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- PDB-6qpa: Halothiobacillus neapolitanus sulfur oxygenase reductase -

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Basic information

Entry
Database: PDB / ID: 6qpa
TitleHalothiobacillus neapolitanus sulfur oxygenase reductase
ComponentsSulfur oxygenase/reductase
KeywordsOXIDOREDUCTASE / SULFUR OXYGENASE REDUCTASE / 2-HIS-1-CARBOXYLATE FACIAL TRIAD / CYSTEINE PERSULPHURATION / BIOGEOCHEMICAL SULFUR CYCLE
Function / homologysulfur oxygenase/reductase / sulfur oxygenase/reductase activity / Sulphur oxygenase reductase / Sulphur oxygenase reductase / Dimeric alpha-beta barrel / metal ion binding / : / Sulfur oxygenase/reductase
Function and homology information
Biological speciesHalothiobacillus neapolitanus (bacteria)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.1 Å
AuthorsFrazao, C. / Klezin, A. / Poell, U. / Veith, A. / Ruehl, P. / Coelho, R.
Funding support Portugal, Germany, 3items
OrganizationGrant numberCountry
Foundation for Science and Technology (FCT)LIOA-01-0145-FEDER-007660 Portugal
German Research Foundation (DFG)Kl885-6/1 Germany
German Research Foundation (DFG)Kl885-7/1 Germany
Citation
Journal: To Be Published
Title: Multiple sulfane modifications in active-site cysteine thiols of two sulfur oxygenase reductases and analysis of substrate/product channels
Authors: Frazao, C. / Klezin, A. / Poell, U. / Veith, A. / Ruehl, P. / Coelho, R.
#1: Journal: J.Bacteriol. / Year: 2012
Title: The sulfur oxygenase reductase from the mesophilic bacterium Halothiobacillus neapolitanus is a highly active thermozyme.
Authors: Veith, A. / Botelho, H.M. / Kindinger, F. / Gomes, C.M. / Kletzin, A.
History
DepositionFeb 13, 2019Deposition site: PDBE / Processing site: PDBE
Revision 1.0Mar 18, 2020Provider: repository / Type: Initial release
Revision 1.1Jan 24, 2024Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id
Revision 1.2Nov 20, 2024Group: Structure summary / Category: pdbx_entry_details / pdbx_modification_feature / Item: _pdbx_entry_details.has_protein_modification

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Sulfur oxygenase/reductase
B: Sulfur oxygenase/reductase
C: Sulfur oxygenase/reductase
D: Sulfur oxygenase/reductase
E: Sulfur oxygenase/reductase
F: Sulfur oxygenase/reductase
G: Sulfur oxygenase/reductase
H: Sulfur oxygenase/reductase
I: Sulfur oxygenase/reductase
J: Sulfur oxygenase/reductase
K: Sulfur oxygenase/reductase
L: Sulfur oxygenase/reductase
M: Sulfur oxygenase/reductase
N: Sulfur oxygenase/reductase
O: Sulfur oxygenase/reductase
P: Sulfur oxygenase/reductase
Q: Sulfur oxygenase/reductase
R: Sulfur oxygenase/reductase
T: Sulfur oxygenase/reductase
U: Sulfur oxygenase/reductase
V: Sulfur oxygenase/reductase
W: Sulfur oxygenase/reductase
Y: Sulfur oxygenase/reductase
Z: Sulfur oxygenase/reductase
hetero molecules


Theoretical massNumber of molelcules
Total (without water)855,66196
Polymers849,70924
Non-polymers5,95172
Water71,2493955
1


  • Idetical with deposited unit
  • defined by author&software
  • Evidence: microscopy
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area144820 Å2
ΔGint-1724 kcal/mol
Surface area223550 Å2
MethodPISA
Unit cell
Length a, b, c (Å)200.840, 212.450, 215.980
Angle α, β, γ (deg.)90.000, 90.000, 90.000
Int Tables number19
Space group name H-MP212121
Noncrystallographic symmetry (NCS)NCS domain:
IDEns-IDDetails
11(chain A and (resid 6 through 210 or resid 212...
21(chain B and (resid 6 through 210 or resid 212...
31(chain C and (resid 6 through 210 or resid 212...
41(chain D and (resid 6 through 210 or resid 212...
51(chain E and (resid 6 through 210 or resid 212...
61(chain F and (resid 6 through 210 or resid 212...
71(chain G and (resid 6 through 210 or resid 212...
81(chain H and (resid 6 through 210 or resid 212...
91(chain I and (resid 6 through 210 or resid 212...
101(chain J and (resid 6 through 210 or resid 212...
111(chain K and (resid 6 through 210 or resid 212...
121(chain L and (resid 6 through 210 or resid 212...
131(chain M and (resid 6 through 210 or resid 212...
141(chain N and (resid 6 through 210 or resid 212...
151(chain O and (resid 6 through 210 or resid 212...
161(chain P and (resid 6 through 210 or resid 212...
171(chain Q and (resid 6 through 210 or resid 212...
181(chain R and (resid 6 through 210 or resid 212...
191(chain T and (resid 6 through 210 or resid 212...
201(chain U and (resid 6 through 210 or resid 212...
211(chain V and (resid 6 through 210 or resid 212...
221(chain W and (resid 6 through 210 or resid 212...
231(chain Y and (resid 6 through 210 or resid 212...
241(chain Z and (resid 6 through 210 or resid 212...

NCS domain segments:
Dom-IDComponent-IDEns-IDSelection detailsAuth asym-IDAuth seq-ID
111(chain A and (resid 6 through 210 or resid 212...A6 - 210
121(chain A and (resid 6 through 210 or resid 212...A212 - 301
131(chain A and (resid 6 through 210 or resid 212...A303 - 312
141(chain A and (resid 6 through 210 or resid 212...A315 - 317
151(chain A and (resid 6 through 210 or resid 212...A319
211(chain B and (resid 6 through 210 or resid 212...B6 - 210
221(chain B and (resid 6 through 210 or resid 212...B212 - 301
231(chain B and (resid 6 through 210 or resid 212...B303 - 312
241(chain B and (resid 6 through 210 or resid 212...B315 - 317
251(chain B and (resid 6 through 210 or resid 212...B319
311(chain C and (resid 6 through 210 or resid 212...C6 - 210
321(chain C and (resid 6 through 210 or resid 212...C212 - 301
331(chain C and (resid 6 through 210 or resid 212...C303 - 312
341(chain C and (resid 6 through 210 or resid 212...C315 - 317
351(chain C and (resid 6 through 210 or resid 212...C320
411(chain D and (resid 6 through 210 or resid 212...D6 - 210
421(chain D and (resid 6 through 210 or resid 212...D212 - 301
431(chain D and (resid 6 through 210 or resid 212...D303 - 312
441(chain D and (resid 6 through 210 or resid 212...D315 - 318
451(chain D and (resid 6 through 210 or resid 212...D320
511(chain E and (resid 6 through 210 or resid 212...E6 - 210
521(chain E and (resid 6 through 210 or resid 212...E212 - 301
531(chain E and (resid 6 through 210 or resid 212...E303 - 312
541(chain E and (resid 6 through 210 or resid 212...E315 - 317
551(chain E and (resid 6 through 210 or resid 212...E320
611(chain F and (resid 6 through 210 or resid 212...F6 - 210
621(chain F and (resid 6 through 210 or resid 212...F212 - 301
631(chain F and (resid 6 through 210 or resid 212...F303 - 312
641(chain F and (resid 6 through 210 or resid 212...F315 - 317
651(chain F and (resid 6 through 210 or resid 212...F319
711(chain G and (resid 6 through 210 or resid 212...G6 - 210
721(chain G and (resid 6 through 210 or resid 212...G212 - 301
731(chain G and (resid 6 through 210 or resid 212...G303 - 312
741(chain G and (resid 6 through 210 or resid 212...G315 - 317
751(chain G and (resid 6 through 210 or resid 212...G319
811(chain H and (resid 6 through 210 or resid 212...H6 - 210
821(chain H and (resid 6 through 210 or resid 212...H212 - 301
831(chain H and (resid 6 through 210 or resid 212...H303 - 312
841(chain H and (resid 6 through 210 or resid 212...H315 - 317
851(chain H and (resid 6 through 210 or resid 212...H320
911(chain I and (resid 6 through 210 or resid 212...I6 - 210
921(chain I and (resid 6 through 210 or resid 212...I212 - 301
931(chain I and (resid 6 through 210 or resid 212...I303 - 312
941(chain I and (resid 6 through 210 or resid 212...I315 - 317
951(chain I and (resid 6 through 210 or resid 212...I319
1011(chain J and (resid 6 through 210 or resid 212...J6 - 210
1021(chain J and (resid 6 through 210 or resid 212...J212 - 301
1031(chain J and (resid 6 through 210 or resid 212...J303 - 312
1041(chain J and (resid 6 through 210 or resid 212...J315 - 317
1051(chain J and (resid 6 through 210 or resid 212...J319
1111(chain K and (resid 6 through 210 or resid 212...K6 - 210
1121(chain K and (resid 6 through 210 or resid 212...K212 - 301
1131(chain K and (resid 6 through 210 or resid 212...K303 - 312
1141(chain K and (resid 6 through 210 or resid 212...K315 - 317
1151(chain K and (resid 6 through 210 or resid 212...K319
1211(chain L and (resid 6 through 210 or resid 212...L6 - 210
1221(chain L and (resid 6 through 210 or resid 212...L212 - 301
1231(chain L and (resid 6 through 210 or resid 212...L303 - 312
1241(chain L and (resid 6 through 210 or resid 212...L315 - 317
1251(chain L and (resid 6 through 210 or resid 212...L320
1311(chain M and (resid 6 through 210 or resid 212...M6 - 210
1321(chain M and (resid 6 through 210 or resid 212...M212 - 301
1331(chain M and (resid 6 through 210 or resid 212...M303 - 312
1341(chain M and (resid 6 through 210 or resid 212...M315 - 317
1351(chain M and (resid 6 through 210 or resid 212...M319
1411(chain N and (resid 6 through 210 or resid 212...N6 - 210
1421(chain N and (resid 6 through 210 or resid 212...N212 - 301
1431(chain N and (resid 6 through 210 or resid 212...N303 - 312
1441(chain N and (resid 6 through 210 or resid 212...N315 - 317
1451(chain N and (resid 6 through 210 or resid 212...N319
1511(chain O and (resid 6 through 210 or resid 212...O6 - 210
1521(chain O and (resid 6 through 210 or resid 212...O212 - 301
1531(chain O and (resid 6 through 210 or resid 212...O303 - 312
1541(chain O and (resid 6 through 210 or resid 212...O315 - 317
1551(chain O and (resid 6 through 210 or resid 212...O319
1611(chain P and (resid 6 through 210 or resid 212...P6 - 210
1621(chain P and (resid 6 through 210 or resid 212...P212 - 301
1631(chain P and (resid 6 through 210 or resid 212...P303 - 312
1641(chain P and (resid 6 through 210 or resid 212...P315 - 317
1651(chain P and (resid 6 through 210 or resid 212...P319
1711(chain Q and (resid 6 through 210 or resid 212...Q6 - 210
1721(chain Q and (resid 6 through 210 or resid 212...Q212 - 301
1731(chain Q and (resid 6 through 210 or resid 212...Q303 - 312
1741(chain Q and (resid 6 through 210 or resid 212...Q315 - 317
1751(chain Q and (resid 6 through 210 or resid 212...Q319
1811(chain R and (resid 6 through 210 or resid 212...R6 - 210
1821(chain R and (resid 6 through 210 or resid 212...R212 - 301
1831(chain R and (resid 6 through 210 or resid 212...R303 - 312
1841(chain R and (resid 6 through 210 or resid 212...R315 - 317
1851(chain R and (resid 6 through 210 or resid 212...R319
1911(chain T and (resid 6 through 210 or resid 212...T6 - 210
1921(chain T and (resid 6 through 210 or resid 212...T212 - 301
1931(chain T and (resid 6 through 210 or resid 212...T303 - 312
1941(chain T and (resid 6 through 210 or resid 212...T315 - 318
1951(chain T and (resid 6 through 210 or resid 212...T320
2011(chain U and (resid 6 through 210 or resid 212...U6 - 210
2021(chain U and (resid 6 through 210 or resid 212...U212 - 301
2031(chain U and (resid 6 through 210 or resid 212...U303 - 312
2041(chain U and (resid 6 through 210 or resid 212...U315 - 317
2051(chain U and (resid 6 through 210 or resid 212...U319
2111(chain V and (resid 6 through 210 or resid 212...V6 - 210
2121(chain V and (resid 6 through 210 or resid 212...V212 - 301
2131(chain V and (resid 6 through 210 or resid 212...V303 - 312
2141(chain V and (resid 6 through 210 or resid 212...V315 - 318
2151(chain V and (resid 6 through 210 or resid 212...V320
2211(chain W and (resid 6 through 210 or resid 212...W6 - 210
2221(chain W and (resid 6 through 210 or resid 212...W212 - 301
2231(chain W and (resid 6 through 210 or resid 212...W303 - 312
2241(chain W and (resid 6 through 210 or resid 212...W315 - 317
2251(chain W and (resid 6 through 210 or resid 212...W319
2311(chain Y and (resid 6 through 210 or resid 212...Y6 - 210
2321(chain Y and (resid 6 through 210 or resid 212...Y212 - 301
2331(chain Y and (resid 6 through 210 or resid 212...Y303 - 312
2341(chain Y and (resid 6 through 210 or resid 212...Y315 - 318
2351(chain Y and (resid 6 through 210 or resid 212...Y320
2411(chain Z and (resid 6 through 210 or resid 212...Z6 - 210
2421(chain Z and (resid 6 through 210 or resid 212...Z212 - 301
2431(chain Z and (resid 6 through 210 or resid 212...Z303 - 312
2441(chain Z and (resid 6 through 210 or resid 212...Z315 - 317
2451(chain Z and (resid 6 through 210 or resid 212...Z319

