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coronavirus
Coronavirus, 2020. Modified from the original illustration by David S. Goodsell@RCSB PDB

The recent outbreak of the Novel Coronavirus disease (COVID-19) is a serious threat to people all over the world. In order to understand and develop an effective drug against this virus (Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2), structural work on the related proteins has already started and the resultant entries are accumulating in the PDB. PDBj provides a portal page for the COVID-19 related entries for our users. New entries will be added simultaneously with the public release from the wwPDB.

An explanation article covering one of the proteins of this virus is available on the "Molecules of the Month" page below:

The tab "All entries" contains all PDB IDs, in case you want to check all independent entries, including group depositions by the same authors. The "Repr. entries" tab contains only representative PDB entries with the highest resolution, excluding duplicate entries with 100% amino acid sequence identitiy, even if they contain a different ligand. Finally, the "Latest entries" tab contains the latest entries released this week.


Created: 2020-10-28 (last edited: more than 1 year ago)2022-09-02
8TMY
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BU of 8tmy by Molmil
Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody CHM-16
Descriptor: CITRATE ANION, Neutralizing antibody CHM-16 Heavy Chain, Neutralizing antibody CHM-16 Light Chain, ...
Authors:Feng, Z, Wilson, I.A.
Deposit date:2023-07-31
Release date:2024-07-31
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Broad Neutralizing Antibodies Against Coronaviruses.
Not published
8VCR
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BU of 8vcr by Molmil
SARS-CoV-2 Spike S2 bound to Fab 54043-5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 54043-5 Fab Heavy Chain, ...
Authors:Johnson, N.V, McLellan, J.S.
Deposit date:2023-12-14
Release date:2024-07-31
Last modified:2024-11-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Discovery and characterization of a pan-betacoronavirus S2-binding antibody.
Structure, 32, 2024
8YWW
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BU of 8yww by Molmil
The structure of HKU1-B S protein with bsAb1
Descriptor: H4B6 heavy chain, H4B6 light chain, Spike glycoprotein, ...
Authors:Xia, L.Y, Zhang, Y.Y, Zhou, Q.
Deposit date:2024-04-01
Release date:2024-07-31
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:A novel bispecific antibody targeting two overlapping epitopes in RBD improves neutralizing potency and breadth against SARS-CoV-2.
Emerg Microbes Infect, 13, 2024
8YWX
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BU of 8ywx by Molmil
the complex structure of the H4B6 Fab with the RBD of Omicron BA.5 S protein
Descriptor: H4B6 Fab's heavy chain, H4B6 Fab's light chain, Spike protein S2'
Authors:Xia, L.Y, Zhang, Y.Y, Zhou, Q.
Deposit date:2024-04-01
Release date:2024-07-31
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:A novel bispecific antibody targeting two overlapping epitopes in RBD improves neutralizing potency and breadth against SARS-CoV-2.
Emerg Microbes Infect, 13, 2024
9BRV
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BU of 9brv by Molmil
SARS-CoV-2 Papain-like Protease (PLpro) with Fragment 5
Descriptor: CHLORIDE ION, N-[2-(dimethylamino)ethyl]-N'-(3-methylphenyl)thiourea, Papain-like protease nsp3, ...
Authors:Amporndanai, K, Zhao, B, Fesik, S.W.
Deposit date:2024-05-11
Release date:2024-07-31
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PL pro ).
Acs Med.Chem.Lett., 15, 2024
9BRW
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BU of 9brw by Molmil
SARS-CoV-2 Papain-like Protease (PLpro) with Fragment 7
Descriptor: CHLORIDE ION, N-(2-chlorophenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Papain-like protease nsp3, ...
Authors:Amporndanai, K, Zhao, B, Fesik, S.W.
Deposit date:2024-05-11
Release date:2024-07-31
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PL pro ).
Acs Med.Chem.Lett., 15, 2024
9BRX
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BU of 9brx by Molmil
