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코로나 바이러스
코로나 바이러스, 2020. David S. Goodsell @ RCSB PDB에 의한 오리지널 일러스트를 수정

신종 코로나바이러스 감염증 (Novel Coronavirus disease 2019:COVID-19)의 확산이 세계적으로 매우 큰 문제가 되고 있습니다. 시급히 새로운 바이러스(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)를 이해하고 효과적인 약을 개발하기 위해, 신속하게 구조 생물학 연구가 시작되고 있습니다. PDBj는 사용자의 편의를 도모하기 위해 신종 코로나바이러스의 특집 페이지를 제공하고 있습니다. 매주 수요일에 최신 항목이 추가됩니다.

바이러스 단백질에 관한 해설기사는 아래의 「이달의 분자」 페이지를 참조하십시오.

「전체 엔트리」 탭에는, 모든 PDB ID가 포함되어 있습니다. 이용자가 전체의 독립된 엔트리를 검색하고 싶을 때 사용하실 수 있으며, 동일 저자에 의한 그룹등록의 엔트리도 전부 구별되어 있습니다. 「대표구조」 탭에는, 분해능이 가장 높은 대표구조만을 표지하고 있습니다. 아미노산 서열이 100 % 일치하는 PDB 엔트리의 경우, 다른 리간드를 포함하여도 대표구조에는 제외됩니다. 「최신 엔트리」 탭은, 이번주 공개된 가장 최근의 엔트리 입니다.

Created: 2020-03-11 (last edited: 4 weeks ago)2020-10-28
전체 엔트리 (550)대표구조 (235)최신 엔트리 (9)
7CT5
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S PROTEIN OF SARS-COV-2 IN COMPLEX BOUND WITH T-ACE2
Descriptor:Spike glycoprotein, Angiotensin-converting enzyme 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, L., Bi, W.W., Zhang, Y.Y., Yan, R.H., Li, Y.N., Zhou, Q., Dang, B.B.
Deposit date:2020-08-18
Release date:2020-11-18
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Engineered Trimeric ACE2 Binds "Three-up" Spike Protein to Potently Inhibit SARS-CoVs and Mutants
To Be Published
7KOA
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ROOM TEMPERATURE STRUCTURE OF SARS-COV-2 NSP10/16 METHYLTRANSFERASE IN A COMPLEX WITH CAP-0 AND SAM DETERMINED BY PINK-BEAM SERIAL CRYSTALLOGRAPHY
Descriptor:2'-O-methyltransferase, Non-structural protein 10, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, ...
Authors:Wilamowski, M., Sherrell, D.A., Minasov, G., Shuvalova, L., Lavens, A., Henning, R., Maltseva, N., Rosas-Lemus, M., Kim, Y., Satchell, K.J.F., Srajer, V., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-11-07
Release date:2020-11-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Room Temperature Structure of SARS-CoV-2 Nsp10/Nsp16 Methyltransferase in a Complex with Cap-0 and SAM Determined by Pink-Beam Serial Crystallography
To Be Published
7CDI
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CRYSTAL STRUCTURE OF SARS-COV-2 ANTIBODY P2C-1F11 WITH RBD
Descriptor:Spike protein S1, antibody P2C-1F11 heavy chain, antibody P2C-1F11 light chain, ...
Authors:Wang, X., Zhang, L., Ge, J., Wang, R.
Deposit date:2020-06-19
Release date:2020-11-18
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Crystal structure of SARS-CoV-2 antibody P2C-1F11 and RBD
To be published
7KOK
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2, C111S MUTANT, IN COMPLEX WITH PLP_SNYDER496
Descriptor:Papain-like protease, 5-[(E)-(hydroxyimino)methyl]-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide, ZINC ION, ...
Authors:Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-11-09
Release date:2020-11-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with PLP_Snyder496
to be published
7KOL
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2 IN COMPLEX WITH PLP_SNYDER496
Descriptor:Papain-Like Protease, 5-[(E)-(hydroxyimino)methyl]-2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]benzamide, ZINC ION, ...
Authors:Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-11-09
Release date:2020-11-18
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:The crystal structure of Papain-Like Protease of SARS CoV-2 in complex with PLP_Snyder496
to be published
7KOJ
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THE CRYSTAL STRUCTURE OF PAPAIN-LIKE PROTEASE OF SARS COV-2, C111S MUTANT, IN COMPLEX WITH PLP_SNYDER494
Descriptor:Papain-like protease, 2-methyl-N-[(1R)-1-(naphthalen-1-yl)ethyl]-5-{[(prop-2-en-1-yl)carbamoyl]amino}benzamide, ZINC ION, ...