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Components

#1: Protein ...
Sulfur oxygenase/reductase


Mass: 35404.555 Da / Num. of mol.: 24 / Mutation: CSS_33, CSS_103
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Halothiobacillus neapolitanus (strain ATCC 23641 / c2) (bacteria)
Gene: Hneap_1222 / Production host: Escherichia coli (E. coli) / References: UniProt: D0L035, sulfur oxygenase/reductase
#2: Chemical...
ChemComp-FE / FE (III) ION


Mass: 55.845 Da / Num. of mol.: 24 / Source method: obtained synthetically / Formula: Fe / Feature type: SUBJECT OF INVESTIGATION
#3: Chemical...
ChemComp-SO4 / SULFATE ION


Mass: 96.063 Da / Num. of mol.: 48 / Source method: obtained synthetically / Formula: SO4 / Feature type: SUBJECT OF INVESTIGATION
#4: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 3955 / Source method: isolated from a natural source / Formula: H2O
Has ligand of interestY
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.63 Å3/Da / Density % sol: 53.16 %
Crystal growTemperature: 298 K / Method: vapor diffusion, sitting drop / pH: 6.4 / Details: 0.1 M ADA pH 6.4, 1 M ammomium sulfate

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: ESRF / Beamline: ID29 / Wavelength: 0.96112 Å
DetectorType: DECTRIS PILATUS 6M / Detector: PIXEL / Date: Jun 20, 2013
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.96112 Å / Relative weight: 1
ReflectionResolution: 2.1→83.695 Å / Num. obs: 532671 / % possible obs: 100 % / Redundancy: 13.534 % / Biso Wilson estimate: 36.88 Å2 / CC1/2: 0.999 / Rmerge(I) obs: 0.153 / Rrim(I) all: 0.159 / Χ2: 0.998 / Net I/σ(I): 14.78 / Num. measured all: 7209077 / Scaling rejects: 854
Reflection shell

Diffraction-ID: 1

Resolution (Å)Redundancy (%)Rmerge(I) obsMean I/σ(I) obsNum. unique obsCC1/2Rrim(I) all% possible all
2.1-2.1711.7170.151.29495180.490.159100
2.17-2.2412.3421.7211.65435400.6221.796100
2.24-2.3114.1331.3952.21384980.751.446100
2.31-2.3914.2271.042.94386510.8451.078100
2.39-2.4814.0910.8053.76377640.90.835100
2.48-2.5813.8350.6344.72359830.9330.658100
2.58-2.713.1270.5015.76364620.9490.522100
2.7-2.8313.7030.3578.1329340.9740.371100
2.83-2.9814.280.27310.62311780.9860.283100
2.98-3.1614.1520.19514.39300390.9930.202100
3.16-3.3813.8930.13320.16286310.9960.138100
3.38-3.6512.9780.09725.82263980.9980.101100
3.65-414.4740.07635244710.9990.079100
4-4.4714.160.05645.03219940.9990.058100
4.47-5.1613.1990.0548.07195610.9990.052100
5.16-6.3213.8330.05344.61166500.9990.055100
6.32-8.9413.7150.04352.2130220.9990.045100
8.94-83.69512.7720.0370.1373770.9990.03299.5

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Processing

Software
NameVersionClassification
PHENIX1.13_2998refinement
XDSdata reduction
XSCALEdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 2cb2

2cb2


Resolution: 2.1→83.695 Å / SU ML: 0.25 / Cross valid method: THROUGHOUT / σ(F): 1.43 / Phase error: 21.57
RfactorNum. reflection% reflectionSelection details
Rfree0.2004 1998 0.38 %thin spherical resolution bins
Rwork0.1622 ---
obs0.1623 532671 99.9 %-
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å
Displacement parametersBiso max: 142.04 Å2 / Biso mean: 45.7773 Å2 / Biso min: 16.2 Å2
Refinement stepCycle: final / Resolution: 2.1→83.695 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms58671 0 264 3955 62890
Biso mean--108.54 48.34 -
Num. residues----7439
Refine LS restraints NCS
Ens-IDDom-IDAuth asym-IDNumberRefine-IDRmsType
11A35820X-RAY DIFFRACTION7.278TORSIONAL
12B35820X-RAY DIFFRACTION7.278TORSIONAL
13C35820X-RAY DIFFRACTION7.278TORSIONAL
14D35820X-RAY DIFFRACTION7.278TORSIONAL
15E35820X-RAY DIFFRACTION7.278TORSIONAL
16F35820X-RAY DIFFRACTION7.278TORSIONAL
17G35820X-RAY DIFFRACTION7.278TORSIONAL
18H35820X-RAY DIFFRACTION7.278TORSIONAL
19I35820X-RAY DIFFRACTION7.278TORSIONAL
110J35820X-RAY DIFFRACTION7.278TORSIONAL
111K35820X-RAY DIFFRACTION7.278TORSIONAL
112L35820X-RAY DIFFRACTION7.278TORSIONAL
113M35820X-RAY DIFFRACTION7.278TORSIONAL
114N35820X-RAY DIFFRACTION7.278TORSIONAL
115O35820X-RAY DIFFRACTION7.278TORSIONAL
116P35820X-RAY DIFFRACTION7.278TORSIONAL
117Q35820X-RAY DIFFRACTION7.278TORSIONAL
118R35820X-RAY DIFFRACTION7.278TORSIONAL
119T35820X-RAY DIFFRACTION7.278TORSIONAL
120U35820X-RAY DIFFRACTION7.278TORSIONAL
121V35820X-RAY DIFFRACTION7.278TORSIONAL
122W35820X-RAY DIFFRACTION7.278TORSIONAL
123Y35820X-RAY DIFFRACTION7.278TORSIONAL
124Z35820X-RAY DIFFRACTION7.278TORSIONAL
LS refinement shell

