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- PDB-6v19: immune receptor complex -

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ID or keywords:

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Basic information

Entry
Database: PDB / ID: 6v19
Titleimmune receptor complex
Components
  • (HLA class II histocompatibility antigen, ...) x 2
  • Fibrinogen beta 72,74cit69-81
  • M134 TCR alpha chain
  • M134 TCR beta chain
KeywordsIMMUNE SYSTEM / Immune receptor
Function / homology
Function and homology information


induction of bacterial agglutination / regulation of interleukin-4 production / regulation of interleukin-10 production / positive regulation of T cell mediated immune response to tumor cell / myeloid dendritic cell antigen processing and presentation / antigen processing and presentation of endogenous peptide antigen via MHC class II / autolysosome membrane / regulation of T-helper cell differentiation / fibrinogen complex / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ...induction of bacterial agglutination / regulation of interleukin-4 production / regulation of interleukin-10 production / positive regulation of T cell mediated immune response to tumor cell / myeloid dendritic cell antigen processing and presentation / antigen processing and presentation of endogenous peptide antigen via MHC class II / autolysosome membrane / regulation of T-helper cell differentiation / fibrinogen complex / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / MHC class II receptor activity / Regulation of TLR by endogenous ligand / positive regulation of CD4-positive, alpha-beta T cell activation / antigen processing and presentation of peptide or polysaccharide antigen via MHC class II / blood coagulation, fibrin clot formation / platelet alpha granule / positive regulation of memory T cell differentiation / cellular response to leptin stimulus / positive regulation of monocyte differentiation / CD4 receptor binding / positive regulation of kinase activity / inflammatory response to antigenic stimulus / MyD88 deficiency (TLR2/4) / intermediate filament / positive regulation of heterotypic cell-cell adhesion / IRAK4 deficiency (TLR2/4) / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / transport vesicle membrane / extracellular matrix structural constituent / T-helper 1 type immune response / polysaccharide binding / plasminogen activation / p130Cas linkage to MAPK signaling for integrins / Translocation of ZAP-70 to Immunological synapse / Phosphorylation of CD3 and TCR zeta chains / positive regulation of peptide hormone secretion / positive regulation of exocytosis / positive regulation of insulin secretion involved in cellular response to glucose stimulus / GRB2:SOS provides linkage to MAPK signaling for Integrins / humoral immune response / macrophage differentiation / negative regulation of type II interferon production / Generation of second messenger molecules / immunological synapse / protein polymerization / PD-1 signaling / epidermis development / cellular response to interleukin-1 / Integrin cell surface interactions / negative regulation of endothelial cell apoptotic process / Common Pathway of Fibrin Clot Formation / positive regulation of substrate adhesion-dependent cell spreading / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / positive regulation of vasoconstriction / negative regulation of T cell proliferation / negative regulation of inflammatory response to antigenic stimulus / fibrinolysis / MHC class II antigen presentation / detection of bacterium / T cell receptor binding / cell-matrix adhesion / Integrin signaling / trans-Golgi network membrane / platelet alpha granule lumen / lumenal side of endoplasmic reticulum membrane / positive regulation of protein secretion / protein tetramerization / clathrin-coated endocytic vesicle membrane / Signaling by high-kinase activity BRAF mutants / MAP2K and MAPK activation / ER to Golgi transport vesicle membrane / structural constituent of cytoskeleton / platelet aggregation / cognition / positive regulation of T cell mediated cytotoxicity / peptide antigen assembly with MHC class II protein complex / response to calcium ion / MHC class II protein