Entry | Database: PDB / ID: 5fgz |
---|
Title | E. coli PBP1b in complex with FPI-1465 |
---|
Components | Penicillin-binding protein 1B |
---|
Keywords | HYDROLASE/HYDROLASE INHIBITOR / Penicillin-binding-protein / inhibitor / complex / HYDROLASE-HYDROLASE INHIBITOR complex |
---|
Function / homology | Function and homology information
positive regulation of bipolar cell growth / cell wall repair / peptidoglycan glycosyltransferase / peptidoglycan glycosyltransferase activity / serine-type D-Ala-D-Ala carboxypeptidase / serine-type D-Ala-D-Ala carboxypeptidase activity / penicillin binding / peptidoglycan biosynthetic process / peptidoglycan-based cell wall / regulation of cell shape ...positive regulation of bipolar cell growth / cell wall repair / peptidoglycan glycosyltransferase / peptidoglycan glycosyltransferase activity / serine-type D-Ala-D-Ala carboxypeptidase / serine-type D-Ala-D-Ala carboxypeptidase activity / penicillin binding / peptidoglycan biosynthetic process / peptidoglycan-based cell wall / regulation of cell shape / outer membrane-bounded periplasmic space / response to antibiotic / proteolysis / membrane / plasma membraneSimilarity search - Function Penicillin-binding protein 1B / Bifunctional transglycosylase second domain / Transglycosylase PBP1b, N-terminal transmembrane domain / Transmembrane domain of transglycosylase PBP1 at N-terminal / Bifunctional transglycosylase second domain / Penicillin binding protein transpeptidase fold / Biosynthetic peptidoglycan transglycosylase-like / Glycosyl transferase, family 51 / Penicillin binding protein transglycosylase domain / Transglycosylase ...Penicillin-binding protein 1B / Bifunctional transglycosylase second domain / Transglycosylase PBP1b, N-terminal transmembrane domain / Transmembrane domain of transglycosylase PBP1 at N-terminal / Bifunctional transglycosylase second domain / Penicillin binding protein transpeptidase fold / Biosynthetic peptidoglycan transglycosylase-like / Glycosyl transferase, family 51 / Penicillin binding protein transglycosylase domain / Transglycosylase / Penicillin-binding protein, transpeptidase / Penicillin binding protein transpeptidase domain / Beta-lactamase / DD-peptidase/beta-lactamase superfamily / Beta-lactamase/transpeptidase-like / Lysozyme-like domain superfamily / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology |
---|
Biological species | ![](img/tx_bacteria.gif) Escherichia coli (E. coli) |
---|
Method | X-RAY DIFFRACTION / SYNCHROTRON / Resolution: 2.85 Å |
---|
Authors | King, D.T. / Strynadka, N.C.J. |
---|
Funding support | Canada, United States, 4items Organization | Grant number | Country |
---|
Canadian Institutes of Health Research (CIHR) | | Canada | Canadian Foundation for Innovation | | Canada | Canada Research Chair Programs | | Canada | Howard Hughes Medical Institute (HHMI) | | United States |
|
---|
Citation | Journal: Acs Chem.Biol. / Year: 2016 Title: Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-beta-Lactamases and Penicillin-Binding Proteins. Authors: King, A.M. / King, D.T. / French, S. / Brouillette, E. / Asli, A. / Alexander, J.A. / Vuckovic, M. / Maiti, S.N. / Parr, T.R. / Brown, E.D. / Malouin, F. / Strynadka, N.C. / Wright, G.D. |
---|
History | Deposition | Dec 21, 2015 | Deposition site: RCSB / Processing site: RCSB |
---|
Revision 1.0 | Jan 20, 2016 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | Apr 27, 2016 | Group: Database references |
---|
Revision 1.2 | Sep 20, 2017 | Group: Author supporting evidence / Derived calculations / Category: pdbx_audit_support / pdbx_struct_oper_list Item: _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation |
---|
Revision 1.3 | Nov 20, 2019 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
---|
|
---|