Refine-ID: X-RAY DIFFRACTION / Rfactor Rfree error: 0

Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection Rwork% reflection obs (%)
2.1-2.15210.34291490.28883722099
2.1521-2.21030.36041490.266937693100
2.2103-2.27530.28131340.247637636100
2.2753-2.34880.26481470.219637742100
2.3488-2.43270.261310.203737710100
2.4327-2.53010.25231480.186537744100
2.5301-2.64530.22151340.185237779100
2.6453-2.78480.21891400.178737845100
2.7848-2.95930.26181570.173737865100
2.9593-3.18780.20161310.165737912100
3.1878-3.50860.1871590.156937912100
3.5086-4.01620.16981140.134938167100
4.0162-5.060.15291760.115338229100
5.06-83.6590.15041290.147139016100
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
10.24240.08170.21580.3741-0.10780.21330.0745-0.1701-0.19260.28060.16450.16840.38870.46240.01570.40480.10420.0020.3145-0.04450.2888-19.8063137.705144.0763
20.0673-0.04110.01950.0391-0.04340.03410.00540.1420.10060.0295-0.05320.08540.1906-0.0430.00010.42390.0279-0.00690.3539-0.03140.4036-15.0813138.7032153.929
30.08690.12490.00370.1694-0.08470.2030.0090.0383-0.1079-0.21180.02970.06410.09360.04120.00010.35070.0448-0.05920.2851-0.04310.3518-28.6985129.8945133.6629
40.0138-0.00520.00980.0398-0.00230.0328-0.1373-0.1983-0.2874-0.1707-0.1037-0.0895-0.03040.09250.00010.40830.0009-0.00650.3073-0.03380.3717-23.3029140.0506150.1677
50.07970.0391-0.04180.0621-0.0220.0558-0.1869-0.06980.05150.1590.0362-0.11970.11220.139-0.00010.4148-0.02710.02960.4036-0.07280.4043-14.6989149.5314153.2857
60.1229-0.06440.00740.1960.25660.3702-0.0612-0.1271-0.06280.0265-0.03140.1359-0.01040.00590.00010.36250.02180.01960.2911-0.04560.3281-26.5253141.3398147.4275
70.255-0.16320.29180.2007-0.16880.2436-0.0749-0.09820.12110.16780.04530.0069-0.31140.068800.33490.01750.05230.307-0.05910.29-30.7509120.1489162.8145
80.1943-0.08670.32680.19940.08260.52780.0265-0.06120.07140.0721-0.02510.0471-0.0284-0.063300.3120.04310.0310.2677-0.06050.3388-38.2489138.5246147.7273
90.05960.0301-0.02050.023-0.01660.03040.08470.34340.5326-0.15530.0202-0.27650.15970.0512-0.0020.39260.01040.03430.39540.02530.4899-9.0034157.2071142.564
100.3261-0.1452-0.02980.2754-0.06310.69510.0483-0.01050.0307-0.042-0.03490.1307-0.0377-0.09600.28940.04390.01110.2398-0.05220.3091-37.7259138.0747143.7955
110.1228-0.09350.16040.1226-0.17520.28670.2518-0.18740.37250.057-0.3182-0.1213-0.13830.4924-0.04050.4166-0.00550.0070.378-0.05370.3584-25.5856132.6638156.7169
120.13990.0076-0.17320.0866-0.09830.2711-0.2137-0.05520.3069-0.2183-0.0408-0.0119-0.03550.2164-0.00770.3229-0.0394-0.02860.3227-0.11230.300518.0288130.7501156.7972
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990.07060.0042-0.11480.06570.03810.1448-0.1049-0.3608-0.19620.4974-0.01470.0798-0.1909-0.03030.00030.29180.0052-0.02580.3834-0.02240.363-9.716648.7408123.7995
1000.08740.02810.0570.02090.03010.1486-0.0649-0.27630.0076-0.11480.14820.02380.00410.0506-0.00020.3350.08420.02360.3632-0.07860.362720.32655.443393.6584
1010.18890.063-0.09070.0337-0.0250.048-0.2145-0.1140.1189-0.28790.26370.27980.6306-0.59540.00150.6086-0.08620.03410.8999-0.11650.97546.776268.357594.8582
1020.0053-0.0132-0.01520.0098-0.00280.01550.15090.0750.16560.1640.2639-0.0714-0.28860.0914-0.00080.52110.03060.04090.5522-0.15270.51597.191250.151990.771
1030.36450.0394-0.19470.3005-0.28210.3206-0.03840.0283-0.0384-0.12060.0099-0.0142-0.0578-0.017200.26050.0350.02170.3669-0.09740.365921.166560.647998.0633
1040.0047-0.0295-0.01020.0416-0.00770.0565-0.25860.378-0.22650.38080.21630.1809-0.0915-0.1927-0.00010.37320.0343-0.07550.507-0.07470.40068.663753.747881.7459
1050.22290.16980.0520.10220.00530.1379-0.04690.0473-0.0973-0.22350.0158-0.22070.13810.044400.26920.02110.0480.3172-0.0850.323122.195656.007892.2427
1060.05160.0236-0.02710.0066-0.02720.02010.03680.018-0.3181-0.1712-0.1535-0.21740.15070.0457-0.00040.25190.04720.00380.321-0.03680.430913.53443.3311118.0753
1070.21430.09030.0930.32440.25820.2459-0.00470.1208-0.1504-0.059-0.0124-0.04820.1234-0.0426-00.21140.06220.01890.2938-0.08030.315729.338952.1759102.6048
1080.0956-0.03080.00520.03010.01820.00950.39480.4314-0.0160.0298-0.20390.1085-0.0187-0.08110.00030.4370.0839-0.02460.5397-0.10730.357412.263559.709572.3226
1090.4384-0.0558-0.17650.446-0.23910.33610.0584-0.0134-0.0089-0.0036-0.0161-0.16290.0160.03480.00770.19060.04810.03820.2815-0.10980.319432.354956.4275100.4002
1100.22420.0113-0.42420.0027-0.02750.90810.11980.5201-0.304-0.2456-0.06690.62890.003-0.53920.10870.2010.00850.04010.3268-0.07910.43515.720948.858103.2163
1110.02080.0466-0.02790.1577-0.13190.0890.13790.1127-0.03410.14490.20280.1682-0.091-0.03420.00110.3022-0.0043-0.11310.3897-0.07420.4075-25.493760.354489.1239
112-0.0130.0422-0.01670.0202-0.00350.00850.38260.1330.17760.3199-0.25120.041-0.41310.0851-0.00060.84230.0353-0.08850.7239-0.0570.6149-14.502570.331884.763
1130.5171-0.36280.21290.3639-0.15550.1762-0.0067-0.0271-0.11590.002-0.04430.0778-0.1044-0.32640.00010.268-0.0391-0.03690.302-0.06660.3164-27.498267.522195.3492
1140.0227-0.0165-0.01050.02170.01880.0084-0.09570.46350.03320.01760.1645-0.01350.05540.60560.01190.377-0.0027-0.06830.3761-0.06130.3359-20.727768.232296.457
1150.0491-0.038-0.02950.0269-0.02260.1497-0.23870.2030.2184-0.3814-0.00130.07150.09490.1042-0.0070.36810.0425-0.0660.4578-0.14130.3541-18.183155.383478.8652
1160.1222-0.0206-0.14050.1687-0.15860.36560.07750.1408-0.133-0.0487-0.08640.10320.16050.0437-0.04550.27540.0313-0.1040.3663-0.13150.3558-23.440557.792791.1297
1170.16410.2216-0.16810.3444-0.26620.2015-0.1840.1894-0.2263-0.57080.1826-0.11510.1833-0.3517-0.04540.38770.0267-0.16060.4769-0.13260.4017-44.790975.808378.5994
1180.0777-0.19090.11050.36120.01030.847-0.0190.0683-0.0929-0.0547-0.05440.10430.0479-0.0543-0.04440.2196-0.0229-0.09120.3032-0.10980.3831-37.764660.99993.8591
1190.79131.1092-0.23932.5306-1.25110.9787-0.04090.0922-0.3235-0.2117-0.4029-0.7191-0.16330.3531-0.16440.35920.0768-0.01480.493-0.14160.4219-4.722550.502884.7844
1200.3950.17940.35890.3898-0.05730.4730.0145-0.0154-0.068-0.0383-0.01230.1009-0.0215-0.069800.2155-0.0061-0.07780.2505-0.09680.3351-35.205959.343498.6436
1210.1384-0.17680.1290.3053-0.24910.20440.02780.4417-0.0301-0.2085-0.3444-0.1906-0.1893-0.0738-0.04190.49250.0253-0.10970.5419-0.08910.4013-32.808267.308382.045
1220.07650.05570.04870.172-0.03670.0584-0.21240.1577-0.0152-0.150.0563-0.0305-0.00040.19260.00030.50230.0980.0150.5946-0.09050.26523.728481.909458.1261
1230.0131-0.0914-0.01850.08450.0255-0.0129-0.2614-0.1750.00540.12690.0858-0.1289-0.25220.1827-0.00190.6810.1349-0.06530.7845-0.09170.54715.784778.251674.5016
1240.42250.29020.14510.21060.01750.06450.07040.05790.1325-0.38660.0511-0.138-0.0396-0.02780.00010.52250.1153-0.03310.4734-0.01970.25563.711191.664964.555
1250.21560.0899-0.10080.044-0.03780.0679-0.1949-0.0777-0.18310.0551-0.0457-0.00750.0567-0.1092-0.02590.49970.1342-0.04550.4776-0.07630.26791.182887.439568.2478
1260.0890.0008-0.04430.169-0.05430.0340.0874-0.045-0.3193-0.2164-0.040.26240.11570.18430.02330.55230.0860.00370.5623-0.12110.35372.944468.385161.2707
1270.00030.0082-0.02470.0249-0.03710.0305-0.1819-0.0326-0.3056-0.32940.01740.01-0.1348-0.3068-0.00060.49720.1123-0.02120.528-0.12420.4215-4.993680.041667.2015
1280.3031-0.28210.24630.87520.00660.23270.0240.44760.1521-0.2347-0.0206-0.2460.02480.2714-0.05230.55780.09990.04980.5081-0.05350.161916.7388.434556.2042
