8XYE
 
 | | Crystal structure of SARS-CoV-2 BA.4 RBD and human ACE2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | | Authors: | Lan, J, Wang, C.H. | | Deposit date: | 2024-01-19 | | Release date: | 2025-01-22 | | Last modified: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (3.32 Å) | | Cite: | Receptor binding mechanism and immune evasion capacity of SARS-CoV-2 BQ.1.1 lineage.
Virology, 600, 2024
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8XYG
 | | Crystal structure of SARS-CoV-2 BQ.1.1 RBD and human ACE2 | | Descriptor: | Processed angiotensin-converting enzyme 2, Spike protein S1 | | Authors: | Lan, J, Wang, C.H. | | Deposit date: | 2024-01-19 | | Release date: | 2025-01-22 | | Last modified: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (3.64 Å) | | Cite: | Receptor binding mechanism and immune evasion capacity of SARS-CoV-2 BQ.1.1 lineage.
Virology, 600, 2024
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8XYO
 | | Cryo-EM structure of CX1 receptor binding domain in complex with human ACE2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein, ... | | Authors: | Xu, Z.P, Li, L.J, Gu, Y.H, Qi, J.X, Gao, G.F. | | Deposit date: | 2024-01-20 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Structural resemblances of bat-origin coronaviruses CX1 and BANAL-20-52 spikes provide further evidence on bat origination of SARS-CoV-2
To Be Published
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8YZB
 | | BA.2.86 RBD protein in complex with ACE2. | | Descriptor: | Angiotensin-converting enzyme 2, Spike glycoprotein,Fibritin,fusion protein | | Authors: | Wang, Y.J, Zhang, X, Sun, L. | | Deposit date: | 2024-04-06 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3.
Nat Commun, 15, 2024
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8YZC
 | | Structure of BA.2.86 spike protein in complex with ACE2. | | Descriptor: | Angiotensin-converting enzyme 2, Spike glycoprotein,Fibritin,Expression Tag | | Authors: | Wang, Y.J, Zang, X, Sun, L. | | Deposit date: | 2024-04-06 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3.
Nat Commun, 15, 2024
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8YZD
 | | Structure of JN.1 RBD protein in complex with ACE2. | | Descriptor: | Angiotensin-converting enzyme 2, Spike glycoprotein,Fibritin,fusion protein | | Authors: | Wang, Y.J, Zhang, X, Sun, L. | | Deposit date: | 2024-04-06 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3.
Nat Commun, 15, 2024
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8YZE
 | | The JN.1 spike protein (S) in complex with ACE2. | | Descriptor: | Angiotensin-converting enzyme 2, Spike glycoprotein,Fibritin,Expression Tag | | Authors: | Wang, Y.J, Zhang, X, Sun, L. | | Deposit date: | 2024-04-06 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3.
Nat Commun, 15, 2024
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9DNU
 | | SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun13296 | | Descriptor: | 1,2-ETHANEDIOL, 2-methyl-5-[(1R,5S)-8-methyl-3,8-diazabicyclo[3.2.1]octan-3-yl]-N-{(1R)-1-[(2P)-2-(1-methyl-1H-pyrazol-4-yl)quinolin-4-yl]ethyl}benzamide, ACETATE ION, ... | | Authors: | Ansari, A, Jadhav, P, Arnold, E, Ruiz, F.X, Wang, J. | | Deposit date: | 2024-09-18 | | Release date: | 2025-01-22 | | Last modified: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates.
Nat Commun, 16, 2025
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9DNV
 | | SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun13308 | | Descriptor: | 2-methyl-5-[(1R,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-N-{(1R)-1-[(2P)-2-(1-methyl-1H-pyrazol-4-yl)quinolin-4-yl]ethyl}benzamide, ACETIC ACID, CHLORIDE ION, ... | | Authors: | Ansari, A, Jadhav, P, Arnold, E, Ruiz, F.X, Wang, J. | | Deposit date: | 2024-09-18 | | Release date: | 2025-01-22 | | Last modified: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates.
Nat Commun, 16, 2025
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9DO1
 | | SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun13307 | | Descriptor: | 2-methyl-N-{(1R)-1-[(2M)-2-(1-methyl-1H-pyrazol-4-yl)quinolin-4-yl]ethyl}-5-{[(2R)-1-methylpyrrolidin-2-yl]methoxy}benzamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Ansari, A, Jadhav, P, Arnold, E, Ruiz, F.X, Wang, J. | | Deposit date: | 2024-09-18 | | Release date: | 2025-01-22 | | Last modified: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates.
