登録情報 | データベース: PDB / ID: 4z8j |
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タイトル | Crystal structure of the SNX27 PDZ domain bound to the C-terminal PTHR PDZ binding motif |
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要素 | - C-terminal PDZ binding motif from parathyroid hormone receptor (PTHR)
- Sorting nexin-27
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キーワード | PROTEIN TRANSPORT / PDZ domain / SNX27 / PTHR |
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機能・相同性 | 機能・相同性情報
postsynaptic early endosome / establishment of protein localization to plasma membrane / positive regulation of AMPA glutamate receptor clustering / neurotransmitter receptor transport to plasma membrane / parathyroid hormone receptor activity / WASH complex / postsynaptic recycling endosome / retromer complex / response to methamphetamine hydrochloride / endosome to plasma membrane protein transport ...postsynaptic early endosome / establishment of protein localization to plasma membrane / positive regulation of AMPA glutamate receptor clustering / neurotransmitter receptor transport to plasma membrane / parathyroid hormone receptor activity / WASH complex / postsynaptic recycling endosome / retromer complex / response to methamphetamine hydrochloride / endosome to plasma membrane protein transport / regulation of synapse maturation / phosphatidylinositol-3-phosphate binding / endocytic recycling / Class B/2 (Secretin family receptors) / G protein-coupled peptide receptor activity / osteoblast development / endosomal transport / positive regulation of inositol phosphate biosynthetic process / endosome to lysosome transport / bone mineralization / peptide hormone binding / immunological synapse / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / chondrocyte differentiation / bone resorption / regulation of postsynaptic membrane neurotransmitter receptor levels / cell maturation / ionotropic glutamate receptor binding / phosphatidylinositol binding / skeletal system development / intracellular protein transport / cellular response to nerve growth factor stimulus / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / Schaffer collateral - CA1 synapse / intracellular calcium ion homeostasis / adenylate cyclase-activating G protein-coupled receptor signaling pathway / calcium-dependent protein binding / nervous system development / early endosome membrane / G alpha (s) signalling events / phospholipase C-activating G protein-coupled receptor signaling pathway / basolateral plasma membrane / in utero embryonic development / early endosome / cell population proliferation / cell surface receptor signaling pathway / receptor complex / postsynapse / endosome / G protein-coupled receptor signaling pathway / apical plasma membrane / negative regulation of cell population proliferation / positive regulation of cell population proliferation / nucleolus / glutamatergic synapse / signal transduction / protein homodimerization activity / nucleus / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 SNX27, atypical FERM-like domain / SNX27, PX domain / SNX27, RA domain / GPCR, family 2, parathyroid hormone receptor / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain profile. / Ras-associating (RA) domain / PhoX homologous domain, present in p47phox and p40phox. / PX domain profile. / PX domain ...SNX27, atypical FERM-like domain / SNX27, PX domain / SNX27, RA domain / GPCR, family 2, parathyroid hormone receptor / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain profile. / Ras-associating (RA) domain / PhoX homologous domain, present in p47phox and p40phox. / PX domain profile. / PX domain / Phox homology / PX domain superfamily / G-protein coupled receptors family 2 signature 1. / : / GPCR, family 2, extracellular hormone receptor domain / G-protein coupled receptors family 2 profile 1. / Domain present in hormone receptors / Hormone receptor domain / GPCR family 2, extracellular hormone receptor domain superfamily / G-protein coupled receptors family 2 signature 2. / GPCR, family 2, secretin-like, conserved site / GPCR, family 2, secretin-like / 7 transmembrane receptor (Secretin family) / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2. / PDZ domain / Pdz3 Domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Ubiquitin-like domain superfamily / Roll / Mainly Beta類似検索 - ドメイン・相同性 Parathyroid hormone/parathyroid hormone-related peptide receptor / Sorting nexin-27類似検索 - 構成要素 |
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生物種 |  Rattus norvegicus (ドブネズミ)
Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 0.95 Å |
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データ登録者 | Clairfeuille, T. / Pavlos, N. / Collins, B.M. |
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引用 | ジャーナル: To Be Published タイトル: Role of SNX27-retromer in PTHR trafficking 著者: Clairfeuille, T. / Teasdale, R.D. / Collins, B.M. / Pavlos, N. |
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履歴 | 登録 | 2015年4月9日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2016年2月24日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年9月27日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / diffrn_source / pdbx_initial_refinement_model / pdbx_prerelease_seq / pdbx_struct_oper_list Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _diffrn_source.pdbx_synchrotron_site / _pdbx_struct_oper_list.symmetry_operation |
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