1290.59720.10660.19190.1241-0.01270.31780.2830.3858-0.7294-0.4033-0.088-0.11330.09590.09910.54570.65030.24110.12630.6445-0.1034-0.497810.196292.454752.5964
1300.0384-0.00630.05730.0123-0.03440.05650.0199-0.2482-0.0622-0.0740.1324-0.05290.1013-0.41390.00010.44330.0623-0.0630.492-0.07150.3127-10.100664.486567.3585
1310.7139-0.0806-0.28670.14210.05280.34550.05180.17660.0657-0.1916-0.0395-0.0564-0.1155-0.043-0.00060.57430.1236-0.04480.5164-0.04420.21731.009194.220353.563
132-0.0091-0.019-0.00550.0192-0.01860.0094-0.0047-0.2537-0.3519-0.10680.0033-0.01290.43740.3065-0.00190.37810.10.01530.5166-0.03120.252115.366584.098259.1821
1330.23090.02470.17920.05080.04690.1349-0.2924-0.00410.0696-0.1438-0.1070.23620.1753-0.13290.00010.39440.01740.02850.3766-0.03310.33741.848110.3333166.5304
134-0.01720.04-0.03520.2266-0.21580.2097-0.179-0.0019-0.0512-0.59510.09840.4782-0.3374-0.01790.00420.745-0.0786-0.08250.5657-0.04040.65492.091998.6245158.6779
1350.58970.0778-0.13690.0843-0.10870.1143-0.0365-0.02160.0773-0.06690.0520.00210.1784-0.006900.3556-0.01-0.03590.2621-0.07420.2919-2.6547114.9666160.4258
1360.4216-0.2114-0.04020.10140.02740.0079-0.17750.0508-0.3838-0.1594-0.1178-0.13210.2242-0.041-0.21820.4029-0.0458-0.00840.3329-0.03680.17912.2612112.2948156.4298
1370.1866-0.0649-0.03990.0239-0.0049-0.01070.00820.0022-0.29530.2891-0.1446-0.08680.3425-0.20940.00020.43290.065-0.0180.3583-0.00560.29817.041499.7517173.8131
1380.16290.1255-0.02830.2603-0.15990.08440.08420.0284-0.03840.0282-0.1002-0.0678-0.1016-0.0877-00.3250.0209-0.00190.344-0.02990.23486.8525111.1078167.1956
1390.0160.05370.02740.09210.0620.00710.0009-0.16250.03230.153-0.02420.22240.02270.0610.00010.40380.00650.06140.342-0.04140.291-24.0889108.8936170.3456
1400.26370.20260.20560.20060.06550.33410.0202-0.09480.01220.11670.03420.06640.0079-0.01810.00010.3245-0.00030.02990.2779-0.06870.2008-6.8075120.6662170.5379
141-0.00020.03730.03410.07880.11270.0649-0.0753-0.0332-0.19620.20260.3554-0.37970.10170.35050.00060.39430.0242-0.03020.3959-0.0530.404821.686199.05168.8539
1420.40370.2662-0.19530.45070.0080.52340.0589-0.07580.09070.020.00590.06360.0053-0.0010.00010.3039-0.0019-0.00570.2672-0.0690.2191-2.557123.6298168.2622
1430.13320.06830.04750.06090.03420.0238-0.11870.2541-0.39280.07790.1853-0.0870.5364-0.15570.01550.3661-0.03590.0170.2663-0.03560.2489-10.4038107.1024169.8174
1440.41410.0071-0.01140.1280.14890.1535-0.18730.2210.05630.0406-0.0173-0.65240.0184-0.0032-0.00240.29520.04180.00650.33570.09760.34622.996872.2766150.0443
1450.1596-0.10780.15150.1754-0.16220.1641-0.08530.611-0.1017-0.3071-0.03180.4326-0.025-0.16780.00830.56840.0471-0.07250.58950.03730.504713.90574.4318152.6234
1460.4865-0.0998-0.33860.67090.4260.4373-0.02010.1156-0.04150.0144-0.0207-0.08180.04410.1072-00.26820.00510.00340.29190.03870.2446-0.072568.1824148.5124
147-0.0039-0.006-0.00680.07180.01660.01670.0924-0.0389-0.0475-0.46660.0012-0.32230.1357-0.0334-0.00030.44310.0131-0.06680.404-0.00560.408211.004976.859163.0299
1480.04540.0340.01880.04990.03610.02-0.1728-0.27270.33870.16540.26230.0420.096-0.0932-0.00010.34090.0693-0.02970.3271-0.02260.3253-1.189877.3684155.2743
1490.194-0.02250.05360.0574-0.00710.011-0.08940.0549-0.15610.13620.0973-0.14630.2390.0911-0.00010.3220.0366-0.00870.30620.02630.27716.116355.3866146.4046
150-0.0020.0064-0.00650.0130.05820.248-0.1359-0.3887-0.77640.19260.0103-0.04910.09850.42210.00490.30050.05520.00010.370.10410.425815.215844.2541136.9218
1510.4904-0.08180.1780.03680.06240.38820.0226-0.0137-0.13940.12060.0236-0.02310.12290.043100.24220.00860.02280.20640.03320.2489-4.790456.8765148.54
1520.06430.08150.06540.08930.08330.08010.2766-0.15540.3640.1031-0.07870.2028-0.02060.14010.0020.41770.03330.0030.3529-0.01360.38494.345683.9944169.1347
1530.3798-0.2115-0.03080.5065-0.10350.1625-0.02640.0369-0.07990.07740.05150.08540.02440.062900.21920.01570.00940.22220.03640.1955-8.998759.5872148.7468
1540.15470.0480.13730.04440.02610.0709-0.00680.06950.11350.220.0467-0.6649-0.07760.04380.00010.31580.05960.00080.369-0.00830.33779.530359.8156147.5992
1550.43750.17720.43040.10930.24460.54030.5301-0.2010.2243-0.0299-0.2801-0.15190.3095-0.36610.01030.29930.0859-0.03580.3686-0.07580.372938.348592.024148.7176
1560.1132-0.09080.05230.0360.04190.24820.28810.44920.2374-0.2476-0.306-0.2772-0.1258-0.1050.00250.7480.1065-0.02350.6866-0.15240.640925.327297.6923151.0018
1570.09940.14140.03090.35770.05540.10440.004-0.0195-0.0011-0.04380.1387-0.2159-0.056-0.06820.00020.3080.0680.00780.3317-0.06290.379639.548195.5893141.3472
1580.05130.04120.09030.06030.0860.30230.0731-0.23470.54080.0627-0.2639-0.18520.2584-0.3067-0.01350.34740.0914-0.02230.3884-0.07470.460532.816893.7798139.6542
1590.20950.0528-0.18480.07540.01140.1187-0.3143-0.15330.03740.29810.2130.01460.047-0.0032-00.38840.0402-0.06890.4232-0.05950.3834.130590.1389162.101
1600.0748-0.0096-0.10660.00030.01720.12380.17680.2273-0.03930.0786-0.0309-0.12480.13530.12500.34070.015-0.03570.3617-0.06640.329637.407587.3348149.6616
1610.4474-0.53320.43470.5954-0.57410.5464-0.2155-0.463-0.01540.09440.4508-0.177-0.07170.15990.16280.25720.0383-0.02730.3951-0.15760.354449.7374116.0904149.6613
162-0.04570.12090.09670.44920.05420.1949-0.0144-0.06210.00650.15740.0725-0.1818-0.0830.07090.00090.23250.0448-0.05280.3721-0.10030.423650.942995.7289144.2677
1630.085-0.0178-0.06030.01720.01210.0192-0.2686-0.1375-0.37860.24780.19060.03330.1161-0.0567-0.00010.39740.0562-0.01150.404-0.03740.439524.925877.8271160.7057
1640.17870.20890.01090.36560.21890.30450.0541-0.0176-0.013-0.02460.0519-0.1465-0.06320.1321-00.23380.0587-0.02710.3487-0.07180.397849.979291.272141.0668
1650.15750.0541-0.0570.059-0.07740.2988-0.0645-0.15530.39360.3195-0.21370.27110.0858-0.2463-0.02280.28920.0724-0.02840.2574-0.09840.348442.938104.1178152.1559
1660.083-0.1125-0.07470.19050.00290.24530.3001-0.3454-0.34070.28280.04170.0123-0.0332-0.03790.00430.3302-0.04860.09040.447-0.03460.39450.613106.4518112.0747
1670.0009-0.007-0.00240.0893-0.01440.0031-0.14270.03810.2279-0.06080.07850.0451-0.6116-0.482-0.00010.50820.02960.03740.7223-0.11420.687751.923196.9038118.1627
1680.10180.11670.06330.29040.19360.49510.02930.0061-0.0749-0.09480.0255-0.0996-0.07230.0682-00.3151-0.01440.110.403-0.05320.507751.43111.9537112.2072
1690.04160.05760.04830.06210.0580.03340.1674-0.55340.4165-0.1248-0.1974-0.14080.13540.29550.00010.3421-0.02760.04140.3829-0.09810.506958.888192.6834110.5147
1700.0131-0.01320.00040.056-0.03270.0163-0.08830.20920.3377-0.11250.10930.0677-0.006-0.01560.00010.3671-0.02170.05450.3838-0.11280.483852.6575103.951104.6683
1710.0285-0.0956-0.01310.2504-0.10290.0316-0.0948-0.0284-0.19580.03580.0164-0.31590.01090.0311-0.09790.2836-0.0410.06970.3367-0.14680.4957.4642117.4777126.5091
1720.07880.0463-0.08080.1496-0.21080.23250.12360.0116-0.2867-0.06160.2321-0.49960.02890.3730.0020.287-0.01780.00320.4839-0.1890.553756.5491120.7493136.0219
1730.5331-0.1439-0.05250.4013-0.34640.2683-0.0189-0.02380.1442-0.06910.0788-0.23-0.09680.14170.00030.2548-0.07370.11110.3487-0.090.44959.9818122.6313112.0695
1740.0233-0.0016-0.04020.0503-0.01040.0187-0.1591-0.0112-0.0705-0.3310.10540.12070.1608-0.1984-0.00030.3968-0.03190.10030.4013-0.09050.501357.910190.329999.147
1750.34420.06870.11350.3550.18810.4570.00190.01450.1434-0.14160.1206-0.1369-0.10180.1063-00.3069-0.05240.14120.3348-0.07840.488156.7731122.4147109.3176
