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- PDB-6vmk: Crystal structure of human Complement Factor D with anti-Factor D... -

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Basic information

Entry
Database: PDB / ID: 6vmk
TitleCrystal structure of human Complement Factor D with anti-Factor D Fab 20D12
Components
  • Complement factor D
  • Fab Y49R heavy chain
  • Fab Y49R light chain
KeywordsHYDROLASE/IMMUNE SYSTEM / CFD / Factor D / Fab / HYDROLASE / HYDROLASE-IMMUNE SYSTEM complex
Function / homology
Function and homology information


complement factor D / Alternative complement activation / complement activation / complement activation, alternative pathway / serine-type peptidase activity / platelet alpha granule lumen / response to bacterium / Platelet degranulation / secretory granule lumen / ficolin-1-rich granule lumen ...complement factor D / Alternative complement activation / complement activation / complement activation, alternative pathway / serine-type peptidase activity / platelet alpha granule lumen / response to bacterium / Platelet degranulation / secretory granule lumen / ficolin-1-rich granule lumen / serine-type endopeptidase activity / Neutrophil degranulation / proteolysis / extracellular exosome / extracellular region
Similarity search - Function
Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin family, serine active site. / Serine proteases, trypsin domain profile. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan
Similarity search - Domain/homology
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.01 Å
AuthorsWu, P. / Harris, S.F. / Eigenbrot, C.
CitationJournal: To Be Published
Title: Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12
Authors: Dion, M. / Wu, P. / Morando, A. / Bullen, G. / Shatz, W. / Harris, S.F. / Eigenbrot, C. / Loyet, K.M. / Yadav, D. / Tassew, N. / Booler, H. / Scheer, J. / Kelley, R.F. / Tesar, D.B.
History
DepositionJan 28, 2020Deposition site: RCSB / Processing site: RCSB
Revision 1.0Feb 3, 2021Provider: repository / Type: Initial release
Revision 1.1Apr 3, 2024Group: Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Revision 1.2Oct 30, 2024Group: Structure summary / Category: pdbx_entry_details / pdbx_modification_feature / Item: _pdbx_entry_details.has_protein_modification

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
W: Complement factor D
L: Fab Y49R light chain
M: Fab Y49R heavy chain
C: Complement factor D
A: Fab Y49R light chain
B: Fab Y49R heavy chain
F: Complement factor D
D: Fab Y49R light chain
E: Fab Y49R heavy chain
I: Complement factor D
G: Fab Y49R light chain
H: Fab Y49R heavy chain
N: Complement factor D
J: Fab Y49R light chain
K: Fab Y49R heavy chain
Q: Complement factor D
O: Fab Y49R light chain
P: Fab Y49R heavy chain
T: Complement factor D
R: Fab Y49R light chain
S: Fab Y49R heavy chain
X: Complement factor D
U: Fab Y49R light chain
V: Fab Y49R heavy chain
a: Complement factor D
Y: Fab Y49R light chain
Z: Fab Y49R heavy chain
d: Complement factor D
b: Fab Y49R light chain
c: Fab Y49R heavy chain
g: Complement factor D
e: Fab Y49R light chain
f: Fab Y49R heavy chain
j: Complement factor D
h: Fab Y49R light chain
i: Fab Y49R heavy chain
m: Complement factor D
k: Fab Y49R light chain
l: Fab Y49R heavy chain
p: Complement factor D
n: Fab Y49R light chain
o: Fab Y49R heavy chain
s: Complement factor D
q: Fab Y49R light chain
r: Fab Y49R heavy chain
v: Complement factor D
t: Fab Y49R light chain
u: Fab Y49R heavy chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)1,146,01876
Polymers1,143,39248
Non-polymers2,62628
Water27,0771503
1
W: Complement factor D
L: Fab Y49R light chain
M: Fab Y49R heavy chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)71,6505
Polymers71,4623
Non-polymers1882
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
C: Complement factor D
A: Fab Y49R light chain
B: Fab Y49R heavy chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)71,6505
Polymers71,4623
Non-polymers1882
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
3
F: Complement factor D
D: Fab Y49R light chain
E: Fab Y49R heavy chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)71,5544
Polymers71,4623
Non-polymers921
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
4
I: Complement factor D
G: Fab Y49R light chain
H: Fab Y49R heavy chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)71,5544
Polymers71,4623
Non-polymers921
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
5
N: Complement factor D
J: Fab Y49R light chain
K: Fab Y49R heavy chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)71,6505
Polymers71,4623
Non-polymers1882
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
6
Q: Complement factor D
O: Fab Y49R light chain
P: Fab Y49R heavy chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)71,6505
Polymers71,4623
Non-polymers1882
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
7
T: Complement factor D
R: Fab Y49R light chain
S: Fab Y49R heavy chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)71,6505
Polymers71,4623
Non-polymers1882
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
8
X: Complement factor D
U: Fab Y49R light chain
V: Fab Y49R heavy chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)71,6505
Polymers71,4623
Non-polymers1882
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
9
a: Complement factor D
Y: Fab Y49R light chain
Z: Fab Y49R heavy chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)71,5544
Polymers71,4623
Non-polymers921
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
10
d: Complement factor D
b: Fab Y49R light chain
c: Fab Y49R heavy chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)71,5544
Polymers71,4623
Non-polymers921
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
11
g: Complement factor D
e: Fab Y49R light chain
f: Fab Y49R heavy chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)71,6505
Polymers71,4623
Non-polymers1882
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
12
j: Complement factor D
h: Fab Y49R light chain
i: Fab Y49R heavy chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)71,6505
Polymers71,4623
Non-polymers1882
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
13
m: Complement factor D
k: Fab Y49R light chain
l: Fab Y49R heavy chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)71,6505
Polymers71,4623
Non-polymers1882
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
14
p: Complement factor D
n: Fab Y49R light chain
o: Fab Y49R heavy chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)71,6505
Polymers71,4623
Non-polymers1882
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
15
s: Complement factor D
q: Fab Y49R light chain
r: Fab Y49R heavy chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)71,6505
Polymers71,4623
Non-polymers1882
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
16
v: Complement factor D
t: Fab Y49R light chain
u: Fab Y49R heavy chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)71,6505
Polymers71,4623
Non-polymers1882
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)263.704, 301.454, 458.842
Angle α, β, γ (deg.)90.000, 90.000, 90.000
Int Tables number23
Space group name H-MI222
Components on special symmetry positions
IDModelComponents
11c-304-

HOH

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Components

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Protein , 1 types, 16 molecules WCFINQTXadgjmpsv

#1: Protein
Complement factor D / Adipsin / C3 convertase activator / Properdin factor D


Mass: 24438.807 Da / Num. of mol.: 16
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: CFD, DF, PFD / Production host: Cricetulus griseus (Chinese hamster) / References: UniProt: P00746, complement factor D

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Antibody , 2 types, 32 molecules LADGJORUYbehknqtMBEHKPSVZcfiloru

#2: Antibody
Fab Y49R light chain


Mass: 23354.807 Da / Num. of mol.: 16
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Escherichia coli (E. coli)
#3: Antibody
Fab Y49R heavy chain


Mass: 23668.393 Da / Num. of mol.: 16
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Escherichia coli (E. coli)

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Non-polymers , 3 types, 1531 molecules

#4: Chemical
ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL


Mass: 92.094 Da / Num. of mol.: 16 / Source method: obtained synthetically / Formula: C3H8O3
#5: Chemical
ChemComp-SO4 / SULFATE ION


Mass: 96.063 Da / Num. of mol.: 12 / Source method: obtained synthetically / Formula: SO4
#6: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 1503 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestN
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 3.99 Å3/Da / Density % sol: 69.15 %
Crystal growTemperature: 277 K / Method: vapor diffusion, sitting drop / pH: 5 / Details: 0.1 M sodium citrate pH 5.0, 8% PEG 8000

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 17-ID / Wavelength: 1 Å
DetectorType: DECTRIS PILATUS 6M / Detector: PIXEL / Date: Nov 14, 2015
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1 Å / Relative weight: 1
ReflectionResolution: 3.001→251.945 Å / Num. obs: 359723 / % possible obs: 99.7 % / Redundancy: 6.8 % / Biso Wilson estimate: 55.29 Å2 / CC1/2: 0.996 / Rmerge(I) obs: 0.142 / Rpim(I) all: 0.059 / Rrim(I) all: 0.154 / Net I/σ(I): 12.9 / Num. measured all: 2447451
Reflection shell

Diffraction-ID: 1

Resolution (Å)Redundancy (%)Rmerge(I) obsNum. measured allNum. unique obsCC1/2Rpim(I) allRrim(I) allNet I/σ(I) obs% possible all
3.001-3.0116.80.8861750325730.7690.3640.9592.370.7
13.927-251.9456.40.0332463238430.9990.0140.03636.298.9

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Processing

Software
NameVersionClassification
PHENIX1.12-2829_finalrefinement
Aimlessdata scaling
PDB_EXTRACT3.25data extraction
XDSdata reduction
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: prior

Resolution: 3.01→49.933 Å / SU ML: 0.32 / Cross valid method: THROUGHOUT / σ(F): 1.89 / Phase error: 22.57
RfactorNum. reflection% reflection
Rfree0.2148 2180 0.61 %
Rwork0.1738 --
obs0.174 357125 99.88 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å
Displacement parametersBiso max: 266.7 Å2 / Biso mean: 66.8256 Å2 / Biso min: 7.61 Å2
Refinement stepCycle: final / Resolution: 3.01→49.933 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms78960 0 156 1503 80619
Biso mean--83.82 49.46 -
Num. residues----10464
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00280944
X-RAY DIFFRACTIONf_angle_d0.533110168
X-RAY DIFFRACTIONf_chiral_restr0.04312416
X-RAY DIFFRACTIONf_plane_restr0.00414240
X-RAY DIFFRACTIONf_dihedral_angle_d11.83648720
LS refinement shell