Nat Commun, 16, 2025
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9DO3
 | | SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun13317 | | Descriptor: | 1,2-ETHANEDIOL, 5-[(3S)-3,4-dimethylpiperazin-1-yl]-2-methyl-N-{(1R)-1-[(2M)-2-(1-methyl-1H-pyrazol-4-yl)quinolin-4-yl]ethyl}benzamide, ACETATE ION, ... | | Authors: | Ansari, A, Jadhav, P, Arnold, E, Ruiz, F.X, Wang, J. | | Deposit date: | 2024-09-18 | | Release date: | 2025-01-22 | | Last modified: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates.
Nat Commun, 16, 2025
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9DO5
 | | SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun12665 | | Descriptor: | 5-[2-(dimethylamino)ethoxy]-N-{(1R)-1-[(2P)-2-{1-[2-(dimethylamino)-2-oxoethyl]-1H-pyrazol-4-yl}quinolin-4-yl]ethyl}-2-methylbenzamide, ACETATE ION, CHLORIDE ION, ... | | Authors: | Ansari, A, Jadhav, P, Arnold, E, Ruiz, F.X, Wang, J. | | Deposit date: | 2024-09-18 | | Release date: | 2025-01-22 | | Last modified: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates.
Nat Commun, 16, 2025
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9DOI
 | | SARS-CoV-2 papain-like protease (PLpro) with inhibitor Jun13306 | | Descriptor: | 2-methyl-N-{(1S)-1-[(2P)-2-(1-methyl-1H-pyrazol-4-yl)quinolin-4-yl]ethyl}-5-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}benzamide, ACETATE ION, CHLORIDE ION, ... | | Authors: | Ansari, A, Jadhav, P, Arnold, E, Ruiz, F.X, Wang, J. | | Deposit date: | 2024-09-19 | | Release date: | 2025-01-22 | | Last modified: | 2025-02-26 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates.
Nat Commun, 16, 2025
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9EXA
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9JS4
 | | Cryo-EM structure of neutralizing antibody 8G3 in complex with BA.1 RBD | | Descriptor: | Heavy chain of 8G3, Light chain of 8G3, Spike glycoprotein | | Authors: | Li, J, Li, H. | | Deposit date: | 2024-09-30 | | Release date: | 2025-01-22 | | Last modified: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Rapid restoration of potent neutralization activity against the latest Omicron variant JN.1 via AI rational design and antibody engineering.
Proc.Natl.Acad.Sci.USA, 122, 2025
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8YZR
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8YZW
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8YZZ
 | | The structure of HLA-A*2402 complex with peptide from SARS-CoV-2 S448-456 NYNYLYRLF(Prototype) | | Descriptor: | Beta-2-microglobulin, MHC class I antigen, Spike protein S1 | | Authors: | Shang, B.L, Zhang, J.N, Tian, J.M, Liu, J. | | Deposit date: | 2024-04-08 | | Release date: | 2025-01-29 | | Last modified: | 2025-05-28 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots.
Nat.Immunol., 26, 2025
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8Z05
 | | The structure of HLA-A*0201 complex with peptide from SARS-CoV-2 N222-230 LLLDRLNKL(BA.2.86/JN.1) | | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A alpha chain, ... | | Authors: | Zhang, J.N, Tian, J.M, Liu, J. | | Deposit date: | 2024-04-09 | | Release date: | 2025-01-29 | | Last modified: | 2025-05-28 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots.
Nat.Immunol., 26, 2025
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8Z06
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8Z07
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8Z08
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8Z6R
 | | Structure of XBB.1.16 S trimer with 3 down-RBDs complex with antibody CYFN1006-1. | | Descriptor: | CYFN1006-1 heavy chain, CYFN1006-1 light chain, Spike glycoprotein,Fibritin,Spike glycoprotein,Fibritin,Spike glycoprotein,Fibritin,Expression Tag | | Authors: | Wang, Y.J, Sun, L. | | Deposit date: | 2024-04-19 | | Release date: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (2.87 Å) | | Cite: | Structure of XBB.1.16 S trimer with 3 down-RBDs complex with antibody CYFN1006-1.
To Be Published
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8Z6T
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8Z6X
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