1760.1070.0450.3380.1821-0.08411.28740.0464-0.3015-0.23530.1403-0.053-0.410.5508-0.33770.02710.2358-0.02670.03380.379-0.07580.386257.99111.3936124.1755
1770.0262-0.10440.06170.402-0.18190.16320.10210.02580.2328-0.5051-0.1873-0.06180.1832-0.14220.00660.2460.0683-0.00560.3138-0.09060.382939.611671.0169130.7495
1780.3094-0.22160.16490.1411-0.10150.0882-0.3191-0.0566-0.2066-0.45370.0551-0.3362-0.2255-0.9285-0.02030.68410.11930.00660.7934-0.14980.69835.098977.2105117.1938
1790.02810.00940.05410.00430.02320.08120.0381-0.0113-0.1789-0.14560.108-0.2956-0.0626-0.19970.00020.32790.07140.00460.427-0.11420.513144.229363.1892121.2301
1800.35820.4818-0.11050.5569-0.0560.05820.1120.02540.1769-0.0262-0.0886-0.1264-0.1381-0.0883-00.2550.0682-0.02450.3397-0.0660.329327.739477.9987135.0782
1810.11870.18090.01880.28350.09330.0529-0.01820.1986-0.2374-0.23430.1418-0.12640.00220.1249-0.00550.24730.05550.04660.3724-0.10160.454550.588669.8971122.4058
1820.03570.1351-0.0990.5035-0.02580.20920.0204-0.11720.0214-0.29950.1141-0.0855-0.00320.07270.02080.23830.08070.02310.3073-0.10670.455541.827572.3308132.9663
1830.070.07290.05280.04870.11480.29740.07740.04010.0195-0.04750.0485-0.420.15180.2525-0.00010.26390.0899-0.03290.3273-0.05470.362424.531352.1648127.8055
1840.1695-0.2569-0.17290.34320.23290.476-0.02420.0186-0.17360.10680.0785-0.14170.11180.10300.22640.0667-0.07540.302-0.05820.358337.720465.5665142.9101
1850.04510.0563-0.00060.05050.00380.275-0.16590.34990.1008-0.3206-0.1218-0.4736-0.21130.3323-0.00110.38250.02970.04210.3947-0.07890.530456.207784.7008120.4038
1860.17540.11260.04190.7503-0.05470.4290.0344-0.0794-0.10590.13060.0328-0.10340.0016-0.03760.00390.20490.0647-0.04740.3043-0.06370.286135.269668.8085143.2584
1870.0059-0.0391-0.0730.0516-0.00810.13160.05170.2903-0.363-0.4794-0.0598-0.00820.14330.11570.00030.30720.0561-0.05730.3493-0.12150.380134.74460.0259127.3324
1880.20710.16670.040.12660.10080.11950.2766-0.07840.7422-0.20920.0438-0.0018-0.45130.4154-0.01610.36940.04060.14010.3981-0.09820.439437.072279.056989.5476
1890.08030.11140.05260.1150.05160.0310.04340.05960.06740.16790.02030.02640.05580.0406-0.00020.44840.01460.08920.4032-0.04480.578946.641984.071989.0862
1900.16160.0280.00440.0797-0.15160.1946-0.02030.0090.2003-0.2030.01970.0947-0.1478-0.1603-00.35530.0416-0.00210.3924-0.06630.387321.743377.381685.7983
1910.0683-0.00730.06930.05220.0160.0495-0.1699-0.1528-0.0057-0.01370.1419-0.2073-0.00080.020900.29320.040.13110.3644-0.05320.418648.055674.80584.7329
1920.0180.01720.02490.02080.00720.0890.2330.4729-0.2357-0.2443-0.1396-0.4115-0.1549-0.33490.00020.35730.01810.01090.3985-0.03660.404350.651877.322497.7921
1930.0720.04170.06240.03690.00820.08550.05050.2275-0.1454-0.0371-0.33680.1270.0367-0.0721-00.29350.05290.05840.4038-0.03520.428838.343672.261992.8697
1940.09950.032-0.04280.0343-0.00260.0043-0.14360.10830.12-0.01420.1615-0.21660.0357-0.08360.00130.47570.02090.11190.4973-0.0110.365141.065589.062666.208
1950.49960.0121-0.14920.23770.21950.61580.0650.1651-0.005-0.0973-0.0919-0.2278-0.03610.0108-0.01610.31110.0690.05880.3684-0.07830.228734.683672.99273.1512
19600.04360.03960.08730.10480.07890.1297-0.16270.20780.31360.0906-0.2070.07360.08520.00040.3150.05920.05190.3612-0.07310.419849.16168.8389105.2908
1970.48230.1846-0.05830.0619-0.00320.5105-0.01680.1796-0.0565-0.1532-0.0418-0.09220.0253-0.052900.29080.07060.03580.3605-0.09050.28831.066169.511475.7423
1980.02060.0352-0.0370.03870.02710.01520.16520.1290.16010.30520.1066-0.3225-0.18770.57010.00030.45760.00010.10050.5151-0.05430.491242.495884.223777.3339
1990.0394-0.0342-0.04290.02330.05670.14920.03110.0709-0.0332-0.19160.0190.0853-0.01050.2185-00.42010.0958-0.03910.34210.00510.3715-33.8772148.0611121.1922
2000.0616-0.05380.04210.05290.04690.0979-0.08030.16560.1978-0.15790.3166-0.21730.04520.5301-0.00060.68030.1563-0.02850.732-0.10510.5506-35.2723136.2988112.4609
2010.22240.1465-0.30910.3511-0.2160.35810.0443-0.06010.1236-0.0366-0.072-0.0032-0.2310.0638-00.4060.0764-0.02340.3501-0.05880.3592-24.8837147.0503121.0166
2020.1050.0715-0.01920.0461-0.01410.0320.09990.0275-0.2871-0.37170.17980.3531-0.03840.12340.01250.41260.1051-0.03850.379-0.0080.3399-27.8645142.0284121.3646
2030.07750.0909-0.1170.0711-0.09770.06550.04190.0244-0.0859-0.615-0.12620.099-0.085-0.2395-0.00020.43050.0818-0.09310.3628-0.02650.4755-47.6448145.1623118.114
2040.1720.03180.20770.0140.00180.2011-0.046-0.04270.0980.28730.1207-0.0645-0.0623-0.1193-0.00010.37280.0947-0.04330.30860.01690.4102-35.0045148.4464124.3248
2050.1219-0.0096-0.0737-0.00650.0160.12410.03160.053-0.0581-0.03150.1010.2186-0.2125-0.4255-0.00010.53030.1107-0.02820.33880.0210.413-22.7386160.6562102.9591
2060.6691-0.31520.37230.1399-0.14270.31660.04280.08230.1703-0.0169-0.05990.088-0.1172-0.04230.00010.40590.06410.00950.2702-0.02320.3953-27.4581159.6761126.394
2070.0220.0295-0.02820.02210.0026-0.0001-0.0360.1595-0.25220.2136-0.13860.35320.5071-0.2161-0.00020.46750.0053-0.04060.4311-0.09120.4627-51.5146134.0797127.2444
2080.1867-0.20280.05570.5374-0.03310.34380.05380.09380.1381-0.0362-0.03970.0074-0.17180.03480.00010.35220.0692-0.00350.2725-0.03550.3465-25.2143156.5393127.9458
2090.06690.01270.06270.01520.00850.03640.26050.33180.2374-0.1807-0.0760.37330.0253-0.042-0.00030.62160.1055-0.07050.3750.04870.4763-31.7411154.3464110.7214
2100.03750.044-0.05950.0745-0.0790.10410.1447-0.1961-0.0895-0.099-0.13710.19470.34240.024-0.00080.39650.0511-0.13190.4439-0.02050.4032-48.4377119.297589.4288
2110.32260.0291-0.05780.12870.00540.13580.0236-0.2913-0.07740.4648-0.40250.09920.2975-0.0092-0.01960.7340.0253-0.03990.98890.21990.9882-39.1874115.6194103.7414
2120.00560.02110.01520.03330.01430.02680.0183-0.0057-0.1801-0.0205-0.068-0.048-0.45080.0584-0.00020.55330.1106-0.14150.4585-0.07080.5948-57.1817116.111100.1671
2130.21320.3591-0.01170.53730.05720.23870.0803-0.0612-0.1976-0.1775-0.12860.0503-0.0952-0.04370.00010.42570.1198-0.14560.3594-0.03050.3401-41.2139116.458287.1444
2140.01910.03640.0280.03330.04080.0607-0.1354-0.0974-0.01530.23220.08440.2258-0.272-0.243100.52430.1201-0.14810.4905-0.12090.5089-56.3461125.5684101.4422
2150.26680.2704-0.30170.3328-0.12430.42610.19260.2720.21450.1104-0.13890.20730.04890.10710.07640.40750.0987-0.17160.3794-0.0590.44-48.651122.374888.0311
2160.07330.1881-0.08160.4334-0.24640.2111-0.09840.0970.1747-0.06720.01540.4585-0.2816-0.50270.0160.36650.1011-0.20510.4542-0.09050.4213-53.42594.699784.1515
2170.16190.0637-0.17860.4303-0.0470.28790.1640.1429-0.0563-0.1211-0.17920.6296-0.0649-0.03540.63010.47480.1946-0.34610.4372-0.03280.3013-48.8215116.986175.9256
2180.1358-0.052-0.0540.03460.06590.1454-0.1041-0.09210.24020.1908-0.1287-0.0601-0.5338-0.0801-0.00370.51080.124-0.12410.4293-0.01770.4558-52.5413137.1371102.3524
2191.03280.2414-0.03030.58040.00810.2481-0.110.1595-0.0691-0.1761-0.07530.1716-0.0757-0.0755-0.35870.40870.1424-0.20440.3826-0.00880.2713-44.385117.038775.0687
2200.02910.0032-0.0379-0.0070.00120.0675-0.0516-0.3503-0.0070.1377-0.14570.116-0.2333-0.4911-0.00040.5140.0631-0.14520.4715-0.02060.5956-53.5348107.97689.0064
2210.05720.03470.06030.06660.08670.10530.1019-0.1893-0.0053-0.2956-0.220.0352-0.14690.20290.00010.61220.0879-0.12180.41080.05890.3998-29.3672137.041578.4513
2220.08480.0389-0.01980.0661-0.05960.0528-0.1182-0.4272-0.4816-0.1987-0.266-0.3106-0.08910.2962-0.00590.66580.0375-0.01340.87910.14370.6899-16.0919130.511377.5004
