登録情報 | データベース: PDB / ID: 5vqm |
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タイトル | Clostridium difficile TcdB-GTD bound to PA41 Fab |
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要素 | - PA41 FAB HEAVY CHAIN
- PA41 FAB LIGHT CHAIN
- Toxin B
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キーワード | TOXIN/IMMUNE SYSTEM / toxin antibody / TOXIN-IMMUNE SYSTEM complex |
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機能・相同性 | 機能・相同性情報
host cell cytosol / glycosyltransferase activity / : / cysteine-type peptidase activity / immunoglobulin complex, circulating / immunoglobulin receptor binding / host cell endosome membrane / complement activation, classical pathway / antigen binding / toxin activity ...host cell cytosol / glycosyltransferase activity / : / cysteine-type peptidase activity / immunoglobulin complex, circulating / immunoglobulin receptor binding / host cell endosome membrane / complement activation, classical pathway / antigen binding / toxin activity / antibacterial humoral response / blood microparticle / immune response / lipid binding / host cell plasma membrane / extracellular space / extracellular exosome / extracellular region / metal ion binding / plasma membrane類似検索 - 分子機能 Arc Repressor Mutant, subunit A - #1780 / Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #1190 / TcdA/TcdB toxin, N-terminal helical domain / TcdB toxin N-terminal helical domain / TcdA/TcdB toxin, catalytic glycosyltransferase domain / TcdA/TcdB catalytic glycosyltransferase domain / Membrane Localization Domain / TcdA/TcdB toxin, pore forming domain / TcdA/TcdB pore forming domain / CGT/MARTX, cysteine protease (CPD) domain ...Arc Repressor Mutant, subunit A - #1780 / Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #1190 / TcdA/TcdB toxin, N-terminal helical domain / TcdB toxin N-terminal helical domain / TcdA/TcdB toxin, catalytic glycosyltransferase domain / TcdA/TcdB catalytic glycosyltransferase domain / Membrane Localization Domain / TcdA/TcdB toxin, pore forming domain / TcdA/TcdB pore forming domain / CGT/MARTX, cysteine protease (CPD) domain / CGT/MARTX, cysteine protease (CPD) domain superfamily / Peptidase C80 family / CGT/MARTX cysteine protease (CPD) domain profile. / Choline-binding repeat / Putative cell wall binding repeat / Cell wall/choline-binding repeat / Cell wall-binding repeat profile. / Nucleotide-diphospho-sugar transferases / Methane Monooxygenase Hydroxylase; Chain G, domain 1 / Immunoglobulin V-Type / Immunoglobulin V-set domain / Immunoglobulin V-set domain / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin subtype / Immunoglobulin / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Arc Repressor Mutant, subunit A / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Immunoglobulin-like fold / Up-down Bundle / Immunoglobulin-like / Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha類似検索 - ドメイン・相同性 Toxin B / Ig-like domain-containing protein / IgG H chain類似検索 - 構成要素 |
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生物種 | Peptoclostridium difficile (バクテリア)
Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.79 Å |
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データ登録者 | Kroh, H.K. / Spiller, B.W. / Lacy, D.B. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | AI095755 | 米国 |
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引用 | ジャーナル: J. Biol. Chem. / 年: 2018 タイトル: A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells. 著者: Kroh, H.K. / Chandrasekaran, R. / Zhang, Z. / Rosenthal, K. / Woods, R. / Jin, X. / Nyborg, A.C. / Rainey, G.J. / Warrener, P. / Melnyk, R.A. / Spiller, B.W. / Lacy, D.B. |
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履歴 | 登録 | 2017年5月9日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年12月6日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年1月31日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year |
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改定 1.2 | 2019年12月11日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.3 | 2023年10月4日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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