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TitleDiscovery and Characterization of Olokizumab: A Humanized Antibody Targeting Interleukin-6 and Neutralizing Gp130-Signaling.
Journal, issue, pagesMabs, Vol. 6, Page 773-, Year 2014
Publish dateJan 22, 2014 (structure data deposition date)
AuthorsShaw, S. / Bourne, T. / Meier, C. / Carrington, B. / Gelinas, R. / Henry, A. / Popplewell, A. / Adams, R. / Baker, T. / Rapecki, S. ...Shaw, S. / Bourne, T. / Meier, C. / Carrington, B. / Gelinas, R. / Henry, A. / Popplewell, A. / Adams, R. / Baker, T. / Rapecki, S. / Marshall, D. / Moore, A. / Neale, H. / Lawson, A.
External linksMabs / PubMed:24670876
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-4cni:
Crystal structure of the Fab portion of Olokizumab in complex with IL- 6
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-TAM:
TRIS(HYDROXYETHYL)AMINOMETHANE / pH buffer*YM

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / CDP6038 / INTERLEUKIN 6

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