Entry Database : PDB / ID : 4cni Structure visualization Downloads & linksTitle Crystal structure of the Fab portion of Olokizumab in complex with IL- 6 ComponentsINTERLEUKIN-6 OLOKIZUMAB HEAVY CHAIN, FAB PORTION OLOKIZUMAB LIGHT CHAIN, FAB PORTION DetailsKeywords IMMUNE SYSTEM / CDP6038 / INTERLEUKIN 6Function / homology Function and homology informationFunction Domain/homology Component
positive regulation of interleukin-21 production / regulation of astrocyte activation / glucagon secretion / regulation of glucagon secretion / negative regulation of interleukin-1-mediated signaling pathway / hepatic immune response / regulation of vascular endothelial growth factor production / negative regulation of primary miRNA processing / T follicular helper cell differentiation / germinal center B cell differentiation ... positive regulation of interleukin-21 production / regulation of astrocyte activation / glucagon secretion / regulation of glucagon secretion / negative regulation of interleukin-1-mediated signaling pathway / hepatic immune response / regulation of vascular endothelial growth factor production / negative regulation of primary miRNA processing / T follicular helper cell differentiation / germinal center B cell differentiation / regulation of microglial cell activation / interleukin-6 receptor complex / positive regulation of extracellular matrix disassembly / positive regulation of receptor signaling pathway via STAT / positive regulation of type B pancreatic cell apoptotic process / positive regulation of apoptotic DNA fragmentation / response to peptidoglycan / hepatocyte proliferation / neutrophil apoptotic process / interleukin-6 receptor binding / negative regulation of collagen biosynthetic process / inflammatory response to wounding / T-helper 17 cell lineage commitment / positive regulation of T-helper 2 cell cytokine production / positive regulation of B cell activation / endocrine pancreas development / positive regulation of acute inflammatory response / regulation of neuroinflammatory response / vascular endothelial growth factor production / negative regulation of chemokine production / positive regulation of neuroinflammatory response / positive regulation of platelet aggregation / neutrophil mediated immunity / positive regulation of cytokine production involved in inflammatory response / negative regulation of bone resorption / positive regulation of leukocyte chemotaxis / positive regulation of leukocyte adhesion to vascular endothelial cell / CD163 mediating an anti-inflammatory response / positive regulation of immunoglobulin production / maintenance of blood-brain barrier / interleukin-6-mediated signaling pathway / Interleukin-6 signaling / negative regulation of fat cell differentiation / MAPK3 (ERK1) activation / positive regulation of interleukin-17 production / Interleukin-10 signaling / MAPK1 (ERK2) activation / monocyte chemotaxis / regulation of insulin secretion / positive regulation of interleukin-10 production / humoral immune response / negative regulation of lipid storage / Transcriptional Regulation by VENTX / positive regulation of vascular endothelial growth factor production / regulation of angiogenesis / positive regulation of osteoblast differentiation / positive regulation of epithelial to mesenchymal transition / positive regulation of chemokine production / positive regulation of T cell proliferation / response to glucocorticoid / positive regulation of tyrosine phosphorylation of STAT protein / positive regulation of glial cell proliferation / positive regulation of interleukin-1 beta production / response to activity / cytokine activity / acute-phase response / positive regulation of interleukin-8 production / positive regulation of translation / liver regeneration / Post-translational protein phosphorylation / positive regulation of smooth muscle cell proliferation / positive regulation of receptor signaling pathway via JAK-STAT / growth factor activity / platelet activation / cellular response to virus / cytokine-mediated signaling pathway / positive regulation of DNA-binding transcription factor activity / negative regulation of neurogenesis / cellular response to hydrogen peroxide / neuron cellular homeostasis / ADORA2B mediated anti-inflammatory cytokines production / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / positive regulation of interleukin-6 production / neuron projection development / positive regulation of tumor necrosis factor production / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of peptidyl-serine phosphorylation / glucose homeostasis / Senescence-Associated Secretory Phenotype (SASP) / cellular response to lipopolysaccharide / Interleukin-4 and Interleukin-13 signaling / defense response to Gram-negative bacterium / defense response to virus / positive regulation of MAPK cascade / defense response to Gram-positive bacterium / inflammatory response / positive regulation of apoptotic process / negative regulation of cell population proliferation / endoplasmic reticulum lumen / positive regulation of cell population proliferation Similarity search - Function Interleukin-6 / Interleukin-6/G-CSF/MGF family / Interleukin-6/GCSF/MGF, conserved site / Interleukin-6 / G-CSF / MGF signature. / Interleukin-6/GCSF/MGF / Interleukin-6 homologues / Growth Hormone; Chain: A; - #10 / Four-helical cytokine-like, core / Growth Hormone; Chain: A; / Immunoglobulins ... Interleukin-6 / Interleukin-6/G-CSF/MGF family / Interleukin-6/GCSF/MGF, conserved site / Interleukin-6 / G-CSF / MGF signature. / Interleukin-6/GCSF/MGF / Interleukin-6 homologues / Growth Hormone; Chain: A; - #10 / Four-helical cytokine-like, core / Growth Hormone; Chain: A; / Immunoglobulins / Up-down Bundle / Immunoglobulin-like / Sandwich / Mainly Beta / Mainly Alpha Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.2 Å DetailsAuthors Shaw, S. / Bourne, T. / Meier, C. / Carrington, B. / Gelinas, R. / Henry, A. / Popplewell, A. / Adams, R. / Baker, T. / Rapecki, S. ...Shaw, S. / Bourne, T. / Meier, C. / Carrington, B. / Gelinas, R. / Henry, A. / Popplewell, A. / Adams, R. / Baker, T. / Rapecki, S. / Marshall, D. / Neale, H. / Lawson, A. CitationJournal : Mabs / Year : 2014Title : Discovery and Characterization of Olokizumab: A Humanized Antibody Targeting Interleukin-6 and Neutralizing Gp130-Signaling.Authors : Shaw, S. / Bourne, T. / Meier, C. / Carrington, B. / Gelinas, R. / Henry, A. / Popplewell, A. / Adams, R. / Baker, T. / Rapecki, S. / Marshall, D. / Moore, A. / Neale, H. / Lawson, A. History Deposition Jan 22, 2014 Deposition site : PDBE / Processing site : PDBERevision 1.0 Apr 30, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Apr 3, 2019 Group : Data collection / Other / Source and taxonomyCategory : entity_src_gen / pdbx_database_proc / pdbx_database_statusItem : _entity_src_gen.pdbx_host_org_cell_line / _pdbx_database_status.recvd_author_approval
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