROSCOPY (3.42 Å)
Cite:	Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617. Nat Commun, 13, 2022

<72 73 74 75 76 77 787980 81 82 83 84 85 86 87 >

Total results:	4406
Displayed results:	25
Sorted by:	Release date (from oldest)