Refine-ID: X-RAY DIFFRACTION / Rfactor Rfree error: 0

Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection Rwork% reflection obs (%)
3.01-3.07510.3091260.267422049100
3.0751-3.14660.30211390.240322040100
3.1466-3.22530.26761350.242722012100
3.2253-3.31250.27451260.221722142100
3.3125-3.410.24441440.205622065100
3.41-3.520.23781220.198322109100
3.52-3.64580.27141350.195122097100
3.6458-3.79170.24061500.185222123100
3.7917-3.96420.21611420.167622149100
3.9642-4.17310.18811590.150122160100
4.1731-4.43440.17551220.135122182100
4.4344-4.77650.15671440.128422190100
4.7765-5.25670.20381320.13122267100
5.2567-6.01630.18351260.154622336100
6.0163-7.57560.22491290.177722422100
7.5756-49.9330.18491490.1782260299
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL112)L122)L132)L222)L232)L332)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T112)T122)T132)T222)T232)T332)Origin x (Å)Origin y (Å)Origin z (Å)
10.0067-0.00710.00210.00450.0010.00950.0661-0.00140.0246-0.0256-0.0546-0.0217-0.0158-0.0482-00.41990.0178-0.01610.27330.05390.3451-65.8189-8.2639-24.7884
20.0572-0.04280.03210.037-0.0370.03840.0660.2061-0.0436-0.1324-0.0543-0.1781-0.00310.07560.00170.2103-0.0078-0.02080.12380.02550.1497-54.1745-20.5379-24.969
30.0294-0.00960.00260.02790.01690.0095-0.03360.11210.05340.0724-0.0005-0.1505-0.02090.0769-0.00010.2667-0.06290.00550.17750.00370.1631-50.5078-17.0461-16.6306
40.00260.0072-0.00450.05630.02730.08-0.0922-0.0002-0.01410.0555-0.0184-0.0194-0.1297-0.0352-0.05760.3762-0.0532-0.01580.2097-0.08240.1892-59.5463-5.2783-7.8761
50.00580.00320.00530.00410.00250.00340.04960.0481-0.06630.01280.00130.06850.0416-0.006700.34210.0052-0.00380.3041-0.03930.2129-71.3177-19.7419-23.8517
60.00490.01040.00670.00810.00610.00370.0025-0.08030.0329-0.00830.0126-0.07670.0040.004400.2594-0.0133-0.01020.1617-0.01250.1697-66.3998-13.7663-2.5143
70.0022-0.0005-0.0026-0.0006-0.00050.0058-0.0278-0.0334-0.07180.02780.0459-0.0304-0.0294-0.1137-00.46370.0750.02280.2748-0.06710.2642-70.5873-15.4604-13.4488
80.0105-0.0037-0.02220.09040.070.1456-0.03250.02570.05390.0024-0.0442-0.0190.0056-0.0669-0.1020.35090.05-0.06440.10630.04150.1965-65.827-14.7236-10.142
90.00060.0041-0.00480.0165-0.02060.0350.0479-0.0110.05240.0660.0392-0.0437-0.04460.00530.02150.2413-0.0254-0.07130.1384-0.03040.291-49.8878-14.1199-8.8469
100.08060.0458-0.06330.0364-0.01360.07780.05680.0071-0.0420.2543-0.01420.159-0.0322-0.16520.00290.4046-0.00890.05280.1699-0.0330.1943-78.1861-32.522715.3384
110.23060.0070.10720.0649-0.01160.0626-0.0782-0.05830.00470.0944-0.16240.12810.0011-0.0528-0.1970.5978-0.06510.14380.2737-0.05730.2481-82.502-31.282122.6486
120.0314-0.0404-0.00250.0630.02490.04330.06110.07360.01670.0939-0.00840.1514-0.0077-0.01170.00661.283-0.1380.36710.708-0.13630.565-87.665-31.841951.1354
130.00260.00140.00260.0010.00160.00210.0373-0.01560.0172-0.04740.00340.04630.0204-0.014500.8583-0.11120.30720.67080.0020.7185-95.4527-27.616548.112
140.0003-0.0013-0.00130.0168-0.01460.01210.0922-0.055-0.02640.0261-0.01720.04610.0291-0.017600.9393-0.03130.27550.50970.03020.5016-84.9397-31.177947.1368
150.00140.0026-0.0030.0041-0.00470.00580.00260.0383-0.08270.10730.0030.0083-0.0857-0.013201.2187-0.10750.56570.8534-0.05140.9013-94.9886-36.537654.2183
160.3663-0.08760.2530.0414-0.06860.185-0.0124-0.0130.15570.3056-0.06540.05430.11940.0557-0.07870.4546-0.04060.03810.1924-0.04890.1792-71.9126-11.125222.8113
170.0033-0.00190.01080.0189-0.00130.03230.0684-0.02570.03170.06410.0546-0.0370.04250.01030.04241.3867-0.10870.21810.6336-0.10780.3782-76.7925-27.115652.7412
180.0575-0.02820.00410.07850.00420.00480.0845-0.15410.0567-0.00680.063-0.0081-0.09210.05590.05321.1735-0.1066-0.00850.6003-0.04160.2619-73.4412-28.803953.1148
190.0056-0.0049-0.00420.00160.0030.00540.0674-0.0354-0.0002-0.06380.08210.03590.04470.0356-00.4085-0.0453-0.1010.21320.01170.3036-56.2122-142.4301-24.6901
200.12610.0771-0.05340.2778-0.13720.0726-0.1380.0536-0.0075-0.0175-0.09520.0715-0.029-0.0539-0.07210.3589-0.0758-0.0210.1175-0.03350.1702-65.2922-130.6581-23.6028
210.19040.0283-0.08750.00960.00050.0850.05030.0909-0.0274-0.03120.01350.0126-0.1009-0.0998-0.00770.2422-0.0177-0.05240.1010.02940.2746-69.7236-127.3105-21.0165
220.00620.00160.00490.10730.01080.0047-0.02380.02230.04760.00980.03610.2160.08770.0447-0.00090.2828-0.0366-0.0680.19530.01550.172-68.0738-130.0889-20.7079
230.0088-0.00780.00940.0112-0.00970.0114-0.06240.0958-0.0670.0209-0.0630.05220.1557-0.0508-0.06450.3727-0.0605-0.12420.2263-0.02420.2984-73.5958-138.9271-24.2206
240.0249-0.0036-0.02020.029-0.01980.037-0.14890.04840.00720.1001-0.0614-0.0360.11330.1332-0.01990.4505-0.0728-0.03570.21230.07010.173-62.5461-145.4314-7.8153
250.00510.0031-0.00530.0047-0.00270.0040.0010.0190.05010.0286-0.0606-0.0813-0.02970.0203-00.381-0.0419-0.10910.24240.01740.2015-50.7238-130.8935-23.7446
260.03620.0751-0.00090.1581-0.03740.0729-0.0332-0.0775-0.0988-0.04230.0518-0.0183-0.0007-0.01390.01160.3446-0.0049-0.06660.19230.060.1178-55.7403-136.9258-2.4359
270.00130.00080.00190.00220.00290.0071-0.0283-0.02640.0329-0.01730.02650.06680.01890.0856-00.49210.0517-0.07480.31880.04790.2693-51.5447-135.2289-13.3683
280.00230.0002-0.00060.0046-0.00830.0162-0.0098-0.0476-0.0845-0.0405-0.01350.0720.00450.1355-00.4815-0.0006-0.03320.2346-0.04740.2266-56.2678-135.9754-10.1079
290.00360.00140.00950.00010.00310.04060.00870.0004-0.05590.0821-0.00330.04410.05120.02640.00070.3577-0.0818-0.04980.15120.03220.3163-72.2067-136.5668-8.8702
300.263-0.03660.07160.0557-0.05460.14390.00550.0170.06520.4296-0.018-0.1824-0.00610.09260.0730.52960.0259-0.08860.13450.00570.1734-42.602-118.353719.5833
310.00260.0006-0.01180.0439-0.00640.0307-0.0002-0.0283-0.00330.057-0.0216-0.053-0.0567-0.01180.00081.4793-0.0695-0.52520.63360.14380.6657-33.8606-119.707849.9468
320.01190.00520.00220.004400.00840.1988-0.0224-0.01010.0298-0.0211-0.0879-0.1656-0.08440.00011.1923-0.0927-0.27120.4892-0.03720.5537-35.092-117.413643.2249
330.0257-0.05670.02710.1398-0.07730.0911-0.02150.05350.06770.0333-0.04560.02140.07230.0325-0.16111.2416-0.0642-0.69860.58760.09460.7658-28.2726-118.499954.8323
340.15680.0029-0.11610.1269-0.03160.0873-0.0770.0297-0.00310.2508-0.0135-0.003-0.1569-0.0522-0.24910.54430.0236-0.03870.14490.05330.0935-50.0862-139.699522.7865
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1200.0540.083-0.05870.1341-0.09060.0704-0.1540.0257-0.08990.0212-0.0376-0.01320.0652-0.0340.0060.41080.17290.13770.58570.16851.23276.5891-86.0253-98.2032
1210.01420.0055-0.00150.00420.0019-0-0.1367-0.0253-0.0610.0074-0.0663-0.0016-0.01590.079500.4149-0.03810.10420.67430.08351.08063.7679-83.9713-95.9337
1220.00410.00140.01170.00550.00440.03210.05390.01040.0147-0.01470.04670.02810.03740.01030.00390.59220.19540.270.6431-0.0411.47979.7197-98.3999-97.6651
1230.0093-0.0011-0.00410.0001-0.00180.00070.0040.0162-0.1044-0.00830.0256-0.04410.00790.0316-00.72050.28960.32660.81990.04681.227115.1093-88.1755-102.1969
1240.4430.0784-0.23450.0479-0.1360.4441-0.3239-0.2259-0.4712-0.0635-0.1516-0.42730.30370.3219-1.12070.26330.25590.13470.12560.58810.6297-26.1678-79.706-77.5726
1250.07480.0169-0.04280.0254-0.0020.02690.04970.00790.00340.02860.0079-0.0040.05990.04390.03580.58760.28240.26360.69890.56241.21550.9826-92.7051-81.2985
1260.0233-0.02450.00970.0221-0.010.0006-0.1228-0.0528-0.14230.21950.02040.09060.04530.189500.69130.23070.04690.86150.54751.52875.9606-86.2999-82.6924
1270.0062-0.01090.00710.0133-0.01250.00660.0527-0.0099-0.00020.09360.1207-0.06790.03620.066701.19970.2551-0.24121.35670.60351.389512.2674-89.1051-75.5834
1280.0229-0.01390.00010.00810.00450.019-0.0578-0.0208-0.0118-0.0636-0.0716-0.0753-0.0077-0.0165-0.02570.20790.04730.11190.36040.05370.4173-11.0416-33.5147-118.5568
1290.01250.0254-0.00480.0779-0.07130.114-0.011-0.0027-0.0736-0.0052-0.0723-0.08030.07580.032-0.0021-0.0574-0.05030.21380.32920.16150.3116-11.3291-48.7895-108.6514
