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COVID-19特辑

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冠状病毒
冠状病毒,2020. 由David S. Goodsell @ RCSB PDB原图修改

最近爆发的新型冠状病毒传染病(Novel Coronavirus disease 2019: COVID-19)对全世界的人们都构成了严重威胁。 为了尽早了解新病毒(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)以开发出有效的抗病毒药物,已经有很多科研人員开始了相关蛋白结构的研究,并且将所获得的结构数据存储于PDB。 PDBj为用户提供了COVID-19相关数据一览的门户页面,并将于每周三更新当日新发布的相关数据。

有关该病毒蛋白质的解说,请参见下面的“当月的分子”页面。

“所有结构”标签的页面则逐一罗列了所有的结构数据,包括由同一研究组提交的系列数据群。 “代表性结构”标签的页面精选具有相同氨基酸序列的结构数据中的高分辨率数据,不重复选择具同一氨基酸序列的数据,即使该数据可能包含不同配体。 “最新条目”标签内包含本周新更新数据。


Created: 2020-09-03 (last edited: more than 1 year ago)2020-12-02
7K9I
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BU of 7k9i by Molmil
SARS-CoV-2 Spike RBD in complex with neutralizing Fab 2B04 (local refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2B04 heavy chain, 2B04 light chain, ...
Authors:Errico, J.M, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-09-29
Release date:2021-09-29
Last modified:2021-11-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD.
Cell Rep, 37, 2021
7K9J
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BU of 7k9j by Molmil
SARS-CoV-2 Spike in complex with neutralizing Fab 2H04 (three down conformation)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2H04 heavy chain, ...
Authors:Errico, J.M, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-09-29
Release date:2021-09-29
Last modified:2021-11-10
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD.
Cell Rep, 37, 2021
7K9K
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BU of 7k9k by Molmil
SARS-CoV-2 Spike RBD in complex with neutralizing Fab 2H04 (local refinement)
Descriptor: 2H04 heavy chain, 2H04 light chain, Spike protein S1, ...
Authors:Errico, J.M, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-09-29
Release date:2021-09-29
Last modified:2021-11-10
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD.
Cell Rep, 37, 2021
7RBR
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BU of 7rbr by Molmil
The crystal structure of Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with a Lys48-linked di-ubiquitin
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Papain-like protease, ...
Authors:Osipiuk, J, Tesar, C, Endres, M, Lanham, B.T, Wydorski, P, Fushman, D, Joachimiak, L, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2021-07-06
Release date:2021-09-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin.
Nat Commun, 14, 2023
7RBS
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BU of 7rbs by Molmil
The crystal structure of Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with human ISG15
Descriptor: Papain-like protease, Ubiquitin-like protein ISG15, ZINC ION
Authors:Osipiuk, J, Tesar, C, Jedrzejczak, R, Endres, M, Wydorski, P, Joachimiak, L, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2021-07-06
Release date:2021-09-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin.
Nat Commun, 14, 2023
7MZF
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BU of 7mzf by Molmil
SARS-CoV-2 receptor binding domain bound to Fab PDI 37
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ...
Authors:Pymm, P, Chan, L.J, Dietrich, M.H, Tan, L.L, Tham, W.H.
Deposit date:2021-05-24
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.493 Å)
Cite:Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Cell Rep, 37, 2021
7MZG
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BU of 7mzg by Molmil
SARS-CoV-2 receptor binding domain bound to Fab PDI 42
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, PDI 42 heavy chain, ...
Authors:Pymm, P, Chan, L.J, Dietrich, M.H, Tan, L.L, Tham, W.H.
Deposit date:2021-05-24
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Cell Rep, 37, 2021
7MZH
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BU of 7mzh by Molmil
SARS-CoV-2 receptor binding domain bound to Fab WCSL 119
Descriptor: Spike protein S1, WCSL 119 heavy chain, WCSL 119 light chain, ...
Authors:Pymm, P, Tan, L.L, Dietrich, M.H, Chan, L.J, Tham, W.H.
Deposit date:2021-05-24
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Cell Rep, 37, 2021
7MZI
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BU of 7mzi by Molmil
SARS-CoV-2 receptor binding domain bound to Fab WCSL 129
Descriptor: GLYCEROL, Spike protein S1, TETRAETHYLENE GLYCOL, ...
Authors:Pymm, P, Tan, L.L, Dietrich, M.H, Chan, L.J, Tham, W.H.
Deposit date:2021-05-24
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Cell Rep, 37, 2021
7MZJ
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BU of 7mzj by Molmil
SARS-CoV-2 receptor binding domain bound to Fab WCSL 129 and Fab PDI 93
Descriptor: GLYCEROL, PDI 93 heavy chain, PDI 93 light chain, ...
Authors:Pymm, P, Dietrich, M.H, Tan, L.L, Chan, L.J, Tham, W.H.
Deposit date:2021-05-24
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Cell Rep, 37, 2021
7MZK
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BU of 7mzk by Molmil
SARS-CoV-2 receptor binding domain bound to Fab WCSL 129 and Fab PDI 96
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, ...
Authors:Pymm, P, Dietrich, M.H, Tan, L.L, Chan, L.J, Tham, W.H.
Deposit date:2021-05-24
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Cell Rep, 37, 2021
7MZL
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BU of 7mzl by Molmil
SARS-CoV-2 receptor binding domain bound to Fab PDI 210
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, PDI 210 heavy chain, PDI 210 light chain, ...
Authors:Pymm, P, Chan, L.J, Dietrich, M.H, Tan, L.L, Tham, W.H.
Deposit date:2021-05-24
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Cell Rep, 37, 2021
7MZM
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BU of 7mzm by Molmil
SARS-CoV-2 receptor binding domain bound to Fab PDI 215
Descriptor: ISOPROPYL ALCOHOL, PDI 215 heavy chain, PDI 215 light chain, ...
