+データを開く
-基本情報
登録情報 | データベース: PDB化学物質要素 / ID: UFP | ||||
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名称 | 名称: ウィキペディア | ウィキペディア - Fluorodeoxyuridylate: Fluorodeoxyuridylate, also known as FdUMP, 5-fluoro-2'-deoxyuridylate, and 5-fluoro-2'-deoxyuridine 5'-monophosphate, is a molecule formed in vivo from 5-fluorouracil and 5-fluorodeoxyuridine.
| FdUMP acts as a suicide inhibitor of thymidylate synthase (TS). By inhibiting the deoxynucleotide biosynthesis, FdUMP stops the rapidly proliferation of fast-growing tumors, and it is therefore widely used as a cancer treatment. Fluorouracil (5-FU) performs as a substrate during part of the catalytic cycle, and it is only during the synthesis of thymine from uridine, when it is combined with other molecules to form 5-FdUMP to produce an irreversible inhibition of the thymidylate synthase functions... コメント | 阻害剤*YM | |
-Chemical information
組成 | 組成式: C9H12FN2O8P / 原子数: 33 / 化学式量: 326.172 / 形式電荷: 0 | ||||
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その他 | タイプ: DNA LINKING / PDB分類: ATOMN / 1文字コード: N / 3文字コード: UFP / モデル座標のPDB-ID: 1TSN | ||||
履歴 |
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外部リンク | Brenda / UniChem / BindingDB / ChEBI / ChEMBL / CompTox / DrugBank / HMDB / KEGG_Ligand / 日化辞 / PubChem / PubChem_TPharma / SureChEMBL / ZINC / ChemSpider / Wikipedia search / Google search |
-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-詳細
-SMILES
ACDLabs 10.04 | CACTVS 3.341 | OpenEye OEToolkits 1.5.0 | |
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-SMILES CANONICAL
CACTVS 3.341 | OpenEye OEToolkits 1.5.0 | |
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-InChI
InChI 1.03 |
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-InChIKey
InChI 1.03 |
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-SYSTEMATIC NAME
ACDLabs 10.04 | OpenEye OEToolkits 1.5.0 | [( | |
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