1300.0115-0.0222-0.00520.05020.00060.0161-0.0195-0.0372-0.14040.10560.04650.0056-0.0713-0.02010.03210.19930.02450.14850.40520.11090.341-9.9473-47.4683-107.898
1310.02680-0.01860.0002-0.00190.01230.00940.04210.0011-0.04450.0406-0.02060.01550.10120.01170.2184-0.05330.06860.4270.05150.441-0.549-46.9558-113.6153
1320.0234-0.0070.00240.00560.0150.04650.07420.01220.0120.0313-0.0087-0.0169-0.07810.06410.00690.1946-0.1170.04020.502-0.05010.3732-1.6384-29.048-103.3365
1330.0117-0.00240.01480.005-0.00170.01790.0061-0.01830.00670.00410.01170.0517-0.0052-0.00010.01750.2138-0.01270.19270.36710.03910.3648-22.5983-36.7847-114.1158
1340.022-0.01930.00810.0454-0.02260.01650.0925-0.06330.0640.01780.0045-0.1081-0.0988-0.00890.0020.2245-0.08660.0590.40110.02750.3216-11.7415-27.5035-96.534
1350.0018-0.0012-0.00250.00440.00080.0029-0.0777-0.0073-0.0769-0.0089-0.03160.009-0.0632-0.054100.3508-0.00840.08870.46760.01140.4315-17.469-30.2711-106.3711
1360.00570.00660.0080.0306-0.0150.0421-0.0220.0462-0.03510.00850.1392-0.0215-0.1210.08650.04490.1956-0.03340.12080.5070.10010.303-12.978-31.5455-102.8541
1370.0006-0.00010.00140.00090.00550.02420.0649-0.0154-0.028-0.00780.0128-0.0173-0.04130.075-0.00180.234-0.00130.01170.47970.12120.4081-0.8444-41.3103-99.1537
1380.0753-0.024-0.02250.144-0.00370.020.1359-0.0640.16350.329-0.09870.023-0.21280.00290.07020.4066-0.190.06090.33650.00510.1795-29.9156-21.3463-69.5821
1390.0486-0.00070.02590.00170.00440.01410.13870.04760.0770.1218-0.05230.0609-0.0841-0.01060.06861.0152-0.18460.25210.5283-0.15120.3982-34.9199-5.3669-44.8726
1400.00410.002-0.00160.0029-0.00270.0030.0636-0.04760.13650.0222-0.0131-0.0085-0.08420.113200.6223-0.2269-0.07760.602-0.1380.6223-6.9887-11.317-69.2411
1410.002-0.0043-0.00380.0086-0.0040.00660.0781-0.0517-0.02210.06280.0255-0.1297-0.16120.0913-00.429-0.1890.07740.5116-0.04780.4473-8.7285-17.8657-78.9506
1420.00510.00230.00270.0218-0.00640.0092-0.0185-0.05150.0590.0696-0.13260.0406-0.0364-0.0262-0.01870.41-0.1970.15460.555-0.05740.3825-15.4047-12.0678-81.5078
1430.00260.0040.00130.00580.00320.00430.10910.00150.00590.09370.06420.0413-0.06560.016400.7122-0.23310.02870.6168-0.05680.6505-9.7772-7.5751-82.2477
144-0.0002-0.0010.00070.0004-0.00010.00370.01770.0250.06990.0250.0020.0386-0.02040.016-00.7077-0.22040.11880.611-0.02570.5456-10.5596-4.6873-74.4066
1450.07850.043-0.00770.0233-0.00320.00070.0757-0.01130.01430.02390.01580.00610.03230.08230.02160.3415-0.1947-0.05710.5804-0.07030.2666-13.8123-20.2347-75.0794
1460.0633-0.0104-0.06130.07370.02140.06-0.0256-0.0312-0.02650.1826-0.06320.03540.0087-0.00470.00520.9109-0.4590.09010.6645-0.18840.539-16.6732-4.7752-48.7468
1470.0010.00230.00440.01410.01390.0144-0.0046-0.00740.01040.0941-0.0014-0.07670.03130.0391-01.3216-0.43890.12660.9646-0.10540.7615-17.8311-9.4725-46.427
1480.0011-0.00040.0009-0-0.00010.00110.0053-0.0111-0.00960.0010.0143-0.032-0.00960.023201.1618-0.0025-0.07350.88630.11680.836-19.4741-20.9008-42.3763
1490.00120.00060.00170.00220.00070.00320.0034-0.02550.00160.00180.00950.00210.0001-0.02501.1184-0.24880.03450.9653-0.11760.8525-21.059-2.8439-53.8327
1500.00160.00340.00070.00510.00270.007-0.0216-0.0042-0.0053-0.04510.0404-0.0133-0.03150.020601.0832-0.1463-0.07630.79310.09860.6869-25.0548-16.5633-37.5274
1510.00470.00410.00220.00340.00230.0051-0.05480.00110.05820.0280.0032-0.03580.00310.0016-01.3994-0.1888-0.06641.29150.01141.1833-15.5617-15.1415-36.8151
1520.0002-0.0003-0.0024-0.00050.00020.0019-0.0037-0.03760.00390.04680.0069-0.05920.0031-0.0253-01.1831-0.0703-0.18191.1583-0.06631.0148-12.4173-8.8409-39.2337
1530.0732-0.0339-0.00150.01580.0020.0059-0.03490.02680.0191-0.03220.04180.02750.00610.0059-0.0230.465-0.1722-0.32730.6382-0.00070.4793-108.3885-117.8351-120.0856
1540.03840.00740.03080.0253-0.01280.02930.05870.09480.0826-0.07740.06680.1478-0.0043-0.07650.2927-0.0256-0.0972-0.36650.50840.06280.3306-108.615-102.155-113.8265
1550.0157-0.00640.00570.0071-0.00460.01520.0411-0.01910.0366-0.02020.05910.05120.0586-0.06960.08840.2172-0.0655-0.24820.43410.080.4859-115.2501-105.0538-107.1051
1560.02370.0385-0.02070.0669-0.04060.02140.05190.03160.02080.00780.01940.09280.0754-0.05770.03680.2753-0.1371-0.17990.55370.02540.4174-118.2903-121.758-104.9912
1570.00490.0007-0.00580.00230.00050.00590.0202-0.003-0.0003-0.06480.0554-0.0297-0.0232-0.02830.00010.426-0.1014-0.16130.5841-0.00890.4719-96.928-114.5836-115.3605
1580.0673-0.0331-0.0040.0340.01490.0117-0.06030.0290.0387-0.01330.05990.05350.00290.0307-0.01090.0738-0.1339-0.12610.5032-0.05490.2641-108.4381-123.2248-97.8664
1590.0025-0.00460.00070.0037-0.00220.00160.01250.018-0.00420.00040.0196-0.01090.05020.076-00.4047-0.0712-0.18940.50070.00070.5047-102.4217-120.8788-107.5576
1600.0060.0053-0.00750.0067-0.00760.0091-0.01920.02880.003-0.0190.04690.0290.0539-0.01160.01310.2277-0.0863-0.16520.584-0.07040.31-106.9466-119.375-104.2589
1610.0152-0.00650.00110.01260.00430.00170.0131-0.0115-0.0083-0.02270.01270.02590.0151-0.02560.03450.1678-0.0913-0.11260.44180.02620.3254-118.9818-109.3402-101.1956
1620.04250.0359-0.01450.0862-0.06450.0520.0322-0.0065-0.07520.1414-0.0654-0.0205-0.0090.0055-0.07520.0224-0.1767-0.13490.2348-0.11710.0659-90.6592-125.1647-75.6516
1630.1386-0.039-0.04290.27610.11720.0616-0.08680.0616-0.11460.1879-0.094-0.03110.0188-0.0235-0.21260.37-0.2251-0.07630.38410.10450.2627-92.449-137.8733-57.4221
1640.005-0.00060.00870.0006-0.00040.01390.04620.0686-0.0168-0.0046-0.0034-0.04540.03720.024500.7924-0.0946-0.04810.6470.14440.387-86.4561-141.9757-47.5208
1650.0744-0.0197-0.02760.01190.00040.01040.1133-0.0328-0.00890.1311-0.0527-0.07130.16630.0770.02950.7515-0.0963-0.13060.5710.18810.4174-87.1644-145.6816-44.2947
1660.2070.01550.21360.2241-0.0250.2204-0.1185-0.06650.01050.0468-0.07490.05510.09970.0146-0.18480.2694-0.07140.18030.265-0.05450.3821-114.0457-138.9531-70.4437
1670.02080.0261-0.00210.05280.0070.01370.0666-0.01470.04150.1618-0.08220.0795-0.0432-0.0616-0.00060.2015-0.0914-0.01570.3548-0.02120.3123-108.6583-134.6009-79.1906
168-0-0.0016-0.00360.00530.00630.009-0.06150.03420.0060.023-0.0699-0.0095-0.0069-0.00850.00010.3019-0.1092-0.04630.4613-0.07460.3675-107.4155-142.557-86.7238
1690.02020.0076-0.01080.0034-0.00020.01660.06290.10530.02770.0583-0.0360.04650.0589-0.12460.02480.2299-0.10820.08630.381-0.06040.3459-111.5355-140.3002-77.7842
1700.10570.01870.07410.02860.06680.1733-0.1069-0.0814-0.05260.0518-0.11630.10070.06690.0065-0.27510.2126-0.14780.10750.3375-0.01970.2809-108.936-138.6785-67.2752
1710.0040.0022-0.00590.0036-0.00180.0075-0.0998-0.0137-0.00390.0409-0.001-0.02780.0309-0.023601.029-0.26980.00940.87670.06940.4765-98.5235-140.9612-38.4698
1720.00010.0018-0.00260.0033-0.00450.0054-0.0559-0.06750.03190.01190.00490.02530.0053-0.0200.8724-0.13720.10750.7087-0.11780.6377-107.5148-139.1628-49.5079
1730.0222-0.0027-0.00260.0083-0.01150.0156-0.024-0.0952-0.08980.03710.09710.06660.001-0.0518-00.7242-0.12210.11910.579-0.06790.3882-99.1626-138.0919-46.4325
1740.00650.0014-0.0033-0.00050.00020.00320.00870.0203-0.05130.05430.01390.0873-0.013-0.02300.7665-0.0740.1051.032-0.10260.7639-108.0846-136.1379-40.7444
1750.0014-0.00110.00130.00010.00170.0031-0.0073-0.0198-0.01630.038-0.03740.0145-0.00930.0186-00.9652-0.06450.24281.0749-0.02730.775-107.8903-141.1365-37.0579
1760.00070.0039-0.00080.0265-0.0150.0108-0.0101-0.01140.00960.0245-0.0475-0.0766-0.0122-0.0044-0.0080.3411-0.0418-0.16330.17790.03230.2773-36.4681-82.5179-2.5716
1770.0041-0.015-0.00770.05520.01910.0103-0.0555-0.02830.06410.1131-0.0568-0.0945-0.05620.1857-0.29110.2082-0.0058-0.35630.15980.07680.0121-35.169-95.25038.4307
1780.0152-0.01410.02110.0146-0.0180.0314-0.1008-0.08030.09280.15310.03950.0063-0.09630.120300.3905-0.0459-0.11710.2224-0.0030.2874-43.4747-92.345212.726
1790.0036-0.00790.00480.0088-0.00830.00790.01360.02630.15460.0996-0.00270.110.06360.0528-00.34990.0338-0.09040.2105-0.0450.3563-53.2296-80.47014.549
