9LDS

Crystal structure of nanobody H145 bound to SARS-CoV-2 spike stem-helix

Summary for 9LDS

• Entry DOI: 10.2210/pdb9lds/pdb
• Descriptor: H145, Spike protein S2' (3 entities in total)
• Functional Keywords: sars-cov-2; spike; stem-helix; nanobody, antiviral protein
• Biological source: Vicugna pacos; More
• Total number of polymer chains: 4
• Total formula weight: 29634.48

Authors

Lu, G.W.,Guo, L.Y.,Lin, S. (deposition date: 2025-01-06, release date: 2025-04-02)

• Primary citation: Guo, L.Y.,Chen, Z.M.,Lin, S.,Yang, F.L.,Yang, J.,Wang, L.L.,Zhang, X.D.,Yuan, X.,He, B.,Cao, Y.,Li, J.,Zhao, Q.,Lu, G.W.; Structural basis and mode of action for two broadly neutralizing nanobodies targeting the highly conserved spike stem-helix of sarbecoviruses including SARS-CoV-2 and its variants; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)