Authors:Osipiuk, J., Tesar, C., Endres, M., Lisnyak, V., Maki, S., Taylor, C., Zhang, Y., Zhou, Z., Azizi, S.A., Jones, K., Kathayat, R., Snyder, S.A., Dickinson, B.C., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-11-09
Release date:2020-11-18
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The crystal structure of Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with PLP_Snyder494
to be published
7CDJ
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CRYSTAL STRUCTURE OF SARS-COV-2 ANTIBODY P2C-1A3 WITH RBD
Descriptor:Spike protein S1, antibody P2C-1A3 heavy chain, antibody P2C-1A3 light chain, ...
Authors:Wang, X., Zhang, L., Ge, J., Wang, R.
Deposit date:2020-06-19
Release date:2020-11-18
Method:X-RAY DIFFRACTION (3.396 Å)
Cite:Crystal structure of SARS-CoV-2 antibody P2C-1A3 and RBD
To Be Published
7KJR
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CRYO-EM STRUCTURE OF SARS-COV-2 ORF3A
Descriptor:Protein 3a, Apolipoprotein A-I, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
Authors:Kern, D.M., Hoel, C.M., Kotecha, A., Brohawn, S.G.
Deposit date:2020-10-26
Release date:2020-11-18
Method:ELECTRON MICROSCOPY (2.08 Å)
Cite:Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs.
Biorxiv, 2020
7KPH
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SARS-COV-2 MAIN PROTEASE IN MATURE FORM
Descriptor:3C-like proteinase
Authors:Noske, G.D., Nakamura, A.M., Gawriljuk, V.O., Lima, G.M.A., Zeri, A.C.M., Nascimento, A.F.Z., Oliva, G., Godoy, A.S.
Deposit date:2020-11-11
Release date:2020-11-18
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:SARS-CoV-2 Main Protease in mature form
To Be Published
7KKK
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SARS-COV-2 SPIKE IN COMPLEX WITH NEUTRALIZING NANOBODY NB6
Descriptor:SARS-CoV-2 spike glycoprotein, Synthetic nanobody Nb6, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
Science, 2020
7D4F
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STRUCTURE OF COVID-19 RNA-DEPENDENT RNA POLYMERASE BOUND TO SURAMIN
Descriptor:Non-structural protein 8, Non-structural protein 7, Non-structural protein 12, ...
Authors:Li, Z., Yin, W., Zhou, Z., Yu, X., Xu, H.
Deposit date:2020-09-23
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (2.57 Å)
Cite:Structural basis for repurposing a 100-years-old drug suramin for treating COVID-19
To Be Published
7KL9
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STRUCTURE OF THE SARS-COV-2 S 6P TRIMER IN COMPLEX WITH THE ACE2 PROTEIN DECOY, CTC-445.2 (STATE 4)
Descriptor:Spike glycoprotein, CTC-445.2 inhibitor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Barnes, C.O., Bjorkman, P.J.
Deposit date:2020-10-29
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2
Science, 2020
7C33
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MACRO DOMAIN OF SARS-COV-2 IN COMPLEX WITH ADP-RIBOSE
Descriptor:Macro domain from non-structural protein 3, ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Lin, M.H., Hsu, C.H.
Deposit date:2020-05-11
Release date:2020-11-11
Method:X-RAY DIFFRACTION (3.83 Å)
Cite:Structural, Biophysical, and Biochemical Elucidation of the SARS-CoV-2 Nonstructural Protein 3 Macro Domain.
Acs Infect Dis., 2020
7CZ4
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STRUCTURE OF SARS-COV-2 MACRO DOMAIN IN COMPLEX WITH ADP-RIBOSE
Descriptor:Macro domain from non-structural protein 3, ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Lin, M.H., Hsu, C.H.
Deposit date:2020-09-07
Release date:2020-11-11
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structural, Biophysical, and Biochemical Elucidation of the SARS-CoV-2 Nonstructural Protein 3 Macro Domain.
Acs Infect Dis., 2020
7KJ4
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SARS-COV-2 SPIKE GLYCOPROTEIN WITH THREE ACE2 BOUND
Descriptor:Spike glycoprotein, Angiotensin-converting enzyme 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, J., Xiao, T.S., Cai, Y.F., Chen, B.