1800.00150.0031-0.0050.0325-0.04090.03940.0459-0.07340.02320.0650.06440.03980.0572-0.0750.00120.2084-0.0225-0.08190.1540.0120.2484-45.0958-89.3004-6.4871
1810.0156-0.0159-0.00230.01510.01210.004-0.20350.0990.07010.16180.02120.04140.02780.0227-0.00410.2852-0.0056-0.07230.21150.01810.2132-55.9761-91.1942-3.7229
1820.0219-0.001-0.0177-0.00030.00170.0214-0.0630.1202-0.0404-0.00330.0680.0083-0.0326-0.10210.00130.254-0.0688-0.08170.1524-0.00090.2117-50.8155-89.4679-2.2521
1830.0044-0.0004-0.00030.00210.00390.0037-0.04520.01820.01120.0508-0.01020.0965-0.0043-0.036300.48430.026-0.00880.1716-0.01360.1845-51.3526-89.786713.7404
1840.0577-0.03860.04330.12940.030.17350.01580.0708-0.16630.0949-0.05820.3106-0.03290.0027-0.07230.1835-0.0427-0.03590.0697-0.04970.3556-82.5048-107.7452-15.1979
1850.10920.0221-0.02320.0048-0.00150.0496-0.06660.0374-0.1195-0.0544-0.12180.0576-0.0324-0.0544-0.19860.3685-0.0791-0.27170.4765-0.14741.3086-111.9462-111.209-22.5138
1860.0583-0.00430.00950.1473-0.00510.07470.0316-0.0171-0.07190.14150.01680.208-0.09510.00810.00710.1795-0.05260.00950.16980.02390.3292-84.3031-87.5548-6.8041
1870.00230.0017-0.00070.00850.00120.0016-0.0328-0.03830.01510.1212-0.1160.10050.1093-0.1144-0.11090.4753-0.20310.15360.41390.09871.1151-110.2796-107.1922-8.1101
1880.00090.0009-0.002500.00040.0010.0718-0.04990.0014-0.00630.0713-0.0039-0.07160.043-00.9606-0.26270.27640.795-0.01811.1221-115.326-106.4672-0.4864
1890.00440.00310.00310.00340.00030.00230.00180.00170.00060.0503-0.04850.0820.0265-0.014600.6006-0.09880.14120.3374-0.00390.3873-85.6793-68.1429-2.742
1900.00550.01150.00910.0140.01110.00760.05190.06330.06340.0459-0.08060.1153-0.0472-0.142100.3709-0.02880.05410.2562-0.0250.2629-84.1895-53.85158.3434
1910.00360.00180.00370.0128-0.01320.0068-0.0399-0.04330.01830.00190.0118-0.02550.0008-0.093800.3238-0.04090.090.2919-0.01370.2785-92.0154-58.11268.039
1920.0174-0.0113-0.00170.00730.00620.0399-0.0028-0.0371-0.08540.0741-0.0579-0.03050.0692-0.113700.4371-0.05120.06530.30960.01670.3119-78.7964-58.369212.5548
1930.0039-0.0036-0.0040.0024-0.0010.0104-0.03620.0312-0.13450.15260.0596-0.02830.0193-0.0322-00.3501-0.01860.07010.15720.00460.26-68.9599-70.20764.4171
1940.0032-0.00360.00390.0036-0.00340.0026-0.08040.0574-0.0004-0.0398-0.09430.0247-0.06130.0480.00010.4415-0.01770.10710.2016-0.03260.3752-84.8481-56.937-8.7712
1950.00230.00560.00470.0070.0060.0036-0.01340.011-0.05090.17750.0692-0.0176-0.00520.087900.2905-0.00980.01750.2014-0.00260.1975-63.659-61.7918-2.552
1960.00450.00060.0020.0039-0.00170.0032-0.07070.0321-0.01910.0427-0.0085-0.0598-0.017-0.001600.36360.02390.11110.3523-0.02150.3525-74.3466-60.8246-7.2544
1970.01150.00560.01110.00340.00520.0087-0.06960.1196-0.0185-0.05170.02270.0936-0.03350.0738-00.3621-0.107-0.00330.24110.01960.2569-71.3415-61.2468-2.3639
1980.07760.0057-0.02710.0009-0.00590.0881-0.011-0.0478-0.04990.0460.0045-0.00180.01290.00030.00810.48740.00010.04480.12520.00680.1444-70.8901-60.912413.6337
1990.08550.01370.03080.0115-0.00280.0176-0.02180.1730.10310.0048-0.07230.01050.0524-0.0569-0.01230.2707-0.0056-0.04380.2128-0.06050.2125-42.6839-40.5296-20.7649
2000.02490.0237-0.02370.0286-0.02630.01850.0210.05610.14550.04630.0256-0.05190.10470.0163-00.2559-0.0301-0.07280.17690.01340.2452-47.1972-43.1277-13.0302
2010.00130.003-0.00960.0064-0.00780.15880.03630.05450.07-0.1229-0.0243-0.20550.041-0.0402-0.00920.18390.01690.00480.15530.01950.4587-24.4914-43.7445-18.9043
2020.0053-0.00540.00620.0013-0.0020.0093-0.09850.0884-0.0115-0.11840.0169-0.09020.0918-0.044100.4755-0.00160.06790.53010.07130.8175-15.4594-38.8795-24.923
2030.0016-0.003-0.0010.00140.00130.002-0.02380.0480.0183-0.0422-0.0001-0.0111-0.00880.0419-00.401-0.09130.19910.45950.020.5275-12.4439-45.8879-30.2939
2040.0014-0.0005-0.00190.00040.00060.0017-0.0444-0.01080.00240.0205-0.049-0.0103-0.01650.004700.4867-0.0113-0.11850.50130.04130.4999-24.4354-33.7978-13.464
2050.01050.00680.0210.00420.0150.0413-0.00370.0128-0.0058-0.0356-0.06710.0018-0.0180.015-0.04230.59640.00670.43730.6339-0.06121.0082-5.84-44.4754-28.6698
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2890.00720.0021-0.00310.0008-0.00220.0024-0.01710.0044-0.0246-0.0440.0018-0.0106-0.02890.01101.11490.06510.04081.07770.40871.1484-70.7107-3.9738-76.7935
2900.0414-0.01780.02020.03440.02220.1040.0075-0.0038-0.008-0.15730.00780.3256-0.2865-0.24820.00730.51080.2-0.15090.4199-0.02650.3575-99.9415-4.8045-39.841
2910.0212-0.01440.00610.035-0.03090.0275-0.04530.2544-0.04370.0468-0.01420.1862-0.2058-0.1163-0.00021.20960.2574-0.21410.6243-0.04370.5377-92.7364-5.4626-74.0106
2920.0457-0.0243-0.02130.09030.06020.1599-0.02430.00390.01940.01-0.0212-0.00750.06870.001-0.06250.46620.158-0.12210.32210.00340.2334-20.7476-125.30424.2317
2930-0.0010.00150.0012-00.00360.027-0.0085-0.01030.054-0.0017-0.00680.0205-0.01620.01970.27160.1305-0.14570.3909-0.010.1983-17.0519-111.9938-2.4063
2940.0481-0.00380.01530.01650.01080.01390.034-0.0322-0.0352-0.020.08030.02610.0384-0.04070.09750.25580.0613-0.21750.26820.01490.3203-18.316-108.3615-7.7947
2950.00180.0060.00280.00990.00480.0046-0.06660.0430.0610.09150.0783-0.06840.03740.1088-0.03070.2291-0.0041-0.18880.2574-0.01890.2465-16.7304-111.6093-5.9647
2960.03370.02260.02060.02470.00430.01820.0297-0.00860.007-0.04160.02190.01340.06580.07820.06820.28260.1443-0.17140.3731-0.06270.2987-7.7513-113.64430.259
2970.00940.00660.00420.00390.0034-0.00070.0067-0.01860.01930.0151-0.0371-0.03530.07830.1341-00.40890.1345-0.09120.3934-0.06960.2929-11.4739-131.1004-10.5829
2980.00610.0006-0.00570.0032-0.0030.00410.05170.02980.04340.04150.04460.01620.0324-0.035300.4346-0.0001-0.09740.29140.10070.3553-31.2722-119.9951-0.6853
2990.06720.0388-0.01120.035-0.00350.0047-0.03280.0150.03150.00580.0043-0.11160.04150.0245-0.00910.33760.0914-0.12460.2773-0.00050.2467-21.2842-130.7656-17.952
3000.00540.00160.0040.0034-0.00310.0066-0.10460.03230.11690.0211-0.1092-0.01170.1181-0.0354-0.00010.46630.0234-0.04820.3417-0.01330.3114-27-127.1636-8.313
3010.001-0.00170.00070.02350.02250.0188-0.0329-0.02720.00250.0150.11580.03610.0541-0.04450.02830.30550.1002-0.14910.3620.02270.2075-22.1437-126.599-11.5926
3020.00290.0026-0.00310.0008-0.00090.00390.05790.00240.0015-0.0135-0.0078-0.04320.00580.1261-00.20390.0772-0.07270.3436-0.01480.2904-8.3831-119.1249-14.5129
3030.00950.0037-0.00660.01060.00530.00780.0085-0.0966-0.0447-0.08020.05170.05480.035-0.05680.08130.4119-0.0032-0.09390.16940.06070.0676-42.4085-132.7476-39.0394
3040.009-0.01130.01180.08160.01830.02070.0420.1315-0.0172-0.1032-0.0503-0.0710.02350.0150.00870.25750.0237-0.04480.23560.04260.1194-36.0267-127.2263-41.5062
3050.20080.0461-0.08530.0655-0.00630.1175-0.11740.0914-0.0673-0.1017-0.06790.0343-0.116-0.0568-0.35190.49330.0773-0.1690.1959-0.05630.1351-39.1198-142.4864-58.7252
3060.0150.0043-0.00050.00470.00240.00530.10070.0155-0.0421-0.01540.00710.05140.0879-0.0073-00.7638-0.0316-0.07520.6046-0.12510.4103-45.5348-145.6549-68.5203
3070.0043-0.0015-0.00010.0055-0.00420.003-0.013-0.0115-0.0132-0.00430.03980.0074-0.0024-0.0246-00.6724-0.1524-0.00790.45460.01840.6376-46.7965-154.8732-67.4389
3080.0098-0.00670.00140.0078-0.00770.0116-0.05570.1485-0.0288-0.0401-0.0425-0.02650.11090.007200.6975-0.07290.02490.3655-0.02950.404-39.8674-146.3148-68.6835
3090.01130.0030.00880.00030.00310.00480.0068-0.01420.0279-0.0862-0.00290.03430.0859-0.036801.009-0.0423-0.19190.8645-0.32340.5998-50.125-149.9079-76.4451
3100.0726-0.0174-0.01860.0127-0.00660.0184-0.0245-0.03790.0731-0.2290.1479-0.18440.29320.07250.00240.42550.0835-0.00770.3733-0.05020.2638-18.6676-143.0495-39.6431
3110.0197-0.0012-0.0216-0.00210.00970.05460.0087-0.0357-0.06570.02930.0247-0.07930.23880.04960.01350.34440.104-0.00840.2047-0.0290.1337-23.6502-147.3324-39.3047
3120.0126-0.0030.00280.01720.00280.01250.06180.16440.0186-0.0480.0503-0.1843-0.0239-0.0142-00.89670.02810.08380.36990.01120.4061-30.7731-145.0514-71.6153
