登録情報 データベース : PDB / ID : 6vgg 構造の表示 ダウンロードとリンクタイトル Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), and mithramycin, in complex with 16mer DNA CAGAGGATGTGGCTTC 要素Core-binding factor subunit beta DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3')DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3')Runt-related transcription factor 2 Transcriptional regulator ERG 詳細キーワード TRANSCRIPTION / Ewing sarcoma / enhancer / transcription factor / oncogenesis / prostate cancer / ETS-family / Runt-family機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
ligamentous ossification / regulation of fibroblast growth factor receptor signaling pathway / RUNX3 regulates RUNX1-mediated transcription / osteoblast fate commitment / RUNX1 regulates transcription of genes involved in BCR signaling / regulation of odontogenesis of dentin-containing tooth / chondrocyte development / RUNX1 regulates transcription of genes involved in interleukin signaling / RUNX2 regulates bone development / core-binding factor complex ... ligamentous ossification / regulation of fibroblast growth factor receptor signaling pathway / RUNX3 regulates RUNX1-mediated transcription / osteoblast fate commitment / RUNX1 regulates transcription of genes involved in BCR signaling / regulation of odontogenesis of dentin-containing tooth / chondrocyte development / RUNX1 regulates transcription of genes involved in interleukin signaling / RUNX2 regulates bone development / core-binding factor complex / RUNX1 regulates expression of components of tight junctions / positive regulation of CD8-positive, alpha-beta T cell differentiation / RUNX2 regulates chondrocyte maturation / negative regulation of CD4-positive, alpha-beta T cell differentiation / bHLH transcription factor binding / positive regulation of chondrocyte differentiation / lymphocyte differentiation / RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) / response to sodium phosphate / RUNX2 regulates genes involved in cell migration / YAP1- and WWTR1 (TAZ)-stimulated gene expression / RUNX2 regulates genes involved in differentiation of myeloid cells / Transcriptional regulation by RUNX2 / endochondral ossification / RUNX1 regulates transcription of genes involved in differentiation of keratinocytes / SMAD protein signal transduction / embryonic cranial skeleton morphogenesis / RUNX3 Regulates Immune Response and Cell Migration / myeloid cell differentiation / definitive hemopoiesis / embryonic forelimb morphogenesis / RUNX1 regulates transcription of genes involved in differentiation of myeloid cells / Regulation of RUNX1 Expression and Activity / osteoblast development / smoothened signaling pathway / RUNX1 regulates transcription of genes involved in WNT signaling / RUNX1 regulates estrogen receptor mediated transcription / positive regulation of stem cell proliferation / bone mineralization / RUNX2 regulates osteoblast differentiation / RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known / odontogenesis of dentin-containing tooth / regulation of cell differentiation / hemopoiesis / RUNX3 regulates p14-ARF / T cell differentiation / regulation of ossification / chondrocyte differentiation / BMP signaling pathway / positive regulation of osteoblast differentiation / cell maturation / ossification / epithelial cell proliferation / positive regulation of epithelial cell proliferation / stem cell proliferation / Regulation of RUNX3 expression and activity / negative regulation of smoothened signaling pathway / stem cell differentiation / chromatin DNA binding / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / Regulation of RUNX2 expression and activity / Transcriptional regulation of granulopoiesis / neuron differentiation / protein polyubiquitination / sequence-specific double-stranded DNA binding / osteoblast differentiation / RUNX1 regulates transcription of genes involved in differentiation of HSCs / DNA-binding transcription activator activity, RNA polymerase II-specific / gene expression / transcription regulator complex / Estrogen-dependent gene expression / sequence-specific DNA binding / transcription by RNA polymerase II / cell differentiation / DNA-binding transcription factor activity, RNA polymerase II-specific / transcription coactivator activity / protein phosphorylation / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / ribonucleoprotein complex / protein domain specific binding / negative regulation of DNA-templated transcription / chromatin binding / positive regulation of gene expression / regulation of transcription by RNA polymerase II / chromatin / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / ATP binding / nucleus / membrane / cytosol / cytoplasm 類似検索 - 分子機能 Runx, central domain superfamily / Acute myeloid leukemia 1 protein (AML1)/Runt / Runt domain / Runx, C-terminal domain / Runt-related transcription factor RUNX / Runt domain / Runx inhibition domain / Runt domain profile. / Core-binding factor, beta subunit / Core-binding factor, beta subunit superfamily ... Runx, central domain superfamily / Acute myeloid leukemia 1 protein (AML1)/Runt / Runt domain / Runx, C-terminal domain / Runt-related transcription factor RUNX / Runt domain / Runx inhibition domain / Runt domain profile. / Core-binding factor, beta subunit / Core-binding factor, beta subunit superfamily / Core binding factor beta subunit / SAM / Pointed domain / Pointed domain / Sterile alpha motif (SAM)/Pointed domain / Pointed (PNT) domain profile. / Ets-domain signature 1. / Ets-domain signature 2. / Ets domain / ETS family / Ets-domain / Ets-domain profile. / erythroblast transformation specific domain / p53/RUNT-type transcription factor, DNA-binding domain superfamily / p53-like transcription factor, DNA-binding / Sterile alpha motif/pointed domain superfamily / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily 類似検索 - ドメイン・相同性 mithramycin / DNA / DNA (> 10) / Transcriptional regulator ERG / Runt-related transcription factor 2 / Core-binding factor subunit beta 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 4.31 Å 詳細データ登録者 Hou, C. / Rohr, J. / Tsodikov, O.V. 資金援助 米国, 2件 詳細 詳細を隠す組織 認可番号 国 Department of Defense (DOD, United States) PC150300P1 米国 Department of Defense (DOD, United States) PC150300P2 米国
引用ジャーナル : Structure / 年 : 2021タイトル : Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.著者 : Hou, C. / Mandal, A. / Rohr, J. / Tsodikov, O.V. 履歴 登録 2020年1月8日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2020年11月25日 Provider : repository / タイプ : Initial release改定 1.1 2020年12月16日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed ... _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name 改定 1.2 2021年5月19日 Group : Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation.year 改定 1.3 2023年10月11日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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