COVID-19特辑

冠状病毒，2020. 由David S. Goodsell @ RCSB PDB原图修改

最近爆发的新型冠状病毒传染病（Novel Coronavirus disease 2019: COVID-19）对全世界的人们都构成了严重威胁。为了尽早了解新病毒（Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2）以开发出有效的抗病毒药物，已经有很多科研人員开始了相关蛋白结构的研究，并且将所获得的结构数据存储于PDB。 PDBj为用户提供了COVID-19相关数据一览的门户页面，并将于每周三更新当日新发布的相关数据。

有关该病毒蛋白质的解说，请参见下面的“当月的分子”页面。

“所有结构”标签的页面则逐一罗列了所有的结构数据，包括由同一研究组提交的系列数据群。 “代表性结构”标签的页面精选具有相同氨基酸序列的结构数据中的高分辨率数据，不重复选择具同一氨基酸序列的数据，即使该数据可能包含不同配体。 “最新条目”标签内包含本周新更新数据。

Created: 2020-09-03 (last edited: more than 1 year ago)

所有结构 (4406)代表性结构 (1944)最新条目 (19)

7VHJ

Furin Site deletion of SARS-CoV-2 spike
Descriptor:	Spike glycoprotein
Authors:	Wang, X, Cui, Z.
Deposit date:	2021-09-22
Release date:	2022-10-19
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Furin Site deletion of SARS-CoV-2 Spike To Be Published

7VHK

S1-S2 deletion S-2P trimer(3 down)
Descriptor:	Spike glycoprotein
Authors:	Wang, X, Cui, Z.
Deposit date:	2021-09-22
Release date:	2022-10-19
Method:	ELECTRON MICROSCOPY (3.6 Å)
Cite:	Furin Site deletion S-2P trimer To Be Published

7VHL

Double deletion S-2P trimer(1 Up)
Descriptor:	Spike glycoprotein
Authors:	Wang, X, Cui, Z.
Deposit date:	2021-09-22
Release date:	2022-10-19
Method:	ELECTRON MICROSCOPY (3.9 Å)
Cite:	Double deletion S-2P trimer(1 Up) To Be Published

7VHM

Double deletion S-2P trimer(3 down)
Descriptor:	Spike glycoprotein
Authors:	Wang, L, Wang, X, Wang, X.
Deposit date:	2021-09-22
Release date:	2022-10-19
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	Double deletion S-2P trimer(3 down) To Be Published

7WSE

Cryo-EM structure of SARS-CoV-2 spike receptor-binding domain complexed with its receptor minke whale ACE2
Descriptor:	Angiotensin-converting enzyme, Spike protein S1, ZINC ION
Authors:	Li, S, Han, P.
Deposit date:	2022-01-29
Release date:	2022-10-19
Method:	ELECTRON MICROSCOPY (2.93 Å)
Cite:	Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals. Natl Sci Rev, 9, 2022

7YE7

Crystal structure of SARS-CoV-2 soluble dimeric ORF9b
Descriptor:	N-OCTANE, ORF9b protein, nonane
Authors:	Jin, X, Chai, Y, Qi, J, Song, H, Gao, G.F.
Deposit date:	2022-07-05
Release date:	2022-10-19
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2.95 Å)
Cite:	Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism. Sci China Life Sci, 66, 2023

7YE8

Crystal structure of SARS-CoV-2 refolded dimeric ORF9b
Descriptor:	N-OCTANE, ORF9b protein
Authors:	Jin, X, Chai, Y, Qi, J, Song, H, Gao, G.F.
Deposit date:	2022-07-05
Release date:	2022-10-19
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (3.01 Å)
Cite:	Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism. Sci China Life Sci, 66, 2023

7YQT

SARS-CoV-2 BA.2.75 S Trimer (1 RBD Up)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Wang, L.
Deposit date:	2022-08-08
Release date:	2022-10-19
Last modified:	2022-11-23
Method:	ELECTRON MICROSCOPY (3.45 Å)
Cite:	Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75. Cell Host Microbe, 30, 2022

7YQU

SARS-CoV-2 BA.2.75 S Trimer (3 RBD Down)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Wang, L.
Deposit date:	2022-08-08
Release date:	2022-10-19
Last modified:	2022-11-23
Method:	ELECTRON MICROSCOPY (3.19 Å)
Cite:	Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75. Cell Host Microbe, 30, 2022

7YQV

pH 5.5 SARS-CoV-2 BA.2.75 S Trimer (1 RBD Up)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Wang, L.
Deposit date:	2022-08-08
Release date:	2022-10-19
Last modified:	2022-11-23
Method:	ELECTRON MICROSCOPY (3.58 Å)
Cite:	Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75. Cell Host Microbe, 30, 2022

7YQW

SARS-CoV-2 BA.2.75 S Trimer (3 RBD Down)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Wang, L.
Deposit date:	2022-08-08
Release date:	2022-10-19
Last modified:	2022-11-23
Method:	ELECTRON MICROSCOPY (3.51 Å)
Cite:	Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75. Cell Host Microbe, 30, 2022

7YQX

SARS-CoV-2 BA.2.75 S Trimer in complex with S309 (state1)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S309 heavy chain, ...
Authors:	Wang, L.
Deposit date:	2022-08-08
Release date:	2022-10-19
Last modified:	2022-11-23
Method:	ELECTRON MICROSCOPY (3.72 Å)
Cite:	Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75. Cell Host Microbe, 30, 2022