3130.0015-0.0002-0.0016-0.00090.00130.00180.06950.0502-0.0018-0.0661-0.0152-0.1781-0.0197-0.0266-00.84750.03310.21020.81540.13120.7425-23.8884-145.3606-77.5863
3140.0038-0.001-0.0023-0.00050.00030.00020.01040.0107-0.00940.0609-0.0513-0.02840.0349-0.0711-00.2731-0.0158-0.01180.21790.00910.3712-75.768-140.9714-91.1828
3150.0175-0.00590.00230.0343-0.02540.03110.0019-0.0751-0.08240.0471-0.0506-0.1010.02140.039-0.1371-0.1487-0.1528-0.09020.0084-0.02560.1981-62.2438-130.8327-91.3876
3160.0409-0.0322-0.00180.03220.00760.0201-0.16120.0687-0.1575-0.099-0.0586-0.13060.20690.014700.3879-0.01260.02060.3176-0.05170.4198-62.7692-138.4773-102.3394
3170.02630.0167-0.00070.0106-0.00420.01450.00460.0534-0.0585-0.06710.0536-0.04930.025-0.02170.03160.2757-0.1071-0.04060.3199-0.11530.35-78.754-134.0332-100.0018
3180.00150.00470.00360.0130.0030.00520.08860.0340.0166-0.0830.0928-0.08430.0046-0.047-00.3461-0.05230.03380.3023-0.09680.2729-76.4474-133.4455-111.0872
3190.00150.00080.00020.00580.00350.013-0.07020.1119-0.0146-0.0030.0212-0.0461-0.073-0.170500.288-0.04390.03110.2404-0.04720.3561-74.8943-135.1472-105.9561
3200.0110.003-0.02670.001-0.01020.073-0.0670.0172-0.0232-0.0604-0.0683-0.00660.0925-0.0429-00.23980.02260.12780.1579-0.06340.4736-59.3108-138.2723-107.3403
3210.00030.00450.00270.0152-0.01010.0079-0.04090.11330.0145-0.11140.04570.0233-0.01090.01750.03540.4625-0.2208-0.14970.5856-0.08820.1146-89.2118-115.6969-131.0712
3220.0449-0.01090.02380.1623-0.10030.0747-0.03230.05880.002-0.1501-0.1265-0.0010.0329-0.0104-0.09050.4998-0.1511-0.01090.5993-0.06840.2287-80.0163-116.4964-129.6293
3230.00020.00710.00620.010.01520.01750.03630.1942-0.0507-0.0917-0.09550.0171-0.08360.0297-0.02620.5943-0.1589-0.04440.7045-0.02960.2529-85.3809-119.2376-133.4749
3240.09040.08290.00940.0785-0.01820.06050.04760.0173-0.02360.0171-0.0904-0.00490.0372-0.0375-0.05330.8453-0.0564-0.23720.8873-0.09190.2357-89.5982-112.6382-164.7455
3250.00690.0006-0.00480.00010.00050.00310.004-0.0639-0.0368-0.06240.00570.06660.01980.031301.0631-0.0972-0.22811.3088-0.31720.6352-94.9399-111.4256-162.273
3260.0024-0.003-0.00360.00260.00420.00530.03750.04370.0371-0.0031-0.10950.0162-0.0158-0.0356-00.9336-0.0608-0.06341.0949-0.02750.4999-92.3938-113.1772-159.476
3270.00650.0005-0.0024-0.00080.00040.00460.0125-0.07810.03020.02020.02910.0113-0.00440.0154-01.2789-0.0685-0.46551.5828-0.2831.0334-100.6076-116.5922-171.1822
3280.0061-0.00680.00170.0053-0.00130.0005-0.0012-0.05440.0164-0.021-0.019-0.00620.01480.011101.28660.1184-0.41891.3965-0.13550.9762-98.1649-105.7073-170.5146
3290.0433-0.04530.00560.0583-0.02250.0166-0.01360.173-0.0942-0.15890.04660.01540.1045-0.0247-0.01150.6962-0.1809-0.00010.68-0.26510.2636-78.2043-138.1318-138.2879
330-0.0005-0.0041-0.0030.01120.01050.0085-0.09250.0335-0.1336-0.0856-0.06930.03920.0068-0.0371-0.00010.6035-0.0679-0.07010.6208-0.22690.5291-86.4744-136.5745-132.2091
3310.0038-0.00570.00090.0118-0.0023-0.0003-0.04650.1391-0.1016-0.2369-0.07570.09870.0112-0.1179-0.12990.6183-0.2373-0.05480.802-0.30810.3274-84.2147-138.2536-141.205
3320.0351-0.01720.00510.0472-0.01970.00820.08320.05950.1107-0.0089-0.1572-0.10430.0273-0.0892-0.00011.45160.0155-0.13661.141-0.00620.4007-82.7807-120.8008-169.2953
3330.00260.00780.00920.01020.01540.0270.06430.12980.056-0.029-0.1339-0.05490.0712-0.044701.4321-0.1044-0.02461.36620.03560.4637-82.1244-116.7424-167.5047
334-0.0011-0.00110.00080.00470.00520.0054-0.03430.00820.02030.0115-0.05230.0037-0.0020.0105-01.38380.022-0.04171.1195-0.13850.7698-78.29-125.2617-172.8653
3350.0269-0.008-0.00260.02520.01610.01110.02840.04050.0507-0.0073-0.0230.0478-0.05850.0667-0.00770.24420.03430.13690.2683-0.02990.3853-44.6547-9.8855-91.6278
3360.06190.0481-0.00710.09490.06770.09790.0801-0.11450.03450.16130.04730.0426-0.1331-0.01150.1930.15450.13350.25520.16930.02470.1227-58.1068-20.0895-92.0178
3370.054-0.0252-0.00250.0578-0.00570.0180.2057-0.02620.1018-0.0163-0.04690.1104-0.2108-0.04910.15180.30830.08190.18820.27750.07330.1709-51.3976-14.3616-102.3847
3380.0411-0.04190.01050.0446-0.01080.02740.208-0.09320.0136-0.03580.05210.0901-0.04530.06720.01230.23410.06310.08790.26370.07370.2191-43.2648-18.0043-111.0202
3390.0079-0.00320.00930.0002-0.00330.01120.07350.01550.03060.0770.04080.057-0.04830.07600.35290.0330.04660.2383-0.01310.2817-44.9411-16.1567-106.2724
3400.00240.0011-0.00090.0061-0.00710.0064-0.0034-0.00110.0115-0.0577-0.0113-0.0034-0.0288-0.0281-0.02580.28090.17620.1050.22950.10670.2284-60.5115-13.1613-108.3455
3410.06960.0175-0.02790.2685-0.17010.10430.01840.1619-0.0708-0.3285-0.0342-0.17540.150.0011-0.03120.147-0.0540.28170.14580.1688-0.1317-33.4521-36.5979-132.8523
3420.0024-0.012-0.0140.07560.00770.0848-0.08180.0205-0.0675-0.1688-0.0843-0.0474-0.06620.052-0.06191.4801-0.10980.60950.8493-0.04410.747-22.6251-38.4349-166.0961
3430.0021-0.00450.00050.0061-0.00560.00960.07660.02360.0002-0.0339-0.0218-0.07560.07180.001400.8656-0.04320.21650.63370.07740.5405-24.0081-39.4848-158.537
3440.0294-0.0108-0.03150.00420.01130.0285-0.01470.0193-0.03340.007-0.0096-0.0202-0.00490.0592-0.05181.32620.03650.76190.9292-0.050.9076-17.2803-40.7939-168.175
345-0.00040.0003-0.00120.00240.0013-0.0002-0.02550.03050.011-0.12570.0121-0.0173-0.0597-0.0365-0.00740.38430.08880.07910.55330.16710.1891-39.5863-13.7266-145.8295
3460.06430.01640.00670.01160.00250.0374-0.00150.02760.0533-0.12110.0012-0.0308-0.0091-0.0735-0.01880.35330.17760.04420.20430.15690.1368-37.5285-15.2513-133.4603
3470.01450.02560.00090.04370.00210.08370.02290.0210.056-0.091-0.0227-0.06640.0372-0.0911-0.0650.42640.06430.0780.36340.1150.2618-34.4718-14.3556-141.4724
348-0.0008-0-0.0017-0-0.00040.006-0.01970.0424-0.0029-0.0105-0.0076-0.0001-0.0057-0.005501.4734-0.02080.04161.0746-0.08191.0294-30.2461-37.8165-174.4627
349-0.00020.0031-0.00590.0025-0.00680.0169-0.0710.0484-0.0511-0.0642-0.03980.05290.0196-0.0428-01.3977-0.14920.05380.85640.09990.5094-34.1282-30.0839-165.8449
3500.0021-0.00010.00220.0013-0.00010.0019-0.02340.0082-0.0071-0.0196-0.03570.0542-0.0131-0.0096-01.3065-0.0481-0.16531.2564-0.06771.2205-42.0794-39.4615-165.3284
3510.0183-0.0102-0.00330.00580.00210.00070.04520.01930.0469-0.0127-0.0079-0.0244-0.0094-0.00970.00031.1038-0.08030.15330.5390.22390.4103-27.2132-26.412-160.8054
3520.00110.0028-0.00010.0052-0.00350.00490.00820.0277-0.00610.0423-0.0165-0.0105-0.0283-0.0117-01.5183-0.2137-0.27191.1706-0.17680.8809-38.4306-44.7766-174.0662
353-0.00030.0019-0.00130.0045-0.00350.0024-0.0476-0.0177-0.0073-0.0213-0.037-0.01340.0227-0.0151-01.4359-0.0816-0.13041.05260.16571.0436-38.5167-28.6196-172.5244
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1chain 'W' and (resid 16 through 29 )W16 - 29
2X-RAY DIFFRACTION2chain 'W' and (resid 30 through 90 )W30 - 90
3X-RAY DIFFRACTION3chain 'W' and (resid 91 through 124A)W91 - 124
4X-RAY DIFFRACTION4chain 'W' and (resid 125 through 140 )W125 - 140
5X-RAY DIFFRACTION5chain 'W' and (resid 141 through 155 )W141 - 155
6X-RAY DIFFRACTION6chain 'W' and (resid 156 through 183 )W156 - 183
7X-RAY DIFFRACTION7chain 'W' and (resid 184 through 197 )W184 - 197
8X-RAY DIFFRACTION8chain 'W' and (resid 198 through 225 )W198 - 225
9X-RAY DIFFRACTION9chain 'W' and (resid 226 through 243 )W226 - 243
10X-RAY DIFFRACTION10chain 'L' and (resid 1 through 90 )L1 - 90
11X-RAY DIFFRACTION11chain 'L' and (resid 91 through 113 )L91 - 113
12X-RAY DIFFRACTION12chain 'L' and (resid 114 through 150 )L114 - 150
13X-RAY DIFFRACTION13chain 'L' and (resid 151 through 163 )L151 - 163
14X-RAY DIFFRACTION14chain 'L' and (resid 164 through 187 )L164 - 187
15X-RAY DIFFRACTION15chain 'L' and (resid 188 through 213 )L188 - 213
16X-RAY DIFFRACTION16chain 'M' and (resid 1 through 121 )M1 - 121
17X-RAY DIFFRACTION17chain 'M' and (resid 122 through 156 )M122 - 156
18X-RAY DIFFRACTION18chain 'M' and (resid 157 through 217 )M157 - 217
