登録情報 | データベース: PDB / ID: 5loh |
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タイトル | Kinase domain of human Greatwall |
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要素 | Serine/threonine-protein kinase greatwall,Serine/threonine-protein kinase greatwall |
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キーワード | TRANSFERASE / Kinase domain / Inhibitor |
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機能・相同性 | 機能・相同性情報
protein serine/threonine kinase activity => GO:0004674 / MASTL Facilitates Mitotic Progression / : / cleavage furrow / protein phosphatase 2A binding / G2/M transition of mitotic cell cycle / kinase activity / mitotic cell cycle / peptidyl-serine phosphorylation / regulation of cell cycle ...protein serine/threonine kinase activity => GO:0004674 / MASTL Facilitates Mitotic Progression / : / cleavage furrow / protein phosphatase 2A binding / G2/M transition of mitotic cell cycle / kinase activity / mitotic cell cycle / peptidyl-serine phosphorylation / regulation of cell cycle / non-specific serine/threonine protein kinase / intracellular signal transduction / cell division / protein serine kinase activity / protein serine/threonine kinase activity / centrosome / DNA damage response / nucleoplasm / ATP binding / nucleus / cytoplasm類似検索 - 分子機能 Serine/threonine-protein kinase greatwall, catalytic domain / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain ...Serine/threonine-protein kinase greatwall, catalytic domain / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 STAUROSPORINE / Serine/threonine-protein kinase greatwall類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.1 Å |
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データ登録者 | Rajasekaran, M.B. / Pearl, L.H. / Oliver, A.W. |
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資金援助 | 英国, 2件 組織 | 認可番号 | 国 |
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Cancer Research UK | C302/A14532 | 英国 | EU 7th Framework | PIIF-GA-2011-301062 | 英国 |
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引用 | ジャーナル: Oncotarget / 年: 2016 タイトル: A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. 著者: Ocasio, C.A. / Rajasekaran, M.B. / Walker, S. / Le Grand, D. / Spencer, J. / Pearl, F.M. / Ward, S.E. / Savic, V. / Pearl, L.H. / Hochegger, H. / Oliver, A.W. |
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履歴 | 登録 | 2016年8月9日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2016年9月7日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年1月18日 | Group: Database references |
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改定 1.2 | 2024年1月10日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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