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Yorodumi- PDB-6i4g: Crystal Structure of Plasmodium falciparum actin I (H74Q) in the ... -
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-Basic information
Entry | Database: PDB / ID: 6i4g | ||||||||||||
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Title | Crystal Structure of Plasmodium falciparum actin I (H74Q) in the Mg-K-ATP state | ||||||||||||
Components |
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Keywords | CONTRACTILE PROTEIN / hydrolase / filamentous / glideosome / cytoskeleton | ||||||||||||
Function / homology | Function and homology information glial filament / plastid inheritance / schizogony / apical ectoplasmic specialization / basal ectoplasmic specialization / Platelet degranulation / Caspase-mediated cleavage of cytoskeletal proteins / actin polymerization-dependent cell-to-cell migration in host / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / striated muscle atrophy ...glial filament / plastid inheritance / schizogony / apical ectoplasmic specialization / basal ectoplasmic specialization / Platelet degranulation / Caspase-mediated cleavage of cytoskeletal proteins / actin polymerization-dependent cell-to-cell migration in host / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / striated muscle atrophy / regulation of establishment of T cell polarity / regulation of plasma membrane raft polarization / regulation of receptor clustering / renal protein absorption / positive regulation of keratinocyte apoptotic process / positive regulation of protein processing in phagocytic vesicle / positive regulation of actin nucleation / phosphatidylinositol 3-kinase catalytic subunit binding / Neutrophil degranulation / actin cap / sequestering of actin monomers / regulation of podosome assembly / myosin II binding / negative regulation of viral entry into host cell / actin filament severing / entry into host cell by a symbiont-containing vacuole / actin filament capping / barbed-end actin filament capping / actin filament depolymerization / actin polymerization or depolymerization / cell projection assembly / cardiac muscle cell contraction / podosome / sarcoplasm / positive regulation of p38MAPK cascade / relaxation of cardiac muscle / phagocytosis, engulfment / cortical actin cytoskeleton / positive regulation of cardiac muscle hypertrophy / hepatocyte apoptotic process / cilium assembly / phagocytic vesicle / cytoskeleton organization / vesicle-mediated transport / ruffle / cellular response to cadmium ion / phosphatidylinositol-4,5-bisphosphate binding / response to muscle stretch / actin filament polymerization / Neutrophil degranulation / central nervous system development / actin filament organization / actin filament / Hydrolases; Acting on acid anhydrides; Acting on acid anhydrides to facilitate cellular and subcellular movement / protein destabilization / structural constituent of cytoskeleton / cellular response to type II interferon / actin filament binding / actin cytoskeleton / lamellipodium / myelin sheath / actin binding / actin cytoskeleton organization / amyloid fibril formation / calcium ion binding / positive regulation of gene expression / perinuclear region of cytoplasm / ATP hydrolysis activity / protein-containing complex / extracellular space / extracellular region / ATP binding / nucleus / plasma membrane / cytosol / cytoplasm Similarity search - Function | ||||||||||||
Biological species | Plasmodium falciparum (malaria parasite P. falciparum) Mus musculus (house mouse) | ||||||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2 Å | ||||||||||||
Authors | Kumpula, E.-P. / Lopez, A.J. / Tajedin, L. / Han, H. / Kursula, I. | ||||||||||||
Funding support | Finland, Norway, 3items
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Citation | Journal: Plos Biol. / Year: 2019 Title: Atomic view into Plasmodium actin polymerization, ATP hydrolysis, and fragmentation. Authors: Kumpula, E.P. / Lopez, A.J. / Tajedin, L. / Han, H. / Kursula, I. | ||||||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6i4g.cif.gz | 687.3 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6i4g.ent.gz | 473.6 KB | Display | PDB format |
PDBx/mmJSON format | 6i4g.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/i4/6i4g ftp://data.pdbj.org/pub/pdb/validation_reports/i4/6i4g | HTTPS FTP |
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-Related structure data
Related structure data | 6i4dC 6i4eC 6i4fC 6i4hC 6i4iC 6i4jC 6i4kC 6i4lC 6i4mC 4cbuS C: citing same article (ref.) S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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