19X-RAY DIFFRACTION19chain 'C' and (resid 16 through 29 )C16 - 29
20X-RAY DIFFRACTION20chain 'C' and (resid 30 through 48 )C30 - 48
21X-RAY DIFFRACTION21chain 'C' and (resid 49 through 68 )C49 - 68
22X-RAY DIFFRACTION22chain 'C' and (resid 69 through 103 )C69 - 103
23X-RAY DIFFRACTION23chain 'C' and (resid 104 through 124A)C104 - 124
24X-RAY DIFFRACTION24chain 'C' and (resid 125 through 140 )C125 - 140
25X-RAY DIFFRACTION25chain 'C' and (resid 141 through 155 )C141 - 155
26X-RAY DIFFRACTION26chain 'C' and (resid 156 through 183 )C156 - 183
27X-RAY DIFFRACTION27chain 'C' and (resid 184 through 197 )C184 - 197
28X-RAY DIFFRACTION28chain 'C' and (resid 198 through 225 )C198 - 225
29X-RAY DIFFRACTION29chain 'C' and (resid 226 through 243 )C226 - 243
30X-RAY DIFFRACTION30chain 'A' and (resid 1 through 121 )A1 - 121
31X-RAY DIFFRACTION31chain 'A' and (resid 122 through 150 )A122 - 150
32X-RAY DIFFRACTION32chain 'A' and (resid 151 through 174 )A151 - 174
33X-RAY DIFFRACTION33chain 'A' and (resid 175 through 213 )A175 - 213
34X-RAY DIFFRACTION34chain 'B' and (resid 1 through 121 )B1 - 121
35X-RAY DIFFRACTION35chain 'B' and (resid 122 through 145 )B122 - 145
36X-RAY DIFFRACTION36chain 'B' and (resid 146 through 179 )B146 - 179
37X-RAY DIFFRACTION37chain 'B' and (resid 180 through 217 )B180 - 217
38X-RAY DIFFRACTION38chain 'F' and (resid 16 through 29 )F16 - 29
39X-RAY DIFFRACTION39chain 'F' and (resid 30 through 90 )F30 - 90
40X-RAY DIFFRACTION40chain 'F' and (resid 91 through 124A)F91 - 124
41X-RAY DIFFRACTION41chain 'F' and (resid 125 through 140 )F125 - 140
42X-RAY DIFFRACTION42chain 'F' and (resid 141 through 183 )F141 - 183
43X-RAY DIFFRACTION43chain 'F' and (resid 184 through 197 )F184 - 197
44X-RAY DIFFRACTION44chain 'F' and (resid 198 through 225 )F198 - 225
45X-RAY DIFFRACTION45chain 'F' and (resid 226 through 243 )F226 - 243
46X-RAY DIFFRACTION46chain 'D' and (resid 1 through 38 )D1 - 38
47X-RAY DIFFRACTION47chain 'D' and (resid 39 through 61 )D39 - 61
48X-RAY DIFFRACTION48chain 'D' and (resid 62 through 90 )D62 - 90
49X-RAY DIFFRACTION49chain 'D' and (resid 91 through 106 )D91 - 106
50X-RAY DIFFRACTION50chain 'D' and (resid 107 through 136 )D107 - 136
51X-RAY DIFFRACTION51chain 'D' and (resid 137 through 150 )D137 - 150
52X-RAY DIFFRACTION52chain 'D' and (resid 151 through 174 )D151 - 174
53X-RAY DIFFRACTION53chain 'D' and (resid 175 through 197 )D175 - 197
54X-RAY DIFFRACTION54chain 'D' and (resid 198 through 213 )D198 - 213
55X-RAY DIFFRACTION55chain 'E' and (resid 1 through 17 )E1 - 17
56X-RAY DIFFRACTION56chain 'E' and (resid 18 through 51 )E18 - 51
57X-RAY DIFFRACTION57chain 'E' and (resid 52 through 67 )E52 - 67
58X-RAY DIFFRACTION58chain 'E' and (resid 68 through 121 )E68 - 121
59X-RAY DIFFRACTION59chain 'E' and (resid 122 through 159 )E122 - 159
60X-RAY DIFFRACTION60chain 'E' and (resid 160 through 190 )E160 - 190
61X-RAY DIFFRACTION61chain 'E' and (resid 191 through 202 )E191 - 202
62X-RAY DIFFRACTION62chain 'E' and (resid 203 through 217 )E203 - 217
63X-RAY DIFFRACTION63chain 'I' and (resid 16 through 29 )I16 - 29
64X-RAY DIFFRACTION64chain 'I' and (resid 30 through 68 )I30 - 68
65X-RAY DIFFRACTION65chain 'I' and (resid 69 through 124A)I69 - 124
66X-RAY DIFFRACTION66chain 'I' and (resid 125 through 140 )I125 - 140
67X-RAY DIFFRACTION67chain 'I' and (resid 141 through 155 )I141 - 155
68X-RAY DIFFRACTION68chain 'I' and (resid 156 through 183 )I156 - 183
69X-RAY DIFFRACTION69chain 'I' and (resid 184 through 197 )I184 - 197
70X-RAY DIFFRACTION70chain 'I' and (resid 198 through 225 )I198 - 225
71X-RAY DIFFRACTION71chain 'I' and (resid 226 through 243 )I226 - 243
72X-RAY DIFFRACTION72chain 'G' and (resid 1 through 90 )G1 - 90
73X-RAY DIFFRACTION73chain 'G' and (resid 91 through 128 )G91 - 128
74X-RAY DIFFRACTION74chain 'G' and (resid 129 through 150 )G129 - 150
75X-RAY DIFFRACTION75chain 'G' and (resid 151 through 213 )G151 - 213
76X-RAY DIFFRACTION76chain 'H' and (resid 1 through 17 )H1 - 17
77X-RAY DIFFRACTION77chain 'H' and (resid 18 through 61 )H18 - 61
78X-RAY DIFFRACTION78chain 'H' and (resid 62 through 76 )H62 - 76
79X-RAY DIFFRACTION79chain 'H' and (resid 77 through 108 )H77 - 108
80X-RAY DIFFRACTION80chain 'H' and (resid 109 through 145 )H109 - 145
81X-RAY DIFFRACTION81chain 'H' and (resid 146 through 161 )H146 - 161
82X-RAY DIFFRACTION82chain 'H' and (resid 162 through 179 )H162 - 179
83X-RAY DIFFRACTION83chain 'H' and (resid 180 through 202 )H180 - 202
84X-RAY DIFFRACTION84chain 'H' and (resid 203 through 217 )H203 - 217
85X-RAY DIFFRACTION85chain 'N' and (resid 16 through 29 )N16 - 29
86X-RAY DIFFRACTION86chain 'N' and (resid 30 through 90 )N30 - 90
87X-RAY DIFFRACTION87chain 'N' and (resid 91 through 124A)N91 - 124
88X-RAY DIFFRACTION88chain 'N' and (resid 125 through 140 )N125 - 140
89X-RAY DIFFRACTION89chain 'N' and (resid 141 through 155 )N141 - 155
90X-RAY DIFFRACTION90chain 'N' and (resid 156 through 183 )N156 - 183
91X-RAY DIFFRACTION91chain 'N' and (resid 184 through 197 )N184 - 197
92X-RAY DIFFRACTION92chain 'N' and (resid 198 through 225 )N198 - 225
93X-RAY DIFFRACTION93chain 'N' and (resid 226 through 243 )N226 - 243
94X-RAY DIFFRACTION94chain 'J' and (resid 1 through 38 )J1 - 38
95X-RAY DIFFRACTION95chain 'J' and (resid 39 through 75 )J39 - 75
96X-RAY DIFFRACTION96chain 'J' and (resid 76 through 102 )J76 - 102
97X-RAY DIFFRACTION97chain 'J' and (resid 103 through 128 )J103 - 128
98X-RAY DIFFRACTION98chain 'J' and (resid 129 through 150 )J129 - 150
99X-RAY DIFFRACTION99chain 'J' and (resid 151 through 174 )J151 - 174
100X-RAY DIFFRACTION100chain 'J' and (resid 175 through 197 )J175 - 197
101X-RAY DIFFRACTION101chain 'J' and (resid 198 through 213 )J198 - 213
102X-RAY DIFFRACTION102chain 'K' and (resid 1 through 121 )K1 - 121
103X-RAY DIFFRACTION103chain 'K' and (resid 122 through 159 )K122 - 159
104X-RAY DIFFRACTION104chain 'K' and (resid 160 through 190 )K160 - 190
105X-RAY DIFFRACTION105chain 'K' and (resid 191 through 217 )K191 - 217
106X-RAY DIFFRACTION106chain 'Q' and (resid 16 through 29 )Q16 - 29
107X-RAY DIFFRACTION107chain 'Q' and (resid 30 through 80 )Q30 - 80
108X-RAY DIFFRACTION108chain 'Q' and (resid 81 through 124A)Q81 - 124
109X-RAY DIFFRACTION109chain 'Q' and (resid 125 through 140 )Q125 - 140
110X-RAY DIFFRACTION110chain 'Q' and (resid 141 through 155 )Q141 - 155
111X-RAY DIFFRACTION111chain 'Q' and (resid 156 through 183 )Q156 - 183
112X-RAY DIFFRACTION112chain 'Q' and (resid 184 through 197 )Q184 - 197
113X-RAY DIFFRACTION113chain 'Q' and (resid 198 through 225 )Q198 - 225
114X-RAY DIFFRACTION114chain 'Q' and (resid 226 through 243 )Q226 - 243
115X-RAY DIFFRACTION115chain 'O' and (resid 1 through 38 )O1 - 38
116X-RAY DIFFRACTION116chain 'O' and (resid 39 through 75 )O39 - 75
117X-RAY DIFFRACTION117chain 'O' and (resid 76 through 102 )O76 - 102
118X-RAY DIFFRACTION118chain 'O' and (resid 103 through 113 )O103 - 113
119X-RAY DIFFRACTION119chain 'O' and (resid 114 through 128 )O114 - 128
120X-RAY DIFFRACTION120chain 'O' and (resid 129 through 150 )O129 - 150
121X-RAY DIFFRACTION121chain 'O' and (resid 151 through 174 )O151 - 174
122X-RAY DIFFRACTION122chain 'O' and (resid 175 through 197 )O175 - 197
123X-RAY DIFFRACTION123chain 'O' and (resid 198 through 213 )O198 - 213
124X-RAY DIFFRACTION124chain 'P' and (resid 1 through 108 )P1 - 108
125X-RAY DIFFRACTION125chain 'P' and (resid 109 through 136 )P109 - 136
126X-RAY DIFFRACTION126chain 'P' and (resid 137 through 190 )P137 - 190
127X-RAY DIFFRACTION127chain 'P' and (resid 191 through 217 )P191 - 217
128X-RAY DIFFRACTION128chain 'T' and (resid 16 through 29 )T16 - 29
129X-RAY DIFFRACTION129chain 'T' and (resid 30 through 68 )T30 - 68
130X-RAY DIFFRACTION130chain 'T' and (resid 69 through 103 )T69 - 103
131X-RAY DIFFRACTION131chain 'T' and (resid 104 through 124A)T104 - 124