complex / peptide antigen binding / endocytic vesicle membrane / extracellular vesicle / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / antigen processing and presentation of exogenous peptide antigen via MHC class II / Interferon gamma signaling / positive regulation of immune response / positive regulation of T cell activation / Signaling by BRAF and RAF1 fusions / Downstream TCR signaling / Platelet degranulation / MHC class II protein complex binding / late endosome membrane / cell cortex / ER-Phagosome pathway / T cell receptor signaling pathway / protein-folding chaperone binding / early endosome membrane / collagen-containing extracellular matrix
Similarity search - Function
Fibrinogen, alpha/beta/gamma chain, coiled coil domain / Fibrinogen alpha chain / Fibrinogen alpha/beta chain family / Fibrinogen alpha/beta chain family / Fibrinogen, conserved site / Fibrinogen C-terminal domain signature. / Fibrinogen-related domains (FReDs) / Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 / Fibrinogen beta and gamma chains, C-terminal globular domain / Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain ...Fibrinogen, alpha/beta/gamma chain, coiled coil domain / Fibrinogen alpha chain / Fibrinogen alpha/beta chain family / Fibrinogen alpha/beta chain family / Fibrinogen, conserved site / Fibrinogen C-terminal domain signature. / Fibrinogen-related domains (FReDs) / Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 / Fibrinogen beta and gamma chains, C-terminal globular domain / Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain / Fibrinogen-like, C-terminal / Fibrinogen C-terminal domain profile. / MHC class II, beta chain, N-terminal / Class II histocompatibility antigen, beta domain / Class II histocompatibility antigen, beta domain / MHC class II, alpha chain, N-terminal / Class II histocompatibility antigen, alpha domain / Class II histocompatibility antigen, alpha domain / MHC class II, alpha/beta chain, N-terminal / MHC classes I/II-like antigen recognition protein / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold
Similarity search - Domain/homology
HLA class II histocompatibility antigen, DR alpha chain / HLA class II histocompatibility antigen, DRB1 beta chain / Fibrinogen beta chain / HLA class II histocompatibility antigen, DRB1 beta chain
Similarity search - Component
Biological speciesHomo sapiens (human)
Mus musculus (house mouse)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.6 Å
AuthorsLim, J.J. / Rossjohn, J.
Funding support Australia, 1items
OrganizationGrant numberCountry
Australian Research Council (ARC)CE140100011 Australia
CitationJournal: Sci Immunol / Year: 2021
Title: The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.
Authors: Lim, J.J. / Jones, C.M. / Loh, T.J. / Ting, Y.T. / Zareie, P. / Loh, K.L. / Felix, N.J. / Suri, A. / McKinnon, M. / Stevenaert, F. / Sharma, R.K. / Klareskog, L. / Malmstrom, V. / Baker, D.G. ...Authors: Lim, J.J. / Jones, C.M. / Loh, T.J. / Ting, Y.T. / Zareie, P. / Loh, K.L. / Felix, N.J. / Suri, A. / McKinnon, M. / Stevenaert, F. / Sharma, R.K. / Klareskog, L. / Malmstrom, V. / Baker, D.G. / Purcell, A.W. / Reid, H.H. / La Gruta, N.L. / Rossjohn, J.
History
DepositionNov 20, 2019Deposition site: RCSB / Processing site: RCSB
Revision 1.0Nov 25, 2020Provider: repository / Type: Initial release
Revision 1.1Jun 9, 2021Group: Database references / Category: citation / citation_author
Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year
Revision 1.2Oct 11, 2023Group: Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Revision 2.0Nov 15, 2023Group: Atomic model / Data collection / Derived calculations
Category: atom_site / atom_site_anisotrop ...atom_site / atom_site_anisotrop / chem_comp_atom / chem_comp_bond / pdbx_validate_peptide_omega / pdbx_validate_rmsd_angle / pdbx_validate_torsion / struct_conn
Item: _atom_site.auth_atom_id / _atom_site.label_atom_id ..._atom_site.auth_atom_id / _atom_site.label_atom_id / _atom_site_anisotrop.pdbx_auth_atom_id / _atom_site_anisotrop.pdbx_label_atom_id / _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_1 / _chem_comp_bond.atom_id_2 / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr2_label_atom_id

