Entry | Database: PDB / ID: 6u8c |
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Title | Crystal structure of an engineered ultra-high affinity Fab-Protein G complex |
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Components | - Antibody heavy chain Fab
- Antibody light chain Fab
- Protein G
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Keywords | IMMUNE SYSTEM / engineered Fab / protein G / high affinity |
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Function / homology | Function and homology information
IgG-binding B / B domain / M protein-type anchor domain / Ubiquitin-like (UB roll) - #10 / GA-like domain / GA-like domain / Immunoglobulin/albumin-binding domain superfamily / YSIRK Gram-positive signal peptide / LPXTG cell wall anchor motif / Gram-positive cocci surface proteins LPxTG motif profile. ...IgG-binding B / B domain / M protein-type anchor domain / Ubiquitin-like (UB roll) - #10 / GA-like domain / GA-like domain / Immunoglobulin/albumin-binding domain superfamily / YSIRK Gram-positive signal peptide / LPXTG cell wall anchor motif / Gram-positive cocci surface proteins LPxTG motif profile. / LPXTG cell wall anchor domain / Ubiquitin-like (UB roll) / Immunoglobulins / Roll / Immunoglobulin-like / Sandwich / Mainly Beta / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Streptococcus sp. 'group G' (bacteria) Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.61 Å |
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Authors | Slezak, T. / Filippova, E.V. / Davydova, E.K. / Kossiakoff, A.A. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Institute of Dental and Craniofacial Research (NIH/NIDCR) | GM117372 | United States |
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Citation | Journal: Protein Sci. / Year: 2020 Title: An engineered ultra-high affinity Fab-Protein G pair enables a modular antibody platform with multifunctional capability. Authors: Slezak, T. / Bailey, L.J. / Jaskolowski, M. / Nahotko, D.A. / Filippova, E.V. / Davydova, E.K. / Kossiakoff, A.A. |
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History | Deposition | Sep 4, 2019 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Oct 23, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 30, 2019 | Group: Data collection / Database references / Category: citation / Item: _citation.pdbx_database_id_PubMed / _citation.title |
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Revision 1.2 | Dec 11, 2019 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 1.3 | Jan 1, 2020 | Group: Database references / Category: citation Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year |
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Revision 1.4 | Oct 11, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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