132X-RAY DIFFRACTION132chain 'T' and (resid 125 through 140 )T125 - 140
133X-RAY DIFFRACTION133chain 'T' and (resid 141 through 155 )T141 - 155
134X-RAY DIFFRACTION134chain 'T' and (resid 156 through 183 )T156 - 183
135X-RAY DIFFRACTION135chain 'T' and (resid 184 through 197 )T184 - 197
136X-RAY DIFFRACTION136chain 'T' and (resid 198 through 225 )T198 - 225
137X-RAY DIFFRACTION137chain 'T' and (resid 226 through 243 )T226 - 243
138X-RAY DIFFRACTION138chain 'R' and (resid 1 through 128 )R1 - 128
139X-RAY DIFFRACTION139chain 'R' and (resid 129 through 213 )R129 - 213
140X-RAY DIFFRACTION140chain 'S' and (resid 1 through 17 )S1 - 17
141X-RAY DIFFRACTION141chain 'S' and (resid 18 through 39 )S18 - 39
142X-RAY DIFFRACTION142chain 'S' and (resid 40 through 60 )S40 - 60
143X-RAY DIFFRACTION143chain 'S' and (resid 61 through 76 )S61 - 76
144X-RAY DIFFRACTION144chain 'S' and (resid 77 through 91 )S77 - 91
145X-RAY DIFFRACTION145chain 'S' and (resid 92 through 108 )S92 - 108
146X-RAY DIFFRACTION146chain 'S' and (resid 109 through 136 )S109 - 136
147X-RAY DIFFRACTION147chain 'S' and (resid 137 through 156 )S137 - 156
148X-RAY DIFFRACTION148chain 'S' and (resid 157 through 167 )S157 - 167
149X-RAY DIFFRACTION149chain 'S' and (resid 168 through 179 )S168 - 179
150X-RAY DIFFRACTION150chain 'S' and (resid 180 through 190 )S180 - 190
151X-RAY DIFFRACTION151chain 'S' and (resid 191 through 202 )S191 - 202
152X-RAY DIFFRACTION152chain 'S' and (resid 203 through 217 )S203 - 217
153X-RAY DIFFRACTION153chain 'X' and (resid 16 through 29 )X16 - 29
154X-RAY DIFFRACTION154chain 'X' and (resid 30 through 90 )X30 - 90
155X-RAY DIFFRACTION155chain 'X' and (resid 91 through 124A)X91 - 124
156X-RAY DIFFRACTION156chain 'X' and (resid 125 through 140 )X125 - 140
157X-RAY DIFFRACTION157chain 'X' and (resid 141 through 155 )X141 - 155
158X-RAY DIFFRACTION158chain 'X' and (resid 156 through 183 )X156 - 183
159X-RAY DIFFRACTION159chain 'X' and (resid 184 through 197 )X184 - 197
160X-RAY DIFFRACTION160chain 'X' and (resid 198 through 225 )X198 - 225
161X-RAY DIFFRACTION161chain 'X' and (resid 226 through 243 )X226 - 243
162X-RAY DIFFRACTION162chain 'U' and (resid 1 through 90 )U1 - 90
163X-RAY DIFFRACTION163chain 'U' and (resid 91 through 128 )U91 - 128
164X-RAY DIFFRACTION164chain 'U' and (resid 129 through 150 )U129 - 150
165X-RAY DIFFRACTION165chain 'U' and (resid 151 through 213 )U151 - 213
166X-RAY DIFFRACTION166chain 'V' and (resid 1 through 17 )V1 - 17
167X-RAY DIFFRACTION167chain 'V' and (resid 18 through 51 )V18 - 51
168X-RAY DIFFRACTION168chain 'V' and (resid 52 through 67 )V52 - 67
169X-RAY DIFFRACTION169chain 'V' and (resid 68 through 99 )V68 - 99
170X-RAY DIFFRACTION170chain 'V' and (resid 100 through 121 )V100 - 121
171X-RAY DIFFRACTION171chain 'V' and (resid 122 through 145 )V122 - 145
172X-RAY DIFFRACTION172chain 'V' and (resid 146 through 159 )V146 - 159
173X-RAY DIFFRACTION173chain 'V' and (resid 160 through 190 )V160 - 190
174X-RAY DIFFRACTION174chain 'V' and (resid 191 through 205 )V191 - 205
175X-RAY DIFFRACTION175chain 'V' and (resid 206 through 217 )V206 - 217
176X-RAY DIFFRACTION176chain 'a' and (resid 16 through 29 )a16 - 29
177X-RAY DIFFRACTION177chain 'a' and (resid 30 through 90 )a30 - 90
178X-RAY DIFFRACTION178chain 'a' and (resid 91 through 124A)a91 - 124
179X-RAY DIFFRACTION179chain 'a' and (resid 125 through 140 )a125 - 140
180X-RAY DIFFRACTION180chain 'a' and (resid 141 through 168 )a141 - 168
181X-RAY DIFFRACTION181chain 'a' and (resid 169 through 197 )a169 - 197
182X-RAY DIFFRACTION182chain 'a' and (resid 198 through 225 )a198 - 225
183X-RAY DIFFRACTION183chain 'a' and (resid 226 through 243 )a226 - 243
184X-RAY DIFFRACTION184chain 'Y' and (resid 1 through 128 )Y1 - 128
185X-RAY DIFFRACTION185chain 'Y' and (resid 129 through 213 )Y129 - 213
186X-RAY DIFFRACTION186chain 'Z' and (resid 1 through 121 )Z1 - 121
187X-RAY DIFFRACTION187chain 'Z' and (resid 122 through 190 )Z122 - 190
188X-RAY DIFFRACTION188chain 'Z' and (resid 191 through 217 )Z191 - 217
189X-RAY DIFFRACTION189chain 'd' and (resid 16 through 29 )d16 - 29
190X-RAY DIFFRACTION190chain 'd' and (resid 30 through 68 )d30 - 68
191X-RAY DIFFRACTION191chain 'd' and (resid 69 through 90 )d69 - 90
192X-RAY DIFFRACTION192chain 'd' and (resid 91 through 124A)d91 - 124
193X-RAY DIFFRACTION193chain 'd' and (resid 125 through 140 )d125 - 140
194X-RAY DIFFRACTION194chain 'd' and (resid 141 through 155 )d141 - 155
195X-RAY DIFFRACTION195chain 'd' and (resid 156 through 183 )d156 - 183
196X-RAY DIFFRACTION196chain 'd' and (resid 184 through 197 )d184 - 197
197X-RAY DIFFRACTION197chain 'd' and (resid 198 through 225 )d198 - 225
198X-RAY DIFFRACTION198chain 'd' and (resid 226 through 243 )d226 - 243
199X-RAY DIFFRACTION199chain 'b' and (resid 1 through 18 )b1 - 18
200X-RAY DIFFRACTION200chain 'b' and (resid 19 through 90 )b19 - 90
201X-RAY DIFFRACTION201chain 'b' and (resid 91 through 128 )b91 - 128
202X-RAY DIFFRACTION202chain 'b' and (resid 129 through 150 )b129 - 150
203X-RAY DIFFRACTION203chain 'b' and (resid 151 through 163 )b151 - 163
204X-RAY DIFFRACTION204chain 'b' and (resid 164 through 174 )b164 - 174
205X-RAY DIFFRACTION205chain 'b' and (resid 175 through 198 )b175 - 198
206X-RAY DIFFRACTION206chain 'b' and (resid 199 through 213 )b199 - 213
207X-RAY DIFFRACTION207chain 'c' and (resid 1 through 17 )c1 - 17
208X-RAY DIFFRACTION208chain 'c' and (resid 18 through 61 )c18 - 61
209X-RAY DIFFRACTION209chain 'c' and (resid 62 through 76 )c62 - 76
210X-RAY DIFFRACTION210chain 'c' and (resid 77 through 136 )c77 - 136
211X-RAY DIFFRACTION211chain 'c' and (resid 137 through 156 )c137 - 156
212X-RAY DIFFRACTION212chain 'c' and (resid 157 through 179 )c157 - 179
213X-RAY DIFFRACTION213chain 'c' and (resid 180 through 190 )c180 - 190
214X-RAY DIFFRACTION214chain 'c' and (resid 191 through 202 )c191 - 202
215X-RAY DIFFRACTION215chain 'c' and (resid 203 through 217 )c203 - 217
216X-RAY DIFFRACTION216chain 'g' and (resid 16 through 29 )g16 - 29
217X-RAY DIFFRACTION217chain 'g' and (resid 30 through 68 )g30 - 68
218X-RAY DIFFRACTION218chain 'g' and (resid 69 through 90 )g69 - 90
219X-RAY DIFFRACTION219chain 'g' and (resid 91 through 124A)g91 - 124
220X-RAY DIFFRACTION220chain 'g' and (resid 125 through 140 )g125 - 140
221X-RAY DIFFRACTION221chain 'g' and (resid 141 through 155 )g141 - 155
222X-RAY DIFFRACTION222chain 'g' and (resid 156 through 168 )g156 - 168
223X-RAY DIFFRACTION223chain 'g' and (resid 169 through 197 )g169 - 197
224X-RAY DIFFRACTION224chain 'g' and (resid 198 through 225 )g198 - 225
225X-RAY DIFFRACTION225chain 'g' and (resid 226 through 243 )g226 - 243
226X-RAY DIFFRACTION226chain 'e' and (resid 1 through 38 )e1 - 38
227X-RAY DIFFRACTION227chain 'e' and (resid 39 through 75 )e39 - 75
228X-RAY DIFFRACTION228chain 'e' and (resid 76 through 102 )e76 - 102
229X-RAY DIFFRACTION229chain 'e' and (resid 103 through 129 )e103 - 129
230X-RAY DIFFRACTION230chain 'e' and (resid 130 through 150 )e130 - 150
231X-RAY DIFFRACTION231chain 'e' and (resid 151 through 174 )e151 - 174
232X-RAY DIFFRACTION232chain 'e' and (resid 175 through 213 )e175 - 213
233X-RAY DIFFRACTION233chain 'f' and (resid 1 through 17 )f1 - 17
234X-RAY DIFFRACTION234chain 'f' and (resid 18 through 51 )f18 - 51
235X-RAY DIFFRACTION235chain 'f' and (resid 52 through 67 )f52 - 67
236X-RAY DIFFRACTION236chain 'f' and (resid 68 through 121 )f68 - 121
237X-RAY DIFFRACTION237chain 'f' and (resid 122 through 145 )f122 - 145
238X-RAY DIFFRACTION238chain 'f' and (resid 146 through 159 )f146 - 159
239X-RAY DIFFRACTION239chain 'f' and (resid 160 through 179 )f160 - 179
240X-RAY DIFFRACTION240chain 'f' and (resid 180 through 190 )f180 - 190
241X-RAY DIFFRACTION241chain 'f' and (resid 191 through 202 )f191 - 202
242X-RAY DIFFRACTION242chain 'f' and (resid 203 through 217 )f203 - 217
243X-RAY DIFFRACTION243chain 'j' and (resid 16 through 29 )j16 - 29