2230.08120.19390.13270.47140.30390.21070.13530.03520.0029-0.1181-0.1850.106-0.03890.06010.00010.49570.1359-0.10150.4687-0.00330.3809-28.0985137.352386.1195
2240.0214-0.0399-0.03030.07560.04620.0137-0.10820.1098-0.1993-0.1920.0029-0.46850.20770.1530.00050.57850.0701-0.12410.4140.02530.4591-26.6388131.55985.178
225-0.00360.04470.03580.14660.08710.0389-0.05050.4480.2205-0.45940.0124-0.2887-0.37840.08620.00120.71330.1414-0.05520.54710.05920.3823-26.2542136.441664.6767
2260.0182-0.0032-0.01730.0353-0.01530.0213-0.1123-0.16220.1425-0.32060.36730.0608-0.1592-0.26670.00020.54980.0895-0.12370.40360.02480.3294-30.4782128.98975.9423
2270.24220.1171-0.11680.0194-0.07580.16650.12860.30660.3898-0.1782-0.10530.1482-0.05650.16340.02260.57630.1454-0.03830.40610.03170.3615-24.6957153.027584.51
2280.5594-0.10780.11610.1006-0.13210.07830.03340.11340.1247-0.1682-0.05420.1277-0.1680.01620.00290.50040.1164-0.090.32210.04470.3778-33.3472149.877386.0316
2291.4040.4915-0.40790.6162-0.24710.1469-0.04680.3518-0.4045-0.649-0.2097-0.2374-0.0325-0.1587-0.09920.6730.1204-0.15480.5558-0.00810.3833-29.3717121.827361.2603
2300.3203-0.01790.01110.59720.04270.25850.07470.10450.0873-0.0957-0.0330.1776-0.15440.050.04730.49060.1228-0.10990.39440.02350.3255-39.0903142.414887.3262
2310.0144-0.0262-0.01610.0304-0.01350.019-0.01790.06250.2968-0.1438-0.2488-0.7664-0.4415-0.10520.00060.6070.0118-0.01230.47340.1090.5536-23.079148.281279.7763
2320.0964-0.12580.05550.1835-0.02050.07080.12690.0402-0.46380.1818-0.2599-0.28180.3451-0.042-0.00770.69370.05510.03360.57610.04140.36957.5999123.834666.1923
2330.00620.0079-0.01540.02990.03410.0488-0.1198-0.0532-0.0138-0.2441-0.1876-0.16870.1397-0.06580.00110.80540.14570.02820.63730.02030.36384.1296117.96457.6879
2340.1339-0.14440.04270.12270.00750.06240.0529-0.24750.0103-0.1062-0.1113-0.3450.07450.125500.560.02810.06830.43740.03760.401820.5082126.897777.619
2350.08080.03050.02880.08980.03840.02320.24160.1495-0.0532-0.2235-0.1486-0.06730.1186-0.49620.00070.68910.05680.05490.47060.06770.366110.4495124.683770.233
2360.0665-0.08040.01160.0404-0.02460.00550.0333-0.0209-0.0507-0.7866-0.04750.19490.14590.0236-0.00020.78240.07920.01260.61720.07330.4007-0.3025126.345753.0227
2370.13490.15560.04570.19150.05720.01530.24990.039-0.0464-0.1069-0.12460.0331-0.34910.009-0.00010.65820.11590.12460.54730.02730.30217.964130.878362.8213
2380.107-0.00350.04130.1319-0.08320.08210.17260.17480.1765-0.6438-0.1018-0.0872-0.23440.14490.0030.70570.08230.16160.640.06090.33127.3189107.575154.8689
2390.4109-0.48660.06320.7692-0.11740.0340.22760.4814-0.1453-0.6191-0.19090.28-0.12510.14950.19790.5570.06780.34380.45330.1443-0.007423.6067127.998760.6141
2400.0680.08050.01250.05830.01880.0426-0.04210.28970.2733-0.11390.19480.64310.12970.21530.00060.64720.1127-0.01630.63160.0660.4333-10.6185134.644559.5308
2410.1056-0.1701-0.24120.58830.37560.4670.09980.06470.0195-0.22630.0309-0.1725-0.0780.1280.01810.61650.0080.1620.43890.10840.342824.0833131.951564.3854
2420.0185-0.0002-0.01790.02260.02480.0292-0.05230.6081-0.5226-0.2621-0.08480.2510.0413-0.0139-00.75880.08540.08490.6129-0.07060.396716.4784116.96157.8897
2430.111-0.0639-0.11190.08340.14020.20230.2566-0.08580.22630.4693-0.01240.3395-0.3374-0.2190.00580.6829-0.01370.1490.3720.10380.401814.1523144.401784.3083
2440.05130.0080.04810.0159-0.01590.0347-0.03050.2837-0.15810.0431-0-0.0372-0.0592-0.077400.7732-0.05490.17280.49080.05090.583418.719152.990789.4792
2450.4325-0.3136-0.04370.21970.0468-0.00710.2233-0.0592-0.1792-0.0984-0.08820.1629-0.2335-0.16230.03460.55760.05710.04230.41360.04340.276-0.4882136.582179.0018
2460.0204-0.05160.01860.14860.01560.11150.316-0.28090.3411-0.0578-0.1404-0.1009-0.2249-0.154-0.00410.6228-0.01850.10630.44860.04720.41169.8357138.928483.4463
2470.0862-0.00820.11330.00760.03190.1037-0.02970.16320.1121-0.09680.119-0.2866-0.32140.3955-00.6671-0.01060.17080.48240.05740.541925.8685153.882482.3899
2480.09260.03390.14330.03820.0630.1244-0.0307-0.1245-0.0812-0.49540.1646-0.1753-0.12920.16780.00010.67250.02230.14380.43640.06460.451416.9738145.717877.0993
2490.24790.09690.04220.01140.01740.1047-0.014-0.15130.2276-0.2624-0.17750.0287-0.53210.2170.00070.65360.04620.03610.37510.08830.462-4.0252164.815190.4298
2500.09690.1419-0.0440.32140.09780.30960.12320.09010.1997-0.2733-0.03440.0468-0.1498-0.06780.0120.5870.07180.07420.36120.12250.30751.9594153.064174.0055
2510.0525-0.009-0.022-0.0106-0.00790.01270.10380.1718-0.0116-0.169-0.12-0.11570.22790.2741-0.00030.64920.02950.15610.53060.04540.51935.6468142.766878.7684
2520.3599-0.1813-0.23740.63080.07690.12340.08520.01640.1719-0.1788-0.1015-0.055-0.171-0.0205-0.00720.63390.06290.08890.41760.13190.26352.2798148.253271.0028
2530.0399-0.00960.07080.0128-0.02090.0595-0.0748-0.02350.04420.3569-0.0069-0.1255-0.18010.27180.00010.759-0.01240.0950.49070.00090.48757.4675157.53886.3489
2540.03730.04540.02790.18130.0840.05220.14190.08110.07360.077-0.1372-0.084-0.208-0.07580.00020.30730.01680.00030.3164-0.06550.3464-51.0663107.8309133.0724
2550.2233-0.0232-0.10810.01180.01260.0083-0.17840.0089-0.2775-0.11850.172-0.646-0.0588-0.02890.00390.55630.0234-0.07050.5278-0.14370.8106-42.4523118.1835127.3194
2560.2596-0.06940.34780.11090.03330.5639-0.04090.05650.11270.18750.0104-0.04790.0662-0.0769-00.2728-0.0137-0.02510.2919-0.03350.4046-43.7851102.7845134.8329
2570.0179-0.05890.00990.0602-0.02190.0690.30990.1430.1103-0.231-0.1937-0.0837-0.4289-0.0666-00.3335-0.0003-0.01920.3826-0.07840.4731-43.5581105.5544129.6032
2580.02230.05510.03060.0685-0.04780.11410.10930.0060.2629-0.0568-0.03110.3822-0.11430.0817-0.00010.40040.0702-0.03050.4103-0.03830.4596-58.6053119.2176128.3881
2590.0237-0.0507-0.04340.370.04880.0228-0.0590.0452-0.1281-0.0828-0.03130.2188-0.0468-0.1668-00.28470.05370.00020.386-0.07860.3716-53.452106.015131.5214
2600.12570.05280.17490.26460.04050.1272-0.0880.027-0.02560.05210.01330.2395-0.08430.0379-0.00010.28860.02250.06070.3063-0.04270.3433-41.3965111.5239155.0275
2610.4315-0.13190.04760.73030.19750.0862-0.0288-0.0250.01960.0493-0.03120.2015-0.0519-0.0423-0.00020.238-0.00660.02990.2954-0.0420.3705-55.022697.6597140.6789
2620.01930.0236-0.01690.0522-0.03210.0272-0.06860.0410.4066-0.29320.22190.2848-0.0212-0.00220.00010.45930.023-0.11730.4273-0.06430.4771-58.7473118.0825112.9655
2630.30510.1223-0.22810.27760.18660.47430.0043-0.0605-0.09090.0267-0.06380.15390.0142-0.1226-0.00120.24010.00570.00320.2971-0.0710.3728-52.023395.7019138.7846
2640.25560.33790.2490.48580.11951.78050.03130.1540.4776-0.26870.23950.1547-0.67490.25580.08160.30680.0260.00410.2498-0.1520.3496-48.3929112.6845144.3365
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1(chain A and resid 4:24)A4 - 24
2X-RAY DIFFRACTION2(chain A and resid 25:47)A25 - 47
3X-RAY DIFFRACTION3(chain A and resid 48:75)A48 - 75
4X-RAY DIFFRACTION4(chain A and resid 76:82)A76 - 82
5X-RAY DIFFRACTION5(chain A and resid 83:105)A83 - 105
6X-RAY DIFFRACTION6(chain A and resid 106:128)A106 - 128
7X-RAY DIFFRACTION7(chain A and resid 129:157)A129 - 157
8X-RAY DIFFRACTION8(chain A and resid 158:211)A158 - 211
9X-RAY DIFFRACTION9(chain A and resid 212:232)A212 - 232
10X-RAY DIFFRACTION10(chain A and resid 233:299)A233 - 299
11X-RAY DIFFRACTION11(chain A and resid 300:313)A300 - 313
12X-RAY DIFFRACTION12(chain B and resid 4:18)B4 - 18
13X-RAY DIFFRACTION13(chain B and resid 19:28)B19 - 28
14X-RAY DIFFRACTION14(chain B and resid 29:41)B29 - 41
