登録情報 データベース : PDB / ID : 6vg8 構造の表示 ダウンロードとリンクタイトル Crystal structure of the DNA binding domains of human FLI1 and Runx2 in complex with 16-mer DNA CAGAGGATGTGGCTTC 要素DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3')DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3')Friend leukemia integration 1 transcription factor Runt-related transcription factor 2 詳細キーワード TRANSCRIPTION / Oncogenesis / Ewing sarcoma / Enhancer / Bone cancer / Leukemia / ETS-family / Runt-family機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
ligamentous ossification / regulation of fibroblast growth factor receptor signaling pathway / osteoblast fate commitment / regulation of odontogenesis of dentin-containing tooth / chondrocyte development / RUNX2 regulates bone development / RUNX2 regulates chondrocyte maturation / bHLH transcription factor binding / positive regulation of chondrocyte differentiation / response to sodium phosphate ... ligamentous ossification / regulation of fibroblast growth factor receptor signaling pathway / osteoblast fate commitment / regulation of odontogenesis of dentin-containing tooth / chondrocyte development / RUNX2 regulates bone development / RUNX2 regulates chondrocyte maturation / bHLH transcription factor binding / positive regulation of chondrocyte differentiation / response to sodium phosphate / hemostasis / YAP1- and WWTR1 (TAZ)-stimulated gene expression / RUNX2 regulates genes involved in cell migration / RUNX2 regulates genes involved in differentiation of myeloid cells / Transcriptional regulation by RUNX2 / endochondral ossification / SMAD protein signal transduction / embryonic cranial skeleton morphogenesis / embryonic forelimb morphogenesis / RUNX1 regulates transcription of genes involved in differentiation of myeloid cells / blood circulation / osteoblast development / megakaryocyte development / smoothened signaling pathway / bone mineralization / positive regulation of stem cell proliferation / regulation of cell differentiation / RUNX2 regulates osteoblast differentiation / odontogenesis of dentin-containing tooth / hemopoiesis / T cell differentiation / regulation of ossification / chondrocyte differentiation / BMP signaling pathway / positive regulation of osteoblast differentiation / negative regulation of smoothened signaling pathway / cell maturation / ossification / epithelial cell proliferation / stem cell proliferation / positive regulation of epithelial cell proliferation / stem cell differentiation / animal organ morphogenesis / neuron differentiation / chromatin DNA binding / osteoblast differentiation / Transcriptional regulation of granulopoiesis / Regulation of RUNX2 expression and activity / sequence-specific double-stranded DNA binding / gene expression / DNA-binding transcription activator activity, RNA polymerase II-specific / transcription regulator complex / nuclear body / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / protein domain specific binding / negative regulation of DNA-templated transcription / chromatin binding / positive regulation of gene expression / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / ATP binding / nucleus / cytoplasm / cytosol 類似検索 - 分子機能 Friend leukemia integration 1 transcription factor, pointed domain / Runx, central domain superfamily / Acute myeloid leukemia 1 protein (AML1)/Runt / Runt domain / Runx, C-terminal domain / Runt-related transcription factor RUNX / Runt domain / Runx inhibition domain / Runt domain profile. / SAM / Pointed domain ... Friend leukemia integration 1 transcription factor, pointed domain / Runx, central domain superfamily / Acute myeloid leukemia 1 protein (AML1)/Runt / Runt domain / Runx, C-terminal domain / Runt-related transcription factor RUNX / Runt domain / Runx inhibition domain / Runt domain profile. / SAM / Pointed domain / Pointed domain / Sterile alpha motif (SAM)/Pointed domain / Pointed (PNT) domain profile. / Ets-domain signature 1. / ETS family / Ets-domain signature 2. / Ets domain / Ets-domain / Ets-domain profile. / erythroblast transformation specific domain / p53/RUNT-type transcription factor, DNA-binding domain superfamily / p53-like transcription factor, DNA-binding / Sterile alpha motif/pointed domain superfamily / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily 類似検索 - ドメイン・相同性 DNA / DNA (> 10) / Friend leukemia integration 1 transcription factor / Runt-related transcription factor 2 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 4.31 Å 詳細データ登録者 Hou, C. / Tsodikov, O.V. 資金援助 米国, 2件 詳細 詳細を隠す組織 認可番号 国 Department of Defense (DOD, United States) PC150300P1 米国 Department of Defense (DOD, United States) PC150300P2 米国
引用ジャーナル : Structure / 年 : 2021タイトル : Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.著者 : Hou, C. / Mandal, A. / Rohr, J. / Tsodikov, O.V. 履歴 登録 2020年1月7日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2020年11月25日 Provider : repository / タイプ : Initial release改定 1.1 2020年12月16日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed ... _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name 改定 1.2 2021年5月19日 Group : Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation.year 改定 1.3 2023年10月11日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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