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: HLA class II histocompatibility antigen, DR alpha chain
B: HLA class II histocompatibility antigen, DRB1-4 beta chain
C: Fibrinogen beta 72,74cit69-81
D: M134 TCR alpha chain
E: M134 TCR beta chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)97,82415
Polymers96,7745
Non-polymers1,05010
Water1,18966
1


  • Idetical with deposited unit
  • defined by author
  • Evidence: surface plasmon resonance
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)149.462, 56.848, 129.762
Angle α, β, γ (deg.)90.000, 91.523, 90.000
Int Tables number5
Space group name H-MC121
Space group name HallC2y
Symmetry operation#1: x,y,z
#2: -x,y,-z
#3: x+1/2,y+1/2,z
#4: -x+1/2,y+1/2,-z

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Components

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HLA class II histocompatibility antigen, ... , 2 types, 2 molecules AB

#1: Protein HLA class II histocompatibility antigen, DR alpha chain / MHC class II antigen DRA


Mass: 21919.594 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: HLA-DRA, HLA-DRA1 / Production host: Homo sapiens (human) / References: UniProt: P01903
#2: Protein HLA class II histocompatibility antigen, DRB1-4 beta chain / MHC class II antigen DRB1*4 / DR4


Mass: 23080.488 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: HLA-DRB1 / Production host: Homo sapiens (human) / References: UniProt: P13760, UniProt: P01911*PLUS

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Protein , 2 types, 2 molecules DE

#4: Protein M134 TCR alpha chain


Mass: 22871.131 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Mus musculus (house mouse) / Production host: Escherichia coli BL21(DE3) (bacteria)
#5: Protein M134 TCR beta chain


Mass: 27609.865 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Mus musculus (house mouse) / Production host: Escherichia coli BL21(DE3) (bacteria)

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Protein/peptide / Sugars , 2 types, 2 molecules C

#3: Protein/peptide Fibrinogen beta 72,74cit69-81


Mass: 1292.422 Da / Num. of mol.: 1 / Source method: obtained synthetically / Source: (synth.) Homo sapiens (human) / References: UniProt: P02675*PLUS
#6: Sugar ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE / N-Acetylglucosamine


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0

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Non-polymers , 2 types, 75 molecules

#7: Chemical
ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL / Glycerol


Mass: 92.094 Da / Num. of mol.: 9 / Source method: obtained synthetically / Formula: C3H8O3
#8: Water ChemComp-HOH / water / Water


Mass: 18.015 Da / Num. of mol.: 66 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.86 Å3/Da / Density % sol: 56.96 %
Crystal growTemperature: 293 K / Method: vapor diffusion, hanging drop / Details: 0.2 M trisodium citrate, 20% PEG 3350

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: Australian Synchrotron / Beamline: MX2 / Wavelength: 0.9537 Å
DetectorType: DECTRIS EIGER X 16M / Detector: PIXEL / Date: Aug 22, 2018
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.9537 Å / Relative weight: 1
ReflectionResolution: 2.6→49.01 Å / Num. obs: 33948 / % possible obs: 100 % / Redundancy: 7 % / Biso Wilson estimate: 47.8778945224 Å2 / CC1/2: 0.995 / Net I/σ(I): 9.1
Reflection shellResolution: 2.6→2.72 Å / Rmerge(I) obs: 1.095 / Mean I/σ(I) obs: 2.2 / Num. unique obs: 4128 / CC1/2: 0.798 / Rrim(I) all: 1.186

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Processing

Software
NameVersionClassification
PHENIX1.10.1_2155refinement
XDSdata reduction
Aimlessdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 6BIL

