Entry | Database: PDB / ID: 5u1q |
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Title | Grb7-SH2 with bicyclic peptide inhibitor |
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Components | - Growth factor receptor-bound protein 7
- LYS-PHE-GLU-GLY-TYR-ASP-ASN-GLU-CST
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Keywords | SIGNALING PROTEIN/PEPTIDE INHIBITOR / Grb7 / SH2 domain / inhibitor / signalling / SIGNALING PROTEIN-PEPTIDE INHIBITOR complex |
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Function / homology | Function and homology information
GRB7 events in ERBB2 signaling / RND1 GTPase cycle / RET signaling / stress granule assembly / Tie2 Signaling / Downstream signal transduction / phosphatidylinositol binding / cell projection / epidermal growth factor receptor signaling pathway / Signaling by SCF-KIT ...GRB7 events in ERBB2 signaling / RND1 GTPase cycle / RET signaling / stress granule assembly / Tie2 Signaling / Downstream signal transduction / phosphatidylinositol binding / cell projection / epidermal growth factor receptor signaling pathway / Signaling by SCF-KIT / cytoplasmic stress granule / negative regulation of translation / positive regulation of cell migration / focal adhesion / protein kinase binding / RNA binding / identical protein binding / plasma membrane / cytosolSimilarity search - Function Growth factor receptor-bound protein 7 / : / BPS (Between PH and SH2) domain / BPS (Between PH and SH2) / GRB/APBB1IP / APBB1IP, PH domain / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain profile. / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain ...Growth factor receptor-bound protein 7 / : / BPS (Between PH and SH2) domain / BPS (Between PH and SH2) / GRB/APBB1IP / APBB1IP, PH domain / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain profile. / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain / SH2 domain / SHC Adaptor Protein / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / SH2 domain superfamily / PH-like domain superfamily / Ubiquitin-like domain superfamily / 2-Layer Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) synthetic construct (others) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / Resolution: 2.1 Å |
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Authors | Watson, G.M. / Wilce, M.C.J. / Wilce, J.A. |
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Funding support | Australia, 1items Organization | Grant number | Country |
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National Health and Medical Research Council (NHMRC, Australia) | | Australia |
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Citation | Journal: J. Med. Chem. / Year: 2017 Title: Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target. Authors: Watson, G.M. / Kulkarni, K. / Sang, J. / Ma, X. / Gunzburg, M.J. / Perlmutter, P. / Wilce, M.C.J. / Wilce, J.A. |
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History | Deposition | Nov 28, 2016 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Nov 15, 2017 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jan 9, 2019 | Group: Data collection / Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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Revision 1.2 | Jan 8, 2020 | Group: Author supporting evidence / Derived calculations / Category: pdbx_audit_support / struct_conn Item: _pdbx_audit_support.funding_organization / _struct_conn.pdbx_leaving_atom_flag |
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