15X-RAY DIFFRACTION15(chain B and resid 42:88)B42 - 88
16X-RAY DIFFRACTION16(chain B and resid 89:105)B89 - 105
17X-RAY DIFFRACTION17(chain B and resid 106:125)B106 - 125
18X-RAY DIFFRACTION18(chain B and resid 126:147)B126 - 147
19X-RAY DIFFRACTION19(chain B and resid 148:211)B148 - 211
20X-RAY DIFFRACTION20(chain B and resid 212:232)B212 - 232
21X-RAY DIFFRACTION21(chain B and resid 233:299)B233 - 299
22X-RAY DIFFRACTION22(chain B and resid 300:313)B300 - 313
23X-RAY DIFFRACTION23(chain C and resid 4:24)C4 - 24
24X-RAY DIFFRACTION24(chain C and resid 25:47)C25 - 47
25X-RAY DIFFRACTION25(chain C and resid 48:68)C48 - 68
26X-RAY DIFFRACTION26(chain C and resid 69:79)C69 - 79
27X-RAY DIFFRACTION27(chain C and resid 80:105)C80 - 105
28X-RAY DIFFRACTION28(chain C and resid 106:125)C106 - 125
29X-RAY DIFFRACTION29(chain C and resid 126:160)C126 - 160
30X-RAY DIFFRACTION30(chain C and resid 161:213)C161 - 213
31X-RAY DIFFRACTION31(chain C and resid 214:232)C214 - 232
32X-RAY DIFFRACTION32(chain C and resid 233:299)C233 - 299
33X-RAY DIFFRACTION33(chain C and resid 300:313)C300 - 313
34X-RAY DIFFRACTION34(chain D and resid 4:24)D4 - 24
35X-RAY DIFFRACTION35(chain D and resid 25:42)D25 - 42
36X-RAY DIFFRACTION36(chain D and resid 43:86)D43 - 86
37X-RAY DIFFRACTION37(chain D and resid 87:105)D87 - 105
38X-RAY DIFFRACTION38(chain D and resid 106:117)D106 - 117
39X-RAY DIFFRACTION39(chain D and resid 118:136)D118 - 136
40X-RAY DIFFRACTION40(chain D and resid 137:147)D137 - 147
41X-RAY DIFFRACTION41(chain D and resid 148:211)D148 - 211
42X-RAY DIFFRACTION42(chain D and resid 212:232)D212 - 232
43X-RAY DIFFRACTION43(chain D and resid 233:299)D233 - 299
44X-RAY DIFFRACTION44(chain D and resid 300:313)D300 - 313
45X-RAY DIFFRACTION45(chain E and resid 4:18)E4 - 18
46X-RAY DIFFRACTION46(chain E and resid 19:36)E19 - 36
47X-RAY DIFFRACTION47(chain E and resid 37:68)E37 - 68
48X-RAY DIFFRACTION48(chain E and resid 69:79)E69 - 79
49X-RAY DIFFRACTION49(chain E and resid 80:105)E80 - 105
50X-RAY DIFFRACTION50(chain E and resid 106:122)E106 - 122
51X-RAY DIFFRACTION51(chain E and resid 123:147)E123 - 147
52X-RAY DIFFRACTION52(chain E and resid 148:212)E148 - 212
53X-RAY DIFFRACTION53(chain E and resid 213:230)E213 - 230
54X-RAY DIFFRACTION54(chain E and resid 231:300)E231 - 300
55X-RAY DIFFRACTION55(chain E and resid 301:313)E301 - 313
56X-RAY DIFFRACTION56(chain F and resid 4:20)F4 - 20
57X-RAY DIFFRACTION57(chain F and resid 21:40)F21 - 40
58X-RAY DIFFRACTION58(chain F and resid 41:88)F41 - 88
59X-RAY DIFFRACTION59(chain F and resid 89:105)F89 - 105
60X-RAY DIFFRACTION60(chain F and resid 106:119)F106 - 119
61X-RAY DIFFRACTION61(chain F and resid 120:147)F120 - 147
62X-RAY DIFFRACTION62(chain F and resid 148:211)F148 - 211
63X-RAY DIFFRACTION63(chain F and resid 212:232)F212 - 232
64X-RAY DIFFRACTION64(chain F and resid 233:295)F233 - 295
65X-RAY DIFFRACTION65(chain F and resid 296:309)F296 - 309
66X-RAY DIFFRACTION66(chain F and resid 310:313)F310 - 313
67X-RAY DIFFRACTION67(chain G and resid 4:18)G4 - 18
68X-RAY DIFFRACTION68(chain G and resid 19:35)G19 - 35
69X-RAY DIFFRACTION69(chain G and resid 36:77)G36 - 77
70X-RAY DIFFRACTION70(chain G and resid 78:88)G78 - 88
71X-RAY DIFFRACTION71(chain G and resid 89:105)G89 - 105
72X-RAY DIFFRACTION72(chain G and resid 106:127)G106 - 127
73X-RAY DIFFRACTION73(chain G and resid 128:157)G128 - 157
74X-RAY DIFFRACTION74(chain G and resid 158:211)G158 - 211
75X-RAY DIFFRACTION75(chain G and resid 212:230)G212 - 230
76X-RAY DIFFRACTION76(chain G and resid 231:299)G231 - 299
77X-RAY DIFFRACTION77(chain G and resid 300:313)G300 - 313
78X-RAY DIFFRACTION78(chain H and resid 4:23)H4 - 23
79X-RAY DIFFRACTION79(chain H and resid 24:39)H24 - 39
80X-RAY DIFFRACTION80(chain H and resid 40:68)H40 - 68
81X-RAY DIFFRACTION81(chain H and resid 69:79)H69 - 79
82X-RAY DIFFRACTION82(chain H and resid 80:105)H80 - 105
83X-RAY DIFFRACTION83(chain H and resid 106:126)H106 - 126
84X-RAY DIFFRACTION84(chain H and resid 127:159)H127 - 159
85X-RAY DIFFRACTION85(chain H and resid 160:211)H160 - 211
86X-RAY DIFFRACTION86(chain H and resid 212:232)H212 - 232
87X-RAY DIFFRACTION87(chain H and resid 233:299)H233 - 299
88X-RAY DIFFRACTION88(chain H and resid 300:313)H300 - 313
89X-RAY DIFFRACTION89(chain I and resid 4:24)I4 - 24
90X-RAY DIFFRACTION90(chain I and resid 25:47)I25 - 47
91X-RAY DIFFRACTION91(chain I and resid 48:68)I48 - 68
92X-RAY DIFFRACTION92(chain I and resid 69:79)I69 - 79
93X-RAY DIFFRACTION93(chain I and resid 80:105)I80 - 105
94X-RAY DIFFRACTION94(chain I and resid 106:122)I106 - 122
95X-RAY DIFFRACTION95(chain I and resid 123:147)I123 - 147
96X-RAY DIFFRACTION96(chain I and resid 148:211)I148 - 211
97X-RAY DIFFRACTION97(chain I and resid 212:233)I212 - 233
98X-RAY DIFFRACTION98(chain I and resid 234:299)I234 - 299
99X-RAY DIFFRACTION99(chain I and resid 300:313)I300 - 313
100X-RAY DIFFRACTION100(chain J and resid 4:17)J4 - 17
101X-RAY DIFFRACTION101(chain J and resid 18:28)J18 - 28
102X-RAY DIFFRACTION102(chain J and resid 29:41)J29 - 41
103X-RAY DIFFRACTION103(chain J and resid 42:89)J42 - 89
104X-RAY DIFFRACTION104(chain J and resid 90:105)J90 - 105
105X-RAY DIFFRACTION105(chain J and resid 106:126)J106 - 126
106X-RAY DIFFRACTION106(chain J and resid 127:147)J127 - 147
107X-RAY DIFFRACTION107(chain J and resid 148:211)J148 - 211
108X-RAY DIFFRACTION108(chain J and resid 212:233)J212 - 233
109X-RAY DIFFRACTION109(chain J and resid 234:299)J234 - 299
110X-RAY DIFFRACTION110(chain J and resid 300:313)J300 - 313
111X-RAY DIFFRACTION111(chain K and resid 4:17)K4 - 17
112X-RAY DIFFRACTION112(chain K and resid 18:36)K18 - 36
113X-RAY DIFFRACTION113(chain K and resid 37:68)K37 - 68
114X-RAY DIFFRACTION114(chain K and resid 69:79)K69 - 79
115X-RAY DIFFRACTION115(chain K and resid 80:105)K80 - 105
116X-RAY DIFFRACTION116(chain K and resid 106:124)K106 - 124
117X-RAY DIFFRACTION117(chain K and resid 125:147)K125 - 147
118X-RAY DIFFRACTION118(chain K and resid 148:211)K148 - 211
119X-RAY DIFFRACTION119(chain K and resid 212:232)K212 - 232
120X-RAY DIFFRACTION120(chain K and resid 233:299)K233 - 299
121X-RAY DIFFRACTION121(chain K and resid 300:313)K300 - 313
122X-RAY DIFFRACTION122(chain L and resid 4:16)L4 - 16
123X-RAY DIFFRACTION123(chain L and resid 17:37)L17 - 37
124X-RAY DIFFRACTION124(chain L and resid 38:68)L38 - 68
125X-RAY DIFFRACTION125(chain L and resid 69:81)L69 - 81
126X-RAY DIFFRACTION126(chain L and resid 82:105)L82 - 105
127X-RAY DIFFRACTION127(chain L and resid 106:117)L106 - 117
128X-RAY DIFFRACTION128(chain L and resid 118:136)L118 - 136
129X-RAY DIFFRACTION129(chain L and resid 137:211)L137 - 211
130X-RAY DIFFRACTION130(chain L and resid 212:232)L212 - 232
131X-RAY DIFFRACTION131(chain L and resid 233:299)L233 - 299
132X-RAY DIFFRACTION132(chain L and resid 300:313)L300 - 313
133X-RAY DIFFRACTION133(chain M and resid 4:18)M4 - 18
134X-RAY DIFFRACTION134(chain M and resid 19:36)M19 - 36
135X-RAY DIFFRACTION135(chain M and resid 37:68)M37 - 68
136X-RAY DIFFRACTION136(chain M and resid 69:79)M69 - 79
137X-RAY DIFFRACTION137(chain M and resid 80:105)M80 - 105
138X-RAY DIFFRACTION138(chain M and resid 106:122)M106 - 122
139X-RAY DIFFRACTION139(chain M and resid 123:147)M123 - 147
140X-RAY DIFFRACTION140(chain M and resid 148:211)M148 - 211
141X-RAY DIFFRACTION141(chain M and resid 212:232)M212 - 232