SARS-CoV-2 Papain-like Protease (PLpro) with Fragment 10
Descriptor: (4R)-N-(2,4-dimethylphenyl)-7-methyl[1,2,4]triazolo[4,3-a]pyrimidin-5-amine, Papain-like protease nsp3, SULFATE ION, ...
Authors:Amporndanai, K, Zhao, B, Fesik, S.W.
Deposit date:2024-05-11
Release date:2024-07-31
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PL pro ).
Acs Med.Chem.Lett., 15, 2024
9CPO
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BU of 9cpo by Molmil
Infectious bronchitis virus core polymerase complex
Descriptor: Non-structural protein 7, Non-structural protein 8, RNA Primer, ...
Authors:Hoferle, P.J, Anderson, T.K, Kirchdoerfer, R.N.
Deposit date:2024-07-18
Release date:2024-07-31
Last modified:2025-06-04
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:A genus-specific nsp12 region impacts polymerase assembly in Alpha- and Gammacoronaviruses.
Biorxiv, 2024
8C9P
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BU of 8c9p by Molmil
Crystal structure of SARS-CoV-2 Mpro-E166V mutant, free enzyme
Descriptor: 3C-like proteinase nsp5
Authors:El Kilani, H, Ibrahim, M, Hilgenfeld, R.
Deposit date:2023-01-23
Release date:2024-08-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of SARS-CoV-2 Mpro-A166V mutant, free enzyme
To Be Published
8C9Q
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BU of 8c9q by Molmil
Crystal structure of SARS-CoV-2 Mpro-Q189K mutant in complex with 13b-K
Descriptor: Non-structural protein 11, ~{tert}-butyl ~{N}-[1-[(2~{S})-3-cyclopropyl-1-oxidanylidene-1-[[(2~{S},3~{R})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-2-oxidanylidene-pyridin-3-yl]carbamate
Authors:El Kilani, H, Hilgenfeld, R.
Deposit date:2023-01-23
Release date:2024-08-07
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal structure of SARS-CoV-2 Mpro-Q189K mutant in complex with 13b-K
To Be Published
8C9U
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BU of 8c9u by Molmil
Crystal structure of SARS-CoV-2 Mpro-Q189K mutant in complex with nirmatrelvir
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, Non-structural protein 11
Authors:El Kilani, H, Hilgenfeld, R.
Deposit date:2023-01-23
Release date:2024-08-07
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of SARS-CoV-2 Mpro-Q189K mutant in complex with nirmatrelvir
To Be Published
8CA6
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BU of 8ca6 by Molmil
Crystal structure of SARS-CoV-2 Mpro-Q189K mutant, free enzyme
Descriptor: Non-structural protein 11
Authors:El Kilani, H, Hilgenfeld, R.
Deposit date:2023-01-24
Release date:2024-08-07
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal structure of SARS-CoV-2 Mpro-Q189K mutant, free enzyme
To Be Published
8CA8
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BU of 8ca8 by Molmil
Crystal structure of SARS-CoV-2 Mpro-H172Y mutant, free enzyme
Descriptor: 3C-like proteinase nsp5, CHLORIDE ION
Authors:El Kilani, H, Ibrahim, M, Hilgenfeld, R.
Deposit date:2023-01-24
Release date:2024-08-07
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of SARS-CoV-2 Mpro-H172Y mutant, free enzyme
To Be Published
8CAC
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BU of 8cac by Molmil
Crystal structure of SARS-CoV-2 Mpro-H172Y mutant in complex with 13b-K
Descriptor: 3C-like proteinase nsp5, CHLORIDE ION, ~{tert}-butyl ~{N}-[1-[(2~{S})-3-cyclopropyl-1-oxidanylidene-1-[[(2~{S},3~{R})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-2-oxidanylidene-pyridin-3-yl]carbamate
Authors:Ibrahim, M, El Kilani, H, Hilgenfeld, R.
Deposit date:2023-01-24
Release date:2024-08-07
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Crystal structure of SARS-CoV-2 Mpro-H172Y mutant in complex with 13b-K
To Be Published
8SDH
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BU of 8sdh by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CC25.56
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Neutralizing antibody CC25.56 Heavy Chain, ...
Authors:Yuan, M, Wilson, I.A.
Deposit date:2023-04-06
Release date:2024-08-07
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift.
Biorxiv, 2023
8VQX
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BU of 8vqx by Molmil
Structure of SARS-CoV-2 main protease with potent peptide aldehyde inhibitor