244X-RAY DIFFRACTION244chain 'j' and (resid 30 through 90 )j30 - 90
245X-RAY DIFFRACTION245chain 'j' and (resid 91 through 124A)j91 - 124
246X-RAY DIFFRACTION246chain 'j' and (resid 125 through 140 )j125 - 140
247X-RAY DIFFRACTION247chain 'j' and (resid 141 through 155 )j141 - 155
248X-RAY DIFFRACTION248chain 'j' and (resid 156 through 183 )j156 - 183
249X-RAY DIFFRACTION249chain 'j' and (resid 184 through 197 )j184 - 197
250X-RAY DIFFRACTION250chain 'j' and (resid 198 through 225 )j198 - 225
251X-RAY DIFFRACTION251chain 'j' and (resid 226 through 243 )j226 - 243
252X-RAY DIFFRACTION252chain 'h' and (resid 1 through 75 )h1 - 75
253X-RAY DIFFRACTION253chain 'h' and (resid 76 through 115 )h76 - 115
254X-RAY DIFFRACTION254chain 'h' and (resid 116 through 129 )h116 - 129
255X-RAY DIFFRACTION255chain 'h' and (resid 130 through 150 )h130 - 150
256X-RAY DIFFRACTION256chain 'h' and (resid 151 through 174 )h151 - 174
257X-RAY DIFFRACTION257chain 'h' and (resid 175 through 190 )h175 - 190
258X-RAY DIFFRACTION258chain 'h' and (resid 191 through 213 )h191 - 213
259X-RAY DIFFRACTION259chain 'i' and (resid 1 through 17 )i1 - 17
260X-RAY DIFFRACTION260chain 'i' and (resid 18 through 39 )i18 - 39
261X-RAY DIFFRACTION261chain 'i' and (resid 40 through 60 )i40 - 60
262X-RAY DIFFRACTION262chain 'i' and (resid 61 through 76 )i61 - 76
263X-RAY DIFFRACTION263chain 'i' and (resid 77 through 91 )i77 - 91
264X-RAY DIFFRACTION264chain 'i' and (resid 92 through 108 )i92 - 108
265X-RAY DIFFRACTION265chain 'i' and (resid 109 through 121 )i109 - 121
266X-RAY DIFFRACTION266chain 'i' and (resid 122 through 145 )i122 - 145
267X-RAY DIFFRACTION267chain 'i' and (resid 146 through 161 )i146 - 161
268X-RAY DIFFRACTION268chain 'i' and (resid 162 through 179 )i162 - 179
269X-RAY DIFFRACTION269chain 'i' and (resid 180 through 190 )i180 - 190
270X-RAY DIFFRACTION270chain 'i' and (resid 191 through 202 )i191 - 202
271X-RAY DIFFRACTION271chain 'i' and (resid 203 through 217 )i203 - 217
272X-RAY DIFFRACTION272chain 'm' and (resid 16 through 29 )m16 - 29
273X-RAY DIFFRACTION273chain 'm' and (resid 30 through 68 )m30 - 68
274X-RAY DIFFRACTION274chain 'm' and (resid 69 through 124A)m69 - 124
275X-RAY DIFFRACTION275chain 'm' and (resid 125 through 140 )m125 - 140
276X-RAY DIFFRACTION276chain 'm' and (resid 141 through 155 )m141 - 155
277X-RAY DIFFRACTION277chain 'm' and (resid 156 through 183 )m156 - 183
278X-RAY DIFFRACTION278chain 'm' and (resid 184 through 197 )m184 - 197
279X-RAY DIFFRACTION279chain 'm' and (resid 198 through 225 )m198 - 225
280X-RAY DIFFRACTION280chain 'm' and (resid 226 through 243 )m226 - 243
281X-RAY DIFFRACTION281chain 'k' and (resid 1 through 18 )k1 - 18
282X-RAY DIFFRACTION282chain 'k' and (resid 19 through 75 )k19 - 75
283X-RAY DIFFRACTION283chain 'k' and (resid 76 through 102 )k76 - 102
284X-RAY DIFFRACTION284chain 'k' and (resid 103 through 113 )k103 - 113
285X-RAY DIFFRACTION285chain 'k' and (resid 114 through 128 )k114 - 128
286X-RAY DIFFRACTION286chain 'k' and (resid 129 through 150 )k129 - 150
287X-RAY DIFFRACTION287chain 'k' and (resid 151 through 174 )k151 - 174
288X-RAY DIFFRACTION288chain 'k' and (resid 175 through 197 )k175 - 197
289X-RAY DIFFRACTION289chain 'k' and (resid 198 through 213 )k198 - 213
290X-RAY DIFFRACTION290chain 'l' and (resid 1 through 121 )l1 - 121
291X-RAY DIFFRACTION291chain 'l' and (resid 122 through 217 )l122 - 217
292X-RAY DIFFRACTION292chain 'p' and (resid 16 through 29 )p16 - 29
293X-RAY DIFFRACTION293chain 'p' and (resid 30 through 50 )p30 - 50
294X-RAY DIFFRACTION294chain 'p' and (resid 51 through 68 )p51 - 68
295X-RAY DIFFRACTION295chain 'p' and (resid 69 through 103 )p69 - 103
296X-RAY DIFFRACTION296chain 'p' and (resid 104 through 124A)p104 - 124
297X-RAY DIFFRACTION297chain 'p' and (resid 125 through 140 )p125 - 140
298X-RAY DIFFRACTION298chain 'p' and (resid 141 through 155 )p141 - 155
299X-RAY DIFFRACTION299chain 'p' and (resid 156 through 183 )p156 - 183
300X-RAY DIFFRACTION300chain 'p' and (resid 184 through 197 )p184 - 197
301X-RAY DIFFRACTION301chain 'p' and (resid 198 through 225 )p198 - 225
302X-RAY DIFFRACTION302chain 'p' and (resid 226 through 243 )p226 - 243
303X-RAY DIFFRACTION303chain 'n' and (resid 1 through 38 )n1 - 38
304X-RAY DIFFRACTION304chain 'n' and (resid 39 through 90 )n39 - 90
305X-RAY DIFFRACTION305chain 'n' and (resid 91 through 128 )n91 - 128
306X-RAY DIFFRACTION306chain 'n' and (resid 129 through 150 )n129 - 150
307X-RAY DIFFRACTION307chain 'n' and (resid 151 through 163 )n151 - 163
308X-RAY DIFFRACTION308chain 'n' and (resid 164 through 187 )n164 - 187
309X-RAY DIFFRACTION309chain 'n' and (resid 188 through 213 )n188 - 213
310X-RAY DIFFRACTION310chain 'o' and (resid 1 through 40 )o1 - 40
311X-RAY DIFFRACTION311chain 'o' and (resid 41 through 121 )o41 - 121
312X-RAY DIFFRACTION312chain 'o' and (resid 122 through 190 )o122 - 190
313X-RAY DIFFRACTION313chain 'o' and (resid 191 through 217 )o191 - 217
314X-RAY DIFFRACTION314chain 's' and (resid 16 through 29 )s16 - 29
315X-RAY DIFFRACTION315chain 's' and (resid 30 through 90 )s30 - 90
316X-RAY DIFFRACTION316chain 's' and (resid 91 through 140 )s91 - 140
317X-RAY DIFFRACTION317chain 's' and (resid 141 through 168 )s141 - 168
318X-RAY DIFFRACTION318chain 's' and (resid 169 through 197 )s169 - 197
319X-RAY DIFFRACTION319chain 's' and (resid 198 through 225 )s198 - 225
320X-RAY DIFFRACTION320chain 's' and (resid 226 through 243 )s226 - 243
321X-RAY DIFFRACTION321chain 'q' and (resid 1 through 38 )q1 - 38
322X-RAY DIFFRACTION322chain 'q' and (resid 39 through 75 )q39 - 75
323X-RAY DIFFRACTION323chain 'q' and (resid 76 through 102 )q76 - 102
324X-RAY DIFFRACTION324chain 'q' and (resid 103 through 128 )q103 - 128
325X-RAY DIFFRACTION325chain 'q' and (resid 129 through 150 )q129 - 150
326X-RAY DIFFRACTION326chain 'q' and (resid 151 through 174 )q151 - 174
327X-RAY DIFFRACTION327chain 'q' and (resid 175 through 198 )q175 - 198
328X-RAY DIFFRACTION328chain 'q' and (resid 199 through 213 )q199 - 213
329X-RAY DIFFRACTION329chain 'r' and (resid 1 through 40 )r1 - 40
330X-RAY DIFFRACTION330chain 'r' and (resid 41 through 60 )r41 - 60
331X-RAY DIFFRACTION331chain 'r' and (resid 61 through 121 )r61 - 121
332X-RAY DIFFRACTION332chain 'r' and (resid 122 through 159 )r122 - 159
333X-RAY DIFFRACTION333chain 'r' and (resid 160 through 196 )r160 - 196
334X-RAY DIFFRACTION334chain 'r' and (resid 197 through 217 )r197 - 217
335X-RAY DIFFRACTION335chain 'v' and (resid 16 through 29 )v16 - 29
336X-RAY DIFFRACTION336chain 'v' and (resid 30 through 90 )v30 - 90
337X-RAY DIFFRACTION337chain 'v' and (resid 91 through 169 )v91 - 169
338X-RAY DIFFRACTION338chain 'v' and (resid 170 through 197 )v170 - 197
339X-RAY DIFFRACTION339chain 'v' and (resid 198 through 225 )v198 - 225
340X-RAY DIFFRACTION340chain 'v' and (resid 226 through 243 )v226 - 243
341X-RAY DIFFRACTION341chain 't' and (resid 1 through 115 )t1 - 115
342X-RAY DIFFRACTION342chain 't' and (resid 116 through 150 )t116 - 150
343X-RAY DIFFRACTION343chain 't' and (resid 151 through 172 )t151 - 172
344X-RAY DIFFRACTION344chain 't' and (resid 173 through 213 )t173 - 213
345X-RAY DIFFRACTION345chain 'u' and (resid 1 through 17 )u1 - 17
346X-RAY DIFFRACTION346chain 'u' and (resid 18 through 60 )u18 - 60
347X-RAY DIFFRACTION347chain 'u' and (resid 61 through 121 )u61 - 121
348X-RAY DIFFRACTION348chain 'u' and (resid 122 through 136 )u122 - 136
349X-RAY DIFFRACTION349chain 'u' and (resid 137 through 156 )u137 - 156
350X-RAY DIFFRACTION350chain 'u' and (resid 157 through 167 )u157 - 167
351X-RAY DIFFRACTION351chain 'u' and (resid 168 through 181 )u168 - 181
352X-RAY DIFFRACTION352chain 'u' and (resid 182 through 196 )u182 - 196
353X-RAY DIFFRACTION353chain 'u' and (resid 197 through 217 )u197 - 217

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