Deposit date:2020-10-25
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro.
Biorxiv, 2020
7KJ2
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SARS-COV-2 SPIKE GLYCOPROTEIN WITH ONE ACE2 BOUND
Descriptor:Spike glycoprotein, Angiotensin-converting enzyme 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, J., Xiao, T.S., Cai, Y.F., Chen, B.
Deposit date:2020-10-25
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro.
Biorxiv, 2020
7KJ3
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SARS-COV-2 SPIKE GLYCOPROTEIN WITH TWO ACE2 BOUND
Descriptor:Spike glycoprotein, Angiotensin-converting enzyme 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, J., Xiao, T.S., Cai, Y.F., Chen, B.
Deposit date:2020-10-25
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro.
Biorxiv, 2020
7KJ5
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SARS-COV-2 SPIKE GLYCOPROTEIN, PREFUSION WITH ONE RBD UP CONFORMATION
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Zhang, J., Xiao, T.S., Cai, Y.F., Chen, B.
Deposit date:2020-10-25
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro.
Biorxiv, 2020
7KKL
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SARS-COV-2 SPIKE IN COMPLEX WITH NEUTRALIZING NANOBODY MNB6
Descriptor:SARS-CoV-2 spike glycoprotein, Synthetic nanobody mNb6, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
Science, 2020
7CJF
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CRYSTAL STRUCTURE OF SARS-COV-2 RBD IN COMPLEX WITH A NEUTRALIZING ANTIBODY FAB
Descriptor:antibody heavy chain, antibody light chain, Spike glycoprotein, ...
Authors:Guo, Y., Li, X., Zhang, G., Fu, D., Schweizer, L., Zhang, H., Rao, Z.
Deposit date:2020-07-10
Release date:2020-11-11
Method:X-RAY DIFFRACTION (2.108 Å)
Cite:Crystal structure of SARS-CoV-2 RBD in complex with an antibody Fab
To Be Published
7KE4
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SARS-COV-2 D614G 3 RBD DOWN SPIKE PROTEIN TRIMER WITHOUT THE P986-P987 STABILIZING MUTATIONS (S-GSAS-D614G SUB-CLASS)
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Gobeil, S., Acharya, P.
Deposit date:2020-10-10
Release date:2020-11-04
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
Biorxiv, 2020
7D7T
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CRYSTAL STRUCTURE OF THE SARS-COV-2 PAPAIN-LIKE PROTEASE (PLPRO) C112S MUTANT BOUND TO COMPOUND S43
Descriptor:papain-like protease, ZINC ION, N-[(3-acetamidophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide
Authors:Liu, J., Wang, Y., Xu, X., Pan, L.
Deposit date:2020-10-05
Release date:2020-11-04
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Crystal structure of the SARS-CoV-2 papain-like protease (PLPro) C112S mutant
To Be Published
7KDL
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SARS-COV-2 D614G 1-RBD UP SPIKE PROTEIN TRIMER WITHOUT THE P986-P987 STABILIZING MUTATIONS (S-GSAS-D614G)
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Gobeil, S., Acharya, P.
Deposit date:2020-10-08
Release date:2020-11-04
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
Biorxiv, 2020
7KE7
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SARS-COV-2 D614G 3-RBD-DOWN SPIKE PROTEIN TRIMER WITHOUT THE P986-P987 STABILIZING MUTATIONS (S-GSAS-D614G SUB-CLASSIFICATION)
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Gobeil, S., Acharya, P.
Deposit date:2020-10-10
Release date:2020-11-04
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
Biorxiv, 2020
7ACS
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THE SARS-COV-2 NUCLEOCAPSID PHOSPHOPROTEIN N-TERMINAL DOMAIN IN COMPLEX WITH 7MER DSRNA
Descriptor:Nucleoprotein, RNA (5'-R(P*CP*AP*CP*UP*GP*AP*C)-3'), RNA (5'-R(P*GP*UP*CP*AP*GP*UP*G)-3')
Authors:Veverka, V.
Deposit date:2020-09-11
Release date:2020-11-04
Method:SOLUTION NMR
Cite:The SARS-CoV-2 nucleocapsid phosphoprotein N-terminal domain in complex with 7mer ssRNA
To Be Published
171313
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