Descriptor: 1,2-ETHANEDIOL, 3C-like proteinase nsp5, DI(HYDROXYETHYL)ETHER, ...
Authors:Dougan, D.R, Lane, W.
Deposit date:2024-01-19
Release date:2024-08-07
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Exploiting high-energy hydration sites for the discovery of potent peptide aldehyde inhibitors of the SARS-CoV-2 main protease with cellular antiviral activity.
Bioorg.Med.Chem., 103, 2024
9AUJ
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BU of 9auj by Molmil
Structure of SARS-CoV-2 Mpro mutant (S144A) in complex with Nirmatrelvir (PF-07321332)
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E.
Deposit date:2024-02-29
Release date:2024-08-07
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.486 Å)
Cite:In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance.
Sci Adv, 10, 2024
9AUL
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BU of 9aul by Molmil
Structure of SARS-CoV-2 Mpro mutant (A173V,T304I)) in complex with Nirmatrelvir (PF-07321332)
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E.
Deposit date:2024-02-29
Release date:2024-08-07
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.421 Å)
Cite:In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance.
Sci Adv, 10, 2024
9AUM
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BU of 9aum by Molmil
Structure of SARS-CoV-2 Mpro mutant (T21I,S144A,T304I) in complex with Nirmatrelvir (PF-07321332)
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E.
Deposit date:2024-02-29
Release date:2024-08-07
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.539 Å)
Cite:In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance.
Sci Adv, 10, 2024
9AUN
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BU of 9aun by Molmil
Structure of SARS-CoV-2 Mpro mutant (T21I,T304I)
Descriptor: 3C-like proteinase nsp5
Authors:Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E.
Deposit date:2024-02-29
Release date:2024-08-07
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance.
Sci Adv, 10, 2024
9AUO
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BU of 9auo by Molmil
Structure of SARS-CoV-2 Mpro mutant (L50F,T304I)
Descriptor: 3C-like proteinase nsp5
Authors:Gajiwala, K.S, Greasley, S.E, Ferre, R.A, Liu, W, Stewart, A.E.
Deposit date:2024-02-29
Release date:2024-08-07
Method:X-RAY DIFFRACTION (2.423 Å)
Cite:In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance.
Sci Adv, 10, 2024
8KDM
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BU of 8kdm by Molmil
Structure of SARS-CoV Spike protein complexed with antibody PW5-5
Descriptor: PW5-5 heavy chain, PW5-5 light chain, Spike glycoprotein
Authors:Sun, L, Mao, Q, Wang, Y.
Deposit date:2023-08-09
Release date:2024-08-14
Last modified:2025-06-18
Method:ELECTRON MICROSCOPY (2.87 Å)
Cite:Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination.
Cell Discov, 10, 2024
8KDR
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BU of 8kdr by Molmil
The local refined map of SARS-CoV-2 XBB Variant Spike protein complexed with antibody PW5-535
Descriptor: PW5-535 heavy chain, PW5-535 light chain, Spike glycoprotein
Authors:Sun, L, Mao, Q, Wang, Y.
Deposit date:2023-08-10
Release date:2024-08-14
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination.
Cell Discov, 10, 2024
8KDS
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BU of 8kds by Molmil
Trimer state of SARS-CoV Spike protein complexed with antibody PW5-535
Descriptor: PW5-535 heavy chain, PW5-535 light chain, Spike glycoprotein
Authors:Sun, L, Mao, Q, Wang, Y.
Deposit date:2023-08-10
Release date:2024-08-14
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination.
Cell Discov, 10, 2024
8KEJ
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BU of 8kej by Molmil
Monomer state of SARS-CoV-2 XBB Variant Spike protein trimer complexed with antibody PW5-5
Descriptor: PW5-5 heavy chain, PW5-5 light chain, Spike glycoprotein
Authors:Sun, L, Mao, Q, Wang, Y.
Deposit date:2023-08-11
Release date:2024-08-14
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.73 Å)
Cite:Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination.
Cell Discov, 10, 2024

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