142X-RAY DIFFRACTION142(chain M and resid 233:299)M233 - 299
143X-RAY DIFFRACTION143(chain M and resid 300:313)M300 - 313
144X-RAY DIFFRACTION144(chain N and resid 4:24)N4 - 24
145X-RAY DIFFRACTION145(chain N and resid 25:38)N25 - 38
146X-RAY DIFFRACTION146(chain N and resid 39:90)N39 - 90
147X-RAY DIFFRACTION147(chain N and resid 91:105)N91 - 105
148X-RAY DIFFRACTION148(chain N and resid 106:117)N106 - 117
149X-RAY DIFFRACTION149(chain N and resid 118:134)N118 - 134
150X-RAY DIFFRACTION150(chain N and resid 135:149)N135 - 149
151X-RAY DIFFRACTION151(chain N and resid 150:211)N150 - 211
152X-RAY DIFFRACTION152(chain N and resid 212:232)N212 - 232
153X-RAY DIFFRACTION153(chain N and resid 233:299)N233 - 299
154X-RAY DIFFRACTION154(chain N and resid 300:313)N300 - 313
155X-RAY DIFFRACTION155(chain O and resid 5:18)O5 - 18
156X-RAY DIFFRACTION156(chain O and resid 19:36)O19 - 36
157X-RAY DIFFRACTION157(chain O and resid 37:67)O37 - 67
158X-RAY DIFFRACTION158(chain O and resid 68:79)O68 - 79
159X-RAY DIFFRACTION159(chain O and resid 80:105)O80 - 105
160X-RAY DIFFRACTION160(chain O and resid 106:122)O106 - 122
161X-RAY DIFFRACTION161(chain O and resid 123:147)O123 - 147
162X-RAY DIFFRACTION162(chain O and resid 148:211)O148 - 211
163X-RAY DIFFRACTION163(chain O and resid 212:232)O212 - 232
164X-RAY DIFFRACTION164(chain O and resid 233:299)O233 - 299
165X-RAY DIFFRACTION165(chain O and resid 300:313)O300 - 313
166X-RAY DIFFRACTION166(chain P and resid 4:24)P4 - 24
167X-RAY DIFFRACTION167(chain P and resid 25:38)P25 - 38
168X-RAY DIFFRACTION168(chain P and resid 39:89)P39 - 89
169X-RAY DIFFRACTION169(chain P and resid 90:105)P90 - 105
170X-RAY DIFFRACTION170(chain P and resid 106:118)P106 - 118
171X-RAY DIFFRACTION171(chain P and resid 119:136)P119 - 136
172X-RAY DIFFRACTION172(chain P and resid 137:157)P137 - 157
173X-RAY DIFFRACTION173(chain P and resid 158:210)P158 - 210
174X-RAY DIFFRACTION174(chain P and resid 211:232)P211 - 232
175X-RAY DIFFRACTION175(chain P and resid 233:300)P233 - 300
176X-RAY DIFFRACTION176(chain P and resid 301:313)P301 - 313
177X-RAY DIFFRACTION177(chain Q and resid 4:18)Q4 - 18
178X-RAY DIFFRACTION178(chain Q and resid 19:33)Q19 - 33
179X-RAY DIFFRACTION179(chain Q and resid 34:46)Q34 - 46
180X-RAY DIFFRACTION180(chain Q and resid 47:79)Q47 - 79
181X-RAY DIFFRACTION181(chain Q and resid 80:105)Q80 - 105
182X-RAY DIFFRACTION182(chain Q and resid 106:125)Q106 - 125
183X-RAY DIFFRACTION183(chain Q and resid 126:160)Q126 - 160
184X-RAY DIFFRACTION184(chain Q and resid 161:213)Q161 - 213
185X-RAY DIFFRACTION185(chain Q and resid 214:231)Q214 - 231
186X-RAY DIFFRACTION186(chain Q and resid 232:299)Q232 - 299
187X-RAY DIFFRACTION187(chain Q and resid 300:313)Q300 - 313
188X-RAY DIFFRACTION188(chain R and resid 4:24)R4 - 24
189X-RAY DIFFRACTION189(chain R and resid 25:47)R25 - 47
190X-RAY DIFFRACTION190(chain R and resid 48:75)R48 - 75
191X-RAY DIFFRACTION191(chain R and resid 76:90)R76 - 90
192X-RAY DIFFRACTION192(chain R and resid 91:105)R91 - 105
193X-RAY DIFFRACTION193(chain R and resid 106:119)R106 - 119
194X-RAY DIFFRACTION194(chain R and resid 120:147)R120 - 147
195X-RAY DIFFRACTION195(chain R and resid 148:211)R148 - 211
196X-RAY DIFFRACTION196(chain R and resid 212:233)R212 - 233
197X-RAY DIFFRACTION197(chain R and resid 234:299)R234 - 299
198X-RAY DIFFRACTION198(chain R and resid 300:313)R300 - 313
199X-RAY DIFFRACTION199(chain T and resid 4:18)T4 - 18
200X-RAY DIFFRACTION200(chain T and resid 19:36)T19 - 36
201X-RAY DIFFRACTION201(chain T and resid 37:68)T37 - 68
202X-RAY DIFFRACTION202(chain T and resid 69:81)T69 - 81
203X-RAY DIFFRACTION203(chain T and resid 82:105)T82 - 105
204X-RAY DIFFRACTION204(chain T and resid 106:125)T106 - 125
205X-RAY DIFFRACTION205(chain T and resid 126:159)T126 - 159
206X-RAY DIFFRACTION206(chain T and resid 160:211)T160 - 211
207X-RAY DIFFRACTION207(chain T and resid 212:232)T212 - 232
208X-RAY DIFFRACTION208(chain T and resid 233:299)T233 - 299
209X-RAY DIFFRACTION209(chain T and resid 300:313)T300 - 313
210X-RAY DIFFRACTION210(chain U and resid 4:18)U4 - 18
211X-RAY DIFFRACTION211(chain U and resid 19:28)U19 - 28
212X-RAY DIFFRACTION212(chain U and resid 29:42)U29 - 42
213X-RAY DIFFRACTION213(chain U and resid 43:86)U43 - 86
214X-RAY DIFFRACTION214(chain U and resid 87:105)U87 - 105
215X-RAY DIFFRACTION215(chain U and resid 106:125)U106 - 125
216X-RAY DIFFRACTION216(chain U and resid 126:157)U126 - 157
217X-RAY DIFFRACTION217(chain U and resid 158:211)U158 - 211
218X-RAY DIFFRACTION218(chain U and resid 212:236)U212 - 236
219X-RAY DIFFRACTION219(chain U and resid 237:299)U237 - 299
220X-RAY DIFFRACTION220(chain U and resid 300:313)U300 - 313
221X-RAY DIFFRACTION221(chain V and resid 4:18)V4 - 18
222X-RAY DIFFRACTION222(chain V and resid 19:34)V19 - 34
223X-RAY DIFFRACTION223(chain V and resid 35:68)V35 - 68
224X-RAY DIFFRACTION224(chain V and resid 69:80)V69 - 80
225X-RAY DIFFRACTION225(chain V and resid 81:105)V81 - 105
226X-RAY DIFFRACTION226(chain V and resid 106:118)V106 - 118
227X-RAY DIFFRACTION227(chain V and resid 119:136)V119 - 136
228X-RAY DIFFRACTION228(chain V and resid 137:211)V137 - 211
229X-RAY DIFFRACTION229(chain V and resid 212:232)V212 - 232
230X-RAY DIFFRACTION230(chain V and resid 233:299)V233 - 299
231X-RAY DIFFRACTION231(chain V and resid 300:313)V300 - 313
232X-RAY DIFFRACTION232(chain W and resid 4:24)W4 - 24
233X-RAY DIFFRACTION233(chain W and resid 25:47)W25 - 47
234X-RAY DIFFRACTION234(chain W and resid 48:68)W48 - 68
235X-RAY DIFFRACTION235(chain W and resid 69:81)W69 - 81
236X-RAY DIFFRACTION236(chain W and resid 82:105)W82 - 105
237X-RAY DIFFRACTION237(chain W and resid 106:122)W106 - 122
238X-RAY DIFFRACTION238(chain W and resid 123:147)W123 - 147
239X-RAY DIFFRACTION239(chain W and resid 148:213)W148 - 213
240X-RAY DIFFRACTION240(chain W and resid 214:233)W214 - 233
241X-RAY DIFFRACTION241(chain W and resid 234:298)W234 - 298
242X-RAY DIFFRACTION242(chain W and resid 299:313)W299 - 313
243X-RAY DIFFRACTION243(chain Y and resid 4:24)Y4 - 24
244X-RAY DIFFRACTION244(chain Y and resid 25:47)Y25 - 47
245X-RAY DIFFRACTION245(chain Y and resid 48:68)Y48 - 68
246X-RAY DIFFRACTION246(chain Y and resid 69:79)Y69 - 79
247X-RAY DIFFRACTION247(chain Y and resid 80:105)Y80 - 105
248X-RAY DIFFRACTION248(chain Y and resid 106:122)Y106 - 122
249X-RAY DIFFRACTION249(chain Y and resid 123:147)Y123 - 147
250X-RAY DIFFRACTION250(chain Y and resid 148:211)Y148 - 211
251X-RAY DIFFRACTION251(chain Y and resid 212:233)Y212 - 233
252X-RAY DIFFRACTION252(chain Y and resid 234:299)Y234 - 299
253X-RAY DIFFRACTION253(chain Y and resid 300:313)Y300 - 313
254X-RAY DIFFRACTION254(chain Z and resid 4:18)Z4 - 18
255X-RAY DIFFRACTION255(chain Z and resid 19:36)Z19 - 36
256X-RAY DIFFRACTION256(chain Z and resid 37:68)Z37 - 68
257X-RAY DIFFRACTION257(chain Z and resid 69:81)Z69 - 81
258X-RAY DIFFRACTION258(chain Z and resid 82:105)Z82 - 105
259X-RAY DIFFRACTION259(chain Z and resid 106:125)Z106 - 125
260X-RAY DIFFRACTION260(chain Z and resid 126:160)Z126 - 160
261X-RAY DIFFRACTION261(chain Z and resid 161:213)Z161 - 213
262X-RAY DIFFRACTION262(chain Z and resid 214:231)Z214 - 231
263X-RAY DIFFRACTION263(chain Z and resid 232:299)Z232 - 299
264X-RAY DIFFRACTION264(chain Z and resid 300:313)Z300 - 313

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