7YQY

SARS-CoV-2 BA.2.75 S Trimer in complex with S309 (state2)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S309 heavy chain, ...
Authors:	Wang, L.
Deposit date:	2022-08-08
Release date:	2022-10-19
Last modified:	2022-11-23
Method:	ELECTRON MICROSCOPY (3.74 Å)
Cite:	Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75. Cell Host Microbe, 30, 2022

7YQZ

SARS-CoV-2 BA.2.75 S Trimer in complex with S309 (state3)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, S309 heavy chain, S309 light chain, ...
Authors:	Wang, L.
Deposit date:	2022-08-08
Release date:	2022-10-19
Last modified:	2022-11-23
Method:	ELECTRON MICROSCOPY (3.84 Å)
Cite:	Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75. Cell Host Microbe, 30, 2022

7YR0

SARS-CoV-2 BA.2.75 S Trimer in complex with S309 (interface)
Descriptor:	Heavy chain of S309, IGK@ protein, Spike protein S1, ...
Authors:	Wang, L.
Deposit date:	2022-08-08
Release date:	2022-10-19
Last modified:	2022-11-23
Method:	ELECTRON MICROSCOPY (3.98 Å)
Cite:	Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75. Cell Host Microbe, 30, 2022

7YR1

SARS-CoV-2 BA.2.75 S Trimer in complex with XG2v024
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Wang, L.
Deposit date:	2022-08-08
Release date:	2022-10-19
Last modified:	2022-11-23
Method:	ELECTRON MICROSCOPY (3.62 Å)
Cite:	Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75. Cell Host Microbe, 30, 2022

7YR2

SARS-CoV-2 BA.2.75 S Trimer in complex with ACE2(state1)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:	Wang, L.
Deposit date:	2022-08-08
Release date:	2022-10-19
Last modified:	2022-11-23
Method:	ELECTRON MICROSCOPY (3.3 Å)
Cite:	Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75. Cell Host Microbe, 30, 2022

7YR3

SARS-CoV-2 BA.2.75 S Trimer in complex with ACE2(state2)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
Authors:	Wang, L.
Deposit date:	2022-08-08
Release date:	2022-10-19
Last modified:	2022-11-23
Method:	ELECTRON MICROSCOPY (3.52 Å)
Cite:	Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75. Cell Host Microbe, 30, 2022

8D8Q

SARS-CoV-2 Spike RBD in complex with DMAbs 2130 and 2196
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2130 heavy chain, 2130 light chain, ...
Authors:	Du, J, Cui, J, Pallesen, J.
Deposit date:	2022-06-08
Release date:	2022-10-19
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2. Nat Commun, 13, 2022

8D8R

SARS-CoV-2 Spike RBD in complex with DMAb 2196
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2196 heavy chain, 2196 light chain, ...
Authors:	Du, J, Cui, J, Pallesen, J.
Deposit date:	2022-06-08
Release date:	2022-10-19
Method:	ELECTRON MICROSCOPY (4.1 Å)
Cite:	DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2. Nat Commun, 13, 2022

7WB5

local structure of hu33 and spike
Descriptor:	Surface glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, hu33 heavy chain, ...
Authors:	Pulan, L.
Deposit date:	2021-12-15
Release date:	2022-10-26
Method:	ELECTRON MICROSCOPY (3.7 Å)
Cite:	A non-ACE2-blocking neutralizing antibody against Omicron-included SARS-CoV-2 variants. Signal Transduct Target Ther, 7, 2022

7ZIT

14-3-3 in complex with SARS-COV2 N phospho-peptide
Descriptor:	14-3-3 protein zeta/delta, ACETATE ION, BENZOIC ACID, ...
Authors:	Eisenreichova, A, Boura, E.
Deposit date:	2022-04-08
Release date:	2022-10-26
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (1.79 Å)
Cite:	Structural basis for SARS-CoV-2 nucleocapsid (N) protein recognition by 14-3-3 proteins. J.Struct.Biol., 214, 2022

8ERQ

SARS-CoV-2 BA.1 spike ectodomain trimer in complex with the S2X324 neutralizing antibody Fab fragment (local refinement of the RBD and S2X324)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, S2X324 Fab heavy chain, S2X324 Fab light chain, ...
Authors:	Park, Y.J, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D.
Deposit date:	2022-10-12
Release date:	2022-10-26
Last modified:	2022-11-23
Method:	ELECTRON MICROSCOPY (3.3 Å)
Cite:	Imprinted antibody responses against SARS-CoV-2 Omicron sublineages. Science, 378, 2022

8ERR

SARS-CoV-2 Omicron BA.1 spike ectodomain trimer in complex with the S2X324 neutralizing antibody Fab fragment
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S2X324 heavy chain, ...
Authors:	Park, Y.J, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler, D.
Deposit date:	2022-10-12
Release date:	2022-10-26
Last modified:	2022-11-23
Method:	ELECTRON MICROSCOPY (3.1 Å)
Cite:	Imprinted antibody responses against SARS-CoV-2 Omicron sublineages. Science, 378, 2022

8GS6

Structure of the SARS-CoV-2 BA.2.75 spike glycoprotein (closed state 1)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:	Anraku, Y, Tabata-Sasaki, K, Kita, S, Fukuhara, H, Maenaka, K, Hashiguchi, T.
Deposit date:	2022-09-05
Release date:	2022-10-26
Last modified:	2023-03-29
Method:	ELECTRON MICROSCOPY (2.86 Å)
Cite:	Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant. Cell Host Microbe, 30, 2022

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