6bil


Resolution: 2.6→49 Å / SU ML: 0.293028033145 / Cross valid method: FREE R-VALUE / σ(F): 1.35 / Phase error: 24.6364798927
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflection
Rfree0.2237 1652 4.86841717502 %
Rwork0.2022 32281 -
obs0.2032 33933 99.9116685805 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 60.133375762 Å2
Refinement stepCycle: LAST / Resolution: 2.6→49 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms6387 0 68 66 6521
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.005499616285626621
X-RAY DIFFRACTIONf_angle_d0.7209644789169005
X-RAY DIFFRACTIONf_chiral_restr0.047261891227986
X-RAY DIFFRACTIONf_plane_restr0.008592274185861161
X-RAY DIFFRACTIONf_dihedral_angle_d21.71767862992345
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
2.61-2.67650.31021420.30132668X-RAY DIFFRACTION99.8933522929
2.6765-2.76290.2914643627361330.2760390662332680X-RAY DIFFRACTION99.822569198
2.7629-2.86170.2955132272971400.2585333152792647X-RAY DIFFRACTION99.9282897096
2.8617-2.97620.2649278636951340.2392061062552676X-RAY DIFFRACTION99.8933522929
2.9762-3.11170.2470652724881450.2230741394352632X-RAY DIFFRACTION99.9640028798
3.1117-3.27570.2374734711461430.2117035565932679X-RAY DIFFRACTION99.9645766915
3.2757-3.48090.2822827469021300.2016168399292711X-RAY DIFFRACTION99.9296517763
3.4809-3.74950.2358147171631380.1935858952162672X-RAY DIFFRACTION99.9644254714
3.7495-4.12670.2044882931171140.1848458638962686X-RAY DIFFRACTION99.9286224126
4.1267-4.72340.1763564351941320.1577231122112745X-RAY DIFFRACTION99.9652536484
4.7234-5.94940.1741215070241270.1819194178642719X-RAY DIFFRACTION99.9297752809
5.9494-490.2131252614191740.2126617559842766X-RAY DIFFRACTION99.8302207131
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
12.15297370766-0.2545747063920.5161015798690.9331120688020.7743562138530.953784565302-0.1867340074940.369693545329-0.624204373983-0.07351585061080.136522684346-0.1353276910920.36363809728-0.1531318048650.006086464110090.504510548998-0.06459073016830.03339736578980.528943023559-0.1382698580390.46366757375-24.117732678811.877917025620.7298418016
21.77673506428-0.364912749154-0.588394675991.785125833040.2932841406221.81603390466-0.003878703792460.28055024934-0.270716822668-0.0888161599107-0.007991574292540.1878866204740.220838525415-0.1938372350940.03439372596870.471871181459-0.0742626241799-0.02594924152350.482058445574-0.1049002920120.389427302712-31.073790058313.052321405523.688512943
30.225438303951-0.0190893344505-0.08327116432821.097196052680.7088180206651.35746494786-0.1409684490020.341154950367-0.272603856087-0.1106901121740.287471281841-0.2790914291730.703475068155-0.0415093055404-0.01092404426480.846306473007-0.0512055094753-0.05646441867070.83553485651-0.3115328797450.808351837876-24.3061098981-2.045356133965.68717985496
40.691169442084-0.354837991372-0.4221917438271.5607192490.6020077801351.386530770920.08770370445430.361117438404-0.50745917305-0.124245789159-0.13277091108-0.02148810750310.557758221075-0.126161188040.005849259407180.91604993394-0.08913583574610.01920900840360.921415169763-0.2716634947120.739373968823-26.8084832463-3.434173848127.44352355276
54.049464958961.68493325435-0.8167384042812.0766186723-0.2655851153932.27898636312-0.1237307158480.335447997018-0.4065390118550.03892006237150.0646864465132-0.006921520696420.255974510248-0.3219153269670.01872429070880.474190840693-0.0188417948453-0.05910079307870.585882846912-0.1140157352190.491679095187-33.915030741915.149580488718.1928752406
60.958987193633-0.8978497787280.05213613971411.257682502760.5920854024921.9119354835-0.1185606077020.422577211486-0.101124117772-0.473940882868-0.05231622749890.212205187434-0.0117632144597-0.3364817871050.03279663943650.522995283362-0.0220966462213-0.03265479991210.665502772307-0.0934686880870.387137320506-32.078961821628.039330228116.7187712471
70.7842984041050.424940336094-1.093029630273.153133379560.5752220255112.51815650174-0.151091419539-0.0557940173991-0.0198811424268-0.340817016126-0.08178388175740.444038457611-0.260214705764-0.4463298614950.1508280588270.375782041450.0341112359492-0.0253784013770.4998447771970.01474878812160.455322488396-36.281896585732.093021943327.1567112157
80.362366739876-0.06412877081320.1067812352860.3701493708540.05786881205230.0630226896625-0.02365353329640.5672722720360.0827055254419-0.325289131764-0.103074804467-0.04493167317780.06402886173210.163750162461-0.0533275657390.456247844809-0.04906937466960.04162209855510.507503673172-0.037460700950.368353477068-17.003316957928.065134733220.7401803728
91.61197123932-0.0594856394160.3654324876371.050766520021.026825136223.92426285013-0.0616436426520.688399527728-0.351395802324-0.243220153356-0.1354585797190.09706434654750.276035131765-0.156087542699-0.0863542219260.717617564359-0.002548351699380.1276443632260.906047833074-0.1804964608220.633760040826-9.7059947054811.4551112514-0.7578252872
