9IN1
 
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9KSH
 
 | Crystal structure of SARS-CoV-2 main protease in complex with compound 1 | 分子名称: | 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-pyridin-3-yl-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione | 著者 | Zhong, Y, Zhao, L, Zhang, W, Peng, W. | 登録日 | 2024-11-29 | 公開日 | 2025-04-02 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Expanding the utilization of binding pockets proves to be effective for noncovalent small molecule inhibitors against SARS-CoV-2 M pro. Eur.J.Med.Chem., 289, 2025
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9KSJ
 
 | Crystal structure of SARS-CoV-2 main protease in complex with compound 8 | 分子名称: | 3-[[(6E)-6-(6-chloranyl-2-methyl-indazol-5-yl)imino-3-[5-(2-methoxyethoxy)pyridin-3-yl]-2,4-bis(oxidanylidene)-1,3,5-triazinan-1-yl]methyl]-4-methyl-benzenecarbonitrile, 3C-like proteinase nsp5 | 著者 | Zhong, Y, Zhao, L, Zhang, W, Peng, W. | 登録日 | 2024-11-29 | 公開日 | 2025-04-02 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Expanding the utilization of binding pockets proves to be effective for noncovalent small molecule inhibitors against SARS-CoV-2 M pro. Eur.J.Med.Chem., 289, 2025
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9LBS
 
 | Cryo-EM structure of Omicron BA.1 RBD complexed with ConBA-998,S309 and S304Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of ConBA-998, Heavy chain of S304 Fab, ... | 著者 | Zhang, Z, Ju, B, Liu, C. | 登録日 | 2025-01-03 | 公開日 | 2025-04-02 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Cryo-EM structure of Omicron BA.1 RBD complexed with ConBA-998,S309 and S304Fabs To Be Published
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9LDS
 
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9LYO
 
 | Alpha SARS-CoV-2 spike protein in complex with REGN10987 Fab homologue. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, REGN10987 Fab homologue (Heavy chain), ... | 著者 | Kocharovskaya, M.V, Pichkur, E.B, Shenkarev, Z.O, Lyukmanova, E.N. | 登録日 | 2025-02-20 | 公開日 | 2025-04-02 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Structure and dynamics of Alpha B.1.1.7 SARS-CoV-2 S-protein in complex with Fab of neutralizing antibody REGN10987. Biochem.Biophys.Res.Commun., 755, 2025
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9LYP
 
 | Alpha SARS-CoV-2 spike protein RBD-down in complex with REGN10987 Fab homologue (local refinement) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, REGN10987 Fab homologue (Heavy chain), REGN10987 Fab homologue (Light chain), ... | 著者 | Kocharovskaya, M.V, Pichkur, E.B, Shenkarev, Z.O, Lyukmanova, E.N. | 登録日 | 2025-02-20 | 公開日 | 2025-04-02 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure and dynamics of Alpha B.1.1.7 SARS-CoV-2 S-protein in complex with Fab of neutralizing antibody REGN10987. Biochem.Biophys.Res.Commun., 755, 2025
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8YWY
 
 | Crystal structure of SARS-Cov-2 main protease E166N mutant in complex with Bofutrelvir | 分子名称: | 3C-like proteinase nsp5, ~{N}-[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide | 著者 | Zhou, X.L, Wang, W.W, Zhang, J, Li, J. | 登録日 | 2024-04-01 | 公開日 | 2025-04-09 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Inhibitory efficacy and structural insights of Bofutrelvir against SARS-CoV-2 M pro mutants and MERS-CoV M pro. Commun Biol, 8, 2025
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8YWZ
 
 | Crystal structure of SARS-Cov-2 main protease H163A mutant in complex with Bofutrelvir | 分子名称: | 3C-like proteinase nsp5, ~{N}-[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide | 著者 | Zou, X.F, Wang, W.W, Zhang, J, Li, J. | 登録日 | 2024-04-01 | 公開日 | 2025-04-09 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Inhibitory efficacy and structural insights of Bofutrelvir against SARS-CoV-2 M pro mutants and MERS-CoV M pro. Commun Biol, 8, 2025
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9INL
 
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9LUF
 
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9LUG
 
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9B4X
 
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9B9U
 
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9BD9
 
 | SARS CoV-2 full-length WT spike protein, 1RBD-up conformation (SPIKE-WT) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Singh, S, Hasan, S.S. | 登録日 | 2024-04-11 | 公開日 | 2025-04-16 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Structure of SARS CoV-2 full-length spike protein, 1RBD-up conformation To Be Published
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9DHY
 
 | Structure of SARS-CoV-2 spike in complex with antibody Fab COVIC-154 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab COVIC-154 Heavy Chain, ... | 著者 | Yu, X, Saphire, E.O. | 登録日 | 2024-09-04 | 公開日 | 2025-04-16 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein. Cell Rep, 44, 2025
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8Z2E
 
 | Crystal structure of nanobody Tnb04-1 with antibody 1F11 fab and SARS-CoV-2 RBD | 分子名称: | 1F11-H, 1F11-L, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wang, X.Q, Zhang, L.Q, Chen, J, Dong, H.D. | 登録日 | 2024-04-12 | 公開日 | 2025-04-23 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of nanobody Tnb04-1 with antibody 1F11 fab and SARS-CoV-2 RBD To Be Published
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9BC1
 
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9KN1
 
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8Z9L
 
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8ZBF
 
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9DU2
 
 | SARS-CoV-2 Mpro in complex with compound 7 | 分子名称: | 3C-like proteinase nsp5, N-[(2S)-3-cyclopropyl-1-{[(1Z,2S)-1-imino-4-(methanesulfonyl)butan-2-yl]amino}-1-oxopropan-2-yl]-4-methoxy-1H-indole-2-carboxamide | 著者 | Bigelow, L, Tang, H, Boguslaw, N, Duda, D.M. | 登録日 | 2024-10-02 | 公開日 | 2025-04-30 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Inhibition of Dimeric SARS-CoV-2 Mpro by Aldehyde and Nitrilebased
Inhibitors Displays Positive Cooperativity and a Mixture of
Covalent and Non-covalent Binding. To Be Published
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9FM4
 
 | Dynamic structure of the apical stem loop of the stem loop 2 motif (s2m) from SCoV-2 Delta variant. | 分子名称: | RNA (25-MER) | 著者 | Wirtz Martin, M.A, Matzel, T, Makowski, J, Kensinger, A, Herr, A, Wacker, A, Richter, C, Jonker, H.R.A, Evanseck, J, Schwalbe, H. | 登録日 | 2024-06-05 | 公開日 | 2025-05-07 | 最終更新日 | 2025-06-04 | 実験手法 | SOLUTION NMR, SOLUTION SCATTERING | 主引用文献 | Characterization of structure and dynamics of the apical stem loop of s2m from SCoV-2 Delta by NMR spectroscopy, validated by MD and SAXS To Be Published
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8X1X
 
 | SARS-CoV-2 Papain like protease (PLpro) in complex with inhibitor Lithocholic acid | 分子名称: | (3beta,5beta,14beta,17alpha)-3-hydroxycholan-24-oic acid, GLYCEROL, Papain-like protease nsp3, ... | 著者 | Choudhary, S, Verma, S, Kumar, P, Tomar, S. | 登録日 | 2023-11-09 | 公開日 | 2025-05-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | SARS-CoV-2 Papain like protease (PLpro) in complex with inhibitor Lithocholic acid To Be Published
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9BLF
 
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