Authors:Pymm, P, Dietrich, M.H, Tan, L.L, Chan, L.J, Tham, W.H.
Deposit date:2021-05-24
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Cell Rep, 37, 2021
7MZN
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BU of 7mzn by Molmil
SARS-CoV-2 receptor binding domain bound to Fab PDI 231
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, PDI 231 heavy chain, PDI 231 light chain, ...
Authors:Pymm, P, Tan, L.L, Dietrich, M.H, Chan, L.J, Tham, W.H.
Deposit date:2021-05-24
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Cell Rep, 37, 2021
7N4I
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BU of 7n4i by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing human antibody WRAIR-2057.
Descriptor: GLYCEROL, Spike protein S1, WRAIR-2057 Antibody Fab Heavy Chain, ...
Authors:Sankhala, R.S, Joyce, M.G.
Deposit date:2021-06-04
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.284 Å)
Cite:Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations.
Nat.Immunol., 22, 2021
7N4J
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BU of 7n4j by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing human antibody WRAIR-2173.
Descriptor: Spike protein S1, WRAIR-2173 antibody Fab heavy chain, WRAIR-2173 antibody Fab light chain, ...
Authors:Sankhala, R.S, Joyce, M.G.
Deposit date:2021-06-04
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.207 Å)
Cite:Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations.
Nat.Immunol., 22, 2021
7RR0
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BU of 7rr0 by Molmil
SARS-CoV-2 receptor binding domain bound to Fab PDI 222
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PDI 222 Fab Heavy Chain, PDI 222 Fab Light Chain, ...
Authors:Pymm, P, Glukhova, A, Black, K.A, Tham, W.H.
Deposit date:2021-08-08
Release date:2021-10-06
Last modified:2021-10-27
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Cell Rep, 37, 2021
7RXD
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BU of 7rxd by Molmil
CryoEM structure of RBD domain of COVID-19 in complex with Legobody
Descriptor: Fab_8D3_2 heavy chain, Fab_8D3_2 light chain, Maltodextrin-binding protein,Immunoglobulin G-binding protein A,Immunoglobulin G-binding protein G, ...
Authors:Wu, X.D, Rapoport, T.A.
Deposit date:2021-08-22
Release date:2021-10-06
Last modified:2021-10-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies).
Proc.Natl.Acad.Sci.USA, 118, 2021
7S0B
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BU of 7s0b by Molmil
Structure of the SARS-CoV-2 RBD in complex with neutralizing antibody N-612-056
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-612-056 Fab Heavy Chain, N-612-056 Light Chain, ...
Authors:Tanaka, S, Barnes, C.O, Bjorkman, P.J.
Deposit date:2021-08-30
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Rapid identification of neutralizing antibodies against SARS-CoV-2 variants by mRNA display.
Cell Rep, 38, 2022
7S0C
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BU of 7s0c by Molmil
Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody N-612-017
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-612-017 Fab Heavy Chain, ...
Authors:Barnes, C.O, Bjorkman, P.J.
Deposit date:2021-08-30
Release date:2021-10-06
Last modified:2022-03-16
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Rapid identification of neutralizing antibodies against SARS-CoV-2 variants by mRNA display.
Cell Rep, 38, 2022
7S0D
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BU of 7s0d by Molmil
Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody N-612-014
Descriptor: N-612-014 Fab Heavy Chain, N-612-014 Light Chain, Spike glycoprotein
Authors:Barnes, C.O, Bjorkman, P.J.
Deposit date:2021-08-30
Release date:2021-10-06
Last modified:2022-03-16
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Rapid identification of neutralizing antibodies against SARS-CoV-2 variants by mRNA display.
Cell Rep, 38, 2022
7S0E
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BU of 7s0e by Molmil
Structure of the SARS-CoV-2 S1 subunit in complex with antibody N-612-004
Descriptor: N-612-004 Fab heavy chain, N-612-004 Light Chain, Spike glycoprotein
Authors:Barnes, C.O, Bjorkman, P.J.
Deposit date:2021-08-30
Release date:2021-10-06
Last modified:2022-03-16
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Rapid identification of neutralizing antibodies against SARS-CoV-2 variants by mRNA display.
Cell Rep, 38, 2022
7V76
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BU of 7v76 by Molmil
Cryo-EM structure of SARS-CoV-2 S-Beta variant (B.1.351), uncleavable form, one RBD-up conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Yang, T.J, Yu, P.Y, Chang, Y.C, Hsu, S.T.D.
Deposit date:2021-08-21
Release date:2021-10-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of SARS-CoV-2 S-Beta variant (B.1.351), uncleavable form, one RBD-up conformation
To Be Published
7V79
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BU of 7v79 by Molmil
Cryo-EM structure of SARS-CoV-2 S-Gamma variant (P.1), one RBD-up conformation 2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Yang, T.J, Yu, P.Y, Chang, Y.C, Hsu, S.T.D.
Deposit date:2021-08-21
Release date:2021-10-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structure of SARS-CoV-2 S-Gamma variant (P.1), one RBD-up conformation 2
To Be Published
7V7E
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BU of 7v7e by Molmil
Cryo-EM structure of SARS-CoV-2 S-Kappa variant (B.1.617.1), one RBD-up conformation 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Yang, T.J, Yu, P.Y, Chang, Y.C, Hsu, S.T.D.
Deposit date:2021-08-21
Release date:2021-10-06
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM structure of SARS-CoV-2 S-Kappa variant (B.1.617.1), one RBD-up conformation 1
To Be Published

221051

数据于2024-06-12公开中

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