100.524979974478-0.875223181003-0.261726807311.538228385470.549498980280.215574912543-0.5324417986831.045791100250.584265675697-0.346611475739-0.3275957948430.0311254736598-0.1371826787850.154435716777-0.1138547211761.04126608589-0.06327426657470.2122211786481.88823486101-0.3634486944580.538840849573-12.141227095712.588384143-19.4698748484
110.7688780689510.4624774067441.130027849220.6959655394390.930283852961.726424729640.1887069936140.788724412964-0.440777199533-0.86692423488-0.0189170115708-0.2867826015430.3293594957760.229237163858-0.06971087071620.829771935656-0.1428998188630.122866758170.953030434937-0.1879177319420.542130795519-16.89245870978.726730194152.38660896636
120.0382675882014-0.003315690855510.08048259613130.0198199388803-0.04766364756970.1970799272780.2202497312960.543443967832-0.529736291001-0.523839824994-0.0300038808414-0.2371098327860.196525999235-0.300119793760.005745706571971.069468540780.2435910802270.07809923883051.88895700578-0.5660371052470.495848910013-10.84531309724.90256460001-20.9813946202
130.483075389186-0.2713015682160.1237757339961.577479554652.23924664973.88275447006-0.09544914754561.07586452417-0.671879925097-0.5672988044570.1709033046660.264353538752-0.476476160151-0.4750503992770.01711706063290.789854132634-6.67338475437E-50.1367527666131.24476021298-0.1982757633170.737205157794-4.2870537365412.8503159235-8.7332420515
141.31123869056-0.6941218174150.5783354254821.422495151250.3395431907121.38329853854-0.210004733310.439208973549-0.1127644716930.1255975052220.151802916044-0.0846089332699-0.0942197014779-0.2254843188220.001679644358520.425724862734-0.009840071014860.0710366372460.520629141753-0.07898521753920.425275186812-26.882118052222.992652152527.731606762
151.926063122581.560296488220.9050840353271.991279481491.23255863421.97083982699-0.04305892769140.293381591838-0.0360580446503-0.1312768252150.0780510460343-0.319913926593-0.0497765741210.115685568981-0.08246626355670.261429361153-0.01510665904050.04425140672570.2789190121430.0051101375790.318804580167-11.577341303137.974516942842.3403727424
161.712854108980.0160542284222-0.1123235551122.475380887791.621368928281.922301844590.000843693542996-0.1888207109090.2211253718530.1313106048460.06099489315490.00233234020439-0.192869284706-0.020823449678-0.06698819354270.2471644636050.0437711572375-0.03300047711920.2186792221830.009240383167060.372933584062-15.561059136855.23526632472.5717114042
172.370943114170.104214795625-0.0485233122482.25695165406-0.4351434683051.82309678576-0.00990059268666-0.0172052060760.04297295995710.151847230736-0.0190788316892-0.213563679537-0.1173783320060.0415209092789-0.05675796298330.296311060109-0.001293073610640.01109157226630.23050163778-0.003677229479120.353732184891-11.037880997353.300874204573.3189664522
180.4221703805110.129823681945-0.4483612189811.04038941351-0.02088123260342.661060820080.009793436669690.0573207932113-0.1891023566780.08274980612340.01042841197070.008860447190590.2477019612640.03525343177960.01273025123110.27101532199-0.01931557601070.03401229264050.2429464336713.74412850317E-60.322210627845-27.513201433623.918555793952.6001785111
191.660503187720.1564931851330.05440954707342.409766415620.602480959181.307693671410.0103021430557-0.0379088110566-0.04645445992970.163459445455-0.00506710317018-0.1493525690460.0532276899334-0.11500756890.0315729139930.2523529182680.003769926386680.02053555790560.2329230090.004894562628940.282517397047-27.526783850246.646078628173.7443366162
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection details
1X-RAY DIFFRACTION1chain 'A' and (resid 4 through 43 )
2X-RAY DIFFRACTION2chain 'A' and (resid 44 through 87 )
3X-RAY DIFFRACTION3chain 'A' and (resid 88 through 123 )
4X-RAY DIFFRACTION4chain 'A' and (resid 124 through 180 )
5X-RAY DIFFRACTION5chain 'B' and (resid 2 through 18 )
6X-RAY DIFFRACTION6chain 'B' and (resid 19 through 51 )
7X-RAY DIFFRACTION7chain 'B' and (resid 52 through 72 )
8X-RAY DIFFRACTION8chain 'B' and (resid 73 through 85 )
9X-RAY DIFFRACTION9chain 'B' and (resid 86 through 130 )
10X-RAY DIFFRACTION10chain 'B' and (resid 131 through 144 )
11X-RAY DIFFRACTION11chain 'B' and (resid 145 through 157 )
12X-RAY DIFFRACTION12chain 'B' and (resid 158 through 171 )
13X-RAY DIFFRACTION13chain 'B' and (resid 172 through 188 )
14X-RAY DIFFRACTION14chain 'C' and (resid 69 through 81 )
15X-RAY DIFFRACTION15chain 'D' and (resid 2 through 120 )
16X-RAY DIFFRACTION16chain 'D' and (resid 121 through 153 )
17X-RAY DIFFRACTION17chain 'D' and (resid 154 through 218 )
18X-RAY DIFFRACTION18chain 'E' and (resid 3 through 136 )
19X-RAY DIFFRACTION19chain 